CN111567797A - 复方茉莉花茶咀嚼片及其制备方法 - Google Patents
复方茉莉花茶咀嚼片及其制备方法 Download PDFInfo
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- CN111567797A CN111567797A CN202010467405.1A CN202010467405A CN111567797A CN 111567797 A CN111567797 A CN 111567797A CN 202010467405 A CN202010467405 A CN 202010467405A CN 111567797 A CN111567797 A CN 111567797A
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- jasmine
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- jasmine tea
- extract
- rhizoma polygonati
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Abstract
本发明公开了一种复方茉莉花茶咀嚼片及其制备方法,该复方茉莉花茶咀嚼片由以下重量份数原料制备而成:茉莉花茶20‑40份、茉莉花提取物15‑25份、黄精提取物5‑15份、铁皮石斛10‑20份、大豆磷脂5‑15份、赋型剂10‑30份、硬脂酸镁0.5‑2份、调味剂5‑10份。本发明的复方茉莉花茶咀嚼片可直接口嚼便于消化吸收,口感好风味佳,可以给人体提供多种营养成分、药用活性成分,同时具有理气安神、降血压血脂、保健心脑血管、抗衰老抗氧化、提高免疫力和记忆力的功效。而且本发明的复方茉莉花茶咀嚼片的制备方法简单,可进行工业化生产;采用本发明的方法制备复方茉莉花茶咀嚼片开发了茉莉花及茉莉花茶的新用途,经济效益好。
Description
技术领域
本发明属于保健食品技术领域,涉及一种复方茉莉花茶咀嚼片及其制备方法。
背景技术
茉莉花,别名:茉莉,拉丁文名:Jasminum sambac (L.) Ait,茉莉的花极香,为著名的花茶原料及重要的香精原料。茉莉花可提取茉莉花油,油中主要成分为苯甲醇及其酯类、茉莉花素、芳樟醇、安息香酸芳樟醇酯。茉莉花性寒,有清肝明目、通便利水、降低血压、理气安神之功效。现代医学研究表明,茉莉花所含成分具有很多药理作用:镇静、抗菌、抗氧化、改善糖尿病、防治抑郁、缓解胃肠道不适、护理口腔、保健心脑血管、提高免疫力等。茉莉花茶是将茶叶和茉莉鲜花进行拼和、窨制,使茶叶吸收花香而成的茶叶;其香气鲜灵持久、滋味醇厚鲜爽、汤色黄绿明亮、叶底嫩匀柔软。经过一系列工艺流程窨制而成的茉莉花茶,具有安神、解抑郁、健脾理气、抗衰老、提高机体免疫力的功效,是一种健康饮品。
咀嚼片是指于口腔中咀嚼后吞服的片剂,因口感良好、服用方便而易于被患者接受。咀嚼片作为一种药物剂型具有其他剂型药物所无可比拟的优点:崩解时间较短、分散状态较好、药物溶出迅速;吸收速度快、生物利用度高、服用很方便,不受时间地点的限制,可以咀嚼,也可以吞服,同样可以含吮或用水分散后服用,进一步减少了药物对胃肠道的刺激。此种剂型特别适合老人、小儿以及吞咽困难的患者服用。另外,有些苦味的片剂为了掩盖其苦味进行包衣,导致成品率低,而将其制成咀嚼片之后可以省去包衣的过程,缩短生产周期,进而提高成品率。
专利申请CN109793066A针对市场上绿茶金银花咀嚼片的产品空白,采用真空冷冻干燥法加工绿茶粉和金银花粉,然后添加微晶纤维素、甘露醇、硬酯酸镁、***胶、安赛蜜、阿斯巴甜等制成一味绿茶咀嚼片,有效保留了绿茶的茶多酚、咖啡碱、维生素和金银花抗炎消肿等成分,具有口腔杀菌、消炎、健齿和清新口气的功效。专利申请CN105767297A公开了一种玫瑰花茶咀嚼片及制备方法,以当年出产经热风干燥的玫瑰花、茶叶为主要原料,按如下重量百分比制成:玫瑰花粉25-45%、茶叶粉25-45%、环糊精5-10%、淀粉5-15%、蔗糖 1-3%、柠檬酸钠0.2-1.5%、苹果酸0.2-1.5%、硬脂酸镁1-3%,所得到咀嚼片较好保留玫瑰花和茶叶特有的香味,入口清凉,使用方便;咀嚼片压片紧密均匀,外观整齐,表面光洁;本发明原料易得、工艺简单,易于生产。专利申请CN102106497A公开了一种复方组合型油菜花粉咀嚼片的制备方法:先将油菜花粉15-60份用粉碎机粉碎后过80-200目筛,分别将大豆磷脂5-20份、当归提取物1-10份、蜂王浆冻干粉0.1-5份、茶多酚0.01-2份、维生素0.1-5份粉碎后过40-60目筛;赋型剂绵白糖和微晶纤维素3-40份粉碎过100目筛;再将粉碎后的原料及赋型剂绵白糖和微晶纤维素与调味剂绵白糖0.1-20份混合,制成软材,制粒,35-65℃烘干,再经整粒后制成颗粒,与润滑剂硬脂酸镁0.1-10份混合,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。制得的复方组合型油菜花粉咀嚼片综合油菜花粉、大豆磷脂、蜂王浆冻干粉、当归等之优点,采用现代食品加工技术制备而成,不仅滋味、口感良好,易于保存,携带和服用方便,富含多种营养物质,而且具有抗氧化、抗衰老、益肠胃、美容养颜、消除大脑疲劳、增强智商、提高人体记忆力等功能。本发明既保留了油菜花粉的营养价值,又凸显了大豆磷脂、蜂王浆冻干粉的多项生理调节功能,从而起到强大的显著的协同作用,故大大的增加了其整体的功效。
广西壮族自治区南宁市横县是全球茉莉花生产中心,茉莉花的产量和质量都居全中国之首。以前茉莉花一般被用来做成香包和枕头、窨制茶叶、制成饮料、提取茉莉花精油等,其中主要还是用来生产茉莉花茶,随着时代变革,茉莉花产量和成本的不断增加,以及市场竞争的加剧,深加工成高附加值的产品是茉莉花及茉莉花茶行业以后发展的必由之路。现已有少量人和企业对茉莉花和茉莉花茶的有效成分进行现代化提取纯化,再进一步加工成食品、药品、化妆品和保健品等附加值更高的产品了,但是至今还未有关于茉莉花茶咀嚼片的报道。
发明内容
本发明的目的是提供一种复方茉莉花茶咀嚼片及其制备方法,该复方茉莉花茶咀嚼片可直接口嚼便于消化吸收,口感好风味佳,可以给人体提供多种营养成分、药用活性成分,同时具有理气安神、降血压血脂、保健心脑血管、抗衰老抗氧化、提高免疫力和记忆力的功效。而且该复方茉莉花茶咀嚼片的制备方法简单,可进行工业化生产;采用本发明的方法制备复方茉莉花茶咀嚼片开发了茉莉花及茉莉花茶的新用途,经济效益好。
本发明的技术方案如下:
一种复方茉莉花茶咀嚼片,由以下重量份数原料制备而成:茉莉花茶20-40份、茉莉花提取物15-25份、黄精提取物5-15份、铁皮石斛10-20份、大豆磷脂5-15份、赋型剂10-30份、硬脂酸镁0.5-2份、调味剂5-10份。
所述茉莉花茶优选由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶。
所述赋型剂是绵白糖和微晶纤维素的混合物,绵白糖和微晶纤维素的重量比为1:2-3。
所述调味剂选自低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种。
所述复方茉莉花茶咀嚼片的制备方法,包括以下步骤:
(1)先将茉莉花茶用粉碎机粉碎后过100-200目筛;铁皮石斛鲜品去叶洗净,切成2-4cm长的小段后晾干,用超微粉碎机粉碎后过500目筛,备用。
(2)分别将茉莉花提取物、黄精提取物、大豆磷脂粉碎后过40-60目筛,赋型剂粉碎后过100目筛,备用。
(3)取以上粉碎后过筛的原料按重量份数与调味剂混合均匀,制成软材。
(4)将制得的软材挤压过20目筛,使其分散成均匀、细粉较少的湿颗粒,40-50℃烘干至物料含水量为3%以下,再经整粒后制成大小均匀一致的颗粒,然后过20目筛,与硬脂酸镁混合均匀,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。
所述茉莉花提取物是采用CO2超临界萃取装置经以下步骤提取得到的茉莉花头香提取物:
(1)选取当日采摘的鲜茉莉花,以去离子水浸泡洗涤,浸泡洗涤时间为10-30min;
(2)将洗涤过的鲜茉莉花装入萃取釜中;
(3)调节萃取釜的温度为308-318K、压强为12-15MPa,调节分离釜的温度为308-318K;开启CO2超临界提取装置的CO2气瓶,并加压;
(4)当加压到茉莉花与CO2形成混合流体后,静置30-90min;
(5)调节CO2流速为1-4L/h,开始动态萃取;60-120min后,萃取结束,开启装置出料即得茉莉花头香提取物。
所述黄精提取物的制备方法,包括以下步骤:
(1)干黄精片经粉碎后过40目筛得到黄精粉末,将黄精粉末放入超高压设备中,加入15-20倍重量水,在压力为245-265MPa条件下保压8-11min;然后进行固液分离,得到黄***提取液。
(2)取步骤(1)的滤渣加入体积浓度为65-75%的乙醇溶液,滤渣与乙醇溶液的料液比为1:12-18,置于50-60℃水浴中超声提取10-20min,进行固液分离得到黄精乙醇提取液。
(3)将以上黄***提取液和黄精乙醇提取液合并后在45-50℃下减压浓缩至干,即得黄精提取物。
关于本发明所用部分原料的介绍如下:
黄精(polygonatum)是百合科(Liliaceaea) 黄精属(Polygonatum) 多年生草本植物滇黄精(Polygonatum kingianum Coll.et Hemsl)、黄精(Polygonatum sibiricum Red.)或多花黄精(Polygonatumcyrtonema Hua)的干燥根茎,现代研究表明:黄精主要含有多糖、甾体皂苷类、蒽醌类、生物碱和氨基酸等多种功能性成分,具有抗氧化、抗炎、降血脂、防动脉硬化、降血糖、提高和改善记忆、抗肿瘤、调节免疫和抗病毒等作用。多糖是黄精的主要活性成分之一。现代医学研究表明:黄精多糖具有降血糖、抑制骨质疏松、延长动物寿命、抗衰老作用,具有抗炎、抗病毒作用,对化学性肝损伤具有保护作用;黄精多糖可以通过改善脑功能来达到延缓衰老、增强大脑的学习记忆功能的目。黄精及其提取物可以通过抗凋亡、抗氧化自由基、调节神经递质的多寡进行调控与保护,从而改善神经血管单元。
铁皮石斛(学名:Dendrobium officinale Kimura et Migo)为兰科石斛属多年生附生草本植物,因表皮呈铁绿色而得名,具有独特的药用价值,被列为“中国九大仙草之首”,与灵芝、人参、冬虫夏草等被列为上品中药,是传统名贵中草药,素有“药中黄金”、“中华仙草”等美誉。铁皮石斛其茎入药,属补益药中的补阴药,具有益胃生津、滋阴清热、增强机体免疫力、抗疲劳、促进胃液分泌助消化、护肝利胆、降血糖、抗肿瘤等功效。
大豆磷脂是从生产大豆油的油脚中提取的产物,是由甘油、脂肪酸、胆碱或胆胺所组成的酯。大豆磷脂除含有有机磷、胆碱、肌醇等多种活性物质外,还含有人体所需的必需脂肪酸,而且不含胆固醇,是人体新陈代谢和健康生存的保证。大豆磷脂具有抗氧化、抗衰老、降血脂、促进血液循环、美容养颜、消除大脑疲劳、提高记忆力等功能。
本发明的有益效果如下:
在本发明的茉莉花茶咀嚼片中,含有茉莉花茶、茉莉花提取物、黄精提取物、铁皮石斛、大豆磷脂多种活性成分。茉莉花茶是由茉莉花和茶叶经窨制后得到的一种绿茶,优选由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶,横县的茉莉花香气浓郁,得到的茉莉花茶质量好、香气鲜灵持久,因为茉莉花茶是直接以微粉入药,选用嫩茶叶口感好,更易被人们所接受。茉莉花茶以微粉入药,茶叶中所含的活性成分及营养成分茶多酚、茶多糖、咖啡碱、维生素等能很好地保留下来。茶叶中的茶多酚是一种天然抗氧化剂,具有抑制病毒活性、抗菌、抗诱变、治疗神经退行性疾病以及抗癌等作用,而且具有捕集机体内游离基、抗衰老、抗辐射、减肥、降血脂以及防癌等多方面的功效。此外,其对于免疫***的疾病,特别是对艾滋病,也有良好的预防和治疗功效。现代医学研究表明,茶多糖是茶叶治疗糖尿病时的主要药理成分之一,茶多糖主要由葡萄糖、***糖、木糖、岩藻糖、核糖、半乳糖等组成。茶多糖通过降血糖、降血脂,从而达到防治糖尿病的作用;同时在抗凝、防血栓形成,保护血相和增强人体非特异性免疫能力等方面均有明显效果。
现代医学研究表明,茉莉花所含成分具有很多药理作用:镇静、抗菌、抗氧化、改善糖尿病、防治抑郁、缓解胃肠道不适、护理口腔、保健心脑血管、提高免疫力等。茉莉花茶综合了茶叶与茉莉花的功效,在本发明中还额外加入了茉莉花提取物,增强了咀嚼片的茉莉花香气并融入茉莉花精油的风味,使咀嚼片从内到外散发出浓郁的茉莉花香且口感甘甜醇香。本发明的茉莉花提取物是采用CO2超临界萃取装置萃取得到茉莉花头香提取物,采用CO2超临界萃取方法对茉莉花进行萃取,茉莉花提取物得率高达0.38%以上,且得到的茉莉花提取物中茉莉花精油纯度高,香气浓郁。
现代医学研究表明,茶多糖、铁皮石斛和黄精都能够抑制α-葡萄糖苷酶活性,通过三种药物组合,药物之间可以起到协同作用,发挥更好的降糖效果。黄精提取物、铁皮石斛均具有降血糖、抗肿瘤作用,在茉莉花茶咀嚼片中加入黄精提取物和铁皮石斛粉,可以有效增强茶叶的降血糖效果。黄精经过粉碎后在超高压条件下进行水提,得到黄***提取液,黄***提取液中黄精多糖的提取率达20-25%,将经超高压水提后的滤渣用65-75%的乙醇溶液进行超声提取,得到黄精乙醇提取液,黄精乙醇提取液中含有黄酮类和甾体皂苷类成分,将黄***提取液和黄精乙醇提取液合并后浓缩至干,得到的黄精提取物中活性成分黄精多糖、黄酮类和甾体皂苷类成分含量高,药效强。人体内有益菌群主要有乳酸菌和双歧杆菌,500目以上的铁皮石斛超微粉可以促进乳杆菌和双歧杆菌的增殖,将铁皮石斛过500目筛后作为咀嚼片的原料,有利于促进肠道有益菌的增殖。
大豆磷脂具有抗氧化、抗衰老、降血脂的作用,在茉莉花茶咀嚼片中加入大豆磷脂,可以增强茶多酚的抗氧化、抗衰老、降血脂作用。在本发明的咀嚼片中茉莉花茶、茉莉花提取物、黄精提取物、铁皮石斛、大豆磷脂在降血糖、降血脂、抗肿瘤、抗氧化、抗衰老、怡神解乏、美容养颜、提高记忆力等方面起到协同作用,具有极佳的保健效果。
在调味剂选择时,选择低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种,糖分低不影响整体的降糖效果。低聚果糖或低聚异麦芽糖可促使人体内的有益细菌-双歧杆菌显著增殖,具有水溶性膳食纤维的功效,可防龋齿,是被广泛应用的功能性低聚糖,也是养肠保健的产品;由于不含葡萄糖,亦是糖尿病人食品中常用的甜味剂。木糖醇在体内新陈代谢不需要胰岛素参与,又不使血糖值升高,并可消除糖尿病人三多(多饮、多尿、多食),因此是糖尿病人安全的甜味剂、营养补充剂和辅助治疗剂。蜂蜜能改善血液的成分,促进心脑和血管功能;对肝脏有保护作用,能促使肝细胞再生,对脂肪肝的形成有一定的抑制作用;并且具有杀菌、促进肠胃蠕动、消除疲劳、增强抵抗力的作用。
在本发明的咀嚼片制备过程中,先将茉莉花提取物、黄精提取物提取准备好,然后将各原料成分经粉碎至合适的尺寸后混合均匀制成软材,再经制粒、整粒,最后与润滑剂混合均匀压片即得,制备方法简单,可进行工业化生产。采用本发明的方法制备复方茉莉花茶咀嚼片开发了茉莉花及茉莉花茶的新用途,经济效益好。
具体实施方式
为了更加详细的介绍本发明,下面结合实施例,对本发明做进一步说明。
实施例1
一种复方茉莉花茶咀嚼片,由以下重量份数原料制备而成:茉莉花茶20份、茉莉花提取物15份、黄精提取物5份、铁皮石斛10份、大豆磷脂5份、赋型剂10份、硬脂酸镁0.5份、调味剂5份。
所述茉莉花茶选用由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶。
所述赋型剂是绵白糖和微晶纤维素的混合物,绵白糖和微晶纤维素的重量比为1:3。
所述调味剂选自低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种。
所述复方茉莉花茶咀嚼片的制备方法,包括以下步骤:
(1)先将茉莉花茶用粉碎机粉碎后过100目筛;铁皮石斛鲜品去叶洗净,切成2-4cm长的小段后晾干,用超微粉碎机粉碎后过500目筛,备用。
(2)分别将茉莉花提取物、黄精提取物、大豆磷脂粉碎后过40目筛,赋型剂粉碎后过100目筛,备用。
(3)取以上粉碎后过筛的原料按重量份数与调味剂混合均匀,制成“手握成团,轻压即散”状态的软材。
(4)将制得的软材挤压过20目筛,使其分散成均匀、细粉较少的湿颗粒,40-50℃烘干至物料含水量为3%以下,再经整粒后制成大小均匀一致的颗粒,然后过20目筛,与硬脂酸镁混合均匀,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。
所述茉莉花提取物是采用CO2超临界萃取装置经以下步骤提取得到的茉莉花头香提取物:
(1)选取当日采摘的鲜茉莉花,以去离子水浸泡洗涤,浸泡洗涤时间为10min;
(2)将洗涤过的鲜茉莉花装入萃取釜中;
(3)调节萃取釜的温度为308-318K、压强为12-15MPa,调节分离釜的温度为308-318K;开启CO2超临界提取装置的CO2气瓶,并加压;
(4)当加压到茉莉花与CO2形成混合流体后,静置30min;
(5)调节CO2流速为4L/h,开始动态萃取;60min后,萃取结束,开启装置出料即得茉莉花头香提取物。
所述黄精提取物的制备方法,包括以下步骤:
(1)干黄精片经粉碎后过40目筛得到黄精粉末,将黄精粉末放入超高压设备中,加入15倍重量水,在压力为245-265MPa条件下保压8min;然后进行固液分离,得到黄***提取液。
(2)取步骤(1)的滤渣加入体积浓度为75%的乙醇溶液,滤渣与乙醇溶液的料液比为1:12,置于50-60℃水浴中超声提取10min,进行固液分离得到黄精乙醇提取液。
(3)将以上黄***提取液和黄精乙醇提取液合并后在45-50℃下减压浓缩至干,即得黄精提取物。
实施例2
一种复方茉莉花茶咀嚼片,由以下重量份数原料制备而成:茉莉花茶30份、茉莉花提取物20份、黄精提取物10份、铁皮石斛15份、大豆磷脂10份、赋型剂20份、硬脂酸镁1.2份、调味剂8份。
所述茉莉花茶选用由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶。
所述赋型剂是绵白糖和微晶纤维素的混合物,绵白糖和微晶纤维素的重量比为1:3。
所述调味剂选自低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种。
所述复方茉莉花茶咀嚼片的制备方法,包括以下步骤:
(1)先将茉莉花茶用粉碎机粉碎后过150目筛;铁皮石斛鲜品去叶洗净,切成2-4cm长的小段后晾干,用超微粉碎机粉碎后过500目筛,备用。
(2)分别将茉莉花提取物、黄精提取物、大豆磷脂粉碎后过50目筛,赋型剂粉碎后过100目筛,备用。
(3)取以上粉碎后过筛的原料按重量份数与调味剂混合均匀,制成“手握成团,轻压即散”状态的软材。
(4)将制得的软材挤压过20目筛,使其分散成均匀、细粉较少的湿颗粒,40-50℃烘干至物料含水量为3%以下,再经整粒后制成大小均匀一致的颗粒,然后过20目筛,与硬脂酸镁混合均匀,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。
所述茉莉花提取物是采用CO2超临界萃取装置经以下步骤提取得到的茉莉花头香提取物:
(1)选取当日采摘的鲜茉莉花,以去离子水浸泡洗涤,浸泡洗涤时间为20min;
(2)将洗涤过的鲜茉莉花装入萃取釜中;
(3)调节萃取釜的温度为308-318K、压强为12-15MPa,调节分离釜的温度为308-318K;开启CO2超临界提取装置的CO2气瓶,并加压;
(4)当加压到茉莉花与CO2形成混合流体后,静置60min;
(5)调节CO2流速为3L/h,开始动态萃取;90min后,萃取结束,开启装置出料即得茉莉花头香提取物。
所述黄精提取物的制备方法,包括以下步骤:
(1)干黄精片经粉碎后过40目筛得到黄精粉末,将黄精粉末放入超高压设备中,加入18倍重量水,在压力为245-265MPa条件下保压10min;然后进行固液分离,得到黄***提取液。
(2)取步骤(1)的滤渣加入体积浓度为70%的乙醇溶液,滤渣与乙醇溶液的料液比为1:15,置于50-60℃水浴中超声提取15min,进行固液分离得到黄精乙醇提取液。
(3)将以上黄***提取液和黄精乙醇提取液合并后在45-50℃下减压浓缩至干,即得黄精提取物。
实施例3
一种复方茉莉花茶咀嚼片,由以下重量份数原料制备而成:茉莉花茶40份、茉莉花提取物25份、黄精提取物15份、铁皮石斛20份、大豆磷脂15份、赋型剂30份、硬脂酸镁2份、调味剂10份。
所述茉莉花茶选用由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶。
所述赋型剂是绵白糖和微晶纤维素的混合物,绵白糖和微晶纤维素的重量比为1:2。
所述调味剂选自低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种。
所述复方茉莉花茶咀嚼片的制备方法,包括以下步骤:
(1)先将茉莉花茶用粉碎机粉碎后过200目筛;铁皮石斛鲜品去叶洗净,切成2-4cm长的小段后晾干,用超微粉碎机粉碎后过500目筛,备用。
(2)分别将茉莉花提取物、黄精提取物、大豆磷脂粉碎后过60目筛,赋型剂粉碎后过100目筛,备用。
(3)取以上粉碎后过筛的原料按重量份数与调味剂混合均匀,制成“手握成团,轻压即散”状态的软材。
(4)将制得的软材挤压过20目筛,使其分散成均匀、细粉较少的湿颗粒,40-50℃烘干至物料含水量为3%以下,再经整粒后制成大小均匀一致的颗粒,然后过20目筛,与硬脂酸镁混合均匀,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。
所述茉莉花提取物是采用CO2超临界萃取装置经以下步骤提取得到的茉莉花头香提取物:
(1)选取当日采摘的鲜茉莉花,以去离子水浸泡洗涤,浸泡洗涤时间为30min;
(2)将洗涤过的鲜茉莉花装入萃取釜中;
(3)调节萃取釜的温度为308-318K、压强为12-15MPa,调节分离釜的温度为308-318K;开启CO2超临界提取装置的CO2气瓶,并加压;
(4)当加压到茉莉花与CO2形成混合流体后,静置90min;
(5)调节CO2流速为1L/h,开始动态萃取;120min后,萃取结束,开启装置出料即得茉莉花头香提取物。
所述黄精提取物的制备方法,包括以下步骤:
(1)干黄精片经粉碎后过40目筛得到黄精粉末,将黄精粉末放入超高压设备中,加入20倍重量水,在压力为245-265MPa条件下保压11min;然后进行固液分离,得到黄***提取液。
(2)取步骤(1)的滤渣加入体积浓度为65%的乙醇溶液,滤渣与乙醇溶液的料液比为1:18,置于50-60℃水浴中超声提取20min,进行固液分离得到黄精乙醇提取液。
(3)将以上黄***提取液和黄精乙醇提取液合并后在45-50℃下减压浓缩至干,即得黄精提取物。
Claims (7)
1.一种复方茉莉花茶咀嚼片,其特征在于,所述复方茉莉花茶咀嚼片由以下重量份数原料制备而成:茉莉花茶20-40份、茉莉花提取物15-25份、黄精提取物5-15份、铁皮石斛10-20份、大豆磷脂5-15份、赋型剂10-30份、硬脂酸镁0.5-2份、调味剂5-10份。
2.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述茉莉花茶是由广西南宁市横县产的茉莉花窨制的一芽一叶或一芽二叶嫩茶叶。
3.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述赋型剂是绵白糖和微晶纤维素的混合物,绵白糖和微晶纤维素的重量比为1:2-3。
4.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述调味剂选自低聚果糖、低聚异麦芽糖、木糖醇、蜂蜜中一种或者多种。
5.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述茉莉花提取物是采用CO2超临界萃取装置提取得到的茉莉花头香提取物,具体提取步骤如下:
(1)选取当日采摘的鲜茉莉花,以去离子水浸泡洗涤,浸泡洗涤时间为10-30min;
(2)将洗涤过的鲜茉莉花装入萃取釜中;
(3)调节萃取釜的温度为308-318K、压强为12-15MPa,调节分离釜的温度为308-318K;开启CO2超临界提取装置的CO2气瓶,并加压;
(4)当加压到茉莉花与CO2形成混合流体后,静置30-90min;
(5)调节CO2流速为1-4L/h,开始动态萃取;60-120min后,萃取结束,开启装置出料即得茉莉花头香提取物。
6.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述黄精提取物的制备方法,包括以下步骤:
(1)干黄精片经粉碎后过40目筛得到黄精粉末,将黄精粉末放入超高压设备中,加入15-20倍重量水,在压力为245-265MPa条件下保压8-11min;然后进行固液分离,得到黄***提取液;
(2)取步骤(1)的滤渣加入体积浓度为65-75%的乙醇溶液,滤渣与乙醇溶液的料液比为1:12-18,置于50-60℃水浴中超声提取10-20min,进行固液分离得到黄精乙醇提取液;
(3)将以上黄***提取液和黄精乙醇提取液合并后在45-50℃下减压浓缩至干,即得黄精提取物。
7.根据权利要求1所述复方茉莉花茶咀嚼片,其特征在于,所述复方茉莉花茶咀嚼片的制备方法,包括以下步骤:
(1)先将茉莉花茶用粉碎机粉碎后过100-200目筛;铁皮石斛鲜品去叶洗净,切成2-4cm长的小段后晾干,用超微粉碎机粉碎后过500目筛,备用;
(2)分别将茉莉花提取物、黄精提取物、大豆磷脂粉碎后过40-60目筛,赋型剂粉碎后过100目筛,备用;
(3)取以上粉碎后过筛的原料按重量份数与调味剂混合均匀,制成软材;
(4)将制得的软材挤压过20目筛,使其分散成均匀、细粉较少的湿颗粒,40-50℃烘干至物料含水量为3%以下,再经整粒后制成大小均匀一致的颗粒,然后过20目筛,与硬脂酸镁混合均匀,经压片机压片制得各种不同型式的片剂,采用防潮包装即得。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113712201A (zh) * | 2021-08-16 | 2021-11-30 | 深圳市萱嘉生物科技有限公司 | 一种药食同源组合物的制备方法和应用 |
CN114680328A (zh) * | 2022-03-30 | 2022-07-01 | 贵州斛多福食品有限公司 | 一种添加铁皮石斛的黄精咀嚼丸的制作方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102106497A (zh) * | 2010-12-29 | 2011-06-29 | 九三粮油工业集团有限公司 | 一种复方组合型油菜花粉咀嚼片及其制备方法 |
CN103463458A (zh) * | 2013-09-26 | 2013-12-25 | 张娥珍 | 铁皮石斛复配咀嚼片及其制备方法 |
CN104522467A (zh) * | 2014-12-22 | 2015-04-22 | 南京师范大学 | 一种黄精多糖咀嚼片及其制备方法 |
CN105614426A (zh) * | 2014-10-27 | 2016-06-01 | 卢雨萍 | 一种茉莉花咀嚼片及其制作方法 |
CN106318637A (zh) * | 2016-08-28 | 2017-01-11 | 广西灏源盛世生物科技有限公司 | 一种茉莉花精油的提取方法 |
CN106615549A (zh) * | 2016-11-17 | 2017-05-10 | 安徽省旌德博仕达农业科技有限公司 | 一种人参黄精含片及其制备方法 |
CN109730314A (zh) * | 2019-03-04 | 2019-05-10 | 宁波易中禾药用植物研究院有限公司 | 一种石斛复合咀嚼片的加工方法 |
-
2020
- 2020-05-28 CN CN202010467405.1A patent/CN111567797A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102106497A (zh) * | 2010-12-29 | 2011-06-29 | 九三粮油工业集团有限公司 | 一种复方组合型油菜花粉咀嚼片及其制备方法 |
CN103463458A (zh) * | 2013-09-26 | 2013-12-25 | 张娥珍 | 铁皮石斛复配咀嚼片及其制备方法 |
CN105614426A (zh) * | 2014-10-27 | 2016-06-01 | 卢雨萍 | 一种茉莉花咀嚼片及其制作方法 |
CN104522467A (zh) * | 2014-12-22 | 2015-04-22 | 南京师范大学 | 一种黄精多糖咀嚼片及其制备方法 |
CN106318637A (zh) * | 2016-08-28 | 2017-01-11 | 广西灏源盛世生物科技有限公司 | 一种茉莉花精油的提取方法 |
CN106615549A (zh) * | 2016-11-17 | 2017-05-10 | 安徽省旌德博仕达农业科技有限公司 | 一种人参黄精含片及其制备方法 |
CN109730314A (zh) * | 2019-03-04 | 2019-05-10 | 宁波易中禾药用植物研究院有限公司 | 一种石斛复合咀嚼片的加工方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113712201A (zh) * | 2021-08-16 | 2021-11-30 | 深圳市萱嘉生物科技有限公司 | 一种药食同源组合物的制备方法和应用 |
CN114680328A (zh) * | 2022-03-30 | 2022-07-01 | 贵州斛多福食品有限公司 | 一种添加铁皮石斛的黄精咀嚼丸的制作方法 |
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