CN111505040A - Special animal coil of liver ECS experiment - Google Patents
Special animal coil of liver ECS experiment Download PDFInfo
- Publication number
- CN111505040A CN111505040A CN202010406625.3A CN202010406625A CN111505040A CN 111505040 A CN111505040 A CN 111505040A CN 202010406625 A CN202010406625 A CN 202010406625A CN 111505040 A CN111505040 A CN 111505040A
- Authority
- CN
- China
- Prior art keywords
- framework
- coil
- constant
- upper framework
- shell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 65
- 238000002474 experimental method Methods 0.000 title claims abstract description 35
- 210000004185 liver Anatomy 0.000 title claims abstract description 31
- 239000000700 radioactive tracer Substances 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims description 31
- 239000000523 sample Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 18
- 238000000429 assembly Methods 0.000 claims description 7
- 230000000712 assembly Effects 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 7
- 238000005192 partition Methods 0.000 claims description 6
- 210000005239 tubule Anatomy 0.000 claims description 6
- 239000013307 optical fiber Substances 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 3
- 238000005259 measurement Methods 0.000 abstract description 11
- 238000003384 imaging method Methods 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 9
- 238000012544 monitoring process Methods 0.000 abstract description 6
- 238000004458 analytical method Methods 0.000 abstract description 4
- 239000012488 sample solution Substances 0.000 abstract description 4
- 238000002595 magnetic resonance imaging Methods 0.000 description 9
- 238000013461 design Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000003068 molecular probe Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
Landscapes
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a special animal coil for liver ECS experiments, which comprises an upper framework and a lower framework, wherein the upper framework is detachably connected with the lower framework; the upper framework and the lower framework form a cylindrical structure; antenna units are arranged in the upper framework and the lower framework; the antenna unit positioned in the upper framework and the antenna unit positioned in the lower framework form a radio frequency coil; a calibration mould is also arranged on the lower framework; the scaling die is positioned on one side of the lower framework, which is close to the upper framework; a channel for placing animals is formed between the scaling mould and the inner wall of the upper framework; the upper framework is an arc-shaped plate. The calibration mould and the animal coil are designed together, so that the synchronization of the measurement process and the animal scanning can be realized, the tracer sample solution and the imaging of a tested object can be simultaneously completed by the same scanning, the measurement stability of a real-time monitoring system can be conveniently monitored, and the analysis and the comparison of subsequent data are facilitated.
Description
Technical Field
The invention relates to an animal coil, in particular to an animal coil special for liver ECS experiments.
Background
A magnetic resonance system is a high-end medical imaging device in which a radio frequency receive coil is a very important component of the magnetic resonance system. The effect of the radio frequency receive coil in this is comparable to that of the adult eye, with the resulting sharpness of the image being directly proportional to its signal-to-noise ratio (sensitivity). In order to improve the image clarity (or signal-to-noise ratio, or sensitivity), the primary principle of coil design is to make the coil as close as possible to the scanning region or object in order to meet the size of the scanning region or object. For example, a head coil is designed with a size that is primarily such that the head of most patients (e.g., greater than 95% of patients) can fit within the coil, but the size of the head coil should not be too large. Since many patients will not be able to use it if the coil size is too small, which in turn reduces the sharpness of the magnetic resonance image.
The radio frequency receive coils may be named according to the name of the scanning site or subject, and are various. When scanning different parts of the human body, special coils are generally needed, for example, a coil for scanning the head is called a head coil, a coil for scanning the knee joint is called a knee joint coil, and a heart coil, a spine coil and the like are also needed. In addition to human body parts, some coils are also specifically designed for imaging certain animals, and these coils may be referred to as animal coils. The biomedical research with animals as objects can avoid the risks brought by experiments on human bodies, strictly control the experimental conditions of the animals and reduce the influence of individual differences. Imaging modalities, especially magnetic resonance imaging, are one of the indispensable tools in animal model research at present. ECS (i.e. extracellular space) studies on the liver have been a medical problem; the Magnetic tracer method is a new Imaging method of ECS which is newly emerged in recent years, and applies Magnetic Resonance Imaging (MRI) as a signal acquisition platform, fully utilizes high spatial resolution and excellent soft tissue resolution of the MRI, and carries out tracer Imaging on a molecular probe [29] introduced into the ECS of a target organ by designing a special three-dimensional MRI sequence (the molecular probe is marked and traced on an MRI image by shortening longitudinal relaxation time of hydrogen nuclei therein), thereby preliminarily realizing dynamic observation of ISF flow of the target organ, and utilizing a classical diffusion equation to realize synchronous quantitative analysis on key indexes such as local ECS tortuosity. However, the existing matched animal coil can only image the animal simply, and cannot image a calibration system (tracer samples with different concentrations), the calibration system is a key step for determining the concentration and the quantity of the introduced tracer, the original design is single measurement before the experiment, the synchronization of the measurement process and animal scanning cannot be realized, and the measurement stability of the real-time monitoring system is inconvenient.
Disclosure of Invention
The invention aims to provide an animal coil special for liver ECS experiments, which aims to solve the technical problems in the prior art, can simultaneously image tracer samples in an animal and a calibration system, can realize the synchronization of a measurement process and animal scanning, and is convenient for monitoring the measurement stability of the system in real time.
The invention provides an animal coil special for liver ECS experiments, which comprises an upper framework and a lower framework, wherein the upper framework is detachably connected with the lower framework; the upper framework and the lower framework form a cylindrical structure; antenna units are arranged in the upper framework and the lower framework; the antenna unit positioned in the upper framework and the antenna unit positioned in the lower framework form a radio frequency coil;
a calibration mould is also arranged on the lower framework; the scaling die is positioned on one side of the lower framework, which is close to the upper framework; a channel for placing animals is formed between the scaling mould and the inner wall of the upper framework; the upper framework is an arc-shaped plate; the upper framework is provided with a medicine leading-in hole; the drug introduction hole is located at the top of the upper frame.
The animal coil special for the liver ECS experiment is characterized in that the calibration mould comprises a shell and a plurality of thin tubes; the shell is arranged on one side of the lower framework close to the upper framework; the thin pipes are arranged in the shell along the axial direction of the lower framework; tracer samples with different concentrations are filled in the thin tube; a constant temperature solution is arranged in the shell.
The animal coil special for the liver ECS experiment is preferably characterized in that a constant-temperature solution inlet and a constant-temperature solution outlet are respectively formed at two ends of the shell; the constant-temperature solution inlet and the constant-temperature solution outlet are communicated with a constant-temperature solution circulating system through pipelines.
The animal coil special for the liver ECS experiment is characterized in that the shell is internally provided with a heat insulation cavity; an MRI compatible fiber optic temperature sensor is positioned within the insulated cavity.
The special animal coil for the liver ECS experiment is characterized in that the inner shell is provided with a baffle plate; the partition plate divides the inner space of the shell into an upper chamber and a lower chamber; the upper chamber and the lower chamber are both sealed chambers; the thin tube and the constant-temperature solution are both positioned in the upper chamber; the constant-temperature solution inlet and the constant-temperature solution outlet are both communicated with the upper chamber; the optical fiber temperature sensor is placed in the lower chamber.
The special animal coil for the liver ECS experiment is characterized in that the thin tube is a cylindrical tube, and the lumen of the cylindrical tube is greater than or equal to 0.5 cm; the number of the cylindrical tubes is not less than 20.
In the above animal coil for liver ECS experiments, preferably, the drug inlet hole is formed along an axial direction of the upper frame; the length of the medicine introducing hole is more than or equal to 8cm, and the width of the medicine introducing hole is more than or equal to 5 cm.
The animal coil special for the liver ECS experiment is characterized in that the lower framework is arranged on a base; the base is provided with a supporting plate; the supporting plate is located at one end of the lower framework, and the upper surface of the supporting plate is flush with the upper surface of the calibration mold.
The animal coil special for the liver ECS experiment is preferably characterized in that the upper framework is provided with a drug introduction probe fixing frame; the drug introducing probe fixing frame comprises a vertical rod and a horizontal rod; the lower end of the vertical rod is fixedly connected with the upper framework; the cross rod is connected with the vertical rod in a sliding manner through a lantern ring; an adjusting screw is connected to the lantern ring in a threaded manner; one end of the adjusting screw rod is abutted against the outer surface of the vertical rod; one end of the cross rod, which is far away from the vertical rod, is provided with a clamping part.
The animal coil special for the liver ECS experiment is characterized in that the calibration mould is provided with a fixing component for fixing an animal; the number of the fixing assemblies is four; the four fixing assemblies are respectively arranged on two opposite sides of the calibration mould; the four fixing assemblies are opposite to each other in pairs; the fixing component comprises a bandage and a magic tape; one end of the bandage is fixed on the scaling die; the other end of the bandage is fixed with a female surface of the magic tape; the sub-surface of the magic tape is fixed on the calibration mould.
Compared with the prior art, the method has the following beneficial effects:
1. the calibration mould and the animal coil are designed together, so that the synchronization of the measurement process and the animal scanning can be realized, the tracer sample solution and the imaging of a tested object can be simultaneously completed by the same scanning, the measurement stability of a real-time monitoring system can be conveniently monitored, and the analysis and the comparison of subsequent data are facilitated.
2. According to the invention, the constant temperature solution is arranged in the shell, so that the temperature of the tracer sample in the thin tube can be kept constant all the time, and the influence on the tracer sample, the display of the scanned image and the experimental result caused by the difference of the external environment temperature is avoided.
Drawings
FIG. 1 is a schematic structural diagram of an animal coil specially used for liver ECS experiments;
FIG. 2 is an exploded view of the special animal coil for liver ECS experiment;
FIG. 3 is a schematic view of the installation structure of the calibration mold and the bandage and magic tape;
FIG. 4 is a front view of FIG. 3;
FIG. 5 is a cross-sectional view A-A of FIG. 4;
FIG. 6 is a schematic view of the mounting structure of the upper frame and the drug introduction probe holder;
fig. 7 is an enlarged view at B in fig. 6.
Description of reference numerals: 1-upper framework, 2-lower framework, 201-positioning bulge, 3-scaling mold, 301-shell, 302-tubule, 303-thermostatic solution inlet, 304-thermostatic solution outlet, 301 a-heat insulation cavity, 4-antenna unit, 101-drug introduction hole, 5-optical fiber temperature sensor, 6-partition plate, 7-base, 8-supporting plate, 9-vertical rod, 10-cross rod, 11-lantern ring, 12-adjusting screw, 13-clamping part, 1301-first clamping plate, 1302-second clamping plate, 14-bandage, 15-magic tape, 16-bolt, 17-nut and 18-lug.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative only and should not be construed as limiting the invention.
The embodiment of the invention comprises the following steps: as shown in fig. 1-7, an animal coil special for liver ECS experiments comprises an upper frame 1 and a lower frame 2, wherein the upper frame 1 is an arc-shaped plate, and the lower frame 2 is also an arc-shaped plate. The upper framework 1 is detachably connected with the lower framework 2, so that an anesthetized animal can be conveniently placed on the lower framework 2, positioning protrusions 201 and positioning grooves can be arranged at the joint of the lower framework 2 and the upper framework 1 in specific implementation, the positioning protrusions 201 can be arranged on the lower framework 2 as shown in fig. 2, the positioning grooves matched with the positioning protrusions 201 are arranged on the upper framework 1, and certainly, in order to better prevent the upper framework 1 from falling off from the lower framework 2, first positioning holes can be arranged on the positioning protrusions 201, second positioning holes communicated with the positioning grooves are formed in the upper framework 1, and the first positioning holes are opposite to the second positioning holes and are connected through inserting rods; the upper framework 1 and the lower framework 2 form a cylindrical structure. The upper framework 1 and the lower framework 2 are both internally provided with an antenna unit 4; the antenna unit 4 positioned in the upper framework 1 and the antenna unit positioned in the lower framework 2 form a radio frequency coil; specifically, go up skeleton 1 with what constitute during 2 locks of skeleton down is a cylinder section of thick bamboo, so, the setting of the antenna element 4 of being convenient for, specific antenna element 4 is four, sets up two in going up skeleton 1, sets up two in the skeleton 2 down, and four independent antenna element 4 become 1 x 4's distribution in the ring direction, constitute a phased array coil, so design has that processing preparation is simple and convenient, the SNR is higher relatively, parallel formation of image is also more nimble. The lower framework 2 is also provided with a calibration mould 3; the scaling die 3 is positioned on one side of the lower framework 2 close to the upper framework 1; a channel for placing animals is formed between the scaling die 3 and the inner wall of the upper framework 1; the upper framework 1 is provided with a medicine leading-in hole 101; the medicine introduction hole 101 is located at the top of the upper frame 1. The radio frequency coil in the present invention is part of an MRI.
According to the invention, the calibration mold 3 is arranged on the lower framework 2, so that the synchronization of the measurement process and the animal scanning can be realized, and the imaging of the tracer sample solution and the tested object can be simultaneously completed by the same scanning, so that the measurement stability of a real-time monitoring system is facilitated, and the analysis and the comparison of subsequent data are facilitated.
Further, the calibration die 3 includes a housing 301 and a plurality of tubules 302; the casing 301 sets up lower skeleton 2 is close to one side of last skeleton 1, the length of casing 301 is the same with the length of lower skeleton 2, and the shape and the lower skeleton 2 looks adaptation of casing 301. The middle part of the upper surface of the shell 301 is slightly recessed inwards to form a containing groove, so that an animal to be tested is prevented from entering the shell 301; a plurality of thin tubes 302 are arranged in the housing 301 along the axial direction of the lower skeleton 2; tracer samples with different concentrations are filled in the thin tube 302; a constant temperature solution is arranged in the shell 301. Two ends of the shell 301 are respectively provided with a constant-temperature solution inlet 303 and a constant-temperature solution outlet 304; the constant-temperature solution inlet 303 and the constant-temperature solution outlet 304 are both communicated with a constant-temperature solution circulating system through pipelines. Through set up the constant temperature solution in casing 301 can make the temperature in tubule 302 remain unchanged throughout, avoids leading to influencing the interior tracer sample of tubule 302 because of external environment temperature's difference to influence the demonstration of scanning back image.
As a further improved improvement, a heat insulation cavity 301a is further arranged in the casing 301; an MRI compatible fiber optic temperature sensor 5 is disposed within the insulated cavity 301 a. The environmental temperature of the tracer sample can be detected in real time through the optical fiber temperature sensor 5, and the temperature of the tracer sample can be conveniently controlled.
In a preferable mode, a partition plate 6 is arranged in the casing 301; the partition plate 6 divides the inner space of the shell 301 into an upper chamber and a lower chamber; the upper chamber and the lower chamber are both sealed chambers; the tubule 302 and the constant temperature solution are both located within the upper chamber; the constant-temperature solution inlet 303 and the constant-temperature solution outlet 304 are both communicated with the upper chamber; the optical fiber temperature sensor 5 is placed in the lower chamber. The lower chamber is the thermal insulation chamber 301a, and the thermal insulation chamber is arranged at the lower part of the shell 301, so that the temperature of the constant-temperature solution can be monitored in real time, the influence of the thermal insulation chamber on animals or the tubules 302 during nuclear magnetic resonance imaging can be reduced, and the imaging definition is improved.
Further, the thin tube 302 is a cylindrical tube, and the lumen of the cylindrical tube has a diameter of 0.5cm or more; the number of the cylindrical tubes is not less than 20. In specific implementation, the diameters and the number of the cylindrical pipes are set according to requirements.
In order to facilitate the drug introduction into the animal placed in the coil, the drug introduction hole 101 may be provided along the axial direction of the upper frame 1; the length of the drug introduction hole 101 is not less than 8cm, and the width is not less than 5 cm.
As a preferred embodiment, the lower framework 2 is arranged on a base 7, and the base 7 can make the whole coil more stable when placed on a laboratory bench; a supporting plate 8 is arranged on the base 7; the layer board 8 is located the one end of lower frame 2, just the upper surface of layer board 8 with the upper surface of scaling mould 3 flushes, can increase the length of whole coil through setting up layer board 8, and the space increase of placing the animal in the time is convenient for place the layer board 8 with the animal of treating the experiment before the experiment begins on.
As a preferred embodiment, a drug introduction probe fixing frame is arranged on the upper framework 1, and the drug introduction probe can be fixed by the drug introduction probe fixing frame, so that the need of human hands for supporting during drug introduction is avoided, the labor intensity of people is reduced, and the damage of nuclear magnetic resonance equipment to human bodies during the experiment process can be reduced. The drug introducing probe fixing frame comprises a vertical rod 9 and a horizontal rod 10; the lower end of the vertical rod 9 is fixedly connected with the upper framework 1; the cross rod 10 is connected with the vertical rod 9 in a sliding way through a lantern ring 11, so that the height and the angle of the cross rod 10 can be conveniently adjusted, and the medicine introducing probe can be conveniently fixed; an adjusting screw 12 is connected to the lantern ring 11 in a threaded manner; one end of the adjusting screw 12 is abutted against the outer surface of the vertical rod 9, and the adjusting screw 12 can be adjusted in place by the cross rod 10 and then fixed by rotating the adjusting screw 12. The end, far away from the vertical rod 9, of the cross rod 10 is provided with a clamping portion 13, the clamping portion 13 comprises a first clamping plate 1301 and a second clamping plate 1302 which are arranged in parallel, clamping grooves are formed in corresponding positions of one sides, close to each other, of the first clamping plate 1301 and the second clamping plate 1302, so that a medicine introducing probe can be conveniently fixed, an installation through hole is formed in one end, far away from the cross rod 10, of the first clamping plate 1301, a threaded hole is formed in one end, far away from the cross rod 10, of the second clamping plate 1302, the installation through hole and the threaded hole are arranged oppositely, and the installation through hole and the threaded hole are connected through a bolt 16; the bolt 16 is fixedly connected with the mounting through hole, the bolt 16 is in threaded connection with the threaded hole of the second clamping plate 1302, and the nut 17 of the bolt 16 is mounted on one side, away from the first clamping plate 1301, of the second clamping plate 1302; in order to facilitate the manual rotation of the nut 17, projections 18 are symmetrically provided on the circumferential side of the nut 17.
As a preferred embodiment, the calibration mold 3 is further provided with a fixing assembly for fixing an animal, so that the animal can be fixed, and the phenomenon that the result of camera shooting is unclear and the experiment is affected due to movement of the animal in the experiment process is avoided; the number of the fixing assemblies is four; the four fixing components are respectively arranged on two opposite sides of the calibration mould 3; the four fixing assemblies are opposite to each other in pairs; the fixing component comprises a bandage 14 and a magic tape 15; one end of the bandage 14 is fixed on the scaling die 3; the other end of the bandage 14 is fixed with the female surface of the magic tape 15; the sub-surface of the magic tape 15 is fixed on the calibration mold 3. During the concrete implementation, fix the four limbs of animal through four bandages 14 respectively, conveniently adjust the elasticity that bandage 14 fixed on the animal through the design of bandage 14 and magic subsides 15.
During practical application, earlier the animal anesthesia, then will be anesthetized the animal place to scale on the mould 3, the four limbs of animal are fixed respectively through fixed subassembly, later with last skeleton 1 lock to skeleton 2 down, insert the position that the animal waited to lead the medicine with leading-in probe through medicine inlet hole 101, for example the liver, then, lead-in probe is fixed with leading-in probe of medicine through the medicine, then it can to start the MRI system and carry out image acquisition, accomplish the formation of image to tracer sample solution when imaging animal liver position, just real-time monitoring system measuring stability, do benefit to the analysis and the contrast of follow-up data.
The construction, features and functions of the present invention are described in detail in the embodiments illustrated in the drawings, which are only preferred embodiments of the present invention, but the present invention is not limited by the drawings, and all equivalent embodiments modified or changed according to the idea of the present invention should fall within the protection scope of the present invention without departing from the spirit of the present invention covered by the description and the drawings.
Claims (10)
1. The special animal coil for the liver ECS experiment is characterized by comprising an upper framework (1) and a lower framework (2), wherein the upper framework (1) is detachably connected with the lower framework (2); the upper framework (1) and the lower framework (2) form a cylindrical structure; the upper framework (1) and the lower framework (2) are internally provided with antenna units (4); the antenna unit (4) positioned in the upper framework (1) and the antenna unit positioned in the lower framework (2) form a radio frequency coil;
the lower framework (2) is also provided with a calibration mould (3); the scaling die (3) is positioned on one side of the lower framework (2) close to the upper framework (1); a channel for placing animals is formed between the scaling die (3) and the inner wall of the upper framework (1); the upper framework (1) is an arc-shaped plate; the upper framework (1) is provided with a medicine leading-in hole (101); the drug introduction hole (101) is located at the top of the upper frame (1).
2. The special animal coil for liver ECS experiments according to claim 1, wherein: the calibration die (3) comprises a shell (301) and a plurality of thin tubes (302); the shell (301) is arranged on one side, close to the upper framework (1), of the lower framework (2); the plurality of thin tubes (302) are arranged in the shell (301) along the axial direction of the lower framework (2); tracer samples with different concentrations are filled in the thin tube (302); a constant-temperature solution is arranged in the shell (301).
3. The special animal coil for liver ECS experiments according to claim 2, wherein: two ends of the shell (301) are respectively provided with a constant-temperature solution inlet (303) and a constant-temperature solution outlet (304); the constant-temperature solution inlet (303) and the constant-temperature solution outlet (304) are communicated with a constant-temperature solution circulating system through pipelines.
4. The special animal coil for liver ECS experiments according to claim 3, wherein: a heat insulation cavity (301a) is further arranged in the shell (301); an MRI compatible fiber optic temperature sensor (5) is disposed within the insulated cavity (301 a).
5. The special animal coil for liver ECS experiments according to claim 4, wherein: a partition plate (6) is arranged in the shell (301); the partition plate (6) divides the inner space of the shell (301) into an upper chamber and a lower chamber; the upper chamber and the lower chamber are both sealed chambers; the tubule (302) and the constant temperature solution are both located in the upper chamber; the constant-temperature solution inlet (303) and the constant-temperature solution outlet (304) are both communicated with the upper chamber; the optical fiber temperature sensor (5) is placed in the lower chamber.
6. The special animal coil for liver ECS experiments according to any one of claims 2 to 5, wherein: the thin tube (302) is a cylindrical tube, and the lumen of the cylindrical tube has a diameter of more than or equal to 0.5 cm; the number of the cylindrical tubes is not less than 20.
7. The special animal coil for liver ECS experiments according to claim 1, wherein: the drug introduction hole (101) is arranged along the axial direction of the upper framework (1); the length of the medicine introducing hole (101) is more than or equal to 8cm, and the width is more than or equal to 5 cm.
8. The special animal coil for liver ECS experiments according to claim 1, wherein: the lower framework (2) is arranged on a base (7); a supporting plate (8) is arranged on the base (7); the supporting plate (8) is located at one end of the lower framework (2), and the upper surface of the supporting plate (8) is flush with the upper surface of the scaling mold (3).
9. The special animal coil for liver ECS experiments according to claim 1, wherein: a drug introduction probe fixing frame is arranged on the upper framework (1); the drug introducing probe fixing frame comprises a vertical rod (9) and a cross rod (10); the lower end of the vertical rod (9) is fixedly connected with the upper framework (1); the cross rod (10) is connected with the vertical rod (9) in a sliding way through a lantern ring (11); an adjusting screw rod (12) is connected to the lantern ring (11) in a threaded manner; one end of the adjusting screw rod (12) is abutted against the outer surface of the vertical rod (9); one end of the cross rod (10) far away from the vertical rod (9) is provided with a clamping part (13).
10. The special animal coil for liver ECS experiments according to claim 1, wherein: the calibration mould (3) is also provided with a fixing component for fixing animals; the number of the fixing assemblies is four; the four fixing components are respectively arranged on two opposite sides of the calibration mould (3); the four fixing assemblies are opposite to each other in pairs; the fixing component comprises a bandage (14) and a magic tape (15); one end of the bandage (14) is fixed on the scaling die (3); the other end of the bandage (14) is fixed with the female surface of the magic tape (15); the sub-surface of the magic tape (15) is fixed on the scaling die (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010406625.3A CN111505040A (en) | 2020-05-14 | 2020-05-14 | Special animal coil of liver ECS experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010406625.3A CN111505040A (en) | 2020-05-14 | 2020-05-14 | Special animal coil of liver ECS experiment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111505040A true CN111505040A (en) | 2020-08-07 |
Family
ID=71876839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010406625.3A Pending CN111505040A (en) | 2020-05-14 | 2020-05-14 | Special animal coil of liver ECS experiment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111505040A (en) |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040030240A1 (en) * | 2002-05-13 | 2004-02-12 | Tokunori Kimura | MRI apparatus, flow quantification apparatus, and flow quantification method for ASL imaging |
| US20050054910A1 (en) * | 2003-07-14 | 2005-03-10 | Sunnybrook And Women's College Health Sciences Centre | Optical image-based position tracking for magnetic resonance imaging applications |
| US20050137475A1 (en) * | 2003-12-19 | 2005-06-23 | Christian Dold | Reducing movement artifacts in magnetic resonance measurements |
| CN201110892Y (en) * | 2007-11-08 | 2008-09-03 | 南通大学附属医院 | Magnetic resonance imaging small animal radio-frequency coil apparatus |
| US20090080600A1 (en) * | 2006-01-26 | 2009-03-26 | Charles Keller | Process and apparatus for imaging |
| US20100264918A1 (en) * | 2009-04-21 | 2010-10-21 | The Regents Of The University Of California | Iron-free variable torque motor compatible with magnetic resonance imaging in integrated spect and mr imaging |
| US20110044524A1 (en) * | 2008-04-28 | 2011-02-24 | Cornell University | Tool for accurate quantification in molecular mri |
| US20120330130A1 (en) * | 2011-05-06 | 2012-12-27 | Rapid Biomedical Gmbh | Assembly to perform imaging on rodents |
| WO2013104132A1 (en) * | 2012-01-13 | 2013-07-18 | Han Hongbin | Method for measuring diffusion parameters of tracer in living organ tissue space and extracellular space |
| US20140093452A1 (en) * | 2012-09-17 | 2014-04-03 | University of Pittsburgh - of the Commonwealth Systems of Higher Education | Magnetic Resonance Imaging Cell Labeling Methods and Compositions |
| US20150323639A1 (en) * | 2014-10-16 | 2015-11-12 | National Institute Of Standards And Technology | Mri phantom, method for making same and acquiring an mri image |
| CN105286864A (en) * | 2014-06-30 | 2016-02-03 | 中国科学院上海生命科学研究院 | Integrated coil, special for non-human primates, in magnetic resonance imaging system |
| US20160282439A1 (en) * | 2015-03-25 | 2016-09-29 | The Catholic University Of Korea Industry - Academic Cooperation Foundation | Phantom for evaluating performance of magnetic resonance imaging apparatus using ultra high field |
| US20160363644A1 (en) * | 2015-06-15 | 2016-12-15 | Wisconsin Alumni Research Foundation | Phantom for quantitative diffusion magnetic resonance imaging |
| US20180275240A1 (en) * | 2015-10-02 | 2018-09-27 | Southem Research Institute | Imaging phantom and systems and methods of using same |
| WO2019180464A1 (en) * | 2018-03-23 | 2019-09-26 | Gold Standard Phantoms Limited | A phantom for multi-parametric calibration in magnetic resonance imaging |
-
2020
- 2020-05-14 CN CN202010406625.3A patent/CN111505040A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040030240A1 (en) * | 2002-05-13 | 2004-02-12 | Tokunori Kimura | MRI apparatus, flow quantification apparatus, and flow quantification method for ASL imaging |
| US20050054910A1 (en) * | 2003-07-14 | 2005-03-10 | Sunnybrook And Women's College Health Sciences Centre | Optical image-based position tracking for magnetic resonance imaging applications |
| US20050137475A1 (en) * | 2003-12-19 | 2005-06-23 | Christian Dold | Reducing movement artifacts in magnetic resonance measurements |
| US20090080600A1 (en) * | 2006-01-26 | 2009-03-26 | Charles Keller | Process and apparatus for imaging |
| CN201110892Y (en) * | 2007-11-08 | 2008-09-03 | 南通大学附属医院 | Magnetic resonance imaging small animal radio-frequency coil apparatus |
| US20110044524A1 (en) * | 2008-04-28 | 2011-02-24 | Cornell University | Tool for accurate quantification in molecular mri |
| US20100264918A1 (en) * | 2009-04-21 | 2010-10-21 | The Regents Of The University Of California | Iron-free variable torque motor compatible with magnetic resonance imaging in integrated spect and mr imaging |
| US20120330130A1 (en) * | 2011-05-06 | 2012-12-27 | Rapid Biomedical Gmbh | Assembly to perform imaging on rodents |
| WO2013104132A1 (en) * | 2012-01-13 | 2013-07-18 | Han Hongbin | Method for measuring diffusion parameters of tracer in living organ tissue space and extracellular space |
| US20140093452A1 (en) * | 2012-09-17 | 2014-04-03 | University of Pittsburgh - of the Commonwealth Systems of Higher Education | Magnetic Resonance Imaging Cell Labeling Methods and Compositions |
| CN105286864A (en) * | 2014-06-30 | 2016-02-03 | 中国科学院上海生命科学研究院 | Integrated coil, special for non-human primates, in magnetic resonance imaging system |
| US20150323639A1 (en) * | 2014-10-16 | 2015-11-12 | National Institute Of Standards And Technology | Mri phantom, method for making same and acquiring an mri image |
| US20160282439A1 (en) * | 2015-03-25 | 2016-09-29 | The Catholic University Of Korea Industry - Academic Cooperation Foundation | Phantom for evaluating performance of magnetic resonance imaging apparatus using ultra high field |
| US20160363644A1 (en) * | 2015-06-15 | 2016-12-15 | Wisconsin Alumni Research Foundation | Phantom for quantitative diffusion magnetic resonance imaging |
| US20180275240A1 (en) * | 2015-10-02 | 2018-09-27 | Southem Research Institute | Imaging phantom and systems and methods of using same |
| WO2019180464A1 (en) * | 2018-03-23 | 2019-09-26 | Gold Standard Phantoms Limited | A phantom for multi-parametric calibration in magnetic resonance imaging |
Non-Patent Citations (4)
| Title |
|---|
| VESCOVO等人: "High-precision calibration of MRS thermometry using valided temperature standards：effects of ionic strength and protein content on the calibration", vol. 26, no. 26, pages 213 - 223 * |
| 倪萍;陈自谦;: "胰岛细胞移植磁共振扫描活体示踪的序列优化", no. 18 * |
| 杨正汉，冯逢，王霄英主编: "创伤骨科与显微外科", vol. 1, 上海科学技术出版社, pages: 579 - 13 * |
| 韩鸿宾;: "应用磁共振成像技术定量测量活体大鼠脑细胞外间隙的扩散参数", no. 05 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2760089C (en) | Imaging device for three dimensional anatomical and functional imaging and methods thereof | |
| US4354499A (en) | Apparatus and method for nuclear magnetic resonance scanning and mapping | |
| US4411270A (en) | Apparatus and method for nuclear magnetic resonance scanning and mapping | |
| US7208951B2 (en) | Magnetic resonance method | |
| Parker et al. | Temperature distribution measurements in two‐dimensional NMR imaging | |
| AU2019388593B2 (en) | Radiotherapy system imaging quality control phantom guided by magnetic resonance | |
| US5177443A (en) | Nuclear magnetic resonance apparatus | |
| EP3371618A1 (en) | Phantoms having reference members with microchannels and diffusion weighted imaging using same | |
| US20120165654A1 (en) | Means and method for performing hyperpolarizing gas imaging | |
| Kłodowski et al. | Innovative anisotropic phantoms for calibration of diffusion tensor imaging sequences | |
| JPH0318323B2 (en) | ||
| CN111505040A (en) | Special animal coil of liver ECS experiment | |
| Vergara Gomez et al. | Wireless coils based on resonant and nonresonant coupled‐wire structure for small animal multinuclear imaging | |
| Wecker et al. | Investigation of insect morphology by MRI: Assessment of spatial and temporal resolution | |
| Maekawa et al. | Time-dependent diffusion in transient splenial lesion: comparison between oscillating-gradient spin-echo measurements and Monte-Carlo simulation | |
| Mallard et al. | Imaging by nuclear magnetic resonance and its bio-medical implications | |
| CN112603347A (en) | Novel CT dose die body and detection method thereof | |
| Righi et al. | Magnetic resonance spectroscopy of live Drosophila melanogaster using magic angle spinning | |
| Masad et al. | A retunable surface coil for high field 31P and 1H magnetic resonance evaluations of the living mouse leg | |
| CN214434256U (en) | Novel CT dose die body | |
| Selwyn | Phantoms for magnetic resonance imaging | |
| Starck et al. | Evaluation of volume selection methods in in vivo MRS: Design of a new test phantom | |
| Shang | Design and Implementation of Magnetic Field Control in Magnetic Resonance Imaging and B0 Shimming | |
| CN109782203B (en) | Dynamic magnetic resonance test body model system | |
| RU2255653C1 (en) | Method for diagnosing the cases of congestive abscesses with tuberculous spondylitis on low field intensity magnetic resonance tomograph |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200807 |