CN111388018B - Method and device for collecting lower respiratory tract sample, air disinfection method and device thereof - Google Patents
Method and device for collecting lower respiratory tract sample, air disinfection method and device thereof Download PDFInfo
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- CN111388018B CN111388018B CN202010201244.1A CN202010201244A CN111388018B CN 111388018 B CN111388018 B CN 111388018B CN 202010201244 A CN202010201244 A CN 202010201244A CN 111388018 B CN111388018 B CN 111388018B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
- A61L9/22—Ionisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/0083—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements for taking gas samples
- A61B2010/0087—Breath samples
Abstract
The invention discloses a method for collecting a lower respiratory tract sample, which is characterized in that gas inhaled by a test object is ionized or exhaled to ionize the gas in an insulating environment, and the lower respiratory tract sample in the exhaled gas is collected by utilizing charges with opposite polarity to the ionized gas. The invention also discloses an insulating device for collecting the lower respiratory tract sample. By the collecting method and the collecting device, the lower respiratory tract sample of the test object can be effectively collected by the test object only through simple breathing operation. The invention further discloses an air disinfection method, which comprises the following steps of: charging the inhaled or exhaled gas of the test subject; causing the atomized sterilant to carry an electrical charge of opposite polarity to the inhaled or exhaled air; causing exhaled air to be attracted to the disinfectant. The invention also discloses an air disinfection device and an immune response excitation device.
Description
Technical Field
The invention relates to a virus sampling technology, in particular to a method and a device for collecting a lower respiratory tract sample, an air disinfection method and a device thereof.
Background
Infectious diseases cause millions of deaths worldwide each year, and many of the most common infectious pathogens cause droplet or aerosol transmission through coughing, sneezing, vomiting, etc. Research shows that 2019 novel coronavirus (2019-nCoV) has strong transmission capability, and the transmission distance in a closed air-conditioning carriage is as long as 4.5m, so that the virus can float in the air at least within 30 minutes and cause infection.
The method for collecting the respiratory tract sample is an important first step for diagnosing whether the respiratory tract sample carries viruses, and the current method for collecting the respiratory tract sample for respiratory tract infectious diseases mainly comprises the following steps: the upper respiratory tract samples were collected by pharyngeal swabs, nasal swabs and nasopharyngeal aspirates, and the lower respiratory tract samples were collected by deep expectoration, respiratory tract aspirates, bronchial lavage, alveolar lavage and lung tissue biopsy specimens. The sample collection method of the upper respiratory tract is convenient and quick, but has the defects of low accuracy and easy false negative phenomenon. Although the accuracy is improved, the lower respiratory tract sample collection method is not widely used due to the relatively complex operation. Therefore, in actual practice, in order to collect more respiratory tract samples of a test subject quickly, the upper respiratory tract samples such as a pharyngeal swab, a nasal swab, and the like are the most taken. The current diagnosis of respiratory infections is largely not limited to analytical techniques, as molecular biological methods such as real-time PCR can provide a sensitive detection system for most pathogens. The difficulty is further to develop a lower respiratory tract sample collection method with convenient operation and high accuracy.
Hagbom, M., nordgren, J., nybom, R.et al, ionizng air affects influenza virus infectivity and prevents airborne-transmission.Sci Rep5,11431 (2015) (Mari Ha Bom, john Nordegrand, rollf Nebom, et al.) ionized air affects the infectivity of influenza virus and prevents air transmission. This document shows that the efficiency of collection after ionisation of viruses is 1000 times or more than that of the non-ionised collector. However, the collector for collecting virus particles by ionizing air disclosed in the literature cannot be applied to a human body.
Therefore, in order to meet the requirements of sample collection efficiency and accuracy at the same time, it is necessary to invent a method and a device for collecting the lower respiratory tract sample with convenient and efficient operation.
In addition, because the residence time of the gas exhaled by the virus carrier in the closed space is long, the transmissibility is strong, and it is necessary to invent an air disinfection method and a device thereof which are convenient and efficient to operate.
For the treatment of infectious diseases, the research of vaccines is a key step, but the research of vaccines usually requires a lot of manpower and financial resources and takes a long time. Therefore, it is necessary to invent a novel immune response stimulating device.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: a method for conveniently and fast collecting a lower respiratory tract sample is provided.
In order to solve the technical problems, the invention adopts the following technical scheme:
a method for collecting lower respiratory tract samples comprises ionizing gas inhaled by a test subject in an insulating environment, and collecting lower respiratory tract samples in exhaled gas by using charges with opposite polarity to the ionized gas.
In order to solve the technical problems, the invention also adopts the following technical scheme:
a method for collecting lower respiratory tract samples comprises the steps of enabling a test object to exhale ionized gas in an insulating environment, and collecting the lower respiratory tract samples in the exhaled gas by utilizing charges with opposite polarities to the ionized gas.
The invention has the beneficial effects that: by the method for collecting the lower respiratory tract sample, firstly, the test object can effectively collect the lower respiratory tract sample of the test object only by carrying out simple breathing operation and without carrying out interventional operations such as anesthesia and the like on the test object; secondly, virus particles of the lower respiratory tract are carried out through expiration, so that the accuracy of the test is improved.
The invention also aims to provide an air disinfection method convenient to operate, which adopts the following technical scheme:
an air disinfection method comprises the following steps in an insulating environment:
a) Charging the inhaled or exhaled gas of the test subject;
b) Causing the atomized sterilant to carry an electrical charge of opposite polarity to the inhaled or exhaled gas in step a);
c) Causing exhaled air to be attracted to the disinfectant.
The invention has the beneficial effects that: by the air disinfection method, virus/bacteria particles exhaled by a test object or carried out by the body surface can be effectively captured and destroyed by the disinfectant.
The invention further aims to provide an insulating device for collecting a lower respiratory tract sample, which is convenient to operate, and adopts the following technical scheme:
the utility model provides an insulating device of collection lower respiratory tract sample, including the first ionization device that is used for providing first ionized gas and the second ionization device that is used for collecting first ionized gas, be equipped with the air inlet channel that the air feed gas got into and supply test object inspiratory air outlet channel on the first ionization device respectively, be equipped with the air inlet channel that supplies test object to exhale and supply air exhaust channel that the air feed is discharged on the second ionization device, the gas of exhaling gets into in the second ionization device by the air inlet channel, lower respiratory tract sample in the gas is attracted by the electric charge that the inside production of second ionization device is opposite with first ionized gas polarity.
The invention has the beneficial effects that: through the insulating device for collecting the lower respiratory tract samples, after the device is used, the test object can effectively collect the lower respiratory tract samples of the test object only by carrying out simple breathing operation without carrying out interventional operations such as anesthesia and the like on the test object; secondly, the device is simple to use, can gather more virus particles in a sample collection, has improved collection efficiency.
Another object of the present invention is to provide an air disinfection device with convenient operation, for which the following technical scheme is adopted:
an air disinfection device comprising first ionization means for ionizing gas exhaled by a test subject, second ionization means for ionizing a disinfectant, and atomizing means for atomizing the disinfectant, the polarity of ions in the first ionization means being opposite to the polarity of ions in the second ionization means such that exhaled gas is attracted by the disinfectant.
The invention has the beneficial effects that: by means of the air disinfection device, virus/bacteria particles exhaled by a test object or carried by the body surface can be effectively captured and destroyed by the disinfectant.
The invention also aims to provide an immune response excitation device convenient to operate, which adopts the following technical scheme:
an immune response elicitor device comprising means for collecting a sample of the lower respiratory tract, test means for testing for the presence of a virus, treatment means for killing the virus and aerosolization means for aerosolizing the killed virus.
The invention has the beneficial effects that: by the above-described immune response stimulating device, the formation of antibodies in the bronchi is stimulated by intact but dead viral proteins, and thus the test subject can be induced to respond to the immune response in a simple manner.
Detailed Description
In order to describe the technical contents, the achieved objects and effects of the present invention in detail, the following description will be made with reference to the embodiments.
The most critical concept of the invention is as follows: the gas inhaled or exhaled by the test subject is charged and then the test subject exhales the charged gas particles, which are collected by the collection means with an opposite polarity charge or are attracted by the disinfectant with an opposite polarity charge.
According to the technical scheme adopted by the invention, in the method for collecting the lower respiratory tract sample, gas inhaled by a test object is ionized in an insulating environment, and the lower respiratory tract sample in exhaled gas is collected by utilizing charges with opposite polarity to the ionized gas.
The working principle of the invention is briefly described as follows: the test subjects inhale ionized air, such as air anions, which deposit charge in the lower respiratory tract. If the lower respiratory tract of the test subject is infected, the viral particles replicate in the surface epithelial cells until the cells rupture. When cells rupture at the surface of the respiratory tract, the viral particles and viral particles are negatively charged and enter the expiratory airflow, and the test subject exhales simultaneously, and the negatively charged viral particles are collected on the positively charged collection device.
From the above description, the beneficial effects of the invention are as follows: the test object can effectively collect the lower respiratory tract sample of the test object only by simple breathing operation without interventional operation such as anesthesia and the like. And more virus particles are released from the respiratory tract through sound vibration, so that the collection efficiency and the test accuracy are improved.
Further, inhalation and exhalation are repeated to continuously collect lower respiratory tract samples.
From the above description, by repeating the collection, more gas particles can be obtained, thereby improving the accuracy of the subsequent test.
Further, oral breathing is employed.
Further, the ionized gas was inhaled into 20-30cc in 6 seconds.
From the above description, the test subject only needs to perform simple breathing operation in a short time, so that the comfort of the test subject during collection can be improved.
Further, the sound is emitted at the same time as the exhalation.
Further, exhalation was performed for 6 seconds continuously and vowels E were continuously emitted.
Further, the intensity of the emitted sound is measured.
From the above description, it is understood that the vibration force can be enhanced by emitting a vowel, thereby increasing the shedding amount of virus particles in the lung, and the stronger the vibration (for example, the larger the vowel), the more virus particles are discharged from the lower respiratory tract. And meanwhile, the test is performed, so that the intensity of vibration can be monitored.
Further, the lower respiratory tract sample in the exhaled air is collected by the ionization collection device, and the ion polarity of the inhaled ionized gas is opposite to that in the ionization collection device.
Further, the ion polarity of the inhaled ionized gas is negative, and the ion polarity in the ionized collecting device is positive.
From the above description, it is clear that the inhaled air and the collecting means are oppositely charged, helping to allow the gas containing the virus particles to be easily captured.
Further, the exhaled gas is sent out after passing through the ionization collection device, and then sequentially through the filter and/or the ionization trap.
From the above description, it is evident that the treatment of the residual gas can remove all remaining pathogens and further decontaminate and disinfect the expired breath.
Further, the amount of inhaled and exhaled gas is measured.
From the above description, it is known that measuring the amount of breathing gas can ensure the effectiveness of the acquisition.
The invention adopts another technical scheme that: a method for collecting lower respiratory tract samples comprises the steps of enabling a test object to exhale ionized gas in an insulating environment, and collecting the lower respiratory tract samples in the exhaled gas by utilizing charges with opposite polarities to the ionized gas.
The working principle of the invention is briefly described as follows: once the test subject is electrostatically charged (e.g., negative static electricity), the static charge is primarily distributed over the body surfaces, including the lower respiratory tract surfaces, and if the lower respiratory tract of the test subject is infected, the viral particles replicate in the surface epithelial cells until the cells rupture. When cells rupture at the surface of the respiratory tract, the viral particles enter the expiratory airflow with a negative charge, pass through the negatively charged airways and eventually reach the positively charged collection device.
From the above description, the beneficial effects of the invention are as follows: the test object can effectively collect the lower respiratory tract sample of the test object only by simple breathing operation without interventional operation such as anesthesia and the like.
Further, an electrostatic generator is used to act on the test object to generate an electric charge on the test object to exhale the ionized gas.
Further, a van der waals motor is used to act on the test object, so that charges are generated on the test object.
Further, the test subject stands or lies on the insulation test platform.
From the above description, during the process of collecting the sample, different collecting postures can be adopted according to different physical states of the test object, so that the comfort level of the test object is improved.
Further, the sound vibration is performed while the exhalation is performed.
From the above description, simultaneous sound vibration is advantageous for releasing more virus particles from the epithelial surface.
Further, a lower respiratory tract sample in the exhaled breath is collected using an ionization collection device having a charge of opposite polarity to the ionized gas.
Further, the exhaled gas is sent out after passing through the ionization collection device, and then sequentially through the filter and/or the ionization trap.
From the above description, it is evident that the treatment of the residual gas can remove all remaining pathogens and further decontaminate and disinfect the expired breath.
Further, exhaled gas enters the ionization collection device through an insulated tube.
Further, the length of the insulating tube is 30 to 50 cm.
As can be seen from the above description, the use of the insulating tube facilitates collection of exhaled air from the test subject and, because the insulating tube is sufficiently long, prevents direct transfer of charge from the charged subject surface to the collection device of charge of the opposite polarity.
The invention also aims to provide an air disinfection method which is convenient and efficient to operate, and the following technical scheme is adopted: an air disinfection method comprises the following steps in an insulating environment: a) Charging the inhaled or exhaled gas of the test subject; b) Causing the atomized sterilant to carry an electrical charge of opposite polarity to the inhaled or exhaled gas in step a); c) Causing exhaled air to be attracted to the disinfectant.
The working principle of the invention is briefly described as follows: firstly, by placing static charges on a test object, virus particles emitted from the test object are charged, and when the surface of the test object including the respiratory tract is charged, any viruses or bacteria in the gas exhaled by the respiratory tract with the charges are charged; or the test subject inhales ionized air; the charged viral or bacterial particles will then be attracted to the nebulizer particles containing the disinfectant and the opposite charge after exhalation by the subject.
From the above description, the beneficial effects of the invention are as follows: the virus/bacteria particles discharged from the surface and the inside of the body of the test subject can be atomized and the charged disinfectant can effectively capture and destroy the virus/bacteria particles only by simple operation.
Further, in step B), the disinfectant is placed in a nebulizer with an opposite polarity to the inhaled or exhaled gas in step a).
Further, in step B), an electrostatic generator is used to generate an electric charge on the atomizer.
From the above description, the disinfectant is dotted and atomized by the aid of the atomizer with charges, and the operation is convenient.
Further, in step a), the clothing of the test subject is charged, and in step C), pathogens on the clothing are attracted by the disinfectant.
From the above description, it is known that pathogens on the clothing of the test subject can be further destroyed.
The invention further aims to provide an insulating device for collecting lower respiratory tract samples, which is convenient and efficient to operate, and adopts the following technical scheme:
the utility model provides an insulating device of collection lower respiratory tract sample, including the first ionization device that is used for providing first ionized gas and the second ionization device that is used for collecting first ionized gas, be equipped with the air inlet channel that the air feed gas got into and supply test object inspiratory air outlet channel on the first ionization device respectively, be equipped with the air inlet channel that supplies test object to exhale and supply air exhaust channel that the air feed is discharged on the second ionization device, the gas of exhaling gets into in the second ionization device by the air inlet channel, lower respiratory tract sample in the gas is attracted by the electric charge that the inside production of second ionization device is opposite with first ionized gas polarity.
From the above description, the beneficial effects of the invention are as follows: through the insulating device for collecting the lower respiratory tract samples, after the device is used, the test object can effectively collect the lower respiratory tract samples of the test object only by carrying out simple breathing operation without carrying out interventional operations such as anesthesia and the like on the test object; secondly, the device is simple to use, can gather more virus particles in a sample collection, has improved collection efficiency.
Further, the device also comprises a filtering device and/or an ionization capturing device, and the second ionization device is sequentially communicated with the filtering device and/or the ionization capturing device through an exhaust passage.
From the above description, the collected residual gas can be processed, any residual pathogens can be removed, and the expired breath can be further purified and disinfected.
Further, an insulating air duct is arranged on the second ionization device, the air inlet channel is arranged in the air duct, and exhaled air enters the second ionization device through the air duct.
Further, the length of the air duct is 12-18 inches.
From the above description, the airway is long enough and dry to prevent charge transfer from the surface of the charged test object to the second ionization device, which is charged with the opposite polarity.
Further, the second ionization device is a metal collector.
Further, the second ionization device is a single or a plurality of metal tubes with the diameter of 5-10mm and the length of 25-100 mm.
From the above description, the metal tube is small and convenient to use.
Further, the device also comprises a flow measuring device for measuring the air outlet quantity of the first ionization device and the air inlet quantity of the second ionization device respectively.
From the above description, it is known that the effectiveness of collection can be ensured by measuring the gas outlet amount and the gas inlet amount using the flow measurement device.
Further, the device also comprises a sound intensity detection device for detecting the sound intensity of the sound emitted by the test object.
As is apparent from the above description, detecting the intensity of sound by the sound intensity detecting means is advantageous in monitoring whether the sound reaches a certain intensity to increase the discharge amount of virus particles.
Further, the test device also comprises an insulation test platform, and the test object inhales and exhales on the insulation test platform.
Further, the first ionization device includes an electrostatic generation device through which the first ionized gas is supplied.
The invention also aims to provide an air disinfection device which is convenient and efficient to operate, and the following technical scheme is adopted for the purpose:
an air disinfection device comprising first ionization means for ionizing gas exhaled by a test subject, second ionization means for ionizing a disinfectant, and atomizing means for atomizing the disinfectant, the polarity of ions in the first ionization means being opposite to the polarity of ions in the second ionization means such that exhaled gas is attracted by the disinfectant.
The working principle of the invention is briefly described as follows: firstly, by placing static charges on a test object, virus particles emitted from the test object are charged, and when the surface of the test object including the respiratory tract is charged, any viruses or bacteria in the gas exhaled by the respiratory tract with the charges are charged; or the test subject inhales ionized air; the charged viral or bacterial particles will then be attracted to the nebulizer particles containing the disinfectant and the opposite charge after exhalation by the subject.
From the above description, the beneficial effects of the invention are as follows: by means of the air disinfection device, virus/bacteria particles exhaled by a user or carried by the body surface can be effectively captured and destroyed by the disinfectant.
The invention also aims to provide an immune response excitation device convenient to operate, which adopts the following technical scheme:
an immune response elicitor device comprising means for collecting a sample of the lower respiratory tract, test means for testing for the presence of a virus, treatment means for killing the virus and aerosolization means for aerosolizing the killed virus.
The working principle of the invention is briefly described as follows: by utilizing the principle that viral proteins can stimulate antibody reaction, the lipid peroxidation process using ozone protects viral proteins while killing viruses, and the dying viruses are inhaled by human body after being atomized, and the light inflammatory activity in the bronchus airways stimulates immune reaction and the formation of complete but dying viral protein antibodies.
From the above description, the beneficial effects of the invention are as follows: by the above-described immune response stimulating device, the formation of antibodies in the bronchi is stimulated by intact but dead viral proteins, and thus the test subject can be induced to respond to the immune response in a simple manner.
Further, the treatment device comprises an ozone treatment device and an ultrasonic treatment device.
Further, the treatment device comprises an alcohol treatment device containing alcohol with concentration of 75%.
From the above description, it is known that viruses can be treated with ozone and ultrasonic waves in combination, and also with alcohol having a concentration of 75%.
Further, the device also comprises a cleaning device for cleaning the outer surface of the collecting device with the virus.
From the above description, it is clear that the use of the cleaning device to clean the outer surface of the collecting device reduces unnecessary virus transmission.
Example 1
The method for collecting a lower respiratory tract sample of the embodiment comprises the following steps: ionizing the gas inhaled by the test object in an insulating environment, wherein the ionized gas is inhaled into the test object within 20-30cc in 6 seconds; the test subject exhales while making a sound and measures the intensity of the emitted sound, preferably continuously exhaling for 6 seconds and continuously emitting vowels E; then collecting a lower respiratory tract sample in the exhaled gas by using an ionization collection device with charges of opposite polarity to the ionized gas; finally, the exhaled gas passes through the ionization collecting device and then sequentially passes through the filter and/or the ionization catcher and is sent out; the above procedure was repeated at least 3 times to continuously collect lower respiratory tract samples. During which the test subject breathes using the mouth and measures the amount of inhaled and exhaled gas.
In addition, the positively charged collection tube should be washed with a virus washing medium to collect the virus for PCR testing.
Example two
The method for collecting a lower respiratory tract sample of the embodiment comprises the following steps: under the insulation environment, a test object stands or lies on an insulation test platform, and an electrostatic generator is adopted to act on the test object so as to generate charges on the test object to exhale ionized gas, wherein the electrostatic generator preferably adopts a Van der Waals starter motor; performing sound vibration while the test subject exhales; passing the exhaled gas through an insulating tube and then collecting a lower airway sample in the exhaled gas using an ionization collection device having a charge of opposite polarity to the ionized gas, wherein the insulating tube has a length of 30 to 50 cm; the expired gas is sent out after passing through the ionization collection device, in turn, through a filter and/or an ionization trap.
Wherein the test platform may be a 12 to 18 inch high plastic bench, or a bed or mattress that is electrically isolated from the ground.
Example III
The air disinfection method of the embodiment performs the following steps in an insulating environment: a) Charging the inhaled or exhaled gas of the test subject and charging the clothing of the test subject; b) Electrically isolating the atomizers and generating an electrical charge on the atomizers using an electrostatic generator (e.g., a van der waals motor), placing the disinfectant in an atomizer having an electrical charge of opposite polarity to the gas inhaled or exhaled in step a), thereby atomizing the disinfectant and having an electrical charge of opposite polarity to the gas inhaled or exhaled in step a); c) After exhalation by the user, the exhaled air and pathogens on the clothing are attracted by the disinfectant.
Example IV
The insulating device for collecting the lower respiratory tract sample comprises a first ionization device for providing first ionized gas, wherein the first ionization device is respectively provided with an air inlet channel for the air to enter and an air outlet channel for the test object to inhale; the device comprises a first ionization device, a second ionization device and a metal collector, wherein the first ionization device is used for collecting first ionized gas, an air inlet channel for exhaling by a test object and an air outlet channel for discharging the air are arranged on the first ionization device, the exhaled air enters the first ionization device from the air inlet channel, a lower respiratory tract sample in the air is attracted by charges which are generated in the first ionization device and have opposite polarities with the first ionized gas, an insulating air duct is arranged on the first ionization device, the air inlet channel is arranged in the air duct, the exhaled air enters the first ionization device through the air duct, the length of the air duct is preferably 12-18 inches, and the second ionization device is preferably a metal collector and is preferably a single metal pipe with a plurality of diameters of 5-10mm and lengths of 25-100 mm; the second ionization device is communicated with the filtering device and/or the ionization capturing device in sequence through an exhaust channel; the device also comprises sound intensity detection means for detecting the sound intensity of the sound emitted by the test object; the test device also comprises an insulation test platform, and the test object inhales and exhales on the insulation test platform.
Example five
The air disinfection device of the embodiment comprises a first ionization device for ionizing gas exhaled by a test object, a second ionization device for ionizing disinfectant and an atomization device for atomizing the disinfectant, wherein the polarity of ions in the first ionization device is opposite to that of ions in the second ionization device, so that the exhaled gas is attracted by the disinfectant.
Example six
The excitation device of the immune response of the embodiment comprises a device for collecting a lower respiratory tract sample, a testing device for testing whether viruses exist or not, a treatment device for killing the viruses, an atomization device for atomizing the dead viruses and a cleaning device for cleaning the outer surface of a collecting device for collecting the viruses, wherein the treatment device comprises an ozone treatment device, an ultrasonic treatment device and an alcohol treatment device containing 75% alcohol; the washing device preferably uses physiological saline or virus washing liquid for washing the collecting device.
The method for generating immunity by using the immune response excitation device comprises the following steps:
1. collecting a lower respiratory tract sample by using a collecting device;
2. if the method for collecting the lower respiratory tract sample by using the inhaled or exhaled gas of the ionized test object, the electric charge on the collecting device is removed by grounding the electric charge; if other methods are adopted, namely the collecting device is not provided with charges, the step is omitted;
3. detecting whether virus particles exist in the sample, and detecting by adopting a PCR test;
4. upon confirming the presence of viral particles in the sample, repeated collection is performed to collect millions of viral particles;
5. using an external surface of a collection device that is cleaned to collect viruses, such as using normal saline or virus wash;
6. killing virus with ozone and ultrasonic treatment and keeping its intact protein, or killing virus with 75% alcohol;
7. placing the dead virus in a nebulizer;
8. the nebulizer distributes the dead virus with intact protein to the bronchial airways of the test subject, thereby stimulating an immune response.
Whether an immune response is generated can be confirmed by IGM and IGG tests.
Ozone can be used to have a fatal effect on viruses while minimizing changes in protein structure. In step 6, the ozone dose for killing viruses should be greater than or equal to 2000min (mg/m 3 ) (i.e., contact time [ min ]]Multiplied by the ozone concentration [ mg/m ] 3 ]). In conjunction with the ozone disinfection process, the virus is sonicated at low intensity, which should be 1 to 5 watts per centimeter at 20 to 40 hertz. The sterilization temperature should be between 0 and 35 degrees celsius, otherwise thermal damage to the viral proteins may occur. Alcohol treatment at a concentration of 75% may also be used to kill viruses without ozone and sonication.
In step 7, 5 to 15 parts per million ozone may be used in combination with compressed air to atomize the dead virus. Because in many cases ozone stimulates inflammatory activity outside the alveoli, contributing to the formation of antibodies IGG and IGM.
Avoiding the placement of the dead virus in the alveoli that may cause pneumonia and respiratory distress is critical. After inhalation of the dead virus, minimal swelling of the airways (e.g. bronchioles) can occur causing mild bronchitis, rather than fatal pneumonia. In particular, mild inflammatory activity in the airways (e.g. bronchial airways) stimulates immune responses and the formation of intact but dead antibodies to viral proteins, and antibody stimulation from the bronchial airways will help to protect the alveoli from pneumonia. IGG and IGM antibodies against the dead viral proteins can thus be formed without causing alveolar inflammation. This is because the virus has died and cannot reproduce, but when used in combination with inhaled ozone, IGG and IGM can still be stimulated against the complete viral proteins.
It should be noted that, if the virus sample can be directly collected, steps 4-8 in the above immunization method can be adopted. The principle of inhalation of dead viruses can also be used to adapt to the immune generation method of other infectious diseases according to the immune generation mechanism of different viruses.
In summary, according to the method for collecting the lower respiratory tract sample provided by the invention, firstly, the test object can effectively collect the lower respiratory tract sample of the test object only by carrying out simple breathing operation without carrying out interventional operations such as anesthesia and the like on the test object; secondly, virus particles of the lower respiratory tract are carried out through expiration, so that the accuracy of the test is improved; thirdly, more virus particles can be released by making the respiratory tract vibrate by making sound, so that more virus particles can be collected in one sample collection, and the collection efficiency is improved; and the accuracy and the safety of acquisition are improved by measuring and monitoring the sound intensity and the breathing gas quantity.
According to the air disinfection method provided by the invention, firstly, the test object can effectively discharge viruses on the surface of the body only by carrying out simple breathing operation without taking medicines or injecting medicaments and the like; secondly, virus/bacteria particles exhaled by the test object or carried by the body surface or the clothing surface can be effectively captured and destroyed.
The insulating device for collecting the lower respiratory tract sample provided by the invention has the advantages that after the insulating device is used, a test object only needs to perform simple breathing operation, and the lower respiratory tract sample of the test object can be effectively collected without performing interventional operations such as anesthesia and the like on the test object; secondly, the device is simple to use, more virus particles can be acquired in one sample acquisition, and the acquisition efficiency is improved; thirdly, the flow measuring device and the sound intensity detecting device are used for measuring and monitoring the breathing gas quantity and the sound intensity, so that the acquisition accuracy and safety are improved.
The invention further provides an air disinfection device, which only needs simple operation, and virus/bacteria particles exhaled by a test object or carried out on the surface of a body or clothes can be effectively captured and destroyed by the disinfectant.
The invention further provides an immune response stimulating device, which can stimulate the formation of antibodies in bronchi by using complete but dead viral proteins, so that a test subject can generate immune response in a simple manner.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent modifications made by the present invention or directly or indirectly applied to the related technical field are included in the scope of the present invention.
Claims (39)
1. A method of collecting a lower respiratory tract sample, wherein a test subject is caused to inhale an ionized gas under an insulating environment, and the lower respiratory tract sample in an exhaled gas is collected using a charge having an opposite polarity to the ionized gas.
2. The method of collecting a lower respiratory tract sample of claim 1, wherein inhalation and exhalation are repeated to continuously collect the lower respiratory tract sample.
3. The method of collecting a lower respiratory tract sample of claim 1 wherein oral breathing is employed.
4. The method of collecting a lower respiratory tract sample of claim 1 wherein the ionized gas is inhaled into the atmosphere in the range of 20-30cc in 6 seconds.
5. The method of collecting a lower respiratory tract sample of claim 1 wherein the sound is emitted simultaneously with exhalation.
6. The method of collecting a lower respiratory tract sample of claim 5 wherein the exhaling is performed for 6 seconds continuously and the vowel E is emitted continuously.
7. The method of collecting a lower respiratory tract sample of claim 5 wherein the intensity of the emitted sound is measured.
8. The method of claim 1, wherein the lower airway sample is collected from the exhaled breath by an ionization collection device, and wherein the inhaled ionized gas has an ionic polarity opposite to the ionic polarity in the ionization collection device.
9. The method of claim 8, wherein the ionic polarity of the inhaled ionized gas is negative and the ionic polarity of the ionized collection device is positive.
10. The method of collecting a lower respiratory tract sample of claim 8 wherein the exhaled gas is passed through the ionization collection device and then sequentially through a filter and/or ionization trap.
11. The method of collecting a lower respiratory tract sample of claim 1 wherein the amount of inhaled and exhaled gas is measured.
12. A method of collecting a lower respiratory tract sample, wherein an ionized gas is directly exhaled by a test subject in an insulating environment, and the lower respiratory tract sample in the exhaled gas is collected using a charge of opposite polarity to the ionized gas.
13. The method of claim 12, wherein the electrostatic generator is used to act on the test subject to generate an electrical charge on the test subject to exhale the ionized gas.
14. The method of claim 13, wherein the test subject is subjected to an electrical charge using a van der waals motor.
15. The method of collecting a lower respiratory tract sample of claim 12, wherein the test subject stands or lies flat on an insulating test platform.
16. The method of collecting a lower respiratory tract sample of claim 12 wherein the exhaling is accompanied by acoustic vibration.
17. The method of claim 12, wherein the lower respiratory tract sample in the exhaled gas is collected using an ionization collection device having a charge of opposite polarity to the ionized gas.
18. The method of claim 17, wherein the exhaled gas is passed through the ionization collection device and then sequentially through a filter and/or ionization trap.
19. The method of collecting a lower respiratory tract sample of claim 17 wherein exhaled gas enters the ionization collection device through an insulated tube.
20. The method of collecting a lower respiratory tract sample of claim 19 wherein the length of the insulating tube is 30 to 50 cm.
21. A method of sterilizing air, characterized by the steps of:
a) Inhaling or directly exhaling a charged gas from a test subject;
b) Causing the atomized sterilant to carry an electrical charge of opposite polarity to the inhaled or exhaled gas in step a);
c) Causing exhaled air to be attracted to the disinfectant.
22. An air disinfection method as claimed in claim 21, wherein in step B) the disinfectant is placed in an atomiser with an opposite polarity to the gas inhaled or exhaled in step a).
23. The method of claim 22, wherein in step B), an electrostatic generator is used to generate an electrical charge on the atomizer.
24. The method of claim 21, wherein in step a) the clothing of the test subject is charged and in step C) pathogens on the clothing are attracted to the disinfectant.
25. The insulation device for collecting the lower respiratory tract samples is characterized by comprising a first ionization device for providing first ionized gas and a second ionization device for collecting the first ionized gas, wherein the first ionization device is respectively provided with an air inlet channel for the air to enter and an air outlet channel for the test object to inhale the first ionized gas, the second ionization device is provided with an air inlet channel for the test object to exhale and an air outlet channel for the air to be discharged, the exhaled air enters the second ionization device through the air inlet channel, and the lower respiratory tract samples in the air are attracted by charges which are generated in the second ionization device and have opposite polarities with the first ionized gas.
26. The insulation device for collecting a lower respiratory tract sample of claim 25, further comprising a filtration device and/or an ionization capture device, wherein the second ionization device is in turn in communication with the filtration device and/or the ionization capture device via an exhaust channel.
27. The insulating device for collecting a lower airway sample of claim 26 wherein the second ionization device is provided with an insulating airway tube, the air inlet passage being provided in the airway tube, and exhaled air entering the second ionization device through the airway tube.
28. The insulation device for collecting a lower respiratory tract sample of claim 27 wherein the airway tube is 12-18 inches in length.
29. The insulation device for collecting a lower respiratory tract sample of claim 25, wherein the second ionization device is a metal collector.
30. The insulation device for collecting a lower respiratory tract sample of claim 29, wherein the second ionization device is a single or a plurality of metal tubes having a diameter of 5-10mm and a length of 25-100 mm.
31. The apparatus of claim 25, further comprising a flow measurement device for measuring the amount of gas exiting the first ionization device and the amount of gas entering the second ionization device, respectively.
32. The insulation device for collecting a lower respiratory tract sample of claim 25, further comprising a sound intensity detection device for detecting the intensity of sound emitted by the subject.
33. The insulation device for collecting a lower respiratory tract sample of claim 25, further comprising an insulation test platform on which the test subject inhales and exhales.
34. The insulation device for collecting a lower respiratory tract sample of claim 25, wherein the first ionization device comprises an electrostatic generation device through which the first ionized gas is provided.
35. An air disinfection apparatus comprising first ionising means for inhaling or directly exhaling ionised gas from a test subject, second ionising means for ionising a disinfectant and atomising means for atomising the disinfectant, the polarity of ions in the first ionising means being opposite to the polarity of ions in the second ionising means so that exhaled gas is attracted to the disinfectant.
36. An immune response elicitation device comprising an insulating device for collecting a lower respiratory tract sample according to any one of claims 25 to 34, a testing device for testing for the presence of a virus, a treatment device for killing the virus and an aerosolization device for aerosolizing a dead virus.
37. The immune response excitation device according to claim 36, wherein the treatment device includes an ozone treatment device and an ultrasonic treatment device.
38. The immune response elicitor device of claim 36, wherein the treatment device includes an alcohol treatment device that includes 75% alcohol.
39. The immune response elicitor device of claim 36, further comprising a means for cleaning the means for collecting a lower respiratory tract sample.
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