CN111494230B - Cold light tooth whitening gel, preparation method and application - Google Patents
Cold light tooth whitening gel, preparation method and application Download PDFInfo
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 72
- 238000002360 preparation method Methods 0.000 title abstract description 10
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000011941 photocatalyst Substances 0.000 claims abstract description 11
- 239000002562 thickening agent Substances 0.000 claims abstract description 11
- 125000000864 peroxy group Chemical group O(O*)* 0.000 claims abstract description 8
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 239000003765 sweetening agent Substances 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000011787 zinc oxide Substances 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical group OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- 235000014749 Mentha crispa Nutrition 0.000 claims 1
- 244000078639 Mentha spicata Species 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 18
- 230000008569 process Effects 0.000 abstract description 9
- NQFHBASTZUVSRZ-UHFFFAOYSA-N hexaneperoxoic acid;isoindole-1,3-dione Chemical compound CCCCCC(=O)OO.C1=CC=C2C(=O)NC(=O)C2=C1 NQFHBASTZUVSRZ-UHFFFAOYSA-N 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 239000000049 pigment Substances 0.000 abstract description 3
- 230000003197 catalytic effect Effects 0.000 abstract description 2
- 239000000686 essence Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- 229960001631 carbomer Drugs 0.000 description 6
- 206010018276 Gingival bleeding Diseases 0.000 description 3
- 206010018286 Gingival pain Diseases 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 201000004328 Pulpitis Diseases 0.000 description 2
- 206010037464 Pulpitis dental Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 150000001451 organic peroxides Chemical class 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 238000006479 redox reaction Methods 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000036347 tooth sensitivity Effects 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of tooth whitening, and discloses a cold light tooth whitening gel, a preparation method and application thereof, wherein the raw materials for preparing the effective components of the cold light tooth whitening gel comprise: phthalimide peroxycaproic acid, a stabilizer, a photocatalyst, a thickening agent, a humectant, a pH regulator, a sweetening agent, essence and deionized water; the prepared cold light tooth whitening gel is smeared on teeth, and is irradiated by LED yellow light to finish tooth whitening. The phthalimide peroxy caproic acid is decomposed under the catalytic action of a photocatalyst to generate strong oxides with enough free radicals, so that pigment tissues on the surface and in the deep layer of the tooth are rapidly decomposed, and the tooth is rapidly whitened; the LED yellow light has small and mild energy and small irritation to eyes and skin, and solves the problem of potential safety hazard caused by using high-intensity blue light and hydrogen peroxide in the cold light tooth whitening process. The cold light tooth whitening gel is suitable for cold light tooth whitening.
Description
Technical Field
The invention belongs to the technical field of tooth whitening, and relates to a tooth whitening gel, in particular to a cold light tooth whitening gel, a preparation method and application.
Background
The cold light tooth whitening is a tooth whitening technology popular in Europe and America, and high-intensity blue light with the wavelength ranging from 480 nm to 520nm is irradiated on a peroxide bleaching agent, so that the bleaching agent generates oxidation-reduction reaction with deposited pigments through enamel and dentin tubules in a short time, and the whitening effect is achieved. Although the technology of cold light tooth whitening is well established, there are still some problems with the cold light tooth whitening products on the market today. First, luminescent dental cosmetics require the application of a high concentration gel containing peroxide, typically hydrogen peroxide, to the teeth. Hydrogen peroxide can cause many side effects to teeth and oral cavity, such as damage of mechanical hardness of enamel surface, soft tissue irritation, tooth sensitivity, acute pulpitis and other problems. Thus, there are many potential risks associated with long-term use. In addition, in the cold light tooth whitening process, high-energy blue light is generally used as an excitation light source to catalyze hydrogen peroxide to perform oxidation-reduction reaction, so that the use concentration of the hydrogen peroxide is reduced, and the tooth whitening efficiency is improved. However, high-energy blue light easily stimulates eyes, which causes eye spots and dazzling, and even increases the probability of eye diseases. Meanwhile, high-energy blue light contacts eyes and skin, and potential safety hazards such as damage to eye structures, inhibition of melatonin secretion, influence on sleep quality and the like can be generated. Although the hazards of short-term use of blue light are not significant, long-term accumulation can still create a safety hazard to the health of the customer. Therefore, how to develop a tooth whitening gel which can be catalyzed by mild light and has no hydrogen peroxide is a problem to be solved for improving the safety and reliability of the cold light tooth whitening technology.
Disclosure of Invention
The invention aims to provide a cold light tooth whitening gel to solve the problem of potential safety hazard caused by using high-intensity blue light and hydrogen peroxide in the cold light tooth whitening process;
another object of the present invention is to provide a method for preparing the above luminescent tooth whitening gel;
it is still another object of the present invention to provide use of the above luminescent tooth whitening gel.
In order to achieve the purpose, the invention adopts the technical scheme that:
the cold light tooth whitening gel comprises the following raw materials of active ingredients in parts by weight: 3-18 parts of phthalimide peroxy caproic acid, 0.01-0.05 part of stabilizer, 5-10 parts of photocatalyst, 0.5-1.5 parts of thickening agent, 20-80 parts of humectant, 0.5-0.8 part of pH regulator, 0.05-0.15 part of sweetening agent, 0.1-0.3 part of essence and 20-40 parts of deionized water.
As a limitation, the stabilizer is disodium edetate;
the photocatalyst is nano porous zinc oxide or nitrogen-doped titanium dioxide;
the thickening agent is carbomer and/or sodium carboxymethylcellulose;
the humectant is glycerol and/or propylene glycol;
the pH regulator is triethanolamine;
the sweetener is saccharin sodium;
the essence is herba Menthae essence and/or herba Menthae Rotundifoliae essence.
The invention also provides a preparation method of the cold light tooth whitening gel, which comprises the following steps in sequence:
1) adding a thickening agent into deionized water, soaking and swelling, adding a humectant after carbomer is completely swelled, and stirring and uniformly mixing to obtain a mixture A;
2) maintaining the stirring condition, adding the stabilizer and the sweetener into the mixture A in batches, uniformly stirring, adding the photocatalyst, and uniformly stirring to obtain a mixture B;
3) maintaining the stirring condition, adding phthalimide peroxy caproic acid into the mixture B, uniformly stirring, adding a pH regulator, and regulating the pH value to completely thicken the thickener carbomer to obtain a mixture C;
4) maintaining the stirring condition, adding essence into the mixture C, and stirring and mixing uniformly to obtain the cold light tooth whitening gel.
As a limitation, the cold light tooth whitening gel is inspected and packaged.
As another limitation, in the step 1), the soaking temperature of the thickening agent is 65-85 ℃;
in the step 3), the final value of the pH value is adjusted to be 5.5-6.5.
The invention also provides an application of the cold light tooth whitening gel, and the application process is that the cold light tooth whitening gel is smeared on teeth and is irradiated by LED yellow light to finish tooth whitening.
As a limitation, the wavelength of the LED yellow light is 570-590 nm, and the irradiation time is 15-30 min.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
the invention relates to a cold light tooth whitening gel, which takes organic peroxide phthalimide peroxy caproic acid as a main raw material and takes nitrogen-doped silicon dioxide and/or nano porous zinc oxide as a photocatalyst. The photocatalyst can be excited by milder LED yellow light, the phthalimide peroxy caproic acid with low concentration is quickly decomposed by photochemical catalysis under the catalytic action of the excited photocatalyst to generate a strong oxide, and the strong oxide contains enough free radicals to promote the pigment tissues on the surface and in the deep layer of the tooth to be quickly decomposed, so that the effect of quickly whitening the tooth is achieved. Compared with blue light, the LED yellow light has small energy and is milder, and the LED yellow light has small irritation to eyes and skin, so that the LED yellow light is safer to use;
according to the invention, the organic peroxide phthalimide peroxycaproic acid is used for replacing hydrogen peroxide, so that the phthalimide peroxycaproic acid is milder and has no stimulation, and the problems of damaged mechanical hardness of the enamel surface, soft tissue stimulation, tooth sensitivity, acute pulpitis and the like caused by the hydrogen peroxide are solved;
the preparation and application process method is simple and safe, convenient to operate, low in equipment requirement and suitable for industrial production.
The cold light tooth whitening gel is suitable for cold light tooth whitening.
Detailed Description
The present invention is further illustrated by the following specific examples, which are to be construed as merely illustrative, and not limitative of the remainder of the disclosure.
Example 1 Cold light tooth whitening gel, preparation method and application
Cold light tooth whitening gel and preparation method thereof
1) Adding 1.2kg carbomer into 28kg deionized water, soaking at 70 deg.CSwelling, adding 20kg of glycerol and 30kg of propylene glycol after carbomer is completely swelled, stirring at 70 ℃ and 2500rpm for 22h, and mixing to obtain a mixture A1；
2) Maintaining stirring, mixture A1Adding disodium edetate 0.03kg and saccharin sodium 0.07kg into 3 batches, stirring at 40 deg.C and 2500rpm for 5 hr, mixing, adding nanometer porous zinc oxide 8kg, stirring at 40 deg.C and 2500rpm for 5 hr, and mixing to obtain mixture B1；
3) Mixture B1Adding 12kg phthalimide peroxy caproic acid, stirring at 40 deg.C and 2500rpm for 4 hr, mixing, detecting pH, adding 0.5kg triethanolamine according to the detection result, adjusting pH to 6.0, and completely thickening thickener carbomer to obtain mixture C1；
4) Mixture C1Adding 0.2kg of mint essence, stirring at 40 ℃ and 2500rpm for 3h, and mixing uniformly to obtain the cold light tooth whitening gel.
5) Filling the cold light tooth whitening gel into a gel pen, and packaging to obtain the commercially available cold light tooth whitening gel.
The obtained cold light tooth whitening gel is suitable for cold light tooth whitening.
II) application of cold light tooth whitening gel
Selecting 100 subjects, and randomly dividing the subjects into two groups, wherein one group is coated with the cold light tooth whitening gel prepared in the example 1 during the test, and the other group is coated with the traditional cold light tooth whitening gel during the test;
a1) the luminescent tooth whitening gel prepared in the embodiment is respectively smeared on the teeth of 50 subjects, the smearing thickness is 0.5mm, the teeth are irradiated for 20min by 570nm LED yellow light, and the tooth whitening can be completed after the luminescent tooth whitening gel is used once a day for ten consecutive days. Significant whitening effect was achieved compared to untreated teeth, and no discomfort symptoms appeared. After 3 months, the cold light tooth whitening gel prepared in example 1 is smeared on the test subject again for 0.5mm, and is irradiated for 20min by 570nm LED yellow light, so that the cold light tooth whitening gel is used once a day for ten consecutive days, and the test operation is repeated for 3 times, so that the remarkable whitening effect can be realized each time, and no uncomfortable symptoms appear.
a2) The conventional cold light tooth whitening gel (purchased from Novashine) was applied to the teeth of another 50 subjects at a thickness of 0.5mm by blue light irradiation at 520nm for 20min, and thus was used once a day for ten consecutive days to complete tooth whitening. Compared with untreated, the whitening effect is remarkable, wherein 48 people have no uncomfortable symptoms, 1 person has tooth bleeding and pain symptoms, and 1 person has eye flower and dazzling symptoms. After 3 months, smearing the traditional cold light tooth whitening gel 0.5mm on the subject again, irradiating for 20min by 520nm blue light, using once a day for ten consecutive days, repeating the test operation for 3 times, and realizing remarkable whitening effect each time, wherein 47 people do not have discomfort, 2 people have gingival bleeding and pain, and 1 person has dim eyesight and dazzling symptoms; the third 45 people have no uncomfortable symptoms, 3 people have gingival bleeding and pain symptoms, and 2 people have dim eyesight and dazzling symptoms; no discomfort symptom appears in 45 people, gingival bleeding and pain symptom appears in 4 people, and eye flower and dazzling symptom appears in 3 people.
a3) The conventional cold light tooth whitening gel (purchased from Novashine) was applied to the teeth of another 50 subjects at a thickness of 0.5mm, and irradiated with 570nm LED yellow light for 20min to complete tooth whitening. The tooth whitening effect was not significant compared to the untreated teeth.
Examples 2-9 Cold light tooth whitening gel, preparation method and application
Examples 2 to 9 are a cold light tooth whitening gel, a preparation method and an application thereof, which have the same steps as example 1 except for the difference of process parameters, and are specifically shown in table 1; their application process is substantially the same as in example 1, except for the differences in trial parameters and results, as detailed in table 2:
TABLE 1 summary of the process parameters of examples 2 to 9
TABLE 2 summary of the process parameters of examples 2 to 9
In examples 2 to 9, the subjects were different persons, and the contents of the other parts were the same as in example 1.
It should be noted that the embodiments 1 to 9 are only preferred embodiments of the present invention, and are not intended to limit the present invention in other forms, and any person skilled in the art may use the above technical contents as a teaching to make changes or modifications to the equivalent embodiments with equivalent changes, but all those simple changes, equivalent changes and modifications made to the above embodiments without departing from the technical spirit of the present invention, and still all those embodiments fall within the scope of the present invention.
Claims (4)
1. The cold light tooth whitening gel is characterized in that raw materials for preparing active ingredients of the gel are packaged in parts by weight
Comprises the following steps: 3-18 parts of phthalimide peroxy caproic acid, 0.01-0.05 part of stabilizer, 5-10 parts of photocatalyst, 0.5-1.5 parts of thickening agent, 20-80 parts of humectant, 0.5-0.8 part of pH regulator, 0.05-0.15 part of sweetening agent, 0.1-0.3 part of essence and 20-40 parts of deionized water;
wherein the content of the first and second substances,
the stabilizer is disodium ethylene diamine tetraacetate;
the photocatalyst is nano porous zinc oxide or nitrogen-doped titanium dioxide;
the thickening agent is sodium carboxymethyl cellulose;
the humectant is glycerol and/or propylene glycol;
the pH regulator is triethanolamine;
the sweetener is saccharin sodium;
the essence is mint essence and/or spearmint essence;
the cold light tooth whitening gel is smeared on teeth and is irradiated by LED yellow light to finish tooth whitening;
the wavelength of the LED yellow light is 570-590 nm, and the irradiation time is 15-30 min.
2. The method of preparing the luminescent tooth whitening gel of claim 1, wherein the method of preparing the same
Comprises the following steps which are carried out in sequence:
1) adding a thickening agent into deionized water for soaking, adding a humectant, and uniformly mixing to obtain a mixture A;
2) adding a stabilizer and a sweetening agent into the mixture A, uniformly mixing, adding a photocatalyst, and uniformly mixing to obtain a mixture B;
3) adding phthalimide peroxy caproic acid into the mixture B, uniformly mixing, adding a pH regulator, and regulating the pH value to obtain a mixture C;
4) and adding essence into the mixture C, and uniformly mixing to obtain the cold light tooth whitening gel.
3. The method of preparing the cold light tooth whitening gel according to claim 2, wherein the cold light tooth whitening gel is inspected and packaged.
4. The method of preparing the cold light tooth whitening gel according to claim 2 or 3,
in the step 1), the soaking temperature of the thickening agent is 65-85 ℃;
in the step 3), the final value of the pH value is adjusted to be 5.5-6.5.
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| CN113476333A (en) * | 2020-08-19 | 2021-10-08 | 唯艺科学研究(深圳)有限公司 | PAP-containing gel |
| CN113041168A (en) * | 2021-04-10 | 2021-06-29 | 江西师范大学 | Active whitening tooth paste and preparation method thereof |
| CN113069374A (en) * | 2021-04-10 | 2021-07-06 | 江西师范大学 | Whitening dentifrice containing organic peroxide and preparation method thereof |
| CN113499767B (en) * | 2021-06-21 | 2024-03-15 | 中国科学院海洋研究所 | Visible light catalytic modified titanium dioxide and preparation method and application thereof |
| CN113995697A (en) * | 2021-12-03 | 2022-02-01 | 唯艺科学研究(深圳)有限公司 | Optical whitening oral care composition and tooth whitening method |
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| ID28828A (en) * | 1998-09-25 | 2001-07-05 | Unilever Nv | COMPOSITION OF MOUTH CARE BY IMPROVING WHITE DENTAL EFFECTS |
| KR101436126B1 (en) * | 2013-09-27 | 2014-09-01 | 주식회사 덴트화이트 | Dental bleaching composition |
| CN106726648A (en) * | 2017-01-23 | 2017-05-31 | 宋光荣 | A kind of nano photo-catalytic tooth whitening gel |
| CN106726702A (en) * | 2017-03-13 | 2017-05-31 | 广州欧诺洁个人护理用品有限公司 | A kind of tooth whitening products without hydrogen peroxide |
| CN107582415B (en) * | 2017-08-03 | 2020-08-04 | 南昌大学 | Whitening toothpaste with visible light excited oxidation-reduction reaction and preparation method thereof |
| CN109998933A (en) * | 2019-03-04 | 2019-07-12 | 西安蓝极医疗电子科技有限公司 | A kind of tooth whitening gel and preparation method thereof, application method |
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