CN111481661A - Preparation method of multi-enzyme oral multifunctional spray - Google Patents
Preparation method of multi-enzyme oral multifunctional spray Download PDFInfo
- Publication number
- CN111481661A CN111481661A CN201910710238.6A CN201910710238A CN111481661A CN 111481661 A CN111481661 A CN 111481661A CN 201910710238 A CN201910710238 A CN 201910710238A CN 111481661 A CN111481661 A CN 111481661A
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- Prior art keywords
- oral
- preparation
- enzyme
- spray
- components
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000007921 spray Substances 0.000 title claims abstract description 8
- 102000004190 Enzymes Human genes 0.000 claims abstract description 11
- 108090000790 Enzymes Proteins 0.000 claims abstract description 11
- 229930012538 Paclitaxel Natural products 0.000 claims abstract description 10
- 229960001592 paclitaxel Drugs 0.000 claims abstract description 10
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 241000237858 Gastropoda Species 0.000 claims abstract description 8
- 241001116389 Aloe Species 0.000 claims abstract description 7
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 235000013361 beverage Nutrition 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 238000011282 treatment Methods 0.000 claims abstract description 6
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000011049 filling Methods 0.000 claims abstract description 5
- 230000001954 sterilising effect Effects 0.000 claims abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 206010006326 Breath odour Diseases 0.000 abstract description 5
- 208000032139 Halitosis Diseases 0.000 abstract description 5
- 239000000341 volatile oil Substances 0.000 abstract description 5
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract description 4
- 235000016257 Mentha pulegium Nutrition 0.000 abstract description 4
- 244000246386 Mentha pulegium Species 0.000 abstract description 4
- 235000004357 Mentha x piperita Nutrition 0.000 abstract description 4
- 235000001050 hortel pimenta Nutrition 0.000 abstract description 4
- 239000000668 oral spray Substances 0.000 abstract description 4
- 208000003445 Mouth Neoplasms Diseases 0.000 abstract description 3
- 201000007100 Pharyngitis Diseases 0.000 abstract description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract description 3
- 201000006549 dyspepsia Diseases 0.000 abstract description 3
- 201000004101 esophageal cancer Diseases 0.000 abstract description 3
- 206010017758 gastric cancer Diseases 0.000 abstract description 3
- 229940041678 oral spray Drugs 0.000 abstract description 3
- 201000001245 periodontitis Diseases 0.000 abstract description 3
- 201000011549 stomach cancer Diseases 0.000 abstract description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract description 2
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 2
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 2
- 230000007812 deficiency Effects 0.000 abstract description 2
- 210000004211 gastric acid Anatomy 0.000 abstract description 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 description 12
- 210000000214 mouth Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010000059 abdominal discomfort Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000922 anti-bactericidal effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 201000005443 oral cavity cancer Diseases 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of a multi-enzyme oral multifunctional spray, which comprises the following raw materials in parts by weight: snail compound enzyme (8-12), paclitaxel 0.01-0.02, aloe gel liquid (90-100), and peppermint essential oil (0, 8-1.2), and mixing the above four components in a high-speed mixer. Finally, the multienzyme paclitaxel oral spray is pumped into an ozone sterilizer by a miniature beverage pump for sterilization treatment and filling, and the sealing bag has no toxic or side effect, and has curative effects on various symptoms caused by oral cancer, esophageal cancer, gastric cancer, oral ulcer, periodontitis, halitosis, pharyngitis, dyspepsia, gastrectasia, gastric acid and multienzyme deficiency.
Description
The technical field is as follows: preparation method of multi-enzyme oral multifunctional spray
The invention relates to a preparation method of a multi-enzyme oral multifunctional spray.
Background art:
at present, a lot of anti-inflammatory and bactericidal medicines are used, especially inflammation of multiple oral cavities, such as periodontitis, pharyngitis, lip cavity ulcer, halitosis caused by dyspepsia and the like, are mostly solved by adopting common oral cavity spray, but the curative effect is slow, namely the spray for preventing and treating oral cavity, esophagus and gastric cancer is needless to say, and the market does not exist.
Recently, oral sprays are marketed for convenience and rapidity of treatment, which are generally synthesized by adding monomeric enzymes such as pepsin to an anti-inflammatory drug, and peppermint oil is sometimes added to remove halitosis caused by stomach discomfort. But its curative effect is not satisfactory.
The invention content is as follows:
the invention aims to overcome the defects of the prior art and provides a preparation method of a multienzyme paclitaxel oral spray which has good curative effect on preventing oral and esophageal cancers and treating oral inflammation and stomach discomfort.
In order to achieve the aim, the invention adopts the following design scheme: firstly, the following raw materials and the weight ratio thereof are selected as the components of the preparation method of the invention: 0.1-0.3 part of paclitaxel, 8-12 parts of snail compound enzyme, 90-100 parts of aloe gel liquid and 0.8-1.2 parts of mint essence, and then the four components are put into a high-speed mixer to be uniformly mixed: finally, the mixture is pumped into an automatic feeding machine by a micro beverage pump to be canned and packaged into a sealing opening to obtain a finished product.
The snail compound enzyme used in the invention is a compound enzyme artificially extracted from the snail body, the variety of the enzyme is more than thirty, the active unit per gram contains more than-hundred thousand, and the compound enzyme can not be artificially synthesized. Paclitaxel is the best special raw material for preventing and treating cancers at present. Aloe gel is natural bactericide, has no side effects on human body, and herba Menthae essential oil can remove halitosis.
The prepared multienzyme paclitaxel oral spray has no adverse side effects, and has therapeutic effect on oral cancer, esophageal cancer, gastric cancer, oral ulcer, periodontitis, halitosis, pharyngitis, dyspepsia, flatulence, gastric acid and various symptoms caused by multienzyme deficiency.
The specific implementation mode is as follows:
example 1:
firstly, the following raw materials and the weight ratio thereof are selected as the components of the preparation method of the invention
Snail compound enzyme 12, aloe gel liquid 90, peppermint essential oil 0.8 and taxol 0.5
Then: the three components are put into a high-speed mixer to be uniformly mixed.
And finally, pumping the mixture into an ozone sterilizer by using a miniature beverage pump for sterilization treatment, and filling, sealing and packaging to obtain a finished product.
Example 2:
firstly, the following raw materials and the weight ratio thereof are selected as the components of the preparation method of the invention
Snail compound enzyme 12, aloe gel liquid 100, peppermint essential oil 1.2 and taxol 0.01
Then the three components are put into a high-speed mixer to be mixed evenly.
And finally, pumping the mixture into an ozone sterilizer by using a miniature beverage pump for sterilization treatment, and filling, sealing and packaging to obtain a finished product.
Example 3:
firstly, the following raw materials and the weight ratio thereof are selected as the components of the preparation method of the invention
Snail compound enzyme 10, aloe gel liquid 95, peppermint essential oil 1 and taxol 0.02
Then putting the three components into a high-speed mixer for mixing: and (4) uniformity.
And finally, pumping the mixture into an ozone sterilizer by using a miniature beverage pump for sterilization treatment, and filling, sealing and packaging to obtain a finished product.
Claims (1)
1. A preparation method of a multi-enzyme oral multifunctional spray is characterized by comprising the following steps: firstly, the following raw materials and the weight ratio thereof are selected as the components of the preparation method of the invention: snail compound enzyme 8-12, aloe gel liquid 90-100, menthol 0.8-1.2, taxol 0.01-0.02, then putting the above four components into high speed mixer and mixing them uniformly. And finally, pumping the mixture into an ozone sterilizer by using a miniature beverage pump for sterilization treatment, filling, sealing and packaging to obtain a finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910710238.6A CN111481661A (en) | 2019-08-02 | 2019-08-02 | Preparation method of multi-enzyme oral multifunctional spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910710238.6A CN111481661A (en) | 2019-08-02 | 2019-08-02 | Preparation method of multi-enzyme oral multifunctional spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111481661A true CN111481661A (en) | 2020-08-04 |
Family
ID=71788692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910710238.6A Pending CN111481661A (en) | 2019-08-02 | 2019-08-02 | Preparation method of multi-enzyme oral multifunctional spray |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111481661A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857201A (en) * | 2014-02-25 | 2015-08-26 | 陈玉柱 | Method for preparing snail multienzyme taxol oral spray |
-
2019
- 2019-08-02 CN CN201910710238.6A patent/CN111481661A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857201A (en) * | 2014-02-25 | 2015-08-26 | 陈玉柱 | Method for preparing snail multienzyme taxol oral spray |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200804 |