CN111417850A - 用于体液检测的电化学传感器和检测装置 - Google Patents

用于体液检测的电化学传感器和检测装置 Download PDF

Info

Publication number
CN111417850A
CN111417850A CN201880001542.7A CN201880001542A CN111417850A CN 111417850 A CN111417850 A CN 111417850A CN 201880001542 A CN201880001542 A CN 201880001542A CN 111417850 A CN111417850 A CN 111417850A
Authority
CN
China
Prior art keywords
detection
electrochemical sensor
body fluid
sample
liquid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880001542.7A
Other languages
English (en)
Other versions
CN111417850B (zh
Inventor
吴峥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOE Technology Group Co Ltd
Original Assignee
BOE Technology Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOE Technology Group Co Ltd filed Critical BOE Technology Group Co Ltd
Publication of CN111417850A publication Critical patent/CN111417850A/zh
Application granted granted Critical
Publication of CN111417850B publication Critical patent/CN111417850B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/301—Reference electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/401—Salt-bridge leaks; Liquid junctions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M8/00—Fuel cells; Manufacture thereof
    • H01M8/16—Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/50—Fuel cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Manufacturing & Machinery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Sustainable Energy (AREA)
  • Pulmonology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

一种用于体液检测的电化学传感器和检测装置。该用于体液检测的电化学传感器包括材料层(110)；材料层(110)包括至少一个亲水区(112)；至少一个检测单元(120)设置在亲水区(112)；亲水区(112)包括采样端口(1120)，被配置为与待检测的液体样品接触；检测单元(120)包括间隔设置的工作电极(121)和对置电极(122)；工作电极(121)包括含有与液体样品中分析物产生化学反应的物质的反应表面(1210)；工作电极(121)和对置电极(122)被配置为检测该化学反应产生的电信号以检测分析物。该用于体液检测的电化学传感器的结构简单，并且可采用纸基材料制作材料层，从而可降低用于体液检测的电化学传感器的成本、便于携带。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201880001542.7A 2018-09-29 2018-09-29 用于体液检测的电化学传感器和检测装置 Active CN111417850B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/108648 WO2020062143A1 (zh) 2018-09-29 2018-09-29 用于体液检测的电化学传感器和检测装置

Publications (2)

Publication Number Publication Date
CN111417850A true CN111417850A (zh) 2020-07-14
CN111417850B CN111417850B (zh) 2023-09-05

Family

ID=69949259

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880001542.7A Active CN111417850B (zh) 2018-09-29 2018-09-29 用于体液检测的电化学传感器和检测装置

Country Status (4)

Country Link
US (1) US11733195B2 (zh)
EP (1) EP3862750A4 (zh)
CN (1) CN111417850B (zh)
WO (1) WO2020062143A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111879838A (zh) * 2020-08-21 2020-11-03 电子科技大学 一种柔性纸基电压型湿度传感器及其制备方法
CN113686941A (zh) * 2021-08-10 2021-11-23 朱浩奇 一种化学传感器

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114113266A (zh) * 2021-12-20 2022-03-01 北京理工大学重庆创新中心 一种用于汗液标志物分析的传感装置

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002054055A1 (en) * 2001-01-04 2002-07-11 Tyson Bioresearch, Inc. Biosensors having improved sample application
CN1370993A (zh) * 2001-02-20 2002-09-25 刘开颜 一种生物传感器及运用该传感器的量化检测方法
US20040245101A1 (en) * 2001-08-29 2004-12-09 Itamar Willner Self-powered biosensor
WO2008088357A1 (en) * 2007-01-18 2008-07-24 Provex Technologies, Llc. Ultrasensitive amperometric saliva glucose sensor strip
WO2009097174A2 (en) * 2008-01-07 2009-08-06 Stc.Unm Electrochemical biosensor
US20100213082A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
US20100243477A1 (en) * 2008-08-27 2010-09-30 Edwards Lifesciences Corporation Analyte Sensor
WO2014149161A2 (en) * 2013-03-15 2014-09-25 Georgetown University Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate
CN105606682A (zh) * 2016-01-26 2016-05-25 南通大学 一种基于纸基电化学装置的测定葡萄糖的方法
CN106104264A (zh) * 2014-01-21 2016-11-09 加利福尼亚大学董事会 唾液生物传感器以及生物燃料电池
US20180030497A1 (en) * 2015-02-05 2018-02-01 The Regents Of The University Of California Multiple-use renewable electrochemical sensors based on direct drawing of enzymatic inks
CN108548858A (zh) * 2018-06-22 2018-09-18 桂林中辉科技发展有限公司 一种快速测量淀粉酶的电化学试纸及其制备与检测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6923894B2 (en) * 1999-11-11 2005-08-02 Apex Biotechnology Corporation Biosensor with multiple sampling ways
JP4183902B2 (ja) * 2000-12-27 2008-11-19 松下電器産業株式会社 バイオセンサ
US7311812B2 (en) * 2003-05-30 2007-12-25 Abbott Laboratories Biosensor
WO2005048834A1 (en) * 2003-11-13 2005-06-02 Medtronic Minimed, Inc. Long term analyte sensor array
EP2075339A1 (en) 2004-08-13 2009-07-01 Egomedical Technologies AG Analyte test system for calculating the concentration of an analyte in a physiological or aqueous fluid
US8062221B2 (en) * 2005-09-30 2011-11-22 Nellcor Puritan Bennett Llc Sensor for tissue gas detection and technique for using the same
US20070169533A1 (en) * 2005-12-30 2007-07-26 Medtronic Minimed, Inc. Methods and systems for detecting the hydration of sensors
US20100169035A1 (en) * 2008-12-29 2010-07-01 Medtronic Minimed, Inc. Methods and systems for observing sensor parameters
WO2013130145A2 (en) * 2011-11-30 2013-09-06 The Regents Of The University Of California Printed biofuel cells
CA2958554C (en) * 2014-08-21 2023-02-28 Qurasense Inc. System and method for non-invasive analysis of bodily fluids
JP2018518655A (ja) 2015-04-03 2018-07-12 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ サンプル分析用デバイス及び方法
CN107096581B (zh) 2017-06-13 2019-07-30 中国科学院电子学研究所 微流控纸芯片及应用其的检测***
WO2019068047A1 (en) 2017-09-29 2019-04-04 W.L. Gore & Associates, Inc. FLUID HANDLING DETECTORS

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002054055A1 (en) * 2001-01-04 2002-07-11 Tyson Bioresearch, Inc. Biosensors having improved sample application
CN1370993A (zh) * 2001-02-20 2002-09-25 刘开颜 一种生物传感器及运用该传感器的量化检测方法
US20040245101A1 (en) * 2001-08-29 2004-12-09 Itamar Willner Self-powered biosensor
WO2008088357A1 (en) * 2007-01-18 2008-07-24 Provex Technologies, Llc. Ultrasensitive amperometric saliva glucose sensor strip
WO2009097174A2 (en) * 2008-01-07 2009-08-06 Stc.Unm Electrochemical biosensor
US20100243477A1 (en) * 2008-08-27 2010-09-30 Edwards Lifesciences Corporation Analyte Sensor
US20100213082A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
WO2014149161A2 (en) * 2013-03-15 2014-09-25 Georgetown University Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate
CN106104264A (zh) * 2014-01-21 2016-11-09 加利福尼亚大学董事会 唾液生物传感器以及生物燃料电池
US20180030497A1 (en) * 2015-02-05 2018-02-01 The Regents Of The University Of California Multiple-use renewable electrochemical sensors based on direct drawing of enzymatic inks
CN105606682A (zh) * 2016-01-26 2016-05-25 南通大学 一种基于纸基电化学装置的测定葡萄糖的方法
CN108548858A (zh) * 2018-06-22 2018-09-18 桂林中辉科技发展有限公司 一种快速测量淀粉酶的电化学试纸及其制备与检测方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张先恩: "《生物传感技术原理与应用》", 31 May 1991, 吉林科学技术出版社, pages: 121 - 123 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111879838A (zh) * 2020-08-21 2020-11-03 电子科技大学 一种柔性纸基电压型湿度传感器及其制备方法
CN113686941A (zh) * 2021-08-10 2021-11-23 朱浩奇 一种化学传感器

Also Published As

Publication number Publication date
CN111417850B (zh) 2023-09-05
US20210325332A1 (en) 2021-10-21
US11733195B2 (en) 2023-08-22
EP3862750A1 (en) 2021-08-11
WO2020062143A1 (zh) 2020-04-02
EP3862750A4 (en) 2022-07-27

Similar Documents

Publication Publication Date Title
Sempionatto et al. Touch-based fingertip blood-free reliable glucose monitoring: Personalized data processing for predicting blood glucose concentrations
CN1273831C (zh) 对生物体液组分采样及测量的装置和***
CN111417850B (zh) 用于体液检测的电化学传感器和检测装置
US20160235346A1 (en) Electrochemical Sensor for a Bandage Type of Continuous Glucose Monitoring System
CN103462615B (zh) 微米尺度葡萄糖传感器微电极
US9354226B2 (en) Transdermal systems, devices, and methods to optically analyze an analyte
CN100574700C (zh) 使用水凝胶对分析物取样和分析的***和方法
US10251605B2 (en) Bandage type of continuous glucose monitoring system
WO2008088357A1 (en) Ultrasensitive amperometric saliva glucose sensor strip
JP2002528190A (ja) イオン導入サンプリングシステムの品質管理試験のためのキットおよび方法
CN109922711B (zh) 电子单次使用化学诊断装置
JP7480234B2 (ja) クレアチニンを検出するための分析物センサ及び検出方法
WO2011084607A1 (en) Transdermal systems, devices, and methods for biological analysis
Phan et al. Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare
CN101762629A (zh) 生物体内成分测定方法以及生物体内成分测定装置
CN110186976A (zh) 葡萄糖监测探头的工作电极及其制作方法
US20240151680A1 (en) Electrochemical sensor device for rapid analyte detection and methods of making and using the same
Oh et al. Closed bipolar electrode-enabled electrochromic sensing of multiple metabolites in whole blood
CN109682873A (zh) 一种唾液检测装置及***
CN102590165A (zh) 一种电学与光学联用尿液分析生化装置及其制造方法
CN115112738B (zh) 一种激光直写石墨烯/酶电极的制备及葡萄糖传感应用
Punter-Villagrasa et al. Amperometric and impedance monitoring systems for biomedical applications
CN113598760B (zh) 生物监测装置
CN203249891U (zh) 生物传感器
CN1296180A (zh) 具多功能取样方式之生化感测器

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant