CN111419387B - Method for preparing balloon surface ablation electrode in piezoelectric spraying mode - Google Patents
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- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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Abstract
The invention discloses a method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode, which comprises the following steps of: (1) Determining an electrode material, namely selecting the electrode material with conductivity, biocompatibility, 4-40% of mass ratio and 0-35 cP of viscosity; (2) Pretreating the electrode material determined in the step (1) and the surface of the saccule; (3) Spraying the electrode material pretreated in the step (2) on the surface of the pretreated balloon in a piezoelectric spraying mode to form an electrode; (4) And drying and curing the sprayed electrode to obtain the balloon surface ablation electrode. Through non-contact piezoelectric spraying, the patterned and customized ablation electrode can be prepared on the surface of the balloon, the defects caused by improper electrode fixing mode are eliminated, and the electrode conductivity and ablation energy can be controlled by controlling the spraying layer number, the drying curing heating temperature and the continuous drying time so as to increase the ablation effect.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode.
Background
The radio frequency ablation has certain application in the fields of atrial fibrillation, hypertension treatment, tumor treatment and the like, and promotes the rapid development of a radio frequency ablation system, and an ablation catheter is one of the core components of the radio frequency ablation system. With the accumulation of catheter ablation applications, ablation catheters of rf ablation systems also present some drawbacks, such as: the improvement of ablation catheters is urgently researched due to insufficient contact between the catheter and ablation tissues, undesirable ablation effect caused by contact between an electrode and the catheter and the like. In recent years, the development of ablation catheters has focused primarily on catheter structures and electrode structures. The improvement of the catheter structure is mainly embodied in the change from a cylindrical catheter to a balloon catheter, and the improvement of the electrode structure is embodied in the aspects of the number of electrodes, the shape of the electrodes, the position and the fixation of the electrodes and the like.
Disclosure of Invention
In view of the above defects of the existing ablation catheter technology, the technical problem to be solved by the present invention is to provide a method for preparing a balloon surface ablation electrode in a piezoelectric spraying manner, which can be used for preparing a novel balloon catheter ablation electrode, has the characteristics of patterned customized electrodes, non-contact spraying, and the like, and can mainly eliminate the defects caused by improper electrode fixing manner, so as to increase ablation energy, reduce surgical ablation time, and improve surgical efficiency.
In order to achieve the purpose, the invention provides a method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode, which comprises the following steps: (1) Determining an electrode material, namely selecting the electrode material with conductivity, biocompatibility, 4-40% of mass ratio and 0-35 cP of viscosity; (2) Pretreating the electrode material determined in the step (1) and the surface of the saccule; (3) Spraying the electrode material pretreated in the step (2) on the surface of the pretreated balloon in a piezoelectric spraying mode to form an electrode; (4) And drying and curing the sprayed electrode to obtain the balloon surface ablation electrode.
Further, the electrode material is one of a nano silver solution, a nano gold solution, a graphene conductive biological solution or a polypyrrole conductive solution.
Further, the balloon is made of one of polyester, poly citrate or nylon.
Further, the pretreatment process of the electrode material comprises the following steps: putting the container containing the electrode material into a water bath, performing ultrasonic treatment for 60-240 s to uniformly disperse the electrode material solution, taking out a certain amount of the electrode material solution by using a needle cylinder, and injecting the electrode material solution into a liquid storage device of a piezoelectric spraying system by matching with a 0.45-micron filter.
Further, the balloon surface pretreatment process comprises the following steps: and (3) putting the saccule into absolute ethyl alcohol, performing ultrasonic cleaning for 120-180 s, taking out, wiping the saccule with dust-free cloth, and naturally drying at room temperature.
Further, in the piezoelectric spraying manner in the step (3), the spraying parameters are set as follows: the diameter of the piezoelectric nozzle is 30-60 mu m, the voltage amplitude is 30-50V, the piezoelectric period is 10-60 mu s, and the number of spraying layers is 5-8.
Further, in the piezoelectric spraying process in the step (3), a needle cylinder is used for filling hot water with the temperature of 80-100 ℃ into the saccule for water bath heating.
Further, the method for drying and curing the sprayed electrode in the step (4) is heating and curing, the adopted equipment is electric heating equipment, the heating temperature is set to be 90-140 ℃, and the continuous drying time is 20-35 min.
The invention has the beneficial effects that:
the invention discloses a method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode. Through non-contact piezoelectric spraying, the patterned and customized ablation electrode can be prepared on the surface of the balloon, the defects caused by improper electrode fixing mode are eliminated, and the electrode conductivity and ablation energy can be controlled by controlling the spraying layer number, the drying curing heating temperature and the continuous drying time so as to increase the ablation effect.
The present invention and the technical effects thereof will be further described in the following with reference to the accompanying drawings and embodiments, so that the objects, features and effects thereof can be fully understood.
Drawings
Fig. 1 is the in vitro ablation effect of the balloon surface ablation electrode of example 1 of the present invention.
Fig. 2 is the effect of ablation in vitro by the balloon surface ablation electrode of example 2 of the present invention.
Fig. 3 is the in vitro ablation effect of the balloon surface ablation electrode of example 3 of the present invention.
Fig. 4 is the in vitro ablation effect of the balloon surface ablation electrode of example 4 of the present invention.
Fig. 5 is an in vitro ablation effect of the balloon surface ablation electrode of example 5 of the present invention.
Fig. 6 shows the in vitro ablation effect of the balloon surface ablation electrode of comparative example 1 of the present invention.
Fig. 7 shows the in vitro ablation effect of the balloon surface ablation electrode of comparative example 2 of the present invention.
Fig. 8 is a photomicrograph of the balloon surface ablation electrodes of example 1 and comparative example 1 of the present invention.
Fig. 9 is a photomicrograph of balloon surface ablation electrodes of example 2 of the present invention and comparative example 2.
Detailed Description
The invention provides a method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode, which comprises the steps of determining an electrode material, pretreating the surface of a balloon and the electrode material, spraying the electrode with piezoelectric, drying and curing, and specifically comprises the following steps: firstly, determining an electrode material, wherein the electrode material has conductivity and biocompatibility, the mass ratio of 4-40% and the viscosity of 0-35 cP; then respectively pretreating the electrode material and the surface of the saccule; then spraying the pretreated electrode material solution on the surface of the pretreated balloon by using a piezoelectric spraying mode to form an electrode; and finally, drying and curing the sprayed electrode to obtain the balloon surface ablation electrode.
In a specific embodiment of the present invention, the electrode material may be one of a nano silver solution, a nano gold solution, a graphene conductive biological solution, or a polypyrrole conductive solution; the material of the balloon may be one of polyester, poly citrate or nylon.
In a specific embodiment of the present invention, the electrode material pretreatment process is: putting the container containing the electrode material into a water bath for ultrasonic treatment for 60-240 s to uniformly disperse the electrode material solution, taking out a certain amount of the electrode material solution by using a needle cylinder, and injecting the electrode material solution into a liquid storage device of a piezoelectric spraying system through a 0.45-micrometer filter to prevent dust and impurities from blocking a spray head of the piezoelectric spraying system in the spraying process.
In a specific embodiment of the present invention, the balloon surface pretreatment process is: and (3) putting the saccule into absolute ethyl alcohol, performing ultrasonic cleaning for 120-180 s, taking out, wiping the saccule with dust-free cloth, and naturally drying at room temperature.
In a specific embodiment of the present invention, the piezoelectric spraying step is performed using a piezoelectric spraying system, and the spraying parameters are set as follows: the diameter of the piezoelectric nozzle is 30-60 mu m, the voltage amplitude is 30-50V, the piezoelectric period is 10-60 mu s, and the number of spraying layers is 5-8. The piezo spray system may use any commercially available piezo spray system, including jetlab4 piezo spray system from MicroFab, USA, and RD-COATER spray system from Shanghai Rui electro-optical technology, inc.
In the specific embodiment of the invention, in order to quickly volatilize the solvent in the electrode material solution sprayed on the surface of the balloon and avoid the influence of the liquid drop flowing phenomenon on the electrode structure, a needle cylinder is used for filling hot water with the temperature of 80-100 ℃ into the balloon for water bath heating in the spraying process.
In the specific embodiment of the invention, the electrode drying and curing method after spraying is heating and curing, the adopted equipment is electric heating equipment comprising an electric heating constant temperature incubator of Shanghai cable zone test equipment Limited company, the heating temperature is set to be 90-140 ℃, and the continuous drying time is 20-35 min.
In the drying and curing process of the ablation electrode on the surface of the balloon, the heating temperature has important influence on the ablation effect of the electrode. The higher the heating temperature is, the lower the resistivity of the electrode is, and the better the electrode ablation effect is; however, when the heating temperature is too high, the surface of the coating can be fractured, and the compactness and the ablation effect of the surface of the coating are influenced. Therefore, in order to effectively control the ablation effect of the electrode, the heating temperature of the ablation electrode on the surface of the balloon in the drying and curing process is strictly controlled. The heating temperature is in the range of 90 to 140 deg.C, preferably 100 to 120 deg.C.
In the process of drying and curing the ablation electrode on the surface of the balloon, the continuous drying time also has an important influence on the ablation effect of the electrode. With the increase of the continuous drying time, the resistivity of the electrode is gradually reduced, and the ablation effect of the electrode is better; however, if the continuous drying time is too long, the surface of the coating will wrinkle and break, which affects the surface compactness and ablation effect of the coating. Therefore, in order to effectively control the ablation effect of the electrode, the continuous drying time of the drying and curing process of the ablation electrode on the surface of the balloon is strictly controlled. The continuous drying time is 20-35 min, preferably 20-30 min.
The working principle of the invention is illustrated below with reference to specific embodiments:
example 1
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 μm, the voltage amplitude is 40V, the piezoelectric period is 20 μ s, and the number of spraying layers is 5. And drying the sprayed electrode for 20min at 120 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Example 2
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 mu m, the voltage amplitude is 40V, the piezoelectric period is 20 mu s, and the number of spraying layers is 5. And drying the sprayed electrode for 25min at 120 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Example 3
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 mu m, the voltage amplitude is 40V, the piezoelectric period is 20 mu s, and the number of spraying layers is 5. And drying the sprayed electrode for 30min at 120 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Example 4
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 μm, the voltage amplitude is 40V, the piezoelectric period is 20 μ s, and the number of spraying layers is 5. And drying the sprayed electrode for 30min at 100 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Example 5
Selecting a nano silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano silver particles, taking out 2mL of the nano silver particles by using a needle cylinder, injecting the nano silver particles into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45-micrometer filter, and spraying the nano silver particles on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 μm, the voltage amplitude is 40V, the piezoelectric period is 20 μ s, and the number of spraying layers is 5. Drying the sprayed electrode for 30min at 110 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Comparative example 1
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 mu m, the voltage amplitude is 40V, the piezoelectric period is 20 mu s, and the number of spraying layers is 5. And drying the sprayed electrode for 20min at 160 ℃ by using an electric heating constant-temperature incubator to finally obtain the balloon surface ablation electrode.
Comparative example 2
Selecting a nano-silver solution with the mass ratio of 30% and the viscosity of 15cP, putting a container containing the nano-silver solution into a water bath for ultrasonic treatment for 120s to uniformly disperse nano-silver particles, taking out 2mL by using a syringe, injecting the obtained solution into a liquid accumulator of a jetlab4 type piezoelectric spraying system through a 0.45 mu m filter, and spraying the obtained solution on the surface of a balloon which is pretreated and is heated in the water bath at 90 ℃ according to the following spraying parameters: the diameter of the piezoelectric nozzle is 30 μm, the voltage amplitude is 40V, the piezoelectric period is 20 μ s, and the number of spraying layers is 5. And drying the sprayed electrode for 40min at 120 ℃ by using an electrothermal constant-temperature incubator to finally obtain the balloon surface ablation electrode.
The in-vitro ablation volumes of the balloon surface ablation electrodes of the comparative examples and the comparative examples can be found that the quality, the conductivity and the ablation effect of the electrodes can be controlled by controlling the heating temperature and the continuous drying time in the drying and curing process of the balloon surface ablation electrode. Fig. 8 shows photomicrographs of balloon surface ablation electrodes of example 1 and comparative example 1, in which the balloon surface ablation electrode coating of example 1 with a dry curing heating temperature of 120 ℃ is uniform and dense, while the balloon surface ablation electrode coating of comparative example 1 with a dry curing heating temperature of 160 ℃ is rough and poor in compactness, even cracks appear, and as can be seen from the in-vitro ablation volume curve of the balloon surface ablation electrode of fig. 6, the balloon surface ablation electrode formed with a dry curing heating temperature of 160 ℃ has a poor effect in the ablation process, and the ablation effect is not significantly improved with the increase of the ablation time. Fig. 9 shows photomicrographs of the balloon surface ablation electrodes of example 2 and comparative example 2, in which the balloon surface ablation electrode coating of example 2 with the drying curing duration and drying time of 25min is uniform and dense, while the balloon surface ablation electrode coating of comparative example 2 with the drying curing duration and drying time of 40min has poor surface compactness, folds and cracks, and as can be seen from the in-vitro ablation volume curve of the balloon surface ablation electrode of fig. 7, the balloon surface ablation electrode formed with the drying curing duration and drying time of 40min has poor effect in the ablation process, and the ablation effect cannot be obviously improved even if the ablation time is increased.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations can be devised by those skilled in the art in light of the above teachings. Therefore, the technical solutions that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the prior art according to the concepts of the present invention should be within the scope of protection determined by the claims.
Claims (6)
1. A method for preparing a balloon surface ablation electrode in a piezoelectric spraying mode is characterized by comprising the following steps: (1) Determining an electrode material, namely selecting the electrode material with conductivity, biocompatibility, 4-40% of mass ratio and 0-35 cP of viscosity; (2) Pretreating the electrode material determined in the step (1) and the surface of the saccule; (3) Spraying the electrode material pretreated in the step (2) on the surface of the pretreated balloon in a piezoelectric spraying manner to form an electrode; (4) Drying and curing the sprayed electrode to obtain a balloon surface ablation electrode;
in the piezoelectric spraying mode in the step (3), the spraying parameters are set as follows: the diameter of the piezoelectric nozzle is 30-60 mu m, the voltage amplitude is 30-50V, the piezoelectric period is 10-60 mu s, and the number of spraying layers is 5-8;
and (4) heating and curing the sprayed electrode, wherein the adopted equipment is electric heating equipment, the heating temperature is set to be 90-140 ℃, and the continuous drying time is 20-35 min.
2. The method for preparing the balloon surface ablation electrode in the piezoelectric spraying manner according to claim 1, wherein the method comprises the following steps: the electrode material is one of a nano silver solution, a nano gold solution, a graphene conductive biological solution or a polypyrrole conductive solution.
3. The method for preparing the balloon surface ablation electrode in the piezoelectric spraying manner according to claim 1, characterized in that: the balloon is made of one of polyester, poly citrate or nylon.
4. The method for preparing the balloon surface ablation electrode in the piezoelectric spraying manner according to claim 1, wherein the pretreatment process of the electrode material comprises the following steps: putting the container containing the electrode material into a water bath for ultrasonic treatment for 60-240 s to uniformly disperse the electrode material solution, taking out a certain amount of the electrode material solution by using a needle cylinder, and injecting the electrode material solution into a liquid storage device of a piezoelectric spraying system by matching with a 0.45 mu m filter.
5. The method for preparing the balloon surface ablation electrode in the piezoelectric spraying manner according to claim 1, wherein the balloon surface pretreatment process comprises the following steps: putting the saccule into absolute ethyl alcohol, ultrasonically cleaning for 120-180 s, taking out, wiping by using dust-free cloth, and naturally drying at room temperature.
6. The method for preparing the ablation electrode on the surface of the balloon in the piezoelectric spraying manner according to claim 1, wherein in the piezoelectric spraying process in the step (3), a needle cylinder is used for filling hot water with the temperature of 80-100 ℃ into the balloon for water bath heating.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE178218T1 (en) * | 1993-02-05 | 1999-04-15 | Joe W And Dorothy Dorsett Brow | ULTRASONIC BALLOON CATHETER FOR ANGIOPLASTY |
| US5991650A (en) * | 1993-10-15 | 1999-11-23 | Ep Technologies, Inc. | Surface coatings for catheters, direct contacting diagnostic and therapeutic devices |
| US9795442B2 (en) * | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
| CN101710537B (en) * | 2009-12-09 | 2011-05-11 | 上海奥威科技开发有限公司 | Electrode for super capacitor and manufacturing method thereof |
| CN103536352A (en) * | 2012-07-09 | 2014-01-29 | 李莉 | Balloon expanding renal artery sympathetic nerve ablation catheter |
| US20140276687A1 (en) * | 2013-03-15 | 2014-09-18 | Volcano Corporation | Assessment of varicose vein ablation via imaging or functional measurement analysis |
| CN204655099U (en) * | 2015-04-14 | 2015-09-23 | 常承忠 | Be used for the treatment of the radio-frequency ablation electrode of the freezing sacculus of hypertensive band |
| CN109925049A (en) * | 2017-12-19 | 2019-06-25 | 上海微创医疗器械（集团）有限公司 | Radio frequency ablation catheter and radio frequency ablation system |
| CN109338269A (en) * | 2018-10-30 | 2019-02-15 | 昆明理工大学 | A kind of preparation method of copper-based conductivity ceramics coating electrode material |
| CN209951387U (en) * | 2019-04-28 | 2020-01-17 | 武汉麦朗医疗科技有限公司 | External wrapping type bipolar ablation electrode |
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