CN111228426A - 一种治疗小儿上呼吸道感染的药食两用中药颗粒剂 - Google Patents
一种治疗小儿上呼吸道感染的药食两用中药颗粒剂 Download PDFInfo
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Abstract
本发明提出了一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,其中药原料组分为:金银花、桑叶、鱼腥草、藿香、芦根、橘红、桔梗、茯苓、薏米、山药、炒杏仁、鸡内金、麦芽、大枣、山楂、莱菔子、罗汉果;其中,按重量份,桑叶、鱼腥草、藿香分别为12份,芦根为8‑10份,剩余各组分均为6份;上述中药原料通过常规煎煮法提取,浓缩或喷雾干燥,加入适量蔗糖粉经过制粒,得到颗粒剂。本发明通过疏风清热,宣肺止咳,消食导滞的组合原则,提高小儿免疫力,达到治疗小儿上呼吸道感染的目的。
Description
技术领域
本发明属于中药领域,涉及一种治疗小儿上呼吸道感染的药食两用中药颗粒剂。
背景技术
上呼吸道感染是小儿最常见疾病,临床上主要表现有发热、咳嗽等症状,同时部分小儿会出现厌食、呕吐、腹泻等症状,上呼吸道感染的少儿普遍食欲较差。
小儿上呼吸道感染临床治疗通常是抗病毒治疗,抗病毒治疗一通常使用利巴韦林片,这种药虽然具有抗病毒的作用,但副作用大,长期使用容易引起抗药性,抑制免疫力。
少儿上呼吸道感染宜采用中药治疗,中药治疗原则通常是清热解毒、宣肺止咳。例如,中药制剂——小儿氨酚黄那敏颗粒用于少儿上呼吸道感染,但是对于比较严重的少儿上呼吸道感染,不能彻底治疗,还需要辅以西药抗病毒治疗,还存在副作用大、抑制免疫力的问题。
中药颗粒剂的制备方法现在是成熟的工艺,是中药材经过煎煮法提取、浓缩制成膏状或以喷雾干燥制成干膏粉,再加入糊精、蔗糖等水溶性辅料制成的一类颗粒制剂。
发明内容
为了克服现有技术中治疗小儿上呼吸道感染的中药制剂存在的弊端,本发明提出一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,通过疏风清热,宣肺止咳,消食导滞的组合原则,提高小儿免疫力,达到治疗的目的。
为此,本发明采用如下技术方案:一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,其特征在于:
中药原料组分为:金银花、桑叶、鱼腥草、藿香、芦根、橘红、桔梗、茯苓、薏米、山药、炒杏仁、鸡内金、麦芽、大枣、山楂、莱菔子、罗汉果;其中,按重量份,桑叶、鱼腥草、藿香分别为12份,芦根为8-10份,剩余各组分均为6份;
上述中药原料通过常规煎煮法提取,浓缩或喷雾干燥,加入适量蔗糖粉经过制粒,得到颗粒剂。
上述技术方案中,芦根最好为9份,以最佳组合体现芦根的清热生津功效。
本发明中,蔗糖粉作为中药颗粒剂制备的辅料,蔗糖粉的用量是现有常规技术;上述技术方案中,按重量份,通常是98-105份。
本发明的有益效果:本发明的治疗原则是疏风清热、宣肺止咳、消食导滞,金银花、桑叶、霍香、芦根配伍以解表、疏散风热、生津润燥;桔梗、鱼腥草、橘红治疗肺热燥咳,配伍罗汉果、杏仁以止咳化痰,利咽,润肠通便;山药、薏米、茯苓、健脾除湿,山楂配伍鸡内金、麦芽、大枣消食健胃和中,莱菔子消食除胀,降气化痰;本发明通过引入消食导滞与疏风清热及宣肺止咳结合的治疗原则,在治疗的过程中避免了小儿厌食,进而提高了小儿免疫力,综合性达到治疗小儿上呼吸道感染的目的。
具体实施方式
下面,结合实施方式及实施例例进一步表达本发明。
实施例1
本发明的实施方式总体介绍:
一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,中药原料组分为:金银花、桑叶、鱼腥草、藿香、芦根、橘红、桔梗、茯苓、薏米、山药、炒杏仁、鸡内金、麦芽、大枣、山楂、莱菔子、罗汉果;其中,按重量份,桑叶、鱼腥草、藿香分别为12份,芦根为8-10份,剩余各组分均为6份;上述中药原料通过常规煎煮法提取,浓缩,加入适量蔗糖粉(按重量份,蔗糖粉的用量通常为98-105份)经过制粒,得到颗粒剂。
其中,炒杏仁是常规技术,具体为:取杏仁置锅内用文火炒至微黄色,取出放凉。
实施例1中,把各种中药原料配比后制备颗粒剂的过程,是现有常规技术。
实施例2
一种治疗小儿上呼吸道感染的药食两用中药颗粒剂的制备:
(1)组分准备
中药原料组分为:金银花、桑叶、鱼腥草、藿香、芦根、橘红、桔梗、茯苓、薏米、山药、炒杏仁、鸡内金、麦芽、大枣、山楂、莱菔子、罗汉果;准备桑叶、鱼腥草、藿香分别为12kg,芦根为9kg,剩余各组分均为6kg;总量为123kg;
(2)颗粒剂制备
以上中药原料加饮用水煎煮两次,按重量,第一次加8-10倍量水煎煮1小时,第二次加5-8倍量水煎煮1小时,合并二次煎液,过滤,浓缩至适量(在50℃时测相对密度为1.2-1.3即可),过60目筛(主要是去掉焦屑),加100目的蔗糖粉适量(100kg)混合并制成颗粒,80℃干燥,取出放凉, 筛除碎末,包装成10g/袋的规格。
实施例2中,芦根的用量比例是实施本发明时是最优化的选择。
实施例3
实施例3与实施例2的区别是:芦根为8kg,蔗糖粉加入量为98 kg。
本发明中,蔗糖粉作为中药颗粒剂制备的辅料,蔗糖粉的用量是现有常规技术。
本发明的功能主治:治疗发热恶风,鼻塞流涕,喉燥咽痛,咳嗽气粗,脘腹胀满,积滞便秘,厌食面黄,夜寐不安,咬指磨牙症状,从而实现疏风清热、宣肺止咳、消食导滞。
本发明的用法用量:每次1袋(10g),每日三次,用温开水冲服。
本发明的药效统计分析如下:对100例病症,采用本发明的中药进行了跟踪治疗,其中,治愈 82例,占82%;好转 14例,占14%;无效4例,占4 %;总有效率为 96%。
采用实施例2的中药,下面结合15个具体病例来对本发明的疗效进一步阐述。
病例1:熊某某,女,4岁2月,2018年10月7日初诊,就诊时患儿体瘦,纳差已一年余,身高不足同龄人,面色偏黄,大便稀少,患儿家长经常给予健胃消食类药口服,效果不甚,可见舌淡红,苔白厚腻,脉细数;患儿服用本发明的中药一周后,患儿食欲增加,大便较前稍多,面色较前红润,遂继续服用本方三周,体重食欲均明显提高。
病例2:王某某,女,11岁,018年10月14日初诊,就诊时患儿已行扁桃体切除术后一周,咳嗽咽痒3天,诉经常便秘,有时3-4天行一次大便,舌红,苔薄黄,脉浮数;患儿服用本发明的中药三天后,咳嗽便秘症状已明显好转。
病例3:王某某,男,3岁6月,2018年10月21日初诊,就诊时患儿已咳嗽伴咳痰2天,患儿呼吸粗大,面色红,咽红充血,舌红,苔白厚,脉浮数;嘱患儿服用本发明的中药四天后,患儿家长代述患儿已不咳嗽。
病例4:唐某某,女,9岁,2018年10月18日初诊,就诊时患儿诉近期纳呆,平时还没放学就感觉饿,最近一周不觉的饿,食量也减少,家长在小区药店购买健胃消食片给予患儿口服两天,不见好转,随来就诊,舌淡红,苔白厚,脉细;嘱患儿服用本发明的中药一周后,复诊时纳呆症状明显好转。
病例5:周某某,男,3岁4月,2018年11月18日初诊,就诊时患儿已反复咳嗽伴气喘10余日,患儿家长述,该患儿已在社区诊所输液治疗3天效果不佳,遂前来就诊,可见咽红充血,舌红,苔白厚,脉滑数;嘱患儿服用本发明的中药3天后来复诊,复诊时患儿咳嗽已明显减少,无气喘症状,遂嘱患儿再服用一周。一周后复诊,患儿已痊愈。
病例6:张某,男,3岁6月,2018年11月18日初诊,家长代述患儿近 2日干咳,总是清嗓子,在家测最高体温37.4℃,纳差,精神欠佳,有时哭闹不安,可见咽红充血,咽喉壁上有小滤泡;嘱患儿服用本发明的中药3天后来复诊,复诊时患儿家长述当天便没有再发热,咳嗽减少,嘱再服用本药3天,再次复诊时患儿已痊愈。
病例7:张某某,男,9岁,2018年11月25日初诊,患儿自述近两日时有腹痛,痛时隐隐,不能确定疼痛部位,大便正常,睡眠不安,家长代述有时听到患儿夜间睡觉磨牙,可见舌红,苔薄白,脉弦滑;嘱患儿服用本发明的中药一周后来复诊,患儿自述已无腹痛,食纳可,大便正常,随后嘱患儿再继续服用本中药一周,巩固疗效。
病例8:谢某某,女,6岁,2018年12月2日初诊,就诊时患儿已咳嗽4天,白天有时可听到有痰,在家口服止咳糖浆两天未见好转,遂来就诊,可见患儿神清,精神可,体偏胖,咽红充血,余无不适,听诊未闻及异常,舌红,苔白厚,脉浮数;嘱患儿服用本发明的中药4天后来复诊,复诊时患儿白天已不咳嗽,夜间偶尔少许咳嗽,不咳痰,嘱患儿继续服用本中药3天,再诊时患儿已愈。
病例9:曹某某,男,12岁,2018年12月16日初诊,就诊时可见患儿体瘦,身高正常,家长代述患儿近1月来食欲减退,不知道饿,饭量也明显减少,大小便正常,去医院检查未发现明显异常,遂来就诊。可见舌淡红,苔白厚,脉滑;嘱患儿服用本发明的中药一周后来复诊,复诊时家长述患儿已恢复如前,为巩固疗效,建议患儿再服用一周。
病例10:方某某,男,11岁,2018年12月23日初诊,就诊时患儿已鼻塞咳嗽2天,有时打喷嚏,咽红充血,鼻粘膜充血,听诊未问及异常,余无不适,夜间睡眠欠佳,二便正常。舌红,苔薄白,脉浮数;嘱患儿服用本发明的中药3天后来复诊,复诊时患儿已好转痊愈。
病例11:包某某,女,2岁,2018年12月23日初诊,就诊时患儿家长代述患儿近一周大便干,有时排大便时哭闹,而且口臭。食纳可,平时喝奶量较以前无变化,夜间睡眠不安,时有哭闹。舌红,苔薄黄,脉细数;嘱患儿服用本发明的中药3天后复诊,复诊时患儿家长代述患儿大便已正常。
病例12:刘某某,男,3岁2月,2018年12月23日初诊,就诊时患儿已咳嗽1天,纳差2天,夜间睡眠不安,易醒,大便稍干,小便如常。咽红,听诊未问及异常,舌红,苔薄白,脉浮数;嘱患儿服用本发明的中药3天后来复诊,复诊时患儿家长述患儿服药第二天咳嗽已好转,食欲较前好转,嘱患儿继续服用本中药2天以巩固疗效。
病例13:代某某,女,8岁,2019年1月6日初诊,就诊时患儿鼻塞打喷嚏2天,咽红,扁桃体I度肿大,听诊未问及异常,纳差,经常清嗓子,二便正常。舌红,苔薄白,脉浮数;嘱患儿服用本发明的中药3天后复诊,复诊时患儿已无鼻塞打喷嚏,扁桃体仍稍肿大,嘱患儿继续服用本中药3天,再次复诊时,已痊愈。
病例14:张某某,女,10个月,2019年1月6日初诊,患儿家长代述患儿近2天哭闹不安,时有咳嗽,夜间睡眠不安,有时哭闹,昨天一天没解大便,小便正常,纳差,咽红充血,舌红,苔薄白,脉浮数。嘱患儿服用本发明的中药3天后来复诊,复诊时家长述患儿服用当天大便已解,已不咳嗽,睡眠很好。
病例15:龚某某,男,6个月,2019年1月20日初诊,患儿家长代述患儿昨日测最高体温38.5℃,大便一天未解,不咳嗽,纳差,经常哭闹不安,神清,精神差,咽红,舌红,苔白厚,脉浮数;嘱患儿服用本发明的中药3天后复诊,复诊时患儿家长述患儿当日服药后已不发热。
Claims (3)
1.一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,其特征在于:
中药原料组分为:金银花、桑叶、鱼腥草、藿香、芦根、橘红、桔梗、茯苓、薏米、山药、炒杏仁、鸡内金、麦芽、大枣、山楂、莱菔子、罗汉果;其中,按重量份,桑叶、鱼腥草、藿香分别为12份,芦根为8-10份,剩余各组分均为6份;
上述中药原料通过常规煎煮法提取,浓缩或喷雾干燥,加入适量蔗糖粉经过制粒,得到颗粒剂。
2.根据权利要求1所述的一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,其特征在于:按重量份,蔗糖粉的用量是98-105份。
3.根据权利要求2所述的一种治疗小儿上呼吸道感染的药食两用中药颗粒剂,其特征在于:按重量份,芦根为9份,蔗糖粉的用量是100份。
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CN113499425A (zh) * | 2021-09-02 | 2021-10-15 | 北京贡源本草生物科技有限公司 | 一种治疗病毒性感冒的组合物及其制备方法 |
CN114053355A (zh) * | 2021-12-21 | 2022-02-18 | 北京中宝嘉亿国际生物科技研究有限公司 | 一种用于治疗呼吸道感染的中药组合物及其制备方法和应用 |
CN115282235A (zh) * | 2022-05-27 | 2022-11-04 | 蚌埠丰原涂山制药有限公司 | 一种清热解毒的中药复方、复方颗粒及其制备方法 |
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Cited By (4)
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CN113499425A (zh) * | 2021-09-02 | 2021-10-15 | 北京贡源本草生物科技有限公司 | 一种治疗病毒性感冒的组合物及其制备方法 |
CN114053355A (zh) * | 2021-12-21 | 2022-02-18 | 北京中宝嘉亿国际生物科技研究有限公司 | 一种用于治疗呼吸道感染的中药组合物及其制备方法和应用 |
CN115282235A (zh) * | 2022-05-27 | 2022-11-04 | 蚌埠丰原涂山制药有限公司 | 一种清热解毒的中药复方、复方颗粒及其制备方法 |
CN115282235B (zh) * | 2022-05-27 | 2023-10-31 | 蚌埠丰原涂山制药有限公司 | 一种清热解毒的中药复方、复方颗粒及其制备方法 |
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