CN111235005B - Full-automatic microorganism drug sensitivity analyzer - Google Patents
Full-automatic microorganism drug sensitivity analyzer Download PDFInfo
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- CN111235005B CN111235005B CN202010069711.XA CN202010069711A CN111235005B CN 111235005 B CN111235005 B CN 111235005B CN 202010069711 A CN202010069711 A CN 202010069711A CN 111235005 B CN111235005 B CN 111235005B
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- 239000003814 drug Substances 0.000 title claims abstract description 176
- 229940079593 drug Drugs 0.000 title claims abstract description 155
- 244000005700 microbiome Species 0.000 title claims abstract description 18
- 230000035945 sensitivity Effects 0.000 title claims abstract description 15
- 238000011534 incubation Methods 0.000 claims abstract description 78
- 238000007599 discharging Methods 0.000 claims abstract description 6
- 238000012258 culturing Methods 0.000 claims abstract description 4
- 230000007246 mechanism Effects 0.000 claims description 53
- 239000002699 waste material Substances 0.000 claims description 35
- 238000012360 testing method Methods 0.000 claims description 34
- 230000033001 locomotion Effects 0.000 claims description 21
- 230000005540 biological transmission Effects 0.000 claims description 11
- 238000007405 data analysis Methods 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 230000000813 microbial effect Effects 0.000 claims description 3
- 230000002906 microbiologic effect Effects 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 14
- 238000012545 processing Methods 0.000 abstract description 3
- 238000004904 shortening Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010206 sensitivity analysis Methods 0.000 description 2
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
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Abstract
The invention relates to a full-automatic microorganism drug sensitive analyzer, which comprises a top disc module arranged in a shell and used for feeding samples to a drug sensitive disc; the centrifugal reading module is used for centrifuging, identifying and reading the drug sensitive disc and drug sensitive information; the incubation module is used for culturing the drug sensitive disc; and a warehouse entry and exit module for moving the drug sensitive disc, comprising: the feeding unit is used for moving the drug sensitive disc from the upper disc module to the centrifugal reading module and moving the drug sensitive disc from the centrifugal reading module to the incubation module; and the discharging unit is used for moving the drug sensitive disc from the incubation module to the centrifugal reading module. Compared with the prior art, the analyzer has the advantages of high automation of sample processing capability, simplicity and convenience in operation, rapidness in interpretation of detection results, great reduction of misoperation of a user, improvement of accuracy of drug sensitivity results and shortening of clinical detection time.
Description
Technical Field
The invention belongs to the field of medical equipment, and particularly relates to a full-automatic microorganism drug sensitivity analyzer.
Background
At present, the mainstream drug sensitivity analysis system on the market generally has the problems of low automation degree, complex operation, long test time and the like, and when the problems are used for carrying out the microbial drug sensitivity test, the problems often lead to inaccurate drug sensitivity result and delay reporting time, thereby bringing clinical trouble.
Patent CN206476988U discloses a microorganism identification and drug sensitivity analysis system, including shell and set up in the inside storage microorganism three-dimensional culture device (1) of placing the identification board of shell, place in storage microorganism three-dimensional culture device one side be used for snatching the grabbing device (2) of the identification board of cultivateing in the storage microorganism three-dimensional culture device, with grabbing device (2) relative setting is used for extracting auxiliary reagent and with the auxiliary reagent of extracting in the identification board of grabbing device sample application device (3) and set up in the detection device (4) that are used for detecting the identification board of extracting auxiliary reagent sample application device (3) below, this patent has realized from the large batch constant temperature cultivation of microorganism to sample application to detect the automatic completion again, but test time is longer, and drug sensitivity result is not accurate enough, and degree of automation is not high.
Disclosure of Invention
The invention aims to solve the problems and provide a full-automatic microorganism drug sensitive analyzer which has the capability of high automatically processing samples, is simple and convenient to operate, can rapidly interpret detection results, greatly reduces misoperation of users, improves the accuracy of drug sensitive results, shortens clinical detection time, and provides more accurate basis for clinically selecting antibiotics.
The aim of the invention is achieved by the following technical scheme:
a full-automatic microorganism drug sensitivity analyzer for detecting drug sensitivity of a sample to be detected comprises a shell and also comprises a sensor, wherein the sensor is arranged in the shell:
the upper disc module is used for sampling the drug sensitive disc;
the centrifugal reading module is used for centrifuging, identifying and reading the drug sensitive disc and drug sensitive information;
the incubation module is used for culturing the drug sensitive disc; and
The business turn over storehouse module for remove the quick dish of medicine includes:
the feeding unit is used for moving the drug sensitive disc from the upper disc module to the centrifugal reading module and moving the drug sensitive disc from the centrifugal reading module to the incubation module; and
And the discharging unit is used for moving the drug sensitive disc from the incubation module to the centrifugal reading module.
Further, go up the dish module and include the support frame, install the objective table track on the support frame, slide locate objective table on the objective table track and install test card frame on objective table upper portion, test card frame has a plurality of medicine sensitive dish to put the position, objective table and test card frame are driven by drive part along objective table track removes. The shell is provided with a sample injection bin gate matched with the upper disc module, and a drug sensitive disc of a sample to be tested is placed in the sample injection bin gate. The object stage is provided with a spring plunger matched with the test card rack, the spring plunger automatically pops out to lock the test card rack after the test card rack is installed in place, and the object stage track is also provided with a disk position detection mechanism for detecting whether each medicine sensitive disk is arranged in each medicine sensitive disk placing position; the medicine sensitive tray placement position is provided with a fool-proof design, so that the problem that an operator prevents wrong directions of the front side and the back side of the medicine sensitive tray is prevented.
Further, the centrifugal reading module comprises:
a centrifugal track serving as a channel for the drug sensitive disc to move from the upper disc module to the incubation module;
the drug sensitive disc positioning mechanism is arranged on one side of the centrifugal track;
the centrifugal driving mechanism is arranged on the other side of the centrifugal track, can move away from or close to the drug sensitive disc positioning mechanism, and is matched with the drug sensitive disc positioning mechanism to finish the centrifugation of the drug sensitive disc;
the code scanning mechanism is used for identifying the drug sensitive disc; and
And the reading mechanism detects the reading value of the drug sensitive hole on the drug sensitive disc and transmits the reading value to the computer module for data analysis.
Further, the centrifugal track comprises an upper centrifugal track and a lower centrifugal track which are connected through a connecting plate, and a notch is arranged on one side of the centrifugal track, which is close to the drug sensitive disc positioning mechanism, so that the drug sensitive disc moves towards the drug sensitive disc positioning mechanism;
the drug sensitive disc positioning mechanism comprises an elastic resetting component and a backup plate connected with the elastic resetting component, a circular through hole is formed in the middle of the backup plate, and a magnet sleeve is arranged in the circular through hole;
the centrifugal driving mechanism comprises a sliding rail, a movable supporting plate, a motion control motor, a centrifugal reading motor and a rotary fixing seat, wherein the sliding rail is arranged on the rack, and the movable supporting plate is slidably arranged on the sliding rail and moves under the drive of the motion control motor; the motion control motor and the centrifugal reading motor are connected with a motor control board, and the motion of the motor control board is controlled by the motor control board;
the centrifugal reading motor is arranged on the movable supporting plate, the rotary fixing seat is in transmission connection with the centrifugal reading motor through a transmission part and rotates, the front end of the rotary fixing seat is matched with the iron sucking sleeve of the backup plate, and the front end of the rotary fixing seat penetrates into the medicine sensitive disc and then is sucked and nested in the iron sucking sleeve of the backup plate to suck the medicine sensitive disc on the fixing seat;
further, the elastic reset component comprises a fixed plate, a sliding rail, a guide pillar and a spring, wherein the fixed plate and the sliding rail are fixed on the rack, the sliding plate is installed on the sliding rail, one end of the guide pillar is fixedly installed on the fixed plate, the other end of the guide pillar is connected with the sliding plate through a connecting block, and the spring is sleeved on the guide pillar.
Further, the incubation module comprises an incubation box, a heating mechanism arranged in the incubation box and an incubation disc rotationally arranged in the middle of the incubation box, wherein a plurality of incubation positions are circumferentially arranged on the incubation disc, and each incubation position accommodates one drug sensitive disc; the incubation plate is connected with the driving mechanism and is driven to rotate by the driving mechanism.
Further, the feeding unit and the discharging unit comprise a push plate and a push plate driving mechanism, and the push plate is in transmission connection with the push plate driving mechanism and is used for moving the drug sensitive disc;
further, the push plate driving mechanism is a servo motor assembly.
Further, the device also comprises a waste collection module for collecting the waste drug sensitive trays, wherein the waste collection module comprises a waste box and a tray discarding track.
Further, the dish-discarding track is arc-shaped, an inlet of the dish-discarding track is connected with the incubation module, an outlet of the dish-discarding track is communicated with the waste bin, and the height of the inlet of the dish-discarding track is higher than that of the outlet of the dish-discarding track;
and a waste disc pushing unit for moving the waste drug sensitive disc in the incubation module from the incubation module to the waste disc track is further arranged in the incubation module.
According to the full-automatic microorganism drug sensitive analyzer, drug sensitive discs after sample injection are transmitted to a centrifugal reading module through a disc loading module, high-speed centrifugation is carried out, two-dimensional code marks on the discs are identified through code scanning, then the drug sensitive discs are transferred to an incubation module for incubation operation, the drug sensitive discs are transferred to the centrifugal reading module for reading in a certain time interval in the incubation process, the drug sensitive discs are transferred to the incubation module for incubation operation after reading is completed, data read by the centrifugal reading module are uploaded to user operation software for result analysis, and all detected drug sensitive discs are unloaded through a waste collection module.
Compared with the prior art, the full-automatic microorganism drug sensitive analyzer can effectively solve the problems of low automation degree, complex operation, long test time and the like of the current mainstream drug sensitive analysis system, has the advantages of high automation of sample processing capability, simplicity and convenience in operation and rapidness in interpretation of detection results, can greatly reduce misoperation of users, improve the accuracy of drug sensitive results, shorten clinical detection time and provide more accurate basis for clinically selecting antibiotics.
Drawings
FIG. 1 is an external perspective view of a fully automated microbial drug sensitive analyzer of the present invention;
FIG. 2 is a schematic view of the internal structure of FIG. 1;
FIGS. 3 and 4 are schematic diagrams of upper disc modules;
FIG. 5 is a schematic view of the structure of the test card holder of the present invention;
FIG. 6 is a schematic diagram of a partial structure of the upper plate module;
fig. 7 and 8 are schematic structural diagrams of the centrifugal reading module and the feeding unit;
FIG. 9 is a schematic front view of FIG. 8;
FIGS. 10 and 11 are schematic diagrams of the centrifugal reading module and other angles of the feeding unit;
FIG. 12 is a schematic diagram of the structure of an incubation module;
FIG. 13 is a schematic view of the interior of the fully automated microbiological drug sensitive analyzer of the present invention;
fig. 14 is a schematic view of an incubation module and a waste collection module.
Detailed Description
The invention will now be described in detail with reference to the drawings and specific examples.
Examples
Referring to fig. 1 and 2, a fully automatic microorganism drug sensitivity analyzer for detecting drug sensitivity of a sample to be measured comprises a housing 10, and further comprises a sensor mounted in the housing 10: the upper disc module 11 is used for sampling the drug sensitive disc;
the centrifugal reading module 12 is used for centrifuging, identifying and reading drug sensitive information of the drug sensitive disc; an incubation module 13 for culturing the drug sensitive disc; and a bin in and out module 14 for moving the drug sensitive disc, comprising a bin in unit 141 for moving the drug sensitive disc from the upper disc module 11 to the centrifugal reading module 12 and for moving the drug sensitive disc from the centrifugal reading module 12 to the incubation module 13; and a discharge unit 142 for moving the drug sensitive disc from the incubation module 13 to the centrifuge reading module 12.
As shown in fig. 3-6, the upper tray module 11 includes a support 1101, a stage rail 1102 mounted on the support 1101, a stage 1103 slidably mounted on the stage rail 1102, and a test card holder 1104 mounted on an upper portion of the stage 1103, the test card holder 1104 being provided with a plurality of medicine-sensitive tray placement positions, and the stage 1103 and the test card holder 1104 being driven by a driving member to move along the stage rail 1102. The housing 10 is provided with a sample injection door matched with the upper disc module 11, and a drug sensitive disc of a sample to be tested is placed in the sample injection door. The objective table is provided with a spring plunger matched with the test card rack, the spring plunger automatically pops out to lock the test card rack after the test card rack is installed in place, and a tray position detection mechanism is further arranged on the objective table track 1102 and used for detecting whether each medicine sensitive tray is arranged in the placement position of each medicine sensitive tray; the medicine sensitive tray placement position has fool-proof design, so that the problem that an operator prevents wrong directions of the front side and the back side of the medicine sensitive tray is prevented. The upper disc module 11 is also provided with an ejection mechanism 1105 for ejecting the drug sensitive disc from the drug sensitive disc placement position, the ejection mechanism 1105 comprises a cylinder and a top plate, and when the test clamping frame 1104 of the upper disc module 11 moves in place, the ejection mechanism 1105 acts to eject the drug sensitive disc, so that the operation of a warehouse entry unit is facilitated.
As shown in fig. 7-11, the centrifuge reading module 12 includes: a centrifugal track 121 as a passage for the drug sensitive disc to move from the upper disc module 11 to the incubation module 13; the drug sensitive disc positioning mechanism 124 is arranged on one side of the centrifugal track 121; the centrifugal driving mechanism 125 is arranged on the other side of the centrifugal track 121, can move away from or close to the drug sensitive disc positioning mechanism 124, and is matched with the drug sensitive disc positioning mechanism 124 to finish the centrifugation of the drug sensitive disc; the code scanning mechanism 122 is used for identifying the drug sensitive disc; and a reading mechanism 123 for detecting the reading value of the drug sensitive hole on the drug sensitive disk and transmitting the reading value to the computer module for data analysis.
The centrifugal track comprises an upper centrifugal track and a lower centrifugal track, which are connected through a connecting plate, and a notch is arranged on one side of the centrifugal track, which is close to the drug sensitive disc positioning mechanism 124, so that the drug sensitive disc moves towards the drug sensitive disc positioning mechanism 124; the drug sensitive disc positioning mechanism 124 comprises an elastic reset component 1241 and a backup plate 1242 connected with the elastic reset component, a circular through hole is arranged in the middle of the backup plate 1242, and a magnet sleeve is arranged in the circular through hole; the centrifugal driving mechanism 125 comprises a sliding rail, a movable supporting plate, a motion control motor 1251, a centrifugal reading motor 1252 and a rotary fixing seat 1253, wherein the sliding rail is arranged on the rack, and the movable supporting plate is slidably arranged on the sliding rail and moves under the driving of the motion control motor 1251; the motion control motor 1251 and the centrifugal reading motor 1252 are connected with a motor control board 1254, and the motion of the motor control board 1254 is controlled by the motor control board 1254; the centrifugal reading motor 1252 is arranged on the movable supporting plate, the rotary fixing seat 1253 is in transmission connection with the centrifugal reading motor 1252 through a transmission part and rotates, the front end of the rotary fixing seat is matched with a magnet sleeve of the backup plate 1242, and the front end of the rotary fixing seat penetrates into the magnet sleeve of the backup plate and then is sucked and nested in the magnet sleeve of the backup plate, so that the magnet plate is sucked and held on the fixing seat; the elastic reset component 1241 comprises a fixed plate, a sliding rail, a guide pillar and a spring, wherein the fixed plate and the sliding rail are fixed on the rack, the sliding plate is installed on the sliding rail, one end of the guide pillar is fixedly installed on the fixed plate, the other end of the guide pillar is connected with the sliding plate through a connecting block, and the spring is sleeved on the guide pillar.
As shown in fig. 12, the incubation module 13 includes an incubation box 131, a heating mechanism disposed in the incubation box 131, and an incubation tray 132 rotatably disposed in the middle of the incubation box 131, wherein the incubation tray 132 is circumferentially provided with a plurality of incubation positions, and each incubation position accommodates a drug sensitive tray; the incubation plate is connected with the driving mechanism and is driven to rotate by the driving mechanism.
The feeding unit 141 and the discharging unit 142 comprise a push plate and a push plate driving mechanism, and the push plate is in transmission connection with the push plate driving mechanism and is used for moving the drug sensitive disc; the push plate driving mechanism is a servo motor assembly.
As shown in fig. 13 and 14, the device further comprises a waste collection module 15 for collecting the waste drug sensitive discs, the waste collection module 15 comprises a waste bin 151 and a waste disc track 152, the waste disc track 152 is arc-shaped, an inlet of the waste disc track 152 is connected with the incubation module 13, an outlet is communicated with the waste bin 151, and an inlet of the waste disc track 152 is higher than the outlet; the incubation module 13 is further provided therein with a waste disc pushing unit 153 for moving the waste drug sensitive disc in the incubation module 13 from the incubation module 13 to the waste disc track.
The device is mainly used for carrying out drug sensitivity detection on a drug-sensitive disc sample so as to obtain a corresponding detection result and meet the use requirement, the drug-sensitive disc is a disc with 95 test holes, different varieties and concentration gradient test drugs are put into each drug according to the requirement of drug sensitivity test, different varieties and concentration gradient test drugs are put into the drug-sensitive disc according to the requirement of centrifugal force effect test of a sample injection device, injected liquid can be uniformly distributed into the 95 holes on the drug-sensitive disc under the centrifugal force effect of the sample injection device, and meanwhile, light-transmitting films are stuck to two sides of each drug-sensitive disc so as to carry out detection.
When the device is specifically used, the test card rack is taken out and placed on the platform, and the drug sensitive disc with the sample injection is placed in the drug sensitive disc placing position of the test card rack. The test card rack can bear a plurality of medicine sensitive discs simultaneously, and an operator puts the test card rack loaded with the medicine sensitive discs into a chute on the objective table and pushes the test card rack to the bottom end of the chute. The test card rack tray position detection device detects whether a drug-sensitive tray is placed on the drug-sensitive tray placement position on each test card rack, and when the drug-sensitive tray is placed on the drug-sensitive tray placement position on the test card rack, the drug-sensitive tray is pushed into the centrifugal track by the feeding unit and is limited at the notch position of the centrifugal track by the matching of the discharging unit. The motor control board controls the motion control motor to enable the drug sensitive disc to move towards the direction of the backup plate through the notch on the centrifugal track, and in the motion process, the permanent seat penetrates the drug sensitive disc and then attracts the magnet sheet nested in the magnet sleeve on the backup plate. The suction force of the suction sheet in the suction sleeve can firmly suck the drug sensitive disc on the fixed seat. The motor control board controls the centrifugal reading motor to act, and drives the drug sensitive disc attracted on the fixed seat through the transmission part. The medicine sensitive disc can firstly rotate at a low speed to be matched with the code scanning module to read the two-dimensional code at the bottom of the medicine sensitive disc, and then high-speed centrifugal action is carried out. After the drug sensitive disc completes the centrifugal action, the motor control board controls the motion control motor to move away from the backup plate, in the motion process, the magnet sheet in the magnet sleeve on the backup plate is gradually separated from the fixing seat, and meanwhile, the drug sensitive disc on the fixing seat can be displaced into the centrifugal track through the notch position on the centrifugal track. The drug sensitive disc is pushed into the incubation disc of the incubation module from the centrifugal track by the feeding unit. The inside of the incubation module heats air through the heater, and simultaneously the incubation tray reaches the preset incubation temperature by matching with at least two fans and an air circulation channel of the incubation box. The incubation tray has a plurality of incubation sites, each of which can accommodate one incubation tray. During the incubation process, the unloading unit of the unloading module pushes the drug sensitive disc out of the incubation disc of the incubation module and enters the centrifugal track within a certain time interval.
The motor control board controls the motion control motor to enable the drug sensitive disc to move towards the direction of the backup plate through the notch on the centrifugal track, and in the motion process, the permanent seat penetrates the drug sensitive disc and then attracts the magnet sheet nested in the magnet sleeve on the backup plate. The suction force of the suction sheet in the suction sleeve can firmly suck the drug sensitive disc on the fixed seat. The motor control board controls the centrifugal reading motor to act, and drives the drug sensitive disc attracted on the fixed seat through the transmission part. The medicine sensitive disc can be firstly subjected to low-speed rotation and matched with a reading device of the centrifugal reading module to detect the reading value of each medicine sensitive hole on the medicine sensitive disc, and the reading value is transmitted to a computer module of a corresponding full-automatic microorganism medicine sensitive analyzer for data analysis. After the drug sensitive disc finishes the reading action, the motor control board controls the motion control motor to move towards the direction away from the backup plate, in the motion process, the magnet sheet in the magnet sleeve on the backup plate is gradually separated from the fixing seat, and meanwhile, the drug sensitive disc on the fixing seat can be displaced into the centrifugal track through the notch position on the centrifugal track. The drug sensitive disc is pushed into the incubation disc of the incubation module from the centrifugal track by the feeding unit to continue incubation. After the drug sensitive disc is detected, the waste disc pushing unit of the waste collection module pushes out the drug sensitive disc in the incubation position of the incubation disc and enters the discarding disc track, and the drug sensitive disc rolls into a waste box body placed in the waste box shell from the discarding disc track. A filling detection module is arranged in the waste box body to detect whether the waste box body is filled by the drug sensitive disc in real time.
The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present invention. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments, and those skilled in the art, based on the present disclosure, should make improvements and modifications without departing from the scope of the present invention.
Claims (6)
1. The full-automatic microorganism drug sensitivity analyzer is used for detecting drug sensitivity of a sample to be detected and comprises a shell (10), and is characterized by further comprising a sensor arranged in the shell (10):
the upper disc module (11) is used for sampling the drug sensitive disc;
the upper disc module (11) comprises a supporting frame (1101), a carrier rail (1102) arranged on the supporting frame (1101), a carrier (1103) arranged on the carrier rail (1102) in a sliding manner, and a test clamping frame (1104) arranged on the upper part of the carrier (1103), wherein the test clamping frame (1104) is provided with a plurality of drug sensitive disc placing positions, and the carrier (1103) and the test clamping frame (1104) are driven by a driving part to move along the carrier rail (1102);
the centrifugal reading module (12) is used for centrifuging, identifying and reading the drug sensitive disc and drug sensitive information;
an incubation module (13) for culturing the drug sensitive disc;
the centrifugal reading module (12) comprises:
a centrifugal track (121) as a channel for movement of a drug sensitive disc from the disc loading module (11) to the incubation module (13);
the drug sensitive disc positioning mechanism (124) is arranged on one side of the centrifugal track (121);
the centrifugal driving mechanism (125) is arranged on the other side of the centrifugal track (121), can move away from or close to the drug sensitive disc positioning mechanism (124), and is matched with the drug sensitive disc positioning mechanism (124) to finish the centrifugation of the drug sensitive disc;
the code scanning mechanism (122) is used for identifying the drug sensitive disc; and
The reading mechanism (123) detects the reading value of the drug sensitive hole on the drug sensitive disc and transmits the reading value to the computer module for data analysis;
the incubation module (13) comprises an incubation box (131), a heating mechanism arranged in the incubation box (131) and an incubation disc (132) rotatably arranged in the middle of the incubation box (131), wherein a plurality of incubation positions are circumferentially and circumferentially arranged on the incubation disc (132), and each incubation position accommodates one drug sensitive disc; the incubation plate is connected with the driving mechanism and is driven to rotate by the driving mechanism;
and
-a cartridge in and out module (14) for moving the drug sensitive disc, comprising:
a warehouse-in unit (141) for moving the drug sensitive disc from the upper disc module (11) to the centrifugal reading module (12) and for moving the drug sensitive disc from the centrifugal reading module (12) to the incubation module (13); and
A discharge unit (142) for moving the drug sensitive disc from the incubation module (13) to the centrifugal reading module (12);
the feeding unit (141) and the discharging unit (142) comprise a push plate and a push plate driving mechanism, and the push plate is in transmission connection with the push plate driving mechanism and is used for moving the drug sensitive disc.
2. The full-automatic microbial drug sensitive analyzer according to claim 1, wherein the centrifugal track comprises an upper centrifugal track and a lower centrifugal track, which are connected by a connecting plate, and a notch is arranged on one side of the centrifugal track, which is close to the drug sensitive disc positioning mechanism (124), so that the drug sensitive disc moves towards the drug sensitive disc positioning mechanism (124);
the drug sensitive disc positioning mechanism (124) comprises an elastic reset component (1241) and a backup plate (1242) connected with the elastic reset component, a circular through hole is formed in the middle of the backup plate (1242), and a magnet sleeve is arranged in the circular through hole;
the centrifugal driving mechanism (125) comprises a sliding rail, a movable supporting plate, a motion control motor (1251), a centrifugal reading motor (1252) and a rotary fixing seat (1253), wherein the sliding rail is arranged on the rack, and the movable supporting plate is slidably arranged on the sliding rail and moves under the driving of the motion control motor (1251); the motion control motor (1251) and the centrifugal reading motor (1252) are connected with a motor control board (1254), and the motion of the motor control board (1254) is controlled by the motor control board;
the centrifugal reading motor (1252) is installed on the movable supporting plate, the rotary fixing seat (1253) is in transmission connection with the centrifugal reading motor (1252) through a transmission part and rotates, and the front end of the rotary fixing seat is matched with a suction sleeve of the backup plate (1242).
3. The full-automatic microorganism drug sensitive analyzer according to claim 2, wherein the elastic reset component (1241) comprises a fixed plate, a sliding rail, a guide post and a spring, wherein the fixed plate and the sliding rail are fixed on a rack, the sliding plate is installed on the sliding rail, one end of the guide post is fixedly installed on the fixed plate, the other end of the guide post is connected with the sliding plate through a connecting block, and the spring is sleeved on the guide post.
4. The fully automated microbiological drug sensitive analyzer of claim 1 wherein the push plate drive mechanism is a servo motor assembly.
5. A fully automated microbiological drug sensitive analyzer according to any of claims 1-4, further comprising a waste collection module (15) for collecting waste drug sensitive trays, the waste collection module (15) comprising a waste bin (151) and a reject tray rail (152).
6. The full-automatic microorganism drug sensitive analyzer according to claim 5, wherein the dish-discarding track (152) is arc-shaped, an inlet of the dish-discarding track (152) is connected with the incubation module (13), an outlet is communicated with the waste bin (151), and an inlet of the dish-discarding track (152) is higher than an outlet;
and a waste disc pushing unit (153) for moving the waste drug sensitive disc in the incubation module (13) from the incubation module (13) to the disc discarding track is further arranged in the incubation module (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010069711.XA CN111235005B (en) | 2020-01-21 | 2020-01-21 | Full-automatic microorganism drug sensitivity analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010069711.XA CN111235005B (en) | 2020-01-21 | 2020-01-21 | Full-automatic microorganism drug sensitivity analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN111235005A CN111235005A (en) | 2020-06-05 |
| CN111235005B true CN111235005B (en) | 2023-10-03 |
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| CN202010069711.XA Active CN111235005B (en) | 2020-01-21 | 2020-01-21 | Full-automatic microorganism drug sensitivity analyzer |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017128806A1 (en) * | 2016-01-27 | 2017-08-03 | 广州万孚生物技术股份有限公司 | Automatic fluorescence quantitative immunoassay analyzer and detection method |
| CN206476988U (en) * | 2016-11-07 | 2017-09-08 | 珠海迪尔生物工程有限公司 | A kind of microbial identification and Analysis of Drug Susceptibility system |
| CN108267607A (en) * | 2018-01-10 | 2018-07-10 | 长沙修恒信息科技有限公司 | A kind of automated sample analyzing detecting method |
| CN208313668U (en) * | 2018-06-05 | 2019-01-01 | 上海复星长征医学科学有限公司 | A kind of centrifugation detection module of micro-fluidic centrifugal pan |
| CN109722379A (en) * | 2019-01-23 | 2019-05-07 | 安图实验仪器(郑州)有限公司 | Full automatic microorganism identification and Analysis of Drug Susceptibility system |
| WO2019140988A1 (en) * | 2018-01-19 | 2019-07-25 | 深圳市亚辉龙生物科技股份有限公司 | Full-automatic western blotting analyzer |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017128806A1 (en) * | 2016-01-27 | 2017-08-03 | 广州万孚生物技术股份有限公司 | Automatic fluorescence quantitative immunoassay analyzer and detection method |
| CN206476988U (en) * | 2016-11-07 | 2017-09-08 | 珠海迪尔生物工程有限公司 | A kind of microbial identification and Analysis of Drug Susceptibility system |
| CN108267607A (en) * | 2018-01-10 | 2018-07-10 | 长沙修恒信息科技有限公司 | A kind of automated sample analyzing detecting method |
| WO2019140988A1 (en) * | 2018-01-19 | 2019-07-25 | 深圳市亚辉龙生物科技股份有限公司 | Full-automatic western blotting analyzer |
| CN208313668U (en) * | 2018-06-05 | 2019-01-01 | 上海复星长征医学科学有限公司 | A kind of centrifugation detection module of micro-fluidic centrifugal pan |
| CN109722379A (en) * | 2019-01-23 | 2019-05-07 | 安图实验仪器(郑州)有限公司 | Full automatic microorganism identification and Analysis of Drug Susceptibility system |
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