CN111329806A - 舒敏修复抗炎组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种舒敏修复抗炎组合物及其制备方法,该舒敏修复抗炎组合物由包括以下重量份数的原料制成:油脂类基质30~60份、天然植物提取物0.01~5份;天然植物提取物包括积雪草提取物和蛇麻草提取物;油脂类基质包括植物油脂,植物油脂中含***二酚,和/或,天然植物提取物还包括***叶提取物。本发明舒敏修复抗炎组合物能够有效起到舒缓过敏、抗炎止痒效果。
Description
技术领域
本发明涉及日用化工技术领域,尤其是涉及一种舒敏修复抗炎组合物及其制备方法。
背景技术
夏季蚊虫肆虐,给人们造成很大的困扰;人体容易被蚊虫叮咬而引起皮肤局部瘙痒、红肿,甚至引发皮炎,虫咬皮炎是夏季皮肤科中最常见的皮炎之一;并且,蚊虫叮咬之后,来自蚊虫的唾液、毒液和分泌物中含有多种抗原成分,进入人体皮肤后,会与人体内的抗体产生免疫反应,引起体内释放组胺,引起过敏,严重时个别患者还会出现局部大疱、出血性坏死等严重反应,非常影响患者的日常生活和工作。
蚊虫叮咬后的治疗一般先以抗过敏、止痒为主。现有的用于蚊虫叮咬止痒消肿的药物多为西药,如皮炎平、艾洛松等,长期使用不仅会产生抗药性,还有可能使创面色素沉淀,进而引起创面皮肤萎缩、继发感染等副作用。而用于蚊虫叮咬的止痒涂抹液,如花露水、风油精等,疗效维持时间短,含有大量的乙醇等刺激性成分,容易刺激皮肤,且含有的防腐剂大多是合成化学成品,对人体也具有一定的潜在风险。
发明内容
本发明旨在至少解决现有技术中存在的技术问题之一。为此,本发明提出一种舒敏修复抗炎组合物及其制备方法,能够有效起到舒缓过敏、抗炎止痒效果。
本发明所采取的技术方案是:
本发明的第一方面,提供一种舒敏修复抗炎组合物,由包括以下重量份数的原料制成:油脂类基质30~60份、天然植物提取物0.01~5份;所述天然植物提取物包括积雪草提取物和蛇麻草提取物;
所述油脂类基质包括植物油脂,所述植物油脂中含***二酚;和/或,所述天然植物提取物包括***叶提取物。
根据本发明的一些实施例,所述植物油脂中含0.01~10wt%的***二酚。
根据本发明的一些实施例,所述植物油脂包括***籽油、火麻精油中的至少一种。其中,***籽油含有丰富的不饱和脂肪酸以及天然抗氧化成分,将其添加制备香膏进而用于皮肤,可具有抗氧化、抗自由基、保湿滋润、抗炎/修复损伤、抗菌、舒缓、镇痛、抗炎、促进皮肤生长的作用。火麻精油具体可由***二酚与火麻油按照质量比(1~10):100混合而成。
根据本发明的一些实施例,所述植物油脂还包括红花籽油、亚麻籽油、月见草油、荷荷巴油、摩洛哥坚果油、紫苏籽油、蓖麻籽油、小烛树蜡、氢化椰油甘油酯、巴西棕榈蜡中的至少一种。
根据本发明的一些实施例,所述油脂类基质还包括动物油脂。
根据本发明的一些实施例,所述动物油脂选自蜂蜡、马油、牛油、羊油中的至少一种。
根据本发明的一些实施例,所述原料还包括1~20份香精。
另外,止痒抗炎组合物的原料中还可包括助剂,助剂可包括抗氧化剂、防腐剂等。
根据本发明的一些实施例,所述原料还包括:抗氧化剂0.01~1份和防腐剂0.01~1份。抗氧化剂可采用二叔丁基对苯酚、抗坏血酸、生育酚、茶多酚(TP)、抗坏血酸棕榈酸酯、丁基羟基茴香醚(BHA)、二丁基羟基甲苯(BHT)、叔丁基对苯二酚(TBHQ)中的至少一种。防腐剂具体可采用卡松。
另外,天然植物提取物的提取方法可采用常规的提取方法,如:溶剂提取法、超声波提取法、超临界流体萃取法、微波辅助提取法等,提取溶剂一般采用油性溶剂。
根据本发明的一些实施例,舒敏修复抗炎组合物的剂型为膏剂;具体可为香膏。
本发明的第二方面,提供一种本发明第一方面所提供的任一种舒敏修复抗炎组合物的制备方法,包括以下步骤:
S1、将油脂类基质加热至完全融化,降温至40~50℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入天然植物提取物,混合均匀。
本发明实施例的有益效果是:
本发明实施例提供了一种舒敏修复抗炎组合物,其原料包括积雪草提取物、蛇麻草提取物,以及含***二酚的植物油脂和/或***叶提取物,***叶提取物中富含***二酚,通过积雪草提取物、蛇麻草提取物和***二酚的协同作用,可有效起到舒缓过敏、抗炎止痒的效果。
具体实施方式
以下将结合实施例对本发明的构思及产生的技术效果进行清楚、完整地描述,以充分地理解本发明的目的、特征和效果。显然,所描述的实施例只是本发明的一部分实施例,而不是全部实施例,基于本发明的实施例,本领域的技术人员在不付出创造性劳动的前提下所获得的其他实施例,均属于本发明保护的范围。
实施例1
一种香膏,按重量份计,其原料包括:蜂蜡10份、***籽油15份、红花籽油5份、香精1份、积雪草提取物0.5份、蛇麻草提取物1份、抗氧化剂二叔丁基对苯酚0.01份和防腐剂卡松0.01份;***籽油中含2wt%的***二酚。其制备方法包括以下步骤:
S1、将蜂蜡、***籽油、红花籽油混合加热至完全融化,而后降温至45℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物、蛇麻草提取物,混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂二叔丁基对苯酚和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
实施例2
一种香膏,按重量份计,其原料包括:氢化椰油甘油酯30份、荷荷巴油15份、香精8份、积雪草提取物1份、蛇麻草提取物2份、***叶提取物2份、抗氧化剂抗坏血酸棕榈酸酯0.5份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将氢化椰油甘油酯和荷荷巴油混合加热至完全融化,而后降温至40℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物、蛇麻草提取物和***叶提取物,混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸棕榈酸酯和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
实施例3
一种香膏,按重量份计,其原料包括:巴西棕榈蜡15份、亚麻籽油15份、火麻精油30份、香精20份、积雪草提取物1.5份、蛇麻草提取物0.5份、***叶提取物1份、抗氧化剂茶多酚1份和防腐剂卡松1份;火麻精油由***二酚与火麻油按照1:20质量比混合而成。该香膏的具体制备方法包括以下步骤:
S1、将巴西棕榈蜡、亚麻籽油和火麻精油混合加热至完全融化,而后降温至50℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物、蛇麻草提取物和***叶提取物,混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂茶多酚和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
实施例4
一种香膏,按重量份计,其原料包括:蜂蜡30份、香精6份、积雪草提取物1.5份、蛇麻草提取物0.5份、***叶提取物3份、抗氧化剂抗坏血酸1份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将蜂蜡加热至完全融化,而后降温至45℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物、蛇麻草提取物和***叶提取物,混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
对比例1
一种香膏,按重量份计,其原料包括:蜂蜡30份、香精6份、抗氧化剂抗坏血酸1份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将蜂蜡加热至完全融化,而后降温至40℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
对比例2
一种香膏,按重量份计,其原料包括:蜂蜡30份、香精6份、积雪草提取物1.5份、蛇麻草提取物0.5份、抗氧化剂抗坏血酸1份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将蜂蜡加热至完全融化,而后降温至50℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物、蛇麻草提取物混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
对比例3
一种香膏,按重量份计,其原料包括:蜂蜡30份、香精6份、积雪草提取物1.5份、***叶提取物3份、抗氧化剂抗坏血酸1份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将蜂蜡加热至完全融化,而后降温至45℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、积雪草提取物和***叶提取物混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
对比例4
一种香膏,按重量份计,其原料包括:蜂蜡30份、香精6份、蛇麻草提取物0.5份、***叶提取物3份、抗氧化剂抗坏血酸1份和防腐剂卡松0.5份。其制备方法包括以下步骤:
S1、将蜂蜡加热至完全融化,而后降温至50℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入香精、蛇麻草提取物和***叶提取物混合均匀,得混合物;
S3、向步骤S2所得的混合物中加入抗氧化剂抗坏血酸和防腐剂卡松,混合均匀,而后装罐,冷却成型,得成品香膏。
性能测试试验
试验例一、香膏的消炎试验
1、试验对象:取90只小鼠,雌雄各半,体重为25-30g。
2、试验材料:实施例1~4和对比例1~4所制得的香膏。
3、试验方法:将90只小鼠随机分为9组,分别为模型组、实施例组和对比例组,模型组为1个小组,实施例组包含4个小组(包括实施例组1~4),对比例组包含4个小组(包括对比例组1~4),每个小组10只;然后在各小组的小鼠右耳均匀涂二甲苯50μL,左耳作对照,致炎后1h后,涂香膏,各小组用量如下:
模型组:取等量的生理盐水涂抹于小鼠耳部的患处;
实施例组:分别取1g/kg实施例1~4所制得香膏对应涂抹于各实施例组小鼠耳部的患处;
对比例组:分别取1g/kg对比例1~4所制得香膏对应涂抹于各对比例组小鼠耳部的患处;
分别涂用3次,间隔30min涂1次。末次涂用后30min脱椎处死,沿耳廓剪下二耳,用8mm打孔器分别在左、右耳同一部位打下圆耳片,称重,计算耳重差,耳重差=右耳圆耳片重-左耳圆耳片重。
4、试验结果
试验所得结果如表1所示。
表1香膏对小鼠耳壳二甲苯致肿的影响
注:与模型组组相比**P<0.01
由上表1可知,与模型组相比,实施例组1~4可以极显著地降低小鼠的耳重差,其消炎效果好,而对比例组1~4的耳重差与模型组相比无统计学意义,说明本发明提供的香膏可以协同增强消炎效果。
试验例二、香膏的止痒试验
1、试验对象:选取90只豚鼠,体重250-300g,雌雄各半。
2、试验材料:实施例1~4和对比例1~4所制得的香膏。
3、试验方法:将90只豚鼠随机分为9组,包括模型组、实施例组(包括实施例组1~4)和对比例组(包括对比例组1~4),每小组10只,试验24h前,给各小组豚鼠右后足背剃毛,按本组剂量于动物右后足背剃毛涂药1次。实验当日,用粗砂纸擦伤右后足剃毛处,面积1cm2,局部再涂膏1次,10min后开始在创面处滴0.01%磷酸组织胺0.05ml/只,各小组涂用量如下:
模型组:取等量的生理盐水涂抹于豚鼠足背部的患处;
实施例组:分别取1g/kg实施例1~4所制得香膏对应涂抹于豚鼠足背部的患处;
对比例组:分别取1g/kg对比例1~4所制得香膏对应涂抹于豚鼠足背部的患处;
此后每隔10min依次用0.02%、0.03%、0.04%增浓度涂药,每次均为0.05ml/只。直至豚鼠回头舔右后足时所给予的磷酸组织胺总量(μg)为致痒阈,记录并比较各组的致痒阈。
4、试验结果
试验所得结果如表2所示。
表2香膏的止痒试验结果
注:与模型组组相比**P<0.01。
由表2可知,本发明实施例1~4所制得的香膏止痒阀大于83.6,止痒效果好,而对比例1~4所制得的香膏止痒效果与模型组相比无统计学意义,说明本发明所提供的香膏中原料组分相互协调起止痒效果。
试验例三、香膏的安全性检测
按照《新药毒理学研究指导原则》的要求对实施例1~4和对比例1~4所制得的香膏进行皮肤刺激性、过敏性评价,所得结果如表3所示。
表3香膏的安全性检测结果
由表3可知,以上各实施例和对比例所制得的香膏对皮肤安全、无刺激,不会引起过敏反应。
试验例四、舒敏试验
选取年龄在20~40周岁肌肤过敏、瘙痒不适的敏感肌志愿者40名,平均分成8组,包括实施例组(包括实施例组1~4)和对比例组(包括对比例组1~4),每小组各5人。其中,实施例组1~4的志愿者分别使用实施例1~4所制得的香膏,对比例组1~4的志愿者分别使用对比例1~4所制得的香膏,在5天后观察各组志愿者的过敏症状。所得结果如表4所示。
表4香膏的抗过敏测试结果
由上表4可知,本发明实施例1~4所制得香膏可有效舒敏,其原料间具有协同增强舒敏效果。
本发明的以上各实施例香膏中,通过在原料中添加积雪草提取物、蛇麻草提取物,以及含***二酚的植物油脂和/或富含***二酚的***叶提取物,通过积雪草提取物、蛇麻草提取物和***二酚的协同作用,可有效起到舒缓过敏、抗炎止痒的效果。当然,除了采用积雪草提取物、蛇麻草提取物和含***二酚的植物油脂和/或富含***二酚的***叶提取物制备香膏外,也可制备成其他剂型的舒敏修复抗炎组合物。
Claims (10)
1.一种舒敏修复抗炎组合物,其特征在于,由包括以下重量份数的原料制成:油脂类基质30~60份、天然植物提取物0.01~5份;所述天然植物提取物包括积雪草提取物和蛇麻草提取物;
所述油脂类基质包括植物油脂,所述植物油脂中含***二酚;和/或,所述天然植物提取物还包括***叶提取物。
2.根据权利要求1所述的舒敏修复抗炎组合物,其特征在于,所述植物油脂中含0.01~10wt%的***二酚。
3.根据权利要求2所述的舒敏修复抗炎组合物,其特征在于,所述植物油脂包括***籽油、火麻精油中的至少一种。
4.根据权利要求3所述的舒敏修复抗炎组合物,其特征在于,所述火麻精油由***二酚与火麻油按照质量比(1~10):100混合而成。
5.根据权利要求3所述的舒敏修复抗炎组合物,其特征在于,所述植物油脂还包括红花籽油、亚麻籽油、月见草油、荷荷巴油、摩洛哥坚果油、紫苏籽油、蓖麻籽油、小烛树蜡、氢化椰油甘油酯、巴西棕榈蜡中的至少一种。
6.根据权利要求1所述的舒敏修复抗炎组合物,其特征在于,所述油脂类基质还包括动物油脂。
7.根据权利要求6所述的舒敏修复抗炎组合物,其特征在于,所述动物油脂选自蜂蜡、马油、牛油、羊油中的至少一种。
8.根据权利要求1至7中任一项所述的舒敏修复抗炎组合物,其特征在于,所述原料还包括:香精1~20份;优选地,所述原料还包括:抗氧化剂0.01~1份和防腐剂0.01~1份。
9.根据权利要求8所述的舒敏修复抗炎组合物,其特征在于,舒敏修复抗炎组合物的剂型为膏剂。
10.权利要求1至9中任一项所述舒敏修复抗炎组合物的制备方法,其特征在于,包括以下步骤:
S1、将油脂类基质加热至完全融化,降温至40~50℃,得基质溶液;
S2、向步骤S1所得的基质溶液中加入天然植物提取物,混合均匀。
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CN112315863A (zh) * | 2020-11-10 | 2021-02-05 | 山东百奥生物医药有限公司 | 一种舒缓光电术中疼痛热感的组合物及制备方法和应用 |
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2020
- 2020-03-24 CN CN202010213619.6A patent/CN111329806A/zh active Pending
Non-Patent Citations (1)
Title |
---|
国家药品监督管理局: "《化妆品禁用植(动)物原料目录》", 26 May 2021 * |
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CN112315863A (zh) * | 2020-11-10 | 2021-02-05 | 山东百奥生物医药有限公司 | 一种舒缓光电术中疼痛热感的组合物及制备方法和应用 |
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