CN111317856B - Preparation method of medical durable sterilization breathable isolating membrane - Google Patents
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- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Abstract
The invention discloses a preparation method of a medical durable bactericidal breathable isolating membrane, which is characterized in that aluminum oxide adsorbed with copper sulfate is coated on the surface of a base membrane, and single-layer coating is adopted, so that the isolating membrane has the advantages of water repellency of the base membrane surface, hydrophilic one-way water permeability of the coated surface, and wound healing efficiency improvement.
Description
Technical Field
The invention belongs to the technical field of load type functional film materials, and particularly relates to a preparation method of a medical durable sterilization breathable isolating membrane.
Background
Most of the traditional wound treatment of patients adopts wiping disinfection solution for disinfection, and after wound dressing, the disinfection effect is difficult to last, meanwhile, the dressing material has poor air permeability, so that the wound of the patient is easy to be sultry, and the risk of bacterial infection is increased.
Patent CN110016222A discloses a method for preparing a bactericidal breathable film, which comprises forming a film from a precursor solution containing carbon nitride, a high molecular polymer and an organic solvent, pre-drying, drying at 110-130 ℃ after the pre-drying is finished, and removing the organic solvent to form a breathable hole. The film prepared by the patent has the functions of ventilation and sterilization, but the ventilation film has hydrophilic or hydrophobic properties on both sides, and when the ventilation film is hydrophilic, the wrapping material absorbs moisture after contacting water, so that the wound of a patient is affected by the water; when the breathable film is hydrophobic, the wound wrapped is sealed for a long time, and the generated moisture is not easy to be discharged, so that the wound is infected again, and the wound healing is influenced.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a preparation method of a medical durable bactericidal breathable isolating membrane, so that the prepared isolating membrane not only has good breathable performance, but also has a durable bactericidal effect, and also has the one-way water permeability of water repellency of a base membrane surface and hydrophilicity of a coating surface.
In order to achieve the purpose, the invention adopts the technical scheme that:
a preparation method of a medical durable bactericidal breathable isolating membrane is characterized by comprising the following steps:
s1: uniformly stirring the nano porous alumina and 0.58-4.64mol/L copper sulfate solution, and drying at 100-200 ℃ to prepare the nano porous alumina adsorbed with copper sulfate;
s2: uniformly mixing the nano porous alumina adsorbed with copper sulfate, a dispersing agent, a wetting agent, a binder, a thickening agent, a cross-linking agent and pure water to prepare alumina slurry containing copper sulfate;
s3: coating the alumina slurry containing copper sulfate on the polymer porous film, baking at 100-200 ℃, and cooling to obtain the isolating membrane.
In the preparation process of the method, the high-molecular porous film is taken as a base film, aluminum oxide slurry containing copper sulfate is uniformly mixed with a dispersing agent, a wetting agent, a binder, a thickening agent and a cross-linking agent, and then aluminum oxide particles adsorbed with copper sulfate are coated on the surface of the base film, so that the isolating film is made to have the advantages that the base film surface is hydrophobic, the coating surface has hydrophilic one-way water permeability, the coating surface is attached to a wound, the wound healing efficiency is improved, and the isolating film has good air permeability and has a lasting sterilization effect of heavy metal ions.
Further, the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 0.1-10. When the content of the copper sulfate solution is more, the antibacterial efficiency of the isolating membrane is higher; when the concentration range of the copper sulfate solution is lower than that of the application, the content of the copper sulfate solution is too low, so that the bacteria removal rate of the isolation membrane is low, and the antibacterial efficiency is greatly reduced. When the concentration range of the copper sulfate solution is higher than that of the application, the content of the copper sulfate solution is continuously increased, the antibacterial property of the isolating membrane to bacteria is saturated, so that the antibacterial efficiency is unchanged, but the surface of the nano porous alumina is completely coated by copper sulfate due to the overhigh copper sulfate solution, so that the hydrophilicity of the isolating membrane is weakened, and the water absorption of the isolating membrane is reduced.
Further, the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 5.
further, the copper sulfate alumina slurry, the dispersing agent, the binder, the thickening agent, the wetting agent and the water are mixed according to the mass percentage of 1: 0.003-0.017: 0.025-0.093: 0.003-0.035: 0.002-0.0096: 1.1-5.5. Preferably, the copper sulfate alumina slurry, the dispersant, the binder, the thickener, the wetting agent and the water are mixed in a mass percentage of 1: 0.001: 0.064: 0.015: 0.0055: 2.5.
further, in step S2, the nano-porous alumina containing copper sulfate, the dispersant and the thickener are stirred and sanded to form a mixed solution a, the particle size of solid particles in the mixed solution is 0.1 μm to 15 μm, and then the mixed solution a, the binder and the wetting agent are uniformly mixed.
Further, the polymer porous film is one of a polypropylene film, a polyethylene film and a polyethylene terephthalate film, and the thickness of the polymer porous film is 1-500 μm; the diameter of the hole of the polymer porous film is 10-500 nm.
Further, the diameter of the pores of the nano porous alumina is 50-500 nm.
Further, the dispersing agent is at least one of water glass, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexyl phosphoric acid, sodium dodecyl sulfate, methyl amyl alcohol, cellulose derivatives, polyacrylamide, Guel gum and fatty acid polyglycol ester.
Further, the wetting agent is one of polysiloxane quaternary ammonium salt-16 and polysiloxane quaternary ammonium salt-18; the binder is one of acrylic acid, methacrylic acid, polyvinyl acetate phthalate and methyl methacrylate; the thickening agent is sodium carboxymethyl acrylate.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, the aluminum oxide adsorbed with copper sulfate is coated on the surface of the base membrane, and single-layer coating is adopted, so that the isolation membrane has the advantages of water repellency on the surface of the base membrane, hydrophilic one-way water permeability of the coated surface, and wound healing efficiency improvement.
(2) The invention controls the weight percentage of the nano porous alumina and the copper sulfate solution to ensure that the isolating membrane has excellent antibacterial efficiency.
Drawings
Fig. 1 is a schematic structural view of the separator in example 1.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the preparation method of the medical durable bactericidal breathable isolating membrane, the thickness of the macromolecular porous membrane, the pore diameter of the nano-porous alumina, and the types of the macromolecular porous membrane, the dispersing agent, the binder, the thickening agent and the wetting agent have little influence on the wound healing rate performance.
Example 1
A preparation method of a medical durable sterilization breathable isolating membrane specifically comprises the following steps:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 7.5kg of 2.5mol/L copper sulfate solution to be uniformly stirred, so that the nano porous alumina with copper sulfate adsorbed is prepared;
s2: 1kg of nano porous alumina adsorbed with copper sulfate is taken to be stirred with 1g of dispersant, 15g of thickener sodium carboxymethyl acrylate solution, 64g of binder acrylic acid and 5.5g of wetting agent polysiloxane quaternary ammonium salt-16, and 2.5kg of water is added to be uniformly mixed; preparing alumina slurry containing copper sulfate;
s3: and (4) coating the alumina slurry containing copper sulfate in the step S2 on a polypropylene film with the thickness of 22 mu m and the pore diameter of 40nm, baking at 150 ℃ after coating, and cooling to obtain the isolating membrane.
Example 2
Example 2 differs from example 1 in that:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 0.15kg of 2.5mol/L copper sulfate solution to be uniformly stirred, and the nano porous alumina with copper sulfate adsorbed is prepared.
Example 3
Example 3 differs from example 1 in that:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 4.5kg of 2.5mol/L copper sulfate solution to be uniformly stirred, and the nano porous alumina with copper sulfate adsorbed is prepared.
Example 4
Example 4 differs from example 1 in that:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 15kg of 2.5mol/L copper sulfate solution to be uniformly stirred, and the nano porous alumina with copper sulfate adsorbed is prepared.
Example 5
Example 5 differs from example 1 in that:
s2: 1kg of nano porous alumina adsorbed with copper sulfate, 17g of dispersant, 35g of thickener sodium carboxymethyl acrylate solution, 93g of binder acrylic acid and 9.6g of wetting agent polysiloxane quaternary ammonium salt-16 are taken, and 5.5kg of water is added and mixed uniformly; an alumina slurry containing copper sulfate was prepared.
Example 6
Example 6 differs from example 1 in that:
s2: 1.1kg of water is added into 1kg of nano porous alumina absorbed with copper sulfate, 3g of dispersant, 3g of thickener sodium carboxymethyl acrylate solution, 25g of binder acrylic acid and 2g of wetting agent polysiloxane quaternary ammonium salt-16 to be uniformly mixed; an alumina slurry containing copper sulfate was prepared.
Example 7
Example 7 differs from example 1 in that:
s2: uniformly mixing 1kg of copper sulfate-adsorbed nano porous alumina, 1g of dispersing agent and 15g of thickener sodium carboxymethyl acrylate solution, stirring and sanding to form a mixed solution A, so that the particle size of solid particles in the mixed solution is 5 mu m, and uniformly mixing the mixed solution A, 64g of binder acrylic acid, 5.5g of wetting agent polysiloxane quaternary ammonium salt-16 and 2.5kg of water; an alumina slurry containing copper sulfate was prepared.
Comparative example 1
Comparative example 1 differs from example 1 in that:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 0.12kg of 2.5mol/L copper sulfate solution to be uniformly stirred, and the nano porous alumina with copper sulfate adsorbed is prepared.
Comparative example 2
Comparative example 2 differs from example 1 in that:
s1: 1.5kg of nano porous alumina with the pore diameter of 200nm is poured into 18kg of 2.5mol/L copper sulfate solution to be uniformly stirred, and the nano porous alumina with copper sulfate adsorbed is prepared.
Comparative example 3
Comparative example 3 differs from example 1 in that:
s2: 1.2kg of nano porous alumina adsorbed with copper sulfate, 20g of dispersant, 40g of thickener sodium carboxymethyl acrylate solution, 100g of binder acrylic acid and 12g of wetting agent polysiloxane quaternary ammonium salt-16 are taken, and 6kg of water is added and uniformly mixed; an alumina slurry containing copper sulfate was prepared.
Comparative example 4
Comparative example 4 differs from example 1 in that:
s2: taking 0.8kg of nano porous alumina adsorbed with copper sulfate, 1g of dispersing agent, 1g of thickener sodium carboxymethyl acrylate solution, 15g of binder acrylic acid and 1g of wetting agent polysiloxane quaternary ammonium salt-16, adding 1kg of water, and uniformly mixing; an alumina slurry containing copper sulfate was prepared.
Comparative example 5
S1: 1kg of nano porous alumina, 1g of dispersing agent, 15g of thickener sodium carboxymethyl acrylate solution, 64g of binder acrylic acid and 5.5g of wetting agent polysiloxane quaternary ammonium salt-16 are stirred, and 2.5kg of water is added and mixed uniformly; preparing alumina slurry;
s2: and (4) coating the alumina slurry obtained in the step S1 on a polypropylene film with the thickness of 22 mu m and the pore diameter of 40nm, baking at 150 ℃ after coating, and cooling to obtain the isolating membrane.
Comparative example 6
S1: taking 0.17kg of nano porous alumina, 0.83kg of 2.5mol/L copper sulfate solution, 1g of dispersing agent, 15g of thickener sodium carboxymethyl acrylate solution, 64g of binder acrylic acid and 5.5g of wetting agent polysiloxane quaternary ammonium salt-16, stirring, adding 2.5kg of water, and uniformly mixing; preparing a mixed solution A;
s2: and (4) coating the mixed solution A in the step S2 on a polypropylene film with the thickness of 22 mu m and the pore diameter of 40nm, baking at 150 ℃ after coating, and cooling to obtain the isolating film.
Application example
The schematic structural diagrams of the separation films prepared in examples 1 to 6 have the same structure, and here, the schematic structural diagram of the separation film in example 1 is selected, and the structure thereof is shown in fig. 1.
The separation membranes prepared in examples 1 to 6 and comparative examples 1 to 4 were used for the antibacterial property test of escherichia coli, and the method of AATCC-l00 was used for the evaluation of antibacterial efficiency, which is shown in table 1 below.
The separators prepared in examples 1 to 6 and comparative examples 1 to 4 were used for the contact angle test, and the contact angles are shown in table 1 below.
TABLE 1 antibacterial effectiveness
In conclusion, it can be understood from the comparison of examples 1 to 4 and comparative examples 1 to 2 that the antibacterial efficiency of the separator is higher as the content of the copper sulfate solution is higher, and when the content of the copper sulfate is continuously increased, since the surface of the nanoporous alumina is coated with the copper sulfate, since the nanoporous alumina can improve the surface structure of the base film, the surface roughness of the separator is increased, and when the nanoporous alumina is decreased, the hydrophilic ability of the separator is decreased. According to comparative example 1, when the concentration range of the copper sulfate solution is lower than that of the present application, since the content of the copper sulfate solution is too low, the removal rate of escherichia coli by the separation membrane is low, and the antibacterial efficiency is greatly reduced. According to comparative example 2, when the concentration range of the copper sulfate solution is higher than that of the present application, the antibacterial property of the barrier film against escherichia coli is saturated and the antibacterial efficiency is not changed when the content of the copper sulfate solution is continuously increased, but the surface of the nanoporous alumina is completely coated with copper sulfate due to the excessively high copper sulfate solution, so that the hydrophilicity of the barrier film is weakened and the water absorption of the barrier film is reduced. Thus, the nanoporous alumina and copper sulfate solution is preferably a 1: 0.1-10.
As can be seen from comparing examples 1, 4, and 5 with comparative examples 3 to 4, the separation membrane prepared has excellent antibacterial efficiency when the respective component ratios within the ranges of the present application are used. When the proportioning and using amount of each component is less, the alumina slurry containing copper sulfate is not dispersed uniformly, so that the antibacterial effect of the isolating membrane is influenced; when the ratio and the dosage of each component are more, the antibacterial efficiency of the prepared isolating membrane has no obvious change, therefore, in order to save the production cost, the copper sulfate alumina slurry is preferably: dispersing agent: adhesive: thickening agent: the mass percentage of the wetting agent is 1: 0.003-0.017: 0.025-0.093: 0.003-0.035: 0.002-0.0096.
When the preparation method in example 6 is adopted, uniform particles are prepared in advance, and then the aluminum oxide slurry containing copper sulfate is prepared, so that the porosity of the aluminum oxide slurry containing copper sulfate above the polypropylene film is uniform, and the air permeability and the antibacterial efficiency of the isolating membrane are improved.
Analysis of the data of comparative example 5 revealed that the separator had poor antibacterial efficiency because it did not contain copper sulfate and failed to exert bactericidal action.
Analysis of the data of comparative example 6 revealed that the antibacterial efficiency of the separator was lowered due to uneven dispersion of copper sulfate in the mixed solution a.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A preparation method of a medical durable bactericidal breathable isolating membrane is characterized by comprising the following steps:
s1: uniformly stirring the nano porous alumina and 0.58-4.64mol/L copper sulfate solution, and drying at 100-200 ℃ to prepare the nano porous alumina adsorbed with copper sulfate;
s2: uniformly mixing the nano porous alumina adsorbed with copper sulfate, a dispersing agent, a wetting agent, a binder, a thickening agent, a cross-linking agent and pure water to prepare alumina slurry containing copper sulfate;
s3: and (4) coating the alumina slurry containing copper sulfate in the step S2 on the polymer porous film, baking at 100-200 ℃ after coating, and cooling to obtain the isolating film.
2. The method for preparing a medical durable sterilization breathable isolating membrane as claimed in claim 1, wherein the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 0.1-10.
3. The method for preparing a medical durable sterilization breathable isolating membrane as claimed in claim 2, wherein the weight percentage of the nano porous alumina to the copper sulfate solution is 1: 5.
4. The method of claim 1, wherein in step S2, the nano porous alumina containing copper sulfate, the dispersant and the thickener are first mixed and sand-milled to form a mixture a, the particle size of the solid particles in the mixture is 0.1 μm to 15 μm, and then the mixture a is mixed with the binder and the wetting agent uniformly.
5. The method for preparing a medical durable sterilization breathable isolating membrane according to claim 1, wherein the polymer porous membrane is one of a polypropylene membrane, a polyethylene membrane and a polyethylene terephthalate membrane, and the thickness of the polymer porous membrane is 1 μm to 500 μm; the diameter of the hole of the polymer porous film is 10-500 nm.
6. A method for preparing a medical durable bactericidal breathable barrier film according to claim 1, wherein the pore diameter of the nanoporous alumina is 50-500 nm.
7. The method for preparing a medical durable bactericidal breathable isolating membrane according to claim 1, wherein the dispersing agent is at least one of water glass, sodium tripolyphosphate, sodium hexametaphosphate, sodium pyrophosphate, triethylhexylphosphoric acid, sodium dodecyl sulfate, methylpentanol, cellulose derivatives, polyacrylamide, guar gum and fatty acid polyglycol ester; the wetting agent is one of polysiloxane quaternary ammonium salt-16 and polysiloxane quaternary ammonium salt-18; the binder is one of acrylic acid, methacrylic acid, polyvinyl acetate phthalate and methyl methacrylate; the thickening agent is sodium carboxymethyl acrylate.
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| CN103772729B (en) * | 2014-01-26 | 2016-01-20 | 江苏科德宝建筑节能科技有限公司 | A kind of preparation method of Antibiotic Membrane |
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