CN111388027B - Bone marrow harvesting device - Google Patents
Bone marrow harvesting device Download PDFInfo
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- CN111388027B CN111388027B CN202010218522.4A CN202010218522A CN111388027B CN 111388027 B CN111388027 B CN 111388027B CN 202010218522 A CN202010218522 A CN 202010218522A CN 111388027 B CN111388027 B CN 111388027B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
- A61B2010/0258—Marrow samples
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The utility model discloses a bone marrow collecting device, which comprises a sleeve and a needle core sleeved in the sleeve, wherein an input channel for inputting impact liquid and an output channel for extracting bone marrow mixture are arranged in the needle core; the system comprises a storage cavity, an impact pump and an impact pipeline, wherein the impact pipeline is communicated with the input channel, and the impact pump is used for outputting impact liquid in the storage cavity to the input channel; the acquisition system comprises an acquisition cavity, and the acquisition cavity is communicated with the output channel through a pipeline. According to the bone marrow collecting device provided by the utility model, the bone marrow cavity is impacted by the high-speed liquid flow of the impact system, so that more bone marrow is extracted in a larger range, and the times of puncturing are reduced.
Description
Technical Field
The utility model relates to medical equipment, in particular to a bone marrow collecting device.
Background
Bone marrow harvesting is known as the main therapy for treating leukemia clinically, and is also commonly used in cytogenetic analysis, etiology examination and other projects, wherein when the bone marrow harvesting is used for treating leukemia, a large amount of bone marrow, namely hematopoietic stem cells, are required to be extracted, and when the examination and analysis are performed, only a small amount of bone marrow is required to be extracted. Since the available bone marrow is limited at each bone marrow puncture site, multiple, multi-point punctures are required to obtain sufficient quantities of hematopoietic stem cells for leukemia treatment.
In the prior art, the reason that each puncture point can only acquire limited hematopoietic stem cells is two, one is that the bone marrow volume of each position is limited, which is an objective fact and cannot be changed, and the other is that the actual extraction amount is limited, because in the prior art, an acquisition needle extends into a bone marrow cavity, and the acquisition of bone marrow is realized by sucking through the acquisition needle, and obviously, only limited bone marrow in the needle head area of the acquisition needle can be sucked. For example, the application publication number is CN109009250a, the application publication date is 12/18/2018, and the utility model patent application named "a bone marrow collecting and filtering device and method" provides such a bone marrow collecting device, and the bone marrow is extracted by a puncture needle extending into the bone marrow cavity. Also provided are such bone marrow harvesting devices as disclosed in the patent issued CN209847319U, CN204394583U, CN205569034U and CN 204293200U.
Above, the prior art has the disadvantage that the number of bone marrow punctures is excessive because the collection needle can only extract limited bone marrow near the needle head, resulting in an excessively small amount of extraction.
Disclosure of Invention
The utility model aims to provide a bone marrow harvesting device which solves the defects in the prior art.
In order to achieve the above object, the present utility model provides the following technical solutions:
the bone marrow collecting device comprises a sleeve and a needle core sleeved in the sleeve, wherein an input channel for inputting impact liquid and an output channel for extracting bone marrow mixture are arranged in the needle core;
the system comprises a storage cavity, an impact pump and an impact pipeline, wherein the impact pipeline is communicated with the input channel, and the impact pump is used for outputting impact liquid in the storage cavity to the input channel; the acquisition system comprises an acquisition cavity, and the acquisition cavity is communicated with the output channel through a pipeline.
According to the bone marrow collecting device, the input channel and the output channel share the same communication port at the needle tip, and the input channel and the output channel work in turn.
According to the bone marrow collection device, the collection system comprises the separation system, and serum separated by the separation system is output to the storage cavity through the pipeline.
According to the bone marrow collection device, the drill opening part is arranged at one end of the end part of the sleeve, the connecting seat is arranged at the other end of the sleeve, the connecting seat is provided with the plug-in part, and the plug-in part is used for the linear plug-in connection of the transmission structure of the motor.
According to the bone marrow collecting device, the connecting seat is of the limiting structure, and when the sleeve bone marrow is sucked, the connecting seat is attached to the skin of a patient.
In the bone marrow collection device, the plug-in part is a plurality of plug-in grooves or plug-in columns.
The bone marrow collecting device further comprises a stirring mechanism, wherein the stirring mechanism comprises a transmission wire and a stirring head arranged at the end part of the transmission wire, and the stirring head and the transmission wire can enter the bone marrow cavity through the input channel.
According to the bone marrow collecting device, the stirring head comprises the elastic stretching mechanism, the elastic stretching mechanism is in a folding state in the input channel, and the elastic stretching mechanism automatically stretches after external pressure disappears.
In the bone marrow harvesting device, the elastic stretching mechanism is of a cage-shaped structure.
In the bone marrow collecting device, the cage-shaped structure is provided with a plurality of elastic extending hooks.
In the technical scheme, the bone marrow collecting device provided by the utility model impacts the bone marrow cavity through the high-speed liquid flow of the impact system, so that more bone marrow is extracted in a larger range, and the number of times of puncture is reduced.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present utility model, and other drawings may be obtained according to these drawings for a person having ordinary skill in the art.
Fig. 1 is a schematic structural diagram of a bone marrow harvesting device according to an embodiment of the present utility model;
FIG. 2 is a schematic view of a cannula and a stylet according to an embodiment of the present utility model;
FIG. 3 is a top view of a sleeve according to an embodiment of the present utility model;
FIG. 4 is a schematic view of a cannula and a stylet according to another embodiment of the present utility model;
FIG. 5 is a side view of an inner core provided in an embodiment of the present utility model;
FIG. 6 is a side view of a resilient pointed end and rounded portion provided in an embodiment of the present utility model;
FIG. 7 is a side view of a stirring head according to an embodiment of the present utility model;
fig. 8 is a schematic structural view of a stirring and cutting mechanism in a first state according to an embodiment of the present utility model;
fig. 9 is a schematic structural diagram of a stirring and cutting mechanism in a second state according to an embodiment of the present utility model.
Reference numerals illustrate:
1. a sleeve; 1.1, a drilling part; 1.2, a connecting seat; 1.21, a plug-in part; 1.22, a magnetic attraction part; 2. a needle core; 2.1, an input channel; 2.2, outputting channels; 3. a communication port; 4. a stirring and cutting mechanism; 4.1, a transmission wire; 4.11, a first transmission wire; 4.12, a second transmission wire; 4.2, stirring and cutting heads; 4.21, a kernel; 4.211, limit groove; 4.22, elastic sharp ends; 4.23, arc part; 5. an impact system; 5.1, a storage cavity; 5.2, an impact pump; 5.3, impacting the pipeline; 6. an acquisition system; 6.1, collecting cavity; 6.2, a separation system.
Detailed Description
In order to make the technical scheme of the present utility model better understood by those skilled in the art, the present utility model will be further described in detail with reference to the accompanying drawings.
As shown in fig. 1-9, the bone marrow harvesting device provided by the embodiment of the utility model comprises a sleeve 1 and a needle core 2 sleeved in the sleeve 1, wherein an input channel 2.1 for inputting impact liquid and an output channel 2.2 for extracting bone marrow mixture are arranged in the needle core 2; the system further comprises an impact system 5 and a collection system 6, wherein the impact system 5 comprises a storage cavity 5.1, an impact pump 5.2 and an impact pipeline 5.3, the impact pipeline 5.3 is communicated with the input channel 2.1, and the impact pump 5.2 is used for outputting impact liquid in the storage cavity 5.1 into the input channel 2.1; the collection system 6 comprises a collection cavity 6.1, and the collection cavity 6.1 is communicated with the output channel 2.2 through a pipeline.
Specifically, the cannula 1 is used for stabilizing a through hole drilled on human tissue through a surgical instrument, the needle core 2 stretches into the cannula 1, the needle tip of the needle core 2 is positioned in a bone marrow cavity, the other end of the needle core 2 is connected with the acquisition system 6 to extract bone marrow in the bone marrow cavity, and the core innovation point of the embodiment is that two channels are arranged in parallel in the needle core 2: the input channel 2.1 and the output channel 2.2, the output channel 2.2 bears the function of the needle core 2 in the prior art, namely, the bone marrow mixture in the bone marrow cavity is pumped out, the input channel 2.1 is connected with the impact system 5, the impact system 5 comprises a storage cavity 5.1, an impact pump 5.2 and an impact pipeline 5.3, the storage cavity 5.1, the impact pump 5.2 and the input channel 2.1 are sequentially connected through the impact pipeline 5.3, and the impact liquid of the storage cavity 5.1 is input into the input channel 2.1 at a high speed through the impact pump 5.2, so that the impact liquid compatible with the bone marrow cavity, such as blood anticoagulation liquid (heparin sodium diluent), serum and the like, is stored in the storage cavity 5.1, and the blood anticoagulation liquid is used for further having the advantages of adding the blood anticoagulation liquid in advance, and the probability of blood coagulation in the pumping process is reduced.
In the bone marrow collecting device provided in this embodiment, in a bone marrow collecting operation, two channels of the needle core 2 are respectively connected with the impact system 5 and the collecting system 6, after the sleeve 1 is implanted on a human body, the needle core 2 is put into the sleeve 1, when the bone marrow is collected, the impact system 5 and the collecting system 6 intermittently work, that is, firstly, the first time of bone marrow extraction and collection is performed through the output channel 2.2, then the first time of impact is performed on the bone marrow cavity through the impact system 5, then the second time of impact is performed on the bone marrow cavity through the impact system 5, and specific impact and collection times are determined according to actual requirements, for example, the number of hematopoietic stem cells in the mixed liquid extracted each time can be determined through experiments of limited times, and the secondary impact is not needed when the ratio is too low.
In this embodiment, the impact speed of the impact system 5 is determined experimentally according to the actual requirement, and the impact speed needs to be controlled to be sufficient to impact the bone marrow in the marrow cavity without adversely affecting the dense layer of the bone, and obviously, different portions of the bone have different requirements, which can be determined one by one according to a limited number of experiments.
According to the bone marrow collecting device provided by the embodiment of the utility model, the bone marrow cavity is impacted by the high-speed liquid flow of the impact system 5, so that more bone marrow is extracted in a larger range, and the times of puncturing are reduced.
In another embodiment provided by the present utility model, as shown in fig. 4, further, the input channel 2.1 and the output channel 2.2 share a communication port 3 at the tip of the needle, and the input channel 2.1 and the output channel 2.2 work in turn, so that the effect is that when the output channel 2.2 sucks bone marrow, broken bone blockage often occurs, and at this time, the blockage is flushed out according to a transient impact through the impact system 5, so as to solve the blockage problem of the suction of the needle core 2 in the prior art.
In still another embodiment of the present utility model, the collecting system 6 further includes a separating system 6.2, where the separating system 6.2 is used to separate the collected bone marrow mixture, and is used to separate and collect the hematopoietic stem cells separately, in this embodiment, the serum after the separating system 6.2 separates the hematopoietic stem cells is output to the storage chamber 5.1 through a pipeline, so that the impact is removed by the tissue fluid of the person to be collected, and the negative impact of other fluids on the human body is reduced.
In still another embodiment of the present utility model, as shown in fig. 2 and 3, further, one end of the end portion of the sleeve 1 is provided with a drilling part 1.1, the drilling part 1.1 is used for assisting in drilling a hole in a bone, the other end of the sleeve 1 is provided with a connecting seat 1.2, the connecting seat 1.2 is provided with a plugging part 1.21, the plugging part 1.21 is used for linearly plugging a transmission structure of a motor, and the plugging part 1.21 is a plurality of plugging grooves, plugging holes or plugging columns. In the prior art, firstly, a drilling tool is used for drilling a hole on a bone, then the drilling tool is withdrawn, firstly, a sleeve 1 is plugged into the bone hole for shaping to form a stable channel, then a needle core 2 is plugged into the sleeve 1 for collecting, and obviously, the withdrawal of the drilling tool and the plugging of the sleeve 1 can bring negative influence to contacted tissues, in the embodiment, at the beginning, the sleeve 1 is a part of the drilling tool, the sleeve 1 is sleeved on the outer side of the drilling tool such as a drill shaft, one end of the sleeve 1 is provided with a sharp tooth-shaped structure like a drill part 1.1, and the other end is provided with a plugging part 1.21 such as a plurality of plugging holes, at the moment, one end of a motor or a manual driving structure is provided with the drill shaft, the drill shaft is plugged into the sleeve 1, and at the same time, the motor or the manual driving structure is provided with a transmission mechanism such as a plurality of inserting posts at the position close to the root of the drill shaft, the inserting posts are correspondingly inserted into corresponding inserting holes one by one, then the drill is started, the drill is started by means of the drill shaft and the drill starting part 1.1 at the end of the sleeve 1, after the drill is started, the motor or the manual driving structure is withdrawn, at the moment, the sleeve 1 is reserved in the bone hole due to the fact that the inserting part 1.21 is in linear insertion with the transmission structure of the motor, only the motor and the drill shaft are withdrawn, and then the needle core 2 is inserted into the sleeve 1 for continuous operation.
Still further, the bottom of spliced eye or spliced eye is provided with a magnetism and inhales portion 1.22, so makes its more convenient and inseparable with transmission structure's connection, when breaking away from, can both hands catch connecting seat 1.2 and transmission structure respectively, realizes breaking away from.
In still another embodiment of the present utility model, the connection seat 1.2 is in a limited structure, when the bone marrow of the cannula 1 is pumped, the connection seat 1.2 is attached to the skin of the patient, the depth of the drilled hole can be obtained according to the detection data such as ultrasound before the operation, and the height of the cannula 1 is prepared according to the depth, so that when the connection seat 1.2 is attached to the skin of the patient during the drilling, the drilling tool drills through the bone to enter the bone marrow cavity, and the cannula 1 can be used as a measuring tool, and because the connection seat 1.2 is attached to the skin of the patient, the stability of the cannula 1 is improved, which is beneficial to the subsequent operation.
In still another embodiment, as shown in fig. 5-9, the present utility model further includes a stirring mechanism 4, where the stirring mechanism 4 includes a driving wire 4.1 and a stirring head 4.2 disposed at an end of the driving wire 4.1, where the driving wire 4.1 is a structure that can be bent to a certain extent and still can perform rotation transmission, such as an alloy wire, a hard plastic wire, etc., and where the stirring head 4.2 is a stirring structure with a sharp end, such as a ball or a cylinder, where a plurality of raised sharp ends are disposed on the ball or the cylinder, and where the stirring head 4.2 and the driving wire 4.1 can enter into the bone marrow cavity through the input channel 2.1, that is, where a radial dimension of the stirring head 4.2 is smaller than that of the input channel 2.1, the effect is that before harvesting, the stirring head 4.2 is extended into the bone marrow cavity through the driving wire 4.1, and then the stirring head 4.2 is driven by a motor at another end of the driving wire 4.1, so that the stirring head 4.2 rotates in the bone marrow cavity to perform further harvesting and further harvesting.
Furthermore, the stirring head 4.2 comprises elastic stretching mechanisms, such as an elastic cage-shaped structure, an annular structure and a frame-shaped structure, which are formed by braiding or welding a plurality of elastic metal wires, so that the elastic stretching mechanisms can be compressed by external force and can be self-unfolded after the external force disappears, so that the elastic stretching mechanisms can be set into a compressed state in advance, and can be compressed by an input pipeline in the compressed state or a thin film jacket is arranged on the elastic stretching mechanisms, and can be folded by the thin film jacket through the input channel 2.1, and after the elastic stretching mechanisms come out of the input channel 2.1, the thin film jacket can be withdrawn by another silk wire to enable the pressure to be small, so that the elastic stretching mechanisms can be unfolded, or the elastic stretching mechanisms can be self-unfolded due to the fact that the external pressure of the input channel 2.1 is small, and the hooked metal wires are arranged on the elastic stretching mechanisms to serve as elastic stretching hooks, so that the stirring of bone marrow can be realized.
In still another embodiment of the present utility model, as shown in fig. 5-9, the stirring mechanism 4 includes an outer sleeve portion and an inner sleeve portion, the inner sleeve portion includes a first transmission wire 4.114.1 and an inner core 4.21 located at one end of the first transmission wire 4.114.1, the outer sleeve portion includes a second transmission wire 4.12 and an elastic sharp end 4.22 located at one end of the second transmission wire 4.12, and the second transmission wire 4.12 is hollow and is sleeved on the first transmission wire 4.114.1, that is, the second transmission wire 4.12 and the first transmission wire 4.114.1 can move with each other, in addition, the elastic sharp end 4.22 and the inner core 4.21 are matched, the inner core 4.21 is provided with a limit slot 4.211, the outer sleeve portion and the inner sleeve portion have two states, as shown in fig. 8, in which the elastic sharp end 4.22 is sleeved on the inner core 4.21, and in an extended state, the elastic sharp end 4.22 and the inner core 4.21 are formed with a larger overall size, which is larger than the input channel 2.1, so that stirring can be realized in a larger range, as shown in fig. 9, the elastic sharp end 4.22 and the inner core 4.21 can be separated from the elastic sharp end 4.21 by the size of the inner core 4.21, and the inner core 4.21 has a smaller radial size than the input channel 2.1. The switching between the first state and the second state can be achieved by the mutual movement of the first transmission wire 4.114.1 and the second transmission wire 4.12, so that the first state and the second state are in the second state at first, so that the first state and the second state enter the marrow cavity through the input channel 2.1, enter the marrow cavity, enter the first state outside through controlling the first transmission wire 4.114.1 and the second transmission wire 4.12, and then are integrally driven through a motor and the like, so that the stirring and cutting mechanism 4 rotates in the marrow cavity. In this way, a stirring and cutting mechanism 4 with a size larger than that of the input channel 2.1 can be sent into the marrow cavity, and the stirring and cutting effect is improved.
Furthermore, the end of the outer sleeve part comprises an arc part 4.23, the arc part 4.23 is connected with a plurality of sharp elastic sheets as elastic sharp ends 4.22, the elastic sheets are triangular, trapezoidal or other structures with thicker bottoms and thinner upper parts, and meanwhile, a plurality of limit grooves 4.211 are formed in the inner shaft. In this embodiment, the connection portion between the circular arc portion 4.23 and the elastic piece may be configured as an elastic structure, so that the elastic piece may swing relative to the circular arc portion 4.23 to have elasticity, and the elastic piece itself may be harder, such as a blade with a hard structure, so that the stirring effect is better when it rotates.
While certain exemplary embodiments of the present utility model have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that modifications may be made to the described embodiments in various different ways without departing from the spirit and scope of the utility model. Accordingly, the drawings and description are to be regarded as illustrative in nature and not as restrictive of the scope of the utility model, which is defined by the appended claims.
Claims (8)
1. The bone marrow collecting device comprises a sleeve and a needle core sleeved in the sleeve, and is characterized in that an input channel for inputting impact liquid and an output channel for extracting bone marrow mixture are arranged in the needle core;
the system comprises a storage cavity, an impact pump and an impact pipeline, wherein the impact pipeline is communicated with the input channel, and the impact pump is used for outputting impact liquid in the storage cavity to the input channel; the acquisition system comprises an acquisition cavity which is communicated with the output channel through a pipeline;
one end of the end part of the sleeve is provided with a drilling part, the other end of the sleeve is provided with a connecting seat, the connecting seat is provided with a plug-in part, and the plug-in part is used for the linear plug-in connection of a transmission structure of the motor;
the stirring and cutting mechanism comprises a transmission wire and a stirring and cutting head arranged at the end part of the transmission wire, and the stirring and cutting head and the transmission wire can enter the marrow cavity through the input channel;
the stirring mechanism comprises an outer sleeve part and an inner shaft part, wherein the inner shaft part comprises a first transmission wire and an inner core positioned at one end of the first transmission wire, the outer sleeve part comprises a second transmission wire and an elastic sharp end positioned at one end of the second transmission wire, the second transmission wire is hollow and sleeved on the first transmission wire, in addition, the elastic sharp end is matched with the inner core, a limiting groove is formed in the inner core, the outer sleeve part and the inner shaft part are in two states, the elastic sharp end is sleeved on the inner core in the first state, the elastic sharp end is in an extending state, the integral size formed by the elastic sharp end and the inner core can be larger than that of an input channel, the elastic sharp end is separated from the inner core in the second state, the radial sizes of the elastic sharp end and the inner core are smaller than that of the input channel, and the first state and the second state are switched through the mutual movement of the first transmission wire and the second transmission wire;
the tip of overcoat part includes circular arc portion, connect a plurality of sharp-pointed elastic pieces on the circular arc portion and regard as elasticity sharp-pointed end, the elastic piece is thicker for the bottom, upper portion thinner structure, set up a plurality of spacing grooves simultaneously on the interior axle, during the use, the elastic piece is gone into spacing groove through the thicker part card in its bottom, the inner core is stretched out to the thinner structure in upper portion simultaneously, and the part that the elastic piece links to each other with circular arc portion has elasticity, thereby the relative circular arc portion of elastic piece can holistic swing thereby realize switching between first state and second state, simultaneously, the tip of inner core is semicircle structure, when both cooperate, circular arc portion is direct to laminate to semicircle structure on, have the guide effect.
2. The bone marrow harvesting device of claim 1, wherein the input and output channels share a common port at the needle tip, the input and output channels operating in turn.
3. The bone marrow harvesting device of claim 1, wherein the harvesting system includes a separation system that outputs serum separated by the separation system to the storage chamber through a conduit.
4. The bone marrow harvesting device of claim 1, wherein the connector is a limiting structure, and wherein the connector engages the skin of the patient when the cannula aspirates bone marrow.
5. The bone marrow harvesting device of claim 1, wherein the mating portion is a plurality of mating grooves or mating posts.
6. The bone marrow harvesting device according to claim 1, wherein the stirring head includes an elastic expansion mechanism that expands itself after the external pressure is removed when the input channel is in a collapsed state.
7. The bone marrow harvesting device of claim 6, wherein the elastic stretching mechanism is a cage-like structure.
8. The bone marrow harvesting device according to claim 7, wherein a plurality of resiliently protruding hooks are provided on the cage structure.
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| CN202010218522.4A CN111388027B (en) | 2020-03-25 | 2020-03-25 | Bone marrow harvesting device |
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| CN202010218522.4A CN111388027B (en) | 2020-03-25 | 2020-03-25 | Bone marrow harvesting device |
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