CN111569468A - Chromatographic column maintenance device - Google Patents
Chromatographic column maintenance device Download PDFInfo
- Publication number
- CN111569468A CN111569468A CN202010539726.8A CN202010539726A CN111569468A CN 111569468 A CN111569468 A CN 111569468A CN 202010539726 A CN202010539726 A CN 202010539726A CN 111569468 A CN111569468 A CN 111569468A
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- China
- Prior art keywords
- column
- connecting plate
- maintenance
- chromatographic column
- supporting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses a chromatographic column maintenance device which comprises a supporting device, a supporting plate, an upper connecting plate, a lifting device, a column casing connecting plate, a stand column bracket, a bottom connecting plate, a cross beam and trundles. The device is provided with a lifting device which can separate the column casing from the piston and the base, and after separation, the column casing is rotated out to carry out maintenance and cleaning work inside the chromatographic column. The whole structure is light and simple, easy to operate, safe to use, easy to disassemble and store and small in space limitation. And the whole structure is made of stainless steel, so that the risk of maintenance and pollution of the chromatographic column is greatly reduced. The design of the rotary column casing does not influence the maintenance space, and simultaneously greatly reduces the difficulty of resetting and installing the chromatographic column after the maintenance is finished.
Description
Technical Field
The invention relates to a chromatographic column maintenance device, in particular to a chromatographic column maintenance device.
Background
The chromatographic technique can separate heat-sensitive or easily inactivated products such as protein, polysaccharide, polypeptide and the like under relatively mild conditions. The chromatographic column is the key to realize chromatographic separation. However, if the diameter of the column is too large, the maintenance or cleaning of the internal components (e.g., valves, seals, screens, distributors, etc.) of the column must be performed by using heavy lifting equipment such as a crane or a hoist to suspend the upper end components (e.g., a top plate, a piston, etc.) from the column casing, and then using heavy overhead lifting equipment to disassemble the column for maintenance or cleaning purposes, which has disadvantages in both disassembly and assembly. One is that sufficient height space is required to accommodate the lifting equipment; secondly, when the chromatographic equipment to be maintained is hoisted overhead, maintenance personnel maintain the chromatographic equipment below, and the personal safety has hidden danger; thirdly, the risk of internal pollution of the chromatographic column is increased by using hoisting equipment; and fourthly, after maintenance and cleaning are finished, the distributor and the column casing must be installed to ensure the coaxiality with the base or other components, otherwise, the precise components of the chromatographic column can be damaged.
Disclosure of Invention
In order to solve the technical problems, the invention provides a chromatographic column maintenance device, which has the following specific technical scheme: a chromatographic column maintenance device comprises a supporting plate 2, an upper connecting plate 3, a lifting device 4, a column casing connecting plate 5, an upright post bracket 6 and a bottom connecting plate 7; wherein the lifting device 4 is fixed on the supporting plate 2, and the supporting plate 2 is fixed on the upright post bracket 6; the upper connecting plate 3 is fixed on the lifting device 4 and is connected with the top plate of the chromatographic column, and the chromatographic column piston and the column cylinder move up and down simultaneously or independently through the lifting device 4; the column casing connecting plate 5 is arranged on the upright post bracket 6 and is connected with the chromatography column casing, so that the chromatography column casing can horizontally move or vertically move by taking the upright post bracket 6 as an axis; the bottom connecting plate 7 is arranged on the upright post bracket 6 and is connected with the chromatography column base; the number of the upright post brackets 6 is more than or equal to 2.
Preferably, the chromatographic column maintenance device further comprises a supporting device 1, when the lifting device 4 is lifted to the maintenance position, the supporting device 1 is arranged to increase the stability of the maintenance device, and the supporting device 1 is detachably connected with the supporting plate 2 and the upper connecting plate 3.
Preferably, the supporting device 1 is a supporting rod.
Preferably, the chromatographic column maintenance device further comprises a cross beam 8 which is detachably connected with the upright post bracket 6.
Preferably, the chromatographic column maintenance device further comprises a caster 9, and the caster 9 is installed on the upright post bracket 6.
Preferably, the lifting device 4 is a hydraulic cylinder, a jack, a screw rod lifter.
Preferably, the number of the upright post brackets 6 is 2.
Preferably, the horizontal movement comprises forward and backward translation, rotation, or a combination of translation and rotation.
The invention has the technical advantages that: the device is provided with a lifting device which can separate the column casing from the piston and the base, and after separation, the column casing is rotated out to carry out maintenance and cleaning work inside the chromatographic column. The whole structure is light and simple, easy to operate, safe to use, easy to disassemble and store and small in space limitation. And the whole structure is made of stainless steel, so that the risk of maintenance and pollution of the chromatographic column is greatly reduced. The design of the rotary column casing does not influence the maintenance space, and simultaneously greatly reduces the difficulty of resetting and installing the chromatographic column after the maintenance is finished.
Drawings
FIG. 1 is a schematic structural diagram of the present invention
FIG. 2 is a left side view of the present invention
FIG. 3 is a schematic view of the process of using the present invention
The specific code numbers in the figure are as follows:
1. supporting device
2. Supporting plate
3. Upper connecting plate
4. Lifting device
5. Column sleeve connecting plate
6. Stand column support
7. Bottom connecting plate
8. Cross beam
9. And a caster.
The above-mentioned solution is further explained with reference to the drawings and the embodiments. The embodiment provides a chromatographic column maintenance device, as shown in fig. 1 and 2, comprising a support device 1, a support plate 2, an upper connecting plate 3, a lifting device 4, a column casing connecting plate 5, a column bracket 6, a bottom connecting plate 7, a cross beam 8 and a caster 9; wherein the lifting device 4 is fixed on the supporting plate 2, and the supporting plate 2 is fixed on the upright post bracket 6; the upper connecting plate 3 is fixed on the lifting device 4 and is connected with the top plate of the chromatographic column, and the chromatographic column piston and the column cylinder can move up and down simultaneously or independently through the lifting device 4; the column casing connecting plate 5 is arranged on the upright post bracket 6 and is connected with the chromatography column casing, so that the chromatography column casing can horizontally move or vertically move by taking the upright post bracket 6 as an axis; the bottom connecting plate 7 is arranged on the upright post bracket 6 and is connected with the chromatography column base; the number of the upright post brackets 6 is 2. The cross beam 8 is detachably connected with the upright post bracket 6; the caster 9 is mounted on the column support 6.
During specific application, as shown in fig. 3, the chromatographic column maintenance device is moved beside a chromatographic column, the upper connecting plate 3 is fixed with the chromatographic column top plate through bolts, the bottom connecting plate 7 is fixed with the chromatographic column base, then the bolts for connecting the column casing with the base are disassembled, the column casing and the base are not in a connection state at the moment, the lifting device 4 is controlled to run upwards, the upper connecting plate 3 is driven to lift the chromatographic column top plate together with the piston and the column casing to a certain height, and the column casing connecting plate 5 and the column casing are fixed through bolts. And (3) detaching the connecting bolt of the top plate and the column casing, keeping the column casing and the top plate in a non-connecting state, continuously moving the top plate and the piston upwards for a certain distance through the lifting device 4, and stopping after the piston and the column casing are separated by a certain gap. The mounting support device 1 ensures the stability of the maintenance device. Finally, the column casing is rotated out, and maintenance or cleaning work of the chromatographic column can be carried out. After maintenance or cleaning, the column casing is rotated back to the original position, the supporting device 1 is disassembled, the lifting device 4 is controlled to lower the top plate and the piston for a certain distance, then the column casing is connected with the top plate through bolts, then the column casing connecting plate 5 is disassembled to be connected with the column casing, the top plate, the piston and the column casing continue to be simultaneously lowered until the column casing returns to the original position, and finally the column casing is connected with the base through bolts. And (3) disassembling the connecting bolt of the upper connecting plate 3 and the chromatographic column top plate, and the connecting bolt of the bottom connecting plate 7 and the chromatographic column base, and removing the maintenance device.
The above embodiments are only for illustrating the technical idea of the present invention, and the protection scope of the present invention is not limited thereby, and any modifications made on the basis of the technical scheme according to the technical idea of the present invention fall within the protection scope of the present invention.
Claims (8)
1. A chromatography column maintenance device, characterized in that: comprises a support plate (2), an upper connecting plate (3), a lifting device (4), a column casing connecting plate (5), a column bracket (6) and a bottom connecting plate (7); wherein the lifting device (4) is fixed on the supporting plate (2), and the supporting plate (2) is fixed on the upright post bracket (6); the upper connecting plate (3) is fixed on the lifting device (4) and is connected with a chromatographic column top plate, and a chromatographic column piston and a column cylinder move up and down simultaneously or independently through the lifting device (4); the column casing connecting plate (5) is arranged on the column bracket (6) and is connected with the chromatographic column casing, so that the chromatographic column casing can horizontally move or vertically move by taking the column bracket (6) as an axis; the bottom connecting plate (7) is arranged on the upright post bracket (6) and is connected with the chromatography column base; the number of the upright post brackets (6) is more than or equal to 2.
2. A chromatography column maintenance device according to claim 1, wherein: the device is characterized by further comprising a supporting device (1), when the lifting device (4) rises to a maintenance position, the supporting device (1) is arranged to increase the stability of the maintenance device, and the supporting device (1) is detachably connected with the supporting plate (2) and the upper connecting plate (3).
3. A chromatography column maintenance device according to claim 2, wherein: the supporting device (1) is a supporting rod.
4. A chromatography column maintenance device according to claim 1 or 2, wherein: the device also comprises a cross beam (8) which is detachably connected with the upright post bracket (6).
5. A chromatography column maintenance device according to claim 1 or 2, wherein: the device also comprises a caster (9), wherein the caster (9) is arranged on the upright post bracket (6).
6. A chromatography column maintenance device according to claim 1 or 2, wherein: the lifting device (4) is a hydraulic oil cylinder, a jack and a screw rod lifter.
7. A chromatography column maintenance device according to claim 1 or 2, wherein: the number of the upright post brackets (6) is 2.
8. A chromatography column maintenance device according to claim 1 or 2, wherein: the horizontal movement comprises forward and backward translation, rotation, or a combination of translation and rotation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010539726.8A CN111569468A (en) | 2020-06-15 | 2020-06-15 | Chromatographic column maintenance device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010539726.8A CN111569468A (en) | 2020-06-15 | 2020-06-15 | Chromatographic column maintenance device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111569468A true CN111569468A (en) | 2020-08-25 |
Family
ID=72116197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010539726.8A Pending CN111569468A (en) | 2020-06-15 | 2020-06-15 | Chromatographic column maintenance device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111569468A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114768302A (en) * | 2022-06-14 | 2022-07-22 | 山东惠民中联生物科技有限公司 | Chromatography device in preparation process of paste bird repellent |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505909A (en) * | 2012-06-21 | 2014-01-15 | 通用电气健康护理生物科学股份公司 | Chromatographic column framework as well as method for maintaining and filling chromatographic column |
| WO2016023395A1 (en) * | 2013-12-17 | 2016-02-18 | 源创精科生物科技(长沙)有限公司 | Fully-automatic chromatographic column |
| CN106413832A (en) * | 2014-04-12 | 2017-02-15 | 通用电气健康护理生物科学股份公司 | Hoisting and holding system for chromatography column |
| CN209596609U (en) * | 2019-01-25 | 2019-11-08 | 荣捷生物工程（苏州）有限公司 | A kind of chromatographic column column cap maintenance mechanism |
| CN212594126U (en) * | 2020-06-15 | 2021-02-26 | 江苏汉邦科技有限公司 | Chromatographic column maintenance device |
-
2020
- 2020-06-15 CN CN202010539726.8A patent/CN111569468A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505909A (en) * | 2012-06-21 | 2014-01-15 | 通用电气健康护理生物科学股份公司 | Chromatographic column framework as well as method for maintaining and filling chromatographic column |
| WO2016023395A1 (en) * | 2013-12-17 | 2016-02-18 | 源创精科生物科技(长沙)有限公司 | Fully-automatic chromatographic column |
| CN106413832A (en) * | 2014-04-12 | 2017-02-15 | 通用电气健康护理生物科学股份公司 | Hoisting and holding system for chromatography column |
| CN209596609U (en) * | 2019-01-25 | 2019-11-08 | 荣捷生物工程（苏州）有限公司 | A kind of chromatographic column column cap maintenance mechanism |
| CN212594126U (en) * | 2020-06-15 | 2021-02-26 | 江苏汉邦科技有限公司 | Chromatographic column maintenance device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114768302A (en) * | 2022-06-14 | 2022-07-22 | 山东惠民中联生物科技有限公司 | Chromatography device in preparation process of paste bird repellent |
| CN114768302B (en) * | 2022-06-14 | 2022-09-16 | 山东惠民中联生物科技有限公司 | Chromatography device in preparation process of paste bird repellent |
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Address after: 223005 no.1-9 Jixian Road, Huaian Economic and Technological Development Zone, Jiangsu Province Applicant after: Jiangsu Hanbang Technology Co.,Ltd. Address before: 223005 no.1-9 Jixian Road, Huaian Economic and Technological Development Zone, Jiangsu Province Applicant before: JIANGSU HANBON SCIENCE & TECHNOLOGY Co.,Ltd. |