CN111308061A - Combined secretion detection workstation and detection method - Google Patents
Combined secretion detection workstation and detection method Download PDFInfo
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- CN111308061A CN111308061A CN202010240359.1A CN202010240359A CN111308061A CN 111308061 A CN111308061 A CN 111308061A CN 202010240359 A CN202010240359 A CN 202010240359A CN 111308061 A CN111308061 A CN 111308061A
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- 238000001514 detection method Methods 0.000 title claims abstract description 130
- 230000028327 secretion Effects 0.000 title claims abstract description 40
- 230000007246 mechanism Effects 0.000 claims abstract description 135
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 69
- 239000000126 substance Substances 0.000 claims abstract description 38
- 238000005070 sampling Methods 0.000 claims abstract description 29
- 238000011534 incubation Methods 0.000 claims abstract description 25
- 238000002347 injection Methods 0.000 claims abstract description 24
- 239000007924 injection Substances 0.000 claims abstract description 24
- 230000007704 transition Effects 0.000 claims abstract description 13
- 239000011521 glass Substances 0.000 claims abstract description 9
- 238000012360 testing method Methods 0.000 claims description 24
- 230000005540 biological transmission Effects 0.000 claims description 20
- 230000002572 peristaltic effect Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000012546 transfer Methods 0.000 claims description 6
- 210000000416 exudates and transudate Anatomy 0.000 claims description 4
- 238000011161 development Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 4
- 210000003756 cervix mucus Anatomy 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 230000007723 transport mechanism Effects 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00108—Test strips, e.g. paper
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
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- G—PHYSICS
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- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
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Abstract
The invention discloses a combined secretion detection workstation, which comprises a shell, wherein a base and a rack are arranged in the shell, and the combined secretion detection workstation is characterized in that a dry chemistry automatic detection module, a microscope microscopic examination module, a circulating sample injection module and a sampling module are arranged on the base, and a reagent pipetting module is arranged at one side of the shell, which is close to the dry chemistry automatic detection module; the dry chemical automatic detection module comprises a card supply mechanism, an incubation device and an image acquisition device, wherein one end of the incubation device is connected with the card supply mechanism, the other end of the incubation device is provided with a card transition pushing device, and the card transition pushing device is arranged below the image acquisition device; the microscope microscopic module comprises a slide supply mechanism and a detection microscope. The slide glass feeding mechanism is arranged at one end of the third rack, the slide glass feeding mechanism is arranged at the other end of the third rack, and the slide glass feeding mechanism is arranged at the other end of the third rack; the circulating sample injection module is arranged corresponding to the sampling module.
Description
Technical Field
The invention belongs to the technical field of secretion detection, and particularly relates to a secretion combined detection workstation and a detection method.
Background
The detection of vaginal secretion is generally divided into two parts, dry chemical detection and microscopic examination. Dry chemistry assays are semi-quantitative. Generally, when the dry chemical detection result shows that the physical index of the patient is abnormal, the dry chemical detection result is subjected to microscope examination again so as to complete the confirmation of the detection result. Current microscopic examination of vaginal secretions is largely by manual detection.
The existing dry chemical detection in the current market is generally manual detection, and errors can be generated due to subjective consciousness of people. The prior art has poor efficiency and accuracy in detecting vaginal secretion by single dry chemical detection or microscopic examination, so that a full-automatic secretion detection workstation with automatic sample introduction, automatic dry chemical detection and automatic microscopic examination is urgently needed.
The prior art therefore remains to be studied further.
Disclosure of Invention
The invention aims to provide a combined secretion detection workstation, which solves the problem of low detection efficiency of single dry chemical detection or microscopic examination at present and solves the problems of low detection efficiency and low precision of manual or semi-automatic detection.
In order to solve the problems, the technical scheme adopted by the invention is as follows: a combined secretion detection workstation comprises a shell, wherein a base and a rack are arranged in the shell, the rack comprises a first rack, a second rack and a third rack which are arranged in parallel, the upper parts of the first rack, the second rack and the third rack are vertical to a fourth rack, a dry chemical automatic detection module, a microscope microscopic examination module and a circulating sample injection module are arranged on the base, and a reagent liquid transfer module is arranged at one side of the shell close to the dry chemical automatic detection module;
the automatic dry chemical detection module comprises a card supply mechanism, an incubation device and an image acquisition device, wherein the card supply mechanism, the incubation device and the image acquisition device are arranged on a first rack;
the microscope microscopic examination module comprises a slide supply mechanism arranged on the second rack, a detection microscope and a slide pushing mechanism arranged on the fourth rack, wherein a slide waiting position is arranged on the third rack, one end of the slide waiting position corresponds to the slide supply mechanism, the other end of the slide waiting position is connected with the slide pushing mechanism, and the detection microscope is arranged at one end of the third rack;
and a sampling module is arranged on one side of the fourth rack, and the circulating sample injection module is arranged corresponding to the sampling module.
Card feed mechanism is including setting up push rod, push rod groove, push rod actuating mechanism and the card box on first frame, hold a plurality of cards in the card box, push rod actuating mechanism includes first motor and first conveyer belt, push rod one end is fixed on first conveyer belt, and the push rod groove is stretched out to the other end, the push rod pushes away the slide and pushes away slide to card transition pusher department along the push rod groove through incubation device in proper order, pushes away the card to image acquisition device department by card transition pusher.
The image acquisition device comprises an upper supporting plate, a lower supporting plate, a camera and a light supplementing lamp, wherein one end of the camera is fixed on the upper supporting plate, the other end of the camera penetrates through the lower supporting plate, the light supplementing lamp is fixed on the lower supporting plate, a plurality of adjusting bolts are uniformly arranged between the upper supporting plate and the lower supporting plate, and the adjusting bolts are all provided with buffer springs.
The slide supply mechanism is structurally identical to the card supply mechanism except that a slide cassette is arranged on the second frame.
The slide pushing mechanism is arranged on the other side of the fourth rack and comprises a second conveying belt and a second conveying motor which are arranged on the fourth rack, a Z-shaped shifting block is arranged on the second conveying belt and corresponds to the slide waiting position.
The detection microscope comprises a microscope body, a detection platform and a driving mechanism, wherein the detection platform and the driving mechanism are arranged on the microscope body, a glass slide clamp is arranged on the detection platform, and the driving mechanism comprises a front driving mechanism, a rear driving mechanism, a vertical driving mechanism and a left and right driving mechanism, wherein the front driving mechanism is used for driving the detection platform to move front and back, the vertical driving mechanism is used for driving the detection platform to move up and down, and the left and right.
The sampling module comprises a capillary fixing block, a third conveying motor and a third conveying belt, the capillary fixing block is fixed on the third conveying belt, and a sliding rail are arranged between the sampling module and the fourth rack.
The circulation advances kind the module and advances kind platform and test-tube rack including the circulation, set up advancing mechanism and ejecting mechanism on the circulation advances kind platform, set up between advancing mechanism and the ejecting mechanism and sweep a yard device, one side that the circulation advances kind platform sets up the transmission device who is used for the test-tube rack transmission, transmission device is including transfer passage and transmission actuating mechanism, advancing mechanism is including advancing actuating mechanism and pushing ram, ejecting mechanism includes dual output shaft motor and swing arm.
The reagent pipetting module comprises a reagent rack, a peristaltic pump and a sample dripping rack, wherein a reagent fixing frame and a reagent sample sucking rack are arranged on the reagent rack, capillary suction tubes are arranged on the reagent sample sucking rack and the sample dripping rack, the capillary suction tubes and the peristaltic pump are connected through latex tubes, and the sample dripping rack is arranged on a first rack; the shell and the reagent pipetting module are correspondingly provided with sample changing windows.
A combined detection method for secretion comprises the following steps:
(1) preparation work: placing secretion samples to be detected on a test tube rack of the circulating sample injection module in sequence; placing the slide in a slide box, placing the card in a card box, and placing the detection reagent on a reagent rack of a reagent pipetting module for later use;
(2) starting the equipment: the circulating sample injection module continuously provides secretion samples to be detected, and the sampling module sucks the secretion samples to be detected from a test tube of the circulating sample injection module and sequentially drips the secretion samples to a card of the dry chemical automatic detection module and a slide of the microscope microscopic examination module;
(3) the reagent pipetting module automatically drips a detection reagent onto a card of the dry chemical automatic detection module, the dry chemical automatic detection module automatically detects, an image acquisition device acquires an image after color development, and a dry chemical detection result is output;
(4) the microscope microscopic module automatically detects and outputs a detection result obtained by the detection microscope;
(5) and (5) analyzing the dry chemical detection structure and the microscopic examination result in the step (3) and the step (4) to obtain an initial result.
The invention has the beneficial effects that:
1. the invention relates to a combined detection workstation for exudates, which comprises a circulating sample introduction platform module, a reagent liquid transfer module, a sampling module, a dry chemical automatic detection module and a microscope microscopic examination module, and realizes the full-automatic combined detection functions of automatic circulating sample introduction, automatic sampling, automatic dry chemical detection and automatic microscope microscopic examination, and the detection efficiency and accuracy are greatly improved by the combined use of the dry chemical detection and the microscope microscopic examination.
2. The invention relates to a secretion joint detection workstation.A circulating sample introduction platform module comprises a propelling mechanism, a pushing-out mechanism and a transmission mechanism, wherein a code scanning device is arranged between the propelling mechanism and the pushing-out mechanism.
3. The invention relates to a secretion joint detection workstation.A dry chemical automatic detection module comprises a card supply mechanism, an incubation device and an image acquisition device, wherein the card supply mechanism automatically provides a card for detection, blood or secretion to be detected is dripped onto the card, then the card is pushed onto the incubation device to be heated, the heated card is developed, then the card is pushed to the image acquisition device by a card transition pushing device to be photographed, and thus, the card is automatically supplied, incubated and an image with developed color is acquired.
4. The invention relates to a secretion joint detection workstation which comprises a slide supply mechanism, a slide pushing mechanism and a detection microscope, wherein the slide supply mechanism is used for continuously supplying slides, a sampling mechanism module is used for dropping liquid to be detected onto the slides to realize the function of automatically preparing the detection slides, then the slide pushing mechanism is used for pushing the slides to the detection microscope, and the detection microscope is automatically adjusted by utilizing a front driving mechanism, a rear driving mechanism, a vertical driving mechanism and a left driving mechanism and a right driving mechanism to finish the work of automatic microscopic examination.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic view of the internal perspective of the present invention;
FIG. 3 is a schematic structural diagram of a circulating sample injection module;
FIG. 4 is a schematic illustration of the propulsion mechanism of FIG. 3;
FIG. 5 is a schematic view of the ejection mechanism of FIG. 3;
FIG. 6 is a schematic diagram of a reagent pipetting module;
FIG. 7 is an enlarged view of A in FIG. 6;
FIG. 8 is a schematic diagram of a sampling module;
FIG. 9 is a schematic diagram of a dry chemical automatic detection module;
FIG. 10 is a schematic view of a portion of the structure of FIG. 9;
FIG. 11 is a schematic view of the image capturing device of FIG. 9;
FIG. 12 is a schematic view of a microscope module;
FIG. 13 is an enlarged schematic view of B of FIG. 12;
FIG. 14 is a schematic plan view of a detection microscope;
FIG. 15 is a schematic view of the front and rear driving mechanism of FIG. 14;
FIG. 16 is a schematic structural view of the left-right driving mechanism in FIG. 14;
FIG. 17 is a schematic view of a 14-center vertical drive mechanism;
fig. 18 is a detection flowchart.
In the figure:
100-shell, 101-pattern changing window, 200-base, 300-frame, 301-first frame, 302-second frame, 303-third frame, 304-fourth frame;
400-dry chemical automatic detection module, 401-card feeding mechanism, 411-push rod, 412-card box, 413-card, 402-incubation device, 421-incubation plate, 403-image acquisition device, 431-upper supporting plate, 432-lower supporting plate, 433-camera, 434-light supplement lamp, 435-adjusting bolt, 436-buffer spring, 404-card transition pushing device, 441-L type push block, 442-fifth motor, 443-fifth conveyor belt;
500-microscope microscopic examination module, 501-slide feeding mechanism, 511-slide box, 502-slide pushing mechanism, 521-sixth conveyor belt, 522-sixth motor, 523-Z type shifting block, 503-detection microscope, 531-microscope body, 532-detection platform, 533-slide clamp, 534-front and back driving mechanism, 5341-first lead screw motor, 535-vertical driving mechanism, 5351-second lead screw motor, 536-left and right driving mechanism, 5361-stepping motor, 5362-vertical lead screw, 5363-driving wheel, 504-slide waiting position, 505-slide pushing plate, 551-seventh motor, 552-seventh conveyor belt and 506-sliding plate;
600-sample circulating module, 601-sample circulating platform, 611-push rod groove, 602-test tube rack, 603-pushing mechanism, 631-push rod, 632-first conveyor belt, 633-first motor, 634-slide block fixing seat, 635-push rod fixing plate, 636-baffle, 604-pushing mechanism, 641-double output shaft motor, 642-swing arm, 643-L type fixing plate, 644-vertical rotating shaft, 605-transmission mechanism, 651-transmission channel, 652-second motor, 653-second conveyor belt and 606-test tube; 607-code scanning means;
700-reagent pipetting module, 701-reagent rack, 711-reagent fixing block, 712-reagent sample sucking rack, 713-first magnetic plate, 714-second magnetic plate, 715-T type fixing seat, 716-containing rack, 717-clamping protrusion, 718-handle, 719-fixing lug, 702-peristaltic pump and 703-sample dropping rack;
800-sampling module, 801-capillary fixed block, 802-third motor and 803-third conveyor belt.
Detailed Description
In order to clearly illustrate the technical features of the present solution, the following explains the present solution by way of specific embodiments and with reference to the accompanying drawings.
As shown in fig. 1 to 17, a combined secretion detecting workstation includes a housing 100, a base 200 and a rack 300 are disposed in the housing 100, and the rack 300 includes a first rack 301, a second rack 302 and a third rack 303 disposed in parallel; the perpendicular fourth frame 304 in top of first frame 301, second frame 302 and third frame 303, set up dry chemistry automated inspection module 400 on the first frame 301, second frame 302 sets up microscope microscopic examination module 500, fourth frame 304 one side sets up sampling module 800, casing 100 one side is close to dry chemistry automated inspection module 400 department and sets up reagent and move liquid module 700, set up circulation and advance kind module 600 on the base 200, circulation and advance kind module 600 and sampling module 800 and correspond the setting, casing 100 moves liquid module 700 with reagent and corresponds and set up and trade appearance window 101.
The sampling module 800 comprises a capillary tube fixing block 801, a third motor 802 and a third conveyor belt 803, the capillary tube fixing block 801 is fixed on the third conveyor belt 803, and a slide rail are arranged between the sampling module 800 and the fourth rack 304; the sampling module 800 and the fourth frame 304 can move laterally in a sliding rail and slider manner, and particularly, the driving and connecting structure is a conventional connection structure, which is not described in detail.
Specifically, during operation, the capillary tube containing the reagent to be dripped is fixed on the capillary tube fixing block 801, the sampling module 800 transversely moves on the fourth rack 304 to obtain the reagent to be dripped, and then the third motor 802 drives the capillary tube fixing block 801 to move up and down, so as to provide the secretion sample to be detected for the dry chemical automatic detection module 400 and the microscope microscopic examination module 500.
The circulating sample injection module 600 comprises a circulating sample injection platform 601 and a test tube rack 602, a pushing mechanism 603 and a pushing mechanism 604 are arranged on the circulating sample injection platform 601, a code scanning device 607 is arranged between the pushing mechanism 603 and the pushing mechanism 604, and a transmission mechanism 605 for transmitting the test tube rack 602 is arranged on one side of the circulating sample injection platform 601.
The propulsion mechanism 603 includes a propulsion driving mechanism and a propulsion rod 631, the circulating sample feeding platform 601 is provided with a propulsion rod groove 611, the propulsion rod 631 moves back and forth along the propulsion rod groove 611, the propulsion driving mechanism includes a first motor 633 and a first conveyor belt 632, and the first conveyor belt 632 is provided with a slider fixing seat 634. A slide block is arranged on one side of the slide block fixing seat 634, and a slide rail is arranged on the circulating sample injection platform 601 corresponding to the slide block; set up push rod fixed plate 635 and baffle 636 on the slider fixing base 634, the one end of pushing ram 631 is fixed on push rod fixed plate 635, pushing ram 631 includes the tip of slope, pushing ram 631 passes through bolt swing joint with push rod fixed plate 635, and this kind of structure can guarantee that pushing ram 631 promotes test-tube rack 602 toward one direction, prevents that test-tube rack 602 from backing up.
Specifically, the first motor 633 drives the pushing bar 631 to move along the pushing bar groove 611, and further the pushing bar pushes the test tube rack 602 to move.
The transmission mechanism 605 comprises a transmission channel 651 and a transmission driving mechanism, the transmission driving mechanism comprises a second motor 652 and a second transmission belt 653, the second transmission belt 653 is provided with a transmission stopper, and the transmission stopper drives the test tube rack 602 to move under the driving of the second transmission belt 653.
The pushing mechanism 604 comprises a double-output-shaft motor 641 and a swing arm 642, an L-shaped fixing plate 643 is arranged on one side of the circular sample injection platform 601, a vertical rotating shaft 644 is arranged on the L-shaped fixing plate 643, one end of the double-output-shaft motor 641 is connected with one end of the vertical rotating shaft 644 through a belt, and the swing arm 642 is arranged on the other ends of the double-output-shaft motor 641 and the vertical rotating shaft 644.
Specifically, the dual-output shaft motor 641 drives the vertical rotating shaft 644 to rotate, and simultaneously drives the two swing arms 642 to move simultaneously, so as to further push out the transported test tube rack 602.
During the use, the sample that the hospital gathered is dripped in test tube 606, will contain the test tube 606 that detects the sample and place on test-tube rack 602, then push away test-tube rack 602 to transport mechanism 605 department by advancing mechanism 603, transport mechanism 605 pushes away test-tube rack 602 to sweep yard device 607 department, sweep yard completion back, sample by sampling module 800, after the sampling is accomplished, continue to push away to advancing mechanism 604 department, then push away test-tube rack 602 by advancing mechanism 604.
The reagent pipetting module 700 comprises a reagent rack 701, a peristaltic pump 702 and a sample dripping rack 703, wherein a reagent fixing block 711 and a reagent sample sucking rack 712 are arranged on the reagent rack 701, capillary straws are arranged on the reagent sample sucking rack 713 and the sample dripping rack 703, the capillary straws are connected with the peristaltic pump 702 through emulsion tubes, and the sample dripping rack 703 is arranged on the first rack 301; the reagent rack 701 is provided with a guide rail, the reagent sample absorbing rack 712 slides up and down along the guide rail, further, the reagent rack 701 is provided with a first magnetic plate 713, the reagent sample absorbing rack 712 is provided with a second magnetic plate 714, the reagent fixing rack 711 comprises a T-shaped fixing seat 715 and a containing rack 716, and specifically, when the reagent sample absorbing rack is used, a reagent tube containing a reagent is fixed on the containing rack 716.
Specifically, when a sample is drawn, the reagent sample drawing rack 712 slides down along the guide rail to the reagent fixing block 711, the capillary pipette on the reagent sample drawing rack 712 extends into the reagent tube on the containing rack 716, and when the reagent tube is replaced, the reagent sample drawing rack 712 slides up along the guide rail to the first magnetic plate 713, and at this time, the second magnetic plate 714 is tightly drawn with the first magnetic plate 713.
T type fixing base 715 is last to be provided with the card and to put protruding 717, hold and put on 716 and correspond with the card and set up the card with protruding 717 and put the groove, hold and set up handle 718 and fixed ear 719 on 716, fixed ear 719 is taken on T type fixing base 715, because set up on casing 100 and trade appearance window 101, can change reagent through trading appearance window 101 and handle 718.
Specifically, the peristaltic pump 702 in the reagent pipetting module 700 will automatically provide the dry chemical automated detection module 400 with detection reagents.
The dry chemical automatic detection module 400 comprises a card supply mechanism 401, an incubation device 402 and an image acquisition device 403 which are arranged on a first frame 301, wherein one end of the incubation device 402 is connected with the card supply mechanism 401, the other end of the incubation device 402 is provided with a card transition pushing device 404, and the card transition pushing device 404 is arranged below the image acquisition device 403;
the card supply mechanism 401 includes a push rod 411, a push rod slot, a push rod driving mechanism and a card box 412, which are arranged on the first frame 301, the card box 412 contains a plurality of cards 413, the push rod driving mechanism includes a fourth motor and a fourth conveyor belt, one end of the push rod 411 is fixed on the fourth conveyor belt 415, and the other end of the push rod extends out of the push rod slot to correspond to the card box 412; the incubation device 402 comprises an incubation plate 421, the incubation plate 421 is a heating plate, and has a conventional structure, and therefore the details are not repeated, the two sides of the incubation plate 421 are provided with a sample dropping frame 703, a capillary tube is arranged on the sample dropping frame 703, and here, the reagent pipetting module 700 drips the detection reagent onto the card 413.
Specifically, the push rod 411 pushes the card 413 to the incubation plate 421, the sampling module 800 sucks the detection sample from the circular sample injection module 600 and drops the detection sample onto the card, after incubation on the incubation plate 421, the detection temperature is simulated by the purpose of human body temperature, and the reagent pipetting module 700 drops the detection reagent onto the card at the sample dropping rack 703 for color development.
The card transition pushing device 404 includes an L-shaped pushing block 441, a fifth motor 442 and a fifth conveyor 443, the L-shaped pushing block 441 and the first frame 301 move relatively via a sliding rail slider, one side of the L-shaped pushing block 441 is fixed on the fifth conveyor 443, and the L-shaped pushing block 441 is disposed on one side of the first frame 301.
Specifically, the card transition pushing device 404 has one end located below the image capturing device 3 and the other end corresponding to the incubation device 402, and the card transition pushing device 404 pushes the card 413 from the incubation device 402 to the image capturing device 403.
The image acquisition device 403 comprises an upper supporting plate 431, a lower supporting plate 432, a camera 433 and a light supplement lamp 434, wherein one end of the camera 433 is fixed on the upper supporting plate 431, the other end of the camera penetrates through the lower supporting plate 432, the light supplement lamp 434 is fixed on the lower supporting plate 432, a plurality of adjusting bolts 435 are uniformly arranged between the upper supporting plate 431 and the lower supporting plate 432, and buffer springs 436 are arranged on the adjusting bolts 435.
Specifically, a plurality of adjusting bolts 435 are uniformly arranged between the upper and lower supporting plates of the image capturing device 403, the levels of the upper supporting plate 431 and the lower supporting plate 432 can be ensured by adjusting the adjusting bolts 435, the levelness of the camera 433 is further adjusted, and the image capturing precision is improved.
The microscope microscopic examination module comprises a slide supply mechanism 501, a slide pushing mechanism 502 and a detection microscope 503 which are arranged on the second rack 302, a slide waiting position 504 is arranged on the third rack 303, one end of the slide waiting position 504 is connected with the slide supply mechanism 502, the other end of the slide waiting position is connected with the slide pushing mechanism 502, and the detection microscope 503 is arranged at one end of the third rack 303;
the slide feeding mechanism 501 is identical to the card feeding mechanism 401 in structure, except that a slide cassette 511 is disposed on the second frame 302, and therefore, the detailed description thereof is omitted.
The slide pushing mechanism 502 is disposed on the other side of the fourth frame 304, the slide pushing mechanism 502 includes a sixth conveying belt 521 and a sixth motor 522 disposed on the fourth frame 304, a Z-shaped shifting block 523 is disposed on the sixth conveying belt 521, and the Z-shaped shifting block 523 is disposed corresponding to the slide waiting position 504.
The third frame 303 is provided with a slide push plate 505, a seventh motor 551, and a seventh transfer belt 552, and the slide push plate 505 is fixed to the seventh transfer belt 552.
Specifically, the slide is pushed to the side of the sampling module 800 below the fourth rack 304, the secretion to be detected is collected from the circulating sample injection module 600 by the sampling module 800, the secretion to be detected is dripped on the slide, and then the slide is pushed to the slide waiting position 504 by the slide pushing mechanism 502, and then the slide is pushed to the detection microscope 503 for detection by the slide pushing plate 505.
Specifically, the seventh motor 551 drives the slide push plate 505 to drive the slide of the slide waiting position 504 to the detection microscope 503.
The detection microscope 503 comprises a microscope body 531, a detection platform 532 arranged on the microscope body 531 and a driving mechanism, wherein a glass clip 533 is arranged on the detection platform 532, and the driving mechanism comprises a front and rear driving mechanism 534 for driving the detection platform 532 to move front and back, a vertical driving mechanism 535 for driving the detection platform 532 to move up and down and a left and right driving mechanism 536 for driving the glass clip 533 to move left and right.
Specifically, the front-back driving mechanism 534 and the vertical driving mechanism 535 can drive the detection platform 532 to move front and back and up and down, so as to drive the slide clamp 533 on the detection platform 532 to move, and the left-right driving mechanism 536 is used for driving the slide clamp 533 to move left and right, so that the slide clamp 533 can drive the detection slide to move front and back, left and right and up and down, and automatic adjustment is realized, so that the microscopic examination work of the secretion is completed.
The front and rear driving mechanism 534 comprises a first lead screw motor 5341, a lead screw of the first lead screw motor 5341 is connected with the detection platform 532, the vertical driving mechanism 535 comprises a second lead screw motor 5351, and a lead screw of the second lead screw motor 5351 is connected with the detection platform 532.
The first lead screw motor 5341 drives the detection platform 532 to move back and forth, and the second lead screw motor 5351 drives the detection platform 532 to move up and down.
The left and right driving mechanism 536 comprises a stepping motor 5361 and a vertical screw 5362 arranged on one side of the stepping motor 5361, driving wheels 5363 are arranged at two ends of the vertical screw 5362, the stepping motor 531 is connected with the vertical screw 5362 through a conveying belt, a sliding plate 506 is arranged on one side of the glass sheet clamp 533, and a sliding rail is correspondingly arranged on the detection platform 532. Specifically, a driven wheel is arranged on the detection platform 402 corresponding to the vertical lead screw 5362, a driving wheel at the upper end of the vertical lead screw 5362 is connected with the driven wheel through a conveying belt, and the sliding plate 506 is fixed on the conveying belt, so that the glass sheet clamp 533 is moved left and right.
As shown in the flowchart of fig. 18, a combined detection method for secretion includes the following steps:
(1) preparation work: placing secretion samples to be detected on a test tube rack 602 of the circulating sample injection module 600 in sequence; placing the slide in a slide box, placing the card in a card box, and placing the detection reagent on a reagent rack of the reagent pipetting module 700 for standby;
(2) starting the equipment: the circulating sample injection module 600 continuously provides secretion samples to be detected, and the sampling module 800 sucks the secretion samples to be detected out of the test tubes of the circulating sample injection module 600 and sequentially drips the secretion samples to be detected onto the card of the dry chemical automatic detection module 400 and the slide of the microscope microscopic examination module 500;
(3) the reagent pipetting module 700 automatically drips the detection reagent onto the card of the dry chemical automatic detection module 400, the dry chemical automatic detection module 400 automatically detects and obtains the color-developed image by the image obtaining device 403, and the dry chemical detection result is output;
(4) the microscope microscopy module 500 automatically detects and outputs the detection result obtained by the detection microscope 503;
(5) and (5) analyzing the dry chemical detection result and the microscopic examination result in the steps (3) and (4) to obtain an initial result. The step (5) can be automatically analyzed by using programming software.
The foregoing is only a preferred embodiment of the present invention, and it will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the principle of the invention, and such modifications and improvements are also considered to be within the scope of the invention.
Claims (10)
1. A combined secretion detection workstation comprises a shell, wherein a base and a rack are arranged in the shell, and the combined secretion detection workstation is characterized in that the rack comprises a first rack, a second rack and a third rack which are arranged in parallel, the upper parts of the first rack, the second rack and the third rack are vertical to a fourth rack, a dry chemical automatic detection module, a microscope microscopic examination module and a circulating sample injection module are arranged on the base, and a reagent liquid transfer module is arranged at one side of the shell, which is close to the dry chemical automatic detection module;
the automatic dry chemical detection module comprises a card supply mechanism, an incubation device and an image acquisition device, wherein the card supply mechanism, the incubation device and the image acquisition device are arranged on a first rack;
the microscope microscopic examination module comprises a slide supply mechanism arranged on the second rack, a detection microscope and a slide pushing mechanism arranged on the fourth rack, wherein a slide waiting position is arranged on the third rack, one end of the slide waiting position corresponds to the slide supply mechanism, the other end of the slide waiting position is connected with the slide pushing mechanism, and the detection microscope is arranged at one end of the third rack;
and a sampling module is arranged on one side of the fourth rack, and the circulating sample injection module is arranged corresponding to the sampling module.
2. A combined secretion detecting workstation as claimed in claim 1, wherein the card supplying mechanism includes a push rod, a push rod groove, a push rod driving mechanism and a card box, the push rod groove, the push rod driving mechanism and the card box are arranged on the first frame, a plurality of cards are contained in the card box, the push rod driving mechanism includes a first motor and a first conveyor belt, one end of the push rod is fixed on the first conveyor belt, the other end of the push rod extends out of the push rod groove, the push rod pushes the slide glass to the card transition pushing device along the push rod groove through the incubation device in sequence, and the card transition pushing device pushes the card to the image acquiring device.
3. A combined secretion detecting workstation as claimed in claim 2, wherein the image capturing device includes an upper supporting plate, a lower supporting plate, a camera and a light compensating lamp, one end of the camera is fixed on the upper supporting plate, the other end of the camera passes through the lower supporting plate, the light compensating lamp is fixed on the lower supporting plate, a plurality of adjusting bolts are uniformly arranged between the upper supporting plate and the lower supporting plate, and the adjusting bolts are all provided with a buffer spring.
4. A combined exudate detection station as claimed in claim 1 wherein said slide feed mechanism is structurally identical to the card feed mechanism except that a cassette is provided on said second frame.
5. A combined secretion detecting workstation as claimed in claim 1, wherein the slide pushing mechanism is disposed on the other side of the fourth frame, the slide pushing mechanism includes a second conveyor belt and a second conveyor motor disposed on the fourth frame, the second conveyor belt is provided with a Z-shaped shifting block, and the Z-shaped shifting block is disposed corresponding to the slide waiting position.
6. A combined secretion testing workstation as claimed in claim 1, wherein said testing microscope includes a microscope body, a testing platform mounted on the microscope body, and a driving mechanism, said testing platform is provided with a slide holder, said driving mechanism includes a front and rear driving mechanism for driving the testing platform to move forward and backward, a vertical driving mechanism for driving the testing platform to move up and down, and a left and right driving mechanism for driving the slide holder to move left and right.
7. A combined exudate detection workstation as claimed in claim 1, wherein said sampling module comprises a capillary fixing block, a third conveyor motor and a third conveyor belt, said capillary fixing block is fixed on the third conveyor belt, and a slide rail are arranged between said sampling module and the fourth frame.
8. A combined secretion detecting workstation according to claim 1, wherein the circulating sample feeding module comprises a circulating sample feeding platform and a test tube rack, the circulating sample feeding platform is provided with a propelling mechanism and an ejecting mechanism, a code scanning device is arranged between the propelling mechanism and the ejecting mechanism, one side of the circulating sample feeding platform is provided with a transmission mechanism for transmission of the test tube rack, the transmission mechanism comprises a transmission channel and a transmission driving mechanism, the propelling mechanism comprises a propelling driving mechanism and a propelling rod, and the ejecting mechanism comprises a double output shaft motor and a swing arm.
9. A combined secretion testing workstation as claimed in claim 1, wherein said reagent pipetting module comprises a reagent rack, a peristaltic pump and a sample dripping rack, said reagent rack is provided with a reagent fixing rack and a reagent pipetting rack, said reagent pipetting rack and said sample dripping rack are both provided with capillary suction tubes, said capillary suction tubes and said peristaltic pump are both connected through latex tubes, and said sample dripping rack is provided on the first frame; the shell and the reagent pipetting module are correspondingly provided with sample changing windows.
10. A combined detection method for exudates, comprising using the combined detection workstation according to any of claims 1-9, further comprising the steps of:
(1) preparation work: placing secretion samples to be detected on a test tube rack of the circulating sample injection module in sequence; placing the slide in a slide box, placing the card in a card box, and placing the detection reagent on a reagent rack of a reagent pipetting module for later use;
(2) starting the equipment: the circulating sample injection module continuously provides secretion samples to be detected, and the sampling module sucks the secretion samples to be detected from a test tube of the circulating sample injection module and sequentially drips the secretion samples to a card of the dry chemical automatic detection module and a slide of the microscope microscopic examination module;
(3) the reagent pipetting module automatically drips a detection reagent onto a card of the dry chemical automatic detection module, the dry chemical automatic detection module automatically detects, an image acquisition device acquires an image after color development, and a dry chemical detection result is output;
(4) the microscope microscopic module automatically detects and outputs a detection result obtained by the detection microscope;
(5) and (5) analyzing the dry chemical detection structure and the microscopic examination result in the step (3) and the step (4) to obtain an initial result.
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