CN111267416A - Adult's pad piece of cloth of preventing and treating bedsore - Google Patents
Adult's pad piece of cloth of preventing and treating bedsore Download PDFInfo
- Publication number
- CN111267416A CN111267416A CN202010084570.9A CN202010084570A CN111267416A CN 111267416 A CN111267416 A CN 111267416A CN 202010084570 A CN202010084570 A CN 202010084570A CN 111267416 A CN111267416 A CN 111267416A
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- Prior art keywords
- layer
- spinning
- coagulating bath
- antibacterial
- fiber
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Links
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
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Abstract
The invention relates to an adult pad towel for preventing and treating bedsore, which increases the contact comfort between a body and a bed by arranging a flexible inflatable ball in the pad towel, increases the elasticity and activity of skin, and greatly reduces the bedsore by matching with the use of antibacterial and anti-inflammatory peptide. Has the advantages of simple preparation, low cost and convenient use, and is suitable for large-area popularization.
Description
Technical Field
The invention relates to the field of adult products, in particular to an adult pad towel for preventing and treating bedsore, a preparation method and application thereof.
Background
Bedsore is the abnormal skin function caused by blood circulation disorder due to long-term compression of local tissues of the body and insufficient nutrition of the tissues. Bedsore is a common clinical complication, and according to related literature reports, more than 50% of people who are bedridden for a long time die of serious infection caused by bedsore instead of the original disease, and about 6 ten thousand people die of bedsore syndrome every year.
The pathogenesis of bedsores is mainly related to the pressure aspect, and the bedsore formed by vertical pressure is mainly characterized in that local tissues are subjected to continuous vertical pressure, particularly the bony prominence part. If a patient lies in bed or sits in a wheelchair for a long time and bears normal pressure exceeding capillary vessels for a long time, serious bedsore can be caused. The skin is affected by the action of friction force and is easy to damage the stratum corneum of the skin. And the shearing force is formed by mutually superposing friction force and vertical pressure when the acting force acts on an object and plane sliding in opposite directions and in parallel occurs. There is close connection in shear force and patient's position, if the patient is the state of crouching flat, when raising the head of a bed, its body can slide down, and skin and bed will produce parallel frictional force this moment to produce the shear force under the influence of perpendicular gravity, make local skin blood circulation obstacle appear, the bedsore finally appears. On the other hand, the nutritional aspect is that in the case of a general nutritional deficiency of the patient, the muscles collapse and the compressed site is not necessarily protected. It is because of systemic dystrophy that protein synthesis and subcutaneous fat in the body are reduced. Under the action of long-term pressure, the skin of the bony protuberance part can bear the external pressure, and the bony protuberance part can press the skin. Because the pressed part is not protected by muscle and adipose tissue, blood circulation is further disturbed, and bedsore is formed. Again, skin resistance is reduced if the patient's skin is wet for a long period of time or is subjected to physical irritation such as rubbing.
In clinical practice, the stages of bedsores in China are as follows: I. stage II, III, and IV, namely, the blood stasis ruddy stage, inflammatory infiltration stage, superficial ulcer stage, and necrotic ulcer stage. The main manifestations of stage I are the chronic stress or damp irritation of the local skin of the patient, which can lead to red swelling, numbness and tenderness. The main manifestation of stage II is that the inflamed area of the patient is continuously compressed, the blood circulation is difficult to improve, the color of the skin on the compressed surface is changed into mauve, the skin becomes thinner and forms blisters under the action of edema, the ulceration probability is directly increased, and the moist and ruddy wound surface is exposed. On the basis, the friction of small unbroken blisters is avoided as much as possible, so that the infection is effectively prevented, and the purpose of self absorption is finally realized. The major manifestation of stage III is that the ulceration has reached deep tissue and appears pale yellow. In order to solve the problem, normal disinfection measures are adopted after the wound surface is cleaned and wiped clean by using normal saline, so that the skin around the bedsore is disinfected. The main manifestations of stage IV are extensive ulceration, deep reaching the muscularis tissue, and the emission of unpleasant odors.
Prevention is an important factor for avoiding bedsore, and six tasks are main preventive measures, namely, turnover, scrubbing, massage, arrangement, replacement and shift. In the aspect of prevention, local tissues of a body are prevented from being compressed for a long time as much as possible, a bedridden patient needs to be encouraged and helped to change the body position regularly, the patient turns over once every 2-3 hours, and the longest time is not allowed to exceed 4 hours. If necessary, should be turned over every other hour. In addition, air rings, soft pillows, water cushions, sponge cushions and the like can be padded on the bone protruding parts which are easy to be pressed. In addition, the body is scrubbed by using warm water regularly, and local friction care can be performed by using hot water. The food which is rich in protein and vitamins and easy to digest is properly supplemented, and the vegetables and the fruits are eaten as much as possible.
Clinically, the pressure sore prevention is carried out on patients who are easy to generate pressure sore by using sponge mattresses, air mattresses and water mattresses. If the air mattress and the water mattress are used for preventing pressure sores and are expensive and difficult to bear, the sponge mattress is usually used for preventing pressure sores by using a soft pillow for making the bone bulge which is easy to be pressed overhead. In the using process, the soft pillow is found to be soft, but the pressure distribution is uneven, the air permeability is poor, the water absorption is good, and the moisture is not easy to dissipate.
CN108338944A discloses a wet tissue for bedsore, which is prepared by soaking carriers such as non-woven fabric, dust-free paper, etc. in a solution containing Chinese herbal medicines such as angelica, liquorice, angelica dahurica, bitter apricot seed, frankincense, calomel, rosemary, etc. The bedsore wet tissue not only has antiseptic and antibacterial effects, but also can be used for treating various skin diseases such as bedsore. However, the wet tissue is complex to prepare, relates to the use of various medicinal materials, is difficult to unify in process standard, is high in cost, and is not suitable for large-scale popularization and use.
The need for a simple, economical, yet effective mattress for the prevention and treatment of bedsores is a pressing need in the art.
Disclosure of Invention
In order to solve the problems of the prior art, the invention provides an improved pad towel capable of preventing and treating bedsore.
On one hand, in order to achieve the purpose, the bedsore-proof cushion towel comprises a cushion body, wherein the cushion body sequentially comprises an antibacterial and anti-inflammatory soft layer and a water absorption layer; a flexible inflatable ball is filled between the antibacterial anti-inflammatory soft layer and the water absorbing layer, the flexible inflatable ball is bound by elastic fibers and arranged in a layer shape, and the diameter of the inflatable elastic ball is 3-5 mm; each layer is 4mm thick; the antibacterial and anti-inflammatory soft layer is prepared by fixing antibacterial active peptide by skin-friendly cotton.
Further, the antibacterial active skin peptide is a polypeptide screened and obtained by the inventor, and the sequence of the polypeptide is SVIHCAQELLMHEFATSWHVCNGS. The active polypeptide carries positive charges and disulfide bonds, has the functions of thermal stability and broad-spectrum bactericidal property, and is uniformly dispersed in fibers in a nano-scale state in the melt blending process, so that the modified fibers have better antibacterial property.
The specific preparation method of the antibacterial, anti-inflammatory and soft layer comprises the steps of preparing the skin-friendly cotton (20-25 parts of cotton fiber, 10-15 parts of modified fiber, 15-20 parts of silk fiber, 25-30 parts of bamboo fiber and 5-10 parts of soybean protein fiber) into yarn by a spinning process and a polypeptide instrument, weaving the yarn into fabric, and drying the fabric at low temperature to obtain the antibacterial, anti-inflammatory and soft layer.
Further, the water absorbing layer is prepared from water absorbing materials commonly used in the field. The preparation method can also adopt the following processes: A) preparing an anti-adhesion layer, namely putting medical non-toxic polyethylene granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, rolling to form anti-adhesion holes, cooling and rolling to obtain a medical non-toxic polyethylene film serving as the anti-adhesion layer; B) preparing a liquid absorption layer, namely sequentially opening and carding mixed fibers mixed by 50-90 parts by weight of viscose fibers and 10-50 parts by weight of high water absorption fibers by an opener, carding, lapping by a lapping machine and needling by a needling machine to obtain non-woven fabric serving as the liquid absorption layer; C) preparing a waterproof breathable layer, namely putting polyurethane granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, cooling and rolling to obtain a polyurethane film serving as the waterproof breathable layer; D) and (3) compounding, namely heating and compounding the anti-adhesion layer (1) obtained in the step A) and one side surface of the liquid absorption layer obtained in the step B), and heating and compounding the waterproof breathable layer obtained in the step C) and the other side surface of the liquid absorption layer to obtain the water absorption layer.
In another aspect of the invention, a method for improving the comfort and softness of a pad towel is provided, which is characterized in that a flexible inflatable ball is added in the pad body.
Advantageous effects
According to the invention, the flexible inflatable ball is arranged in the pad towel to increase the contact comfort between the body and the bed, increase the elasticity and activity of the skin, and greatly reduce the bedsore by matching with the use of the antibacterial and anti-inflammatory peptide. Has the advantages of simple preparation, low cost and convenient use, and is suitable for large-area popularization.
Drawings
The pad towel shown in figure 1 has the structure that 1 is an antibacterial and anti-inflammatory soft layer, 2 is an antibacterial and anti-inflammatory soft layer, 3 is a flexible inflatable ball, and 4 is a water absorption layer.
Detailed Description
The following describes in further detail embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
EXAMPLE 1 Synthesis of antimicrobial peptides
Adopting a 9-fluorenylmethyloxycarbonyl (Fmoc) synthesis strategy to synthesize from the C end to the N end. 10mg of Rink-Amide-Resin (AAPPTac, cat # RRZ001) was used as a carrier to which 5mg of the carboxyl group of the first amino acid (Fmoc-S-NH2) amino-protected by Fmoc was attached by virtue of the active group of the carrier itself.
Washing the resin with N-methyl pyrrolidine (NMP) to remove excessive protected amino acid, adding 20% piperidine/NMP solution (volume fraction) to a reactor (solid phase synthesizer) to remove Fmoc group, reacting for 20min, emptying the reactor, washing the resin with 5ml NMP oscillation, repeating for 3 times to remove Fmoc protection of the first amino acid residue; the exposed reactive amino group was attached to the carboxyl group of the next amino acid (5mg) amino-protected by Fmoc to form the first peptide bond (S-V). This sequence of steps was repeated (except that each time the corresponding amino acid protected by Fmoc amino acid was used) until the synthesis of the polypeptide sequence Ac-SVIHCAQELLMHEFATSWHVCNGS-NH2 was complete, yielding approximately 22mg of linear polypeptide. After 20mg of linear polypeptide was coupled to the last amino acid, 10% DMSO/TFA solution was prepared for oxidation and reaction at 25 ℃ for 12h to allow disulfide bond formation between CCs. Trifluoroacetic acid with 50mL of peptide-cleaving reagent: thioanisole: phenol: ethanedithiol: and (2) cracking the polypeptide after disulfide bond formation from the carrier resin by double distilled water (volume ratio is 82.5:5:5:2.5:5), adding 100ml of ether precooled at 4 ℃ after 2 hours to precipitate the polypeptide, centrifuging to collect precipitate, washing for 3 times by using ether, vacuumizing, purifying the obtained crude polypeptide by reverse liquid chromatography, freeze-drying the purified polypeptide, and performing HPLC purity detection and mass spectrum identification. Detecting the HPLC chromatographic column to be 250 x 4.6mm, Kromasil-C18-5 μm; mobile phase A: 0.1% TFA/acetonitrile, mobile phase B: 0.1% TFA/H2O; linear elution gradient: 15% A-100% A; the flow rate is 1ml/min, and the detection wavelength is 220 nm; the amount of the sample to be added at one time was 10. mu.l. HPLC and MS detection results show that the purity of the synthesized polypeptide is 98.73%, the molecular weight is 2.71kDa, and the molecular weight is basically consistent with the predicted molecular weight.
EXAMPLE 2 preparation of an antibacterial, anti-inflammatory and Mild layer
Uniformly mixing the polypeptide prepared in example 1 with spinning solution prepared from 25 parts of spinnable cotton fiber, 15 parts of modified fiber, 15 parts of silk fiber, 30 parts of bamboo fiber and 10 parts of soybean protein fiber to form mixed spinning solution of the polypeptide and the spinning solution, wherein the content of the polypeptide in the spinning solution is 1 wt%, the concentration of the spinning solution is 30%, and the viscosity is 30 seconds. And (3) spinning and post-treating the mixed spinning solution obtained in the step to obtain the polypeptide regenerated fiber.
The spinning and post-treatment comprises the following steps:
1. spinning, namely filtering, defoaming and ripening the mixed spinning solution obtained in the step, then sending the mixed spinning solution to a spinning machine, and extruding the mixed spinning solution from spinneret orifices of a spinneret of the spinning machine through a metering pump to form spinning trickle, wherein the aperture of each spinneret orifice is 0.05mm, and the stretching multiple of the spinneret is 1.3 times;
2. coagulating and drawing, wherein the spinning fine flow formed in the step 1 enters a first coagulating bath to form tows, the temperature of the first coagulating bath is 40 ℃, and the first coagulating bath contains 75g/L of H2SO4190g/L of Na2SO4And 12g/L of ZnSO4(ii) a The tows passing through the first coagulating bath are sent to a second coagulating bath by a first drawing roller, the drawing rate of the first drawing roller is 60 percent, the temperature of the second coagulating bath is 73 ℃, and the second coagulating bath comprises 15 DEGg/L sulfuric acid; the tows after passing through the second coagulating bath are sent into a third coagulating bath by a second drawing roller, the drawing rate of the second drawing roller is 51 percent, the temperature of the third coagulating bath is 75 ℃, and the third coagulating bath comprises H with the pH value of 1.52SO4The tows after the first to third coagulating baths are output after being drafted by a third drafting roller, and the drafting rate of the third drafting roller is 8 percent, so that the polypeptide fiber is obtained;
3. cleaning and drying, namely cleaning the polypeptide fiber by using a NaOH aqueous solution, wherein the temperature of the NaOH aqueous solution is 40 ℃, and the concentration of the NaOH aqueous solution is 4 g/L; then washing with hot water, wherein the temperature of the hot water is 38 ℃; and finally, drying at the temperature of 80 ℃, and then spinning the fabric to prepare the antibacterial and anti-inflammatory soft layer.
Example 3 preparation of Water-absorbing layer
The water absorbing layer is prepared by adopting the following process: A) preparing an anti-adhesion layer, namely putting medical non-toxic polyethylene granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, rolling to form anti-adhesion holes, cooling and rolling to obtain a medical non-toxic polyethylene film serving as the anti-adhesion layer; B) preparing a liquid absorption layer, namely sequentially opening and carding mixed fibers mixed by 50-90 parts by weight of viscose fibers and 10-50 parts by weight of high water absorption fibers by an opener, carding, lapping by a lapping machine and needling by a needling machine to obtain non-woven fabric serving as the liquid absorption layer; C) preparing a waterproof breathable layer, namely putting polyurethane granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, cooling and rolling to obtain a polyurethane film serving as the waterproof breathable layer; D) and (3) compounding, namely heating and compounding the anti-adhesion layer (1) obtained in the step A) and one side surface of the liquid absorption layer obtained in the step B), and heating and compounding the waterproof breathable layer obtained in the step C) and the other side surface of the liquid absorption layer to obtain the water absorption layer.
EXAMPLE 4 Synthesis of a towelette
Preparing a flexible inflatable ball: the flexible inflatable ball comprises a hollow ball core and a ball body formed by filling around the hollow ball core, and air is filled in the ball body. Placing the hollow spherical core in a spherical body pouring area of a mold, and propping and fixing the hollow spherical core at the central position of the spherical body pouring area by more than one plastic thimble so as to ensure that the wall thickness of the spherical body formed after pouring is consistent; and (3) pouring, molding and demolding by adopting a PU material with an elastic function, and then flattening the plastic ejector pins protruding out of the surface of the ball body to obtain the hollow elastic ball. The diameter of the elastic ball is controlled to be 3-5 mm. The flexible inflatable balls are bound by elastic fibers to be arranged in a layer shape, the flexible inflatable balls are clamped between the antibacterial and anti-inflammatory soft layer and the water absorbing layer and are formed by compression molding or sewing, each piece of cloth liner is formed by sewing the double-layer antibacterial and anti-inflammatory soft layer, the inflatable balls and the water absorbing layer in a back-to-back mode, and finally the cloth liner is prepared.
Example 5 pad towel Water absorption Rate verification
A pad towel with a standard 2010640016 on the market (mechanical) is used as a control. 2g of the pad prepared in example 4 and a control pad were taken. A200 mL beaker with a rotor was charged with 50g of a 0.9% aqueous sodium chloride solution, and after the beaker was kept at a constant temperature in a constant-temperature water tank at 25 ℃ for 20 minutes, the beaker was placed on a magnetic stirrer and stirred at a speed of 600 rpm, 2.0g of a sample was put into a vortex and a stopwatch was used to time the vortex, and the time was terminated when the vortex disappeared and the liquid surface became horizontal. This time is the absorption rate of the sample, unit: and S. The results are shown in table 1 (duplicate runs, mean values in the table).
TABLE 1 Water absorption Rate
Name (R) | Absorption rate |
The invention | 28S |
Contrast pad towel | 43S |
As can be seen from Table 1, the tissue of the present invention absorbs water faster, and has certain advantages over the prior art control tissue.
Example 6 drape antibacterial function verification
The pad towel and the control pad towel are respectively sterilized and applied to patients, and no detection is carried out once in 1 day, 3 days and 7 days from the day of changing the pad towel of clinical patients. The autoclaved unused control pad towel was a blank control. Sampling: respectively cutting 3 cm-diameter circular samples with scissors according to a preset time, respectively cutting 3 pieces of the circular samples, placing the circular samples on the surface of a disposable aseptic AATCC agar plate, uniformly cooling 1ml of agar semisolid culture medium to be solidified on the surface of the samples, placing the agar semisolid culture medium in a 35 ℃ incubator for 48h after the agar semisolid culture medium is condensed, counting the number of bacterial colonies on the surface of the whole circular sample, and dividing the bacterial colonies by the area of the circular sample to obtain the number of bacteria/cm2. Specific results are shown in table 2 below.
TABLE 2 bacteria count
Name (R) | Bacteria count/ |
The invention | 3.5*102 |
Contrast pad towel | 5.3*105 |
As can be seen from the table 2, the cushion towel of the invention has better effect of inhibiting the growth of fungi. The polypeptide has a better function of inhibiting the growth of bacteria.
Example 7 towelette efficacy validation
The conventional method is to prepare a bed, and if necessary, to spread a tarpaulin and a middle sheet. When lying on bed, the patient's head pillow is not wetted by the cotton space pillow, the sacral caudal region and heel part are respectively placed on the soft pillows with different specifications, and the patient turns over every 2h and massages the skin for 1 time. When lying on side, the soft pad is placed on greater trochanter of femur and internal and external condyles, and the soft pad can also be placed on chest, abdomen and back.
30 patients who can not take care of themselves apply the cushion towel of the invention, no 1 patient has pressure sore after 4 days to 2 months, and the success rate is 100 percent.
It is to be understood that the invention is not necessarily limited in its application to the details of construction and the arrangement of components set forth in the following description and/or illustrated in the drawings. The invention is capable of embodiments in addition to those described and of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein, as well as the abstract, are for the purpose of description and should not be regarded as limiting.
As such, those skilled in the art will appreciate that the conception, upon which this disclosure is based, may readily be utilized as a basis for the designing of other structures, methods and systems for carrying out the several purposes of the present invention. It is important, therefore, that the claims be regarded as including such equivalent constructions insofar as they do not depart from the spirit and scope of the present invention.
While the invention has been described and illustrated in detail as being sufficient to enable those skilled in the art to make and use it, various alternatives, modifications, and improvements should be apparent without departing from the spirit and scope of the invention. The examples provided herein represent preferred embodiments, are exemplary, and are not intended as limitations on the scope of the invention. Modifications thereof and other uses will occur to those skilled in the art. Such modifications are encompassed within the spirit of the invention and are defined by the scope of the claims.
Claims (4)
1. An adult's pad piece of cloth of prevention and cure bedsore which characterized in that: it can reduce bedsore.
2. An adult's pad piece of cloth of prevention and cure bedsore which characterized in that: comprises a pad body, wherein the pad body sequentially comprises an antibacterial and anti-inflammatory soft layer and a water absorption layer; a flexible inflatable ball is filled between the antibacterial anti-inflammatory soft layer and the water absorbing layer, the flexible inflatable ball is bound by elastic fibers and arranged in a layer shape, and the diameter of the inflatable elastic ball is 3-5 mm; each layer is 4mm thick; the antibacterial and anti-inflammatory soft layer is prepared by fixing antibacterial active peptide by skin-friendly cotton; the sequence of the antibacterial active skin peptide is SVIHCAQELLMHEFATSWHVCNGS.
3. The adult mat as defined in claim 2, wherein: the preparation method of the antibacterial and anti-inflammatory soft layer comprises the following steps: uniformly mixing the antibacterial skin-activating peptide with spinning solution prepared from 25 parts of spinnable cotton fiber, 15 parts of modified fiber, 15 parts of silk fiber, 30 parts of bamboo fiber and 10 parts of soybean protein fiber to form mixed spinning solution of polypeptide and spinning solution, wherein the content of collagen polypeptide in the spinning solution is 1 wt%, the concentration of the spinning solution is 30%, and the viscosity is 30 seconds, and spinning and post-treating the mixed spinning solution obtained in the step to obtain polypeptide regenerated fiber;
the spinning and post-treatment comprises the following steps:
1) spinning, namely filtering, defoaming and ripening the mixed spinning solution obtained in the step, then sending the mixed spinning solution to a spinning machine, and extruding the mixed spinning solution from spinneret orifices of a spinneret of the spinning machine through a metering pump to form spinning trickle, wherein the aperture of each spinneret orifice is 0.05mm, and the stretching multiple of the spinneret is 1.3 times;
2) coagulating and drawing, wherein the spinning fine flow formed in the step 1 enters a first coagulating bath to form tows, the temperature of the first coagulating bath is 40 ℃, and the first coagulating bath contains 75g/L of H2SO4190g/L of Na2SO4And 12g/L of ZnSO4(ii) a The tows passing through the first coagulating bath are sent to a second coagulating bath by a first drawing roller, the drawing rate of the first drawing roller is 60%, the temperature of the second coagulating bath is 73 ℃, and the second coagulating bath comprises 15g/L sulfuric acid; the tows after passing through the second coagulating bath are sent into a third coagulating bath by a second drawing roller, the drawing rate of the second drawing roller is 51 percent, the temperature of the third coagulating bath is 75 ℃, and the pH value of the third coagulating bath is1.5, drafting the tows subjected to the first to third coagulating baths by a third drafting roller and outputting the tows, wherein the drafting rate of the third drafting roller is 8 percent, and thus obtaining the polypeptide fiber;
3) cleaning and drying, namely cleaning the polypeptide fiber by using a NaOH aqueous solution, wherein the temperature of the NaOH aqueous solution is 40 ℃, and the concentration of the NaOH aqueous solution is 4 g/L; then washing with hot water, wherein the temperature of the hot water is 38 ℃; and finally, drying at the temperature of 80 ℃, and then spinning the fabric to prepare the antibacterial and anti-inflammatory soft layer.
4. The adult mat as defined in claim 2, wherein: the water absorbing layer is prepared by adopting the following process: A) preparing an anti-adhesion layer, namely putting medical non-toxic polyethylene granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, rolling to form anti-adhesion holes, cooling and rolling to obtain a medical non-toxic polyethylene film serving as the anti-adhesion layer; B) preparing a liquid absorption layer, namely sequentially opening and carding mixed fibers mixed by 50-90 parts by weight of viscose fibers and 10-50 parts by weight of high water absorption fibers by an opener, carding, lapping by a lapping machine and needling by a needling machine to obtain non-woven fabric serving as the liquid absorption layer; C) preparing a waterproof breathable layer, namely putting polyurethane granules into a screw extruder for melt extrusion, and sequentially performing casting film forming, cooling and rolling to obtain a polyurethane film serving as the waterproof breathable layer; D) and (3) compounding, namely heating and compounding the anti-adhesion layer (1) obtained in the step A) and one side surface of the liquid absorption layer obtained in the step B), and heating and compounding the waterproof breathable layer obtained in the step C) and the other side surface of the liquid absorption layer to obtain the water absorption layer.
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CN113499434A (en) * | 2021-08-24 | 2021-10-15 | 宜春希宇生物制品有限公司 | Shampoo for treating hair loss and alopecia |
CN113499434B (en) * | 2021-08-24 | 2023-10-31 | 海碧诗(海南)实业集团有限公司 | Shampoo for treating few hairs and alopecia |
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