CN111202833A

CN111202833A - Constant-temperature long-acting spontaneous heating plaster for treating osteoarthritis

Info

Publication number: CN111202833A
Application number: CN202010032569.1A
Authority: CN
Inventors: 王照伟
Original assignee: Yanji Wangmazi Comprehensive Outpatient Department
Current assignee: Yanji Wangmazi Comprehensive Outpatient Department
Priority date: 2020-01-13
Filing date: 2020-01-13
Publication date: 2020-05-29

Abstract

The embodiment of the invention discloses a constant-temperature long-acting self-heating plaster for treating osteoarthritis, belonging to the technical field of traditional Chinese medicines. The plaster is prepared from radix Angelicae sinensis, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, Myrrha, ramulus Mori, Carthami flos, Glycyrrhrizae radix, Olibanum, lignum Dalbergiae Odoriferae, radix Arnebiae, lignum sappan, Bungarus Parvus, semen Momordicae, rhizoma Smilacis Glabrae, ramulus Sophorae, herba Chelidonii, Catechu, Camphora, Borneolum Syntheticum, sanguis Draxonis, rhizoma corydalis, herba Ephedrae, ramulus Cinnamomi, cortex Cinnamomi Japonici, Zingiberis rhizoma, Zaocys, and Bufo siccus. Due to the particularity of the formula and the process, when the plaster is applied to an affected part, the plaster can generate heat for 24 hours at a constant temperature (the body feeling temperature is 35-42 ℃), the local blood circulation is increased, the channels and collaterals are dredged, all wind, cold, dampness, phlegm, knots and extravasated blood at the affected part are quickly decomposed and dispersed to disappear, and the improvement of the state of an illness is accelerated. The plaster has good curative effect on osteoarthritis, is convenient to use, has low price, has no toxic or side effect in the clinical treatment process, is safe and reliable, and is worthy of popularization and application.

Description

Constant-temperature long-acting spontaneous heating plaster for treating osteoarthritis

Technical Field

The embodiment of the invention relates to the technical field of traditional Chinese medicines, and in particular relates to a constant-temperature long-acting self-heating plaster for treating osteoarthritis.

Background

Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage and secondary hyperosteogeny, one of the most common chronic diseases in orthopedics, and is usually occult in disease and slow in progression, mainly manifested by pain, stiffness, hypertrophic arthritis and dysfunction of joints and their surroundings. Osteoarthritis has a morbidity rate of more than 80% in China and is better developed for middle-aged and old women. The treatment method mainly comprises the following steps:

1. general treatment: mainly keeps warm, limits movement and reduces joint abrasion. Is commonly used for the early treatment of osteoarthritis.

2. And (3) drug treatment: the common medicines comprise non-steroidal anti-inflammatory drugs, including sitagliptin, fenpicide and the like; chondroprotective agents including aminodextran sulfate, chondroitin sulfate, sodium hyaluronate, and the like; diacerein can inhibit inflammatory factors in joint tissues, reduce cartilage destruction and prolong the joint life. The medicine has certain curative effect on relieving symptoms at a moment, but has large side effect, and aggravates joint degeneration after long-term use.

3. And (3) surgical treatment: patients with advanced joint destruction, which affects joint function, require symptomatic relief by joint replacement surgery. With some risk and expense.

The traditional Chinese medicine has the advantages of small toxic and side effects, low price, definite curative effect and the like. Osteoarthritis belongs to the category of arthralgia, and generally in clinical practice, the pathogenesis of osteoarthritis is closely related to three organs, namely kidney, spleen and liver, the pathogenesis of osteoarthritis is various, and the main pathogenies are fall injury, wind, cold, stasis, deficiency and dampness, and the pathogenesis of osteoarthritis is related to factors such as age, strain and the like.

The traditional Chinese medicine for treating osteoarthritis plays a certain role in clinical application, but still has the problem of insufficient curative effect.

Disclosure of Invention

Therefore, the constant-temperature long-acting self-heating plaster for treating osteoarthritis provided by the embodiment of the invention can generate heat for 24 hours at a constant temperature (the body sensing temperature is 35-42 ℃) when being applied to an affected part, increase the local blood circulation, dredge the channels and collaterals, and rapidly decompose and disperse all wind, cold, dampness, phlegm, stagnation and extravasated blood at the affected part to disappear, so that the improvement of the disease condition is accelerated. The plaster has good curative effect on osteoarthritis, is convenient to use, has low price, has no toxic or side effect in the clinical treatment process, is safe and reliable, and is worthy of popularization and application so as to solve the problems in the prior art.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

according to a first aspect of the embodiments of the present invention, the embodiments of the present invention provide a constant-temperature long-acting self-heating plaster for treating osteoarthritis, comprising the following medicinal materials, by weight: 8-15 parts of angelica sinensis, 8-12 parts of prepared monkshood, 8-12 parts of prepared kusnezoff monkshood root, 8-12 parts of myrrh, 8-12 parts of mulberry twig, 3-7 parts of safflower, 3-7 parts of liquorice, 9-11 parts of frankincense, 9-11 parts of dalbergia wood, 3-7 parts of lithospermum, 8-12 parts of sappan wood, 9-11 parts of bungarus parvus, 8-12 parts of momordica cochinchinensis, 4-6 parts of glabrous greenbrier rhizome, 8-12 parts of sophora japonica branch, 18-23 parts of celandine, 3-6 parts of catechu, 3-6 parts of camphor, 4-6 parts of borneol, 4-7 parts of dragon's blood, 16-22 parts of rhizoma corydalis, 7-13 parts of ephedra, 8-12 parts of cassia twig, 8-12 parts of cassia bark, 6-10 parts of dried ginger, 8-10 parts of za.

Further, the traditional Chinese medicine composition comprises the following medicinal materials in parts by weight: 10 parts of angelica, 10 parts of radix aconiti preparata, 10 parts of radix aconiti kusnezoffii preparata, 10 parts of myrrh, 10 parts of mulberry twig, 5 parts of safflower, 5 parts of liquorice, 10 parts of frankincense, 10 parts of dalbergia wood, 5 parts of lithospermum, 10 parts of sappan wood, 10 parts of bungarus parvus, 10 parts of cochinchina momordica seed, 5 parts of glabrous greenbrier rhizome, 10 parts of sophora japonica branch, 20 parts of celandine, 5 parts of catechu, 5 parts of camphor, 5 parts of borneol, 5 parts of dragon's blood, 20 parts of rhizoma corydalis, 10 parts of ephedra, 10 parts of cassia twig, 10 parts of cassia bark, 10 parts of dried ginger, 10 parts.

Further, the preparation method of the plaster comprises the following steps:

1) preparing the raw materials according to the proportion;

2) adding all the raw materials into soybean oil, soaking for 7 days, decocting for the next 7 days under stirring for 2 hr each day, turning off fire, and filtering to remove residue to obtain medicinal oil;

3) boiling the medicinal oil, adding Plumbum Preparatium, and stirring to obtain black asphalt paste;

4) slowly pouring the paste into cold water, repeatedly stretching to obtain twist shape, pouring out water, adding new cold water, changing water every day, soaking for 15 days, putting all twist-shaped paste into a pot, firing, stirring to boil, coating, and cooling to obtain the plaster.

According to a third aspect of embodiments of the present invention, there is provided the use of a plaster as described above in the manufacture of a medicament for the treatment of osteoarthritis.

Chinese angelica: sweet, pungent and warm. It enters liver, heart and spleen meridians. The functions of the medicine are mainly replenishing blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease.

Radix aconiti preparata: pungent, bitter and warm in flavor. It enters heart, liver, kidney and spleen meridians. Has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia due to cold-dampness, and hernia pain.

Preparing kusnezoff monkshood root: is a processed product of radix Aconiti Kusnezoffii. Pungent, bitter and hot; is toxic. It enters heart, liver, kidney and spleen meridians. The functions are mainly used for dispelling wind and eliminating dampness, warming meridians and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia, and pain due to anesthesia.

Myrrh: bitter and neutral. The functions are mainly used for dissipating blood stasis and relieving pain, and swelling and tissue regeneration are realized by external application. Can be used for treating traumatic injury, blood stasis, swelling and pain, carbuncle, cellulitis, and pain of chest and abdomen; it is indicated for long-term sore without astringency.

Mulberry twig: slightly bitter and mild. It enters liver meridian. The functions are mainly used for dispelling wind-damp and benefiting joints. Can be used for treating soreness and numbness of shoulder, arm, and joint.

Safflower: pungent and warm. Enter heart and liver meridians. The functional indications are as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain. It is indicated for amenorrhea, abdominal mass, dystocia, dead fetus, postpartum lochiorrhea, pain due to blood stasis, carbuncle, swelling and traumatic injury.

Licorice root: sweet and neutral. It enters heart, lung, spleen and stomach meridians. The functions are mainly used for tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Frankincense: pungent, bitter and warm. The functions are mainly used for promoting blood circulation and relieving pain. Can be used for treating pain of heart and abdomen, spasm of tendons and vessels, traumatic injury, skin ulcer, carbuncle, and swelling and pain; it can be used topically for detumescence and granulation promotion.

And (3) rosewood heart wood: pungent and warm. It enters liver and spleen meridians. The functions are mainly used for promoting qi and blood circulation, relieving pain and stopping bleeding. Can be used for treating abdominal pain, hypochondriac pain due to stagnation of liver-qi, thoracic obstruction, traumatic injury, and traumatic hemorrhage.

Lithospermum: sweet, salty and cold. It enters heart and liver meridians. The functions are mainly cooling blood, promoting blood circulation, detoxifying and promoting eruption. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water and fire.

Sappan wood: sweet, salty and neutral. It enters heart, liver and spleen meridians. The functions are mainly for promoting blood circulation, removing blood stasis, relieving swelling and pain. Can be used for treating amenorrhea, dysmenorrhea, puerperal stagnation, thoracico-abdominal pain, and traumatic swelling and pain.

Bungarus minimus: sweet, salty and warm; is toxic. It enters liver meridian. The functions are mainly to dispel wind, dredge collaterals and stop convulsion. Can be used for treating rheumatism, numbness, spasm, facial distortion, hemiplegia, convulsion, tetanus, leprosy, scabies, lymphoid tuberculosis, and malignant sore.

Semen momordicae: bitter, slightly sweet and cool; is toxic. It enters liver, spleen and stomach meridians. The functions are mainly used for dissipating stagnation, reducing swelling, counteracting toxic substances and treating sore. Can be used for treating pyocutaneous disease, pyogenic infection, acute mastitis, scrofula, anal fistula, tinea, and tinea.

Glabrous greenbrier rhizome: sweet, bland and mild. It enters liver and stomach meridians. The functions are mainly used for removing dampness, detoxifying and easing joint movement. Can be used for treating damp-heat stranguria with turbid discharge, leukorrhagia, carbuncle swelling, scrofula, scabies, tinea, syphilis and limb spasm and arthralgia and myalgia caused by mercury poisoning.

And (3) pagodatree branches: is bitter in taste; neutral nature and heart returning; the liver meridian. The function is mainly used for dissipating blood stasis and stopping bleeding; clearing heat and eliminating dampness; dispel wind and kill parasites. Main uterine bleeding; leucorrhea with reddish discharge; hemorrhoids; itching scrotum; heartburn; conjunctival congestion; scabies and tinea.

Herba Chelidonii: bitter and cool. Is toxic. The functions are mainly used for clearing away heat and toxic material, relieving pain and relieving cough. Can be used for treating gastritis, gastric ulcer, abdominal pain, enteritis, dysentery, jaundice, chronic tracheitis, and pertussis; it can be used for treating dermatitis in paddy field and insect bite by external application.

Catechu: bitter, astringent and slightly cold. It enters lung meridian. The function is mainly used for eliminating dampness, promoting granulation and healing wound. Can be used for treating unhealed ulcer, eczema, aphtha, traumatic injury, traumatic hemorrhage.

Camphor: pungent and warm. The functions are mainly used for dredging orifices and removing dirt, warming middle-jiao and relieving pain, and promoting diuresis and killing insects. Can be used for treating vomiting and diarrhea due to cold-dampness, and stomach and abdominal pain; it is externally used for treating scabies, tinea and pain caused by dental caries.

Borneol: pungent, bitter and slightly cold. It enters heart, spleen and lung meridians. The functions are mainly used for inducing resuscitation and refreshing mind, and clearing heat and relieving pain. Can be used for treating fever unconsciousness, convulsion syncope, apoplexy with phlegm syncope, qi stagnation and sudden syncope, coma, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.

Dragon's blood: sweet, salty and neutral. It enters heart and liver meridians. The functions are mainly used for removing blood stasis, relieving pain, stopping bleeding and promoting tissue regeneration. Can be used for treating traumatic injury, internal injury, blood stasis and pain; bleeding caused by trauma is not limited.

Rhizoma corydalis: yan Hu Suo is pungent, bitter and warm. It enters liver and spleen meridians. The functions are mainly to activate blood, promote qi circulation and relieve pain. Can be used for treating chest and hypochondrium, abdominal pain, amenorrhea, dysmenorrhea, puerperal blood stasis, traumatic injury, and swelling and pain.

Herba ephedrae: pungent, slightly bitter and warm. It enters lung and bladder meridians. The functions are mainly used for sweating and dispelling cold, freeing lung and relieving asthma, and inducing diuresis and reducing edema. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema; bronchial asthma. Honey Chinese ephedra can moisten lung and relieve cough. It is often indicated for exterior syndrome, asthma and cough.

Cassia twig: pungent, sweet and warm. It enters heart, lung and bladder meridians. The functions are mainly used for sweating and relieving muscles, warming and activating meridians, supporting yang and regulating qi, and calming the Chong and descending qi. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.

Cassia bark: the academic name of Chaihu, also called Xianggui, is pungent, sweet and hot. Has little toxicity. The functions are mainly used for dispelling wind cold, stopping vomiting, eliminating dampness and arthralgia and dredging channels and collaterals. Can be used for treating emesis, dysphagia, chest distress, abdominal pain, bone and muscle pain, lumbago, knee pain, and traumatic injury.

Dried ginger: pungent and hot. It enters spleen, stomach, kidney, heart and lung meridians. The main functions are to warm the middle-jiao and dispel cold, return yang and dredge collaterals, dry dampness and eliminate phlegm of dried ginger. Can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, phlegm retention, asthma, and cough.

Black-tail snake: sweet and neutral. It enters liver meridian. The functions are mainly to dispel wind, dredge collaterals and stop convulsion. Can be used for treating rheumatism, numbness, spasm, facial distortion, hemiplegia, convulsion, tetanus, leprosy, scabies, and lymphoid tuberculosis.

Toad: pungent, cool and toxic in nature and flavor. Enter heart, liver, spleen and lung meridians. The functions are mainly used for breaking the crux of a disease, promoting diuresis, eliminating toxicity, killing parasites and relieving pain. It is used to treat furuncle, carbuncle of the yin-yang, scrofula, malignant boil, abdominal mass, tympanites, edema, infantile malnutrition, and chronic tracheitis.

The traditional Chinese medicine external treatment method adopts a transdermal principle under the guidance of the traditional medical theory, simplifies the administration route, directly acts on the affected part by directly absorbing through the skin to directly reach the affected part, and enhances the local medicine concentration, thereby improving the curative effect.

The embodiment of the invention has the following advantages:

the plaster provided by the embodiment of the invention takes angelica sinensis, radix aconiti preparata, radix aconiti kusnezoffii preparata, myrrh, ramulus mori, safflower, liquorice, frankincense, dalbergia wood, lithospermum, sappan wood, bungarus parvus, cochinchina momordica seed, rhizoma smilacis glabrae, sophora japonica branch, celandine, catechu, camphor, borneol, dragon blood, rhizoma corydalis, ephedra, cassia twig, cassia bark, dried ginger, zaocys dhumnade and toad as raw materials, wherein the frankincense, the myrrh, the zaocys dhumnade, the bungarus parvus, the radix aconiti preparata, the radix aconiti kusnezoffii preparata and the toad have the effects: the angelica, the dalbergia wood, the safflower, the dragon's blood, the rhizoma corydalis, the sappan wood, the cochinchina momordica seed and the lithospermum have the functions of eliminating dampness and dispelling cold and are used as ministerial drugs; chelidonium majus, cassia bark, dried ginger, mulberry twig, cassia twig, ephedra herb and sophora twig have the functions of removing evil and strengthening healthy energy and are used as adjuvant drugs together; the liquorice, the borneol, the glabrous greenbrier rhizome, the camphor and the catechu have the function of harmonizing and are used as guiding drugs together. The medicines are combined to play the effects of warming and activating meridian, promoting blood circulation by removing blood stasis, dispelling wind and removing dampness.

Due to the particularity of the formula and the process, when the plaster is applied to an affected part, a human body can feel constant temperature (the body feeling temperature is 35-42 ℃) and generate heat for 24 hours, the local blood circulation can be increased, the channels and collaterals are dredged, all wind, cold, dampness, phlegm, knots and extravasated blood at the affected part are quickly decomposed and dispersed to disappear under the action of the heat, and the improvement of the state of an illness is accelerated.

The plaster is obtained by a large amount of compatibility research of the inventor, has better curative effect on osteoarthritis, is convenient to use, has low price, has no toxic or side effect in the clinical treatment process, is safe and reliable, and is worthy of popularization and application.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The constant-temperature long-acting self-heating plaster for treating osteoarthritis comprises the following components in parts by weight:

1) the following medicinal materials are prepared: 12 g of angelica, 8 g of prepared monkshood, 8 g of prepared kusnezoff monkshood root, 12 g of myrrh, 10 g of mulberry twig, 3 g of safflower, 6 g of liquorice, 9 g of frankincense, 11 g of dalbergia wood, 6 g of lithospermum, 8 g of sappan wood, 9 g of bungarus parvus, 12 g of cochinchina momordica seed, 6 g of glabrous greenbrier rhizome, 12 g of sophora twig, 20 g of celandine, 3 g of catechu, 6 g of camphor, 4 g of borneol, 7 g of dragon's blood, 18 g of rhizoma corydalis, 12 g of ephedra, 8 g of cassia twig, 8 g of cassia bark, 10 g of dried ginger, 10 g of;

4) slowly pouring the paste into cold water, repeatedly stretching to obtain twist shape, pouring out water, adding new cold water, changing water every day, soaking for 15 days, putting all twist-shaped paste into a pot, and stirring to obtain paste.

The following examples were prepared according to the same method as example 1, except for the formulation.

Example 2

The constant-temperature long-acting self-heating plaster for treating osteoarthritis comprises: 10 g of angelica, 10 g of prepared monkshood, 10 g of prepared kusnezoff monkshood root, 10 g of myrrh, 10 g of mulberry twig, 5 g of safflower, 5 g of liquorice, 10 g of frankincense, 10 g of dalbergia wood, 5 g of lithospermum, 10 g of sappan wood, 10 g of bungarus parvus, 10 g of cochinchina momordica seed, 5 g of glabrous greenbrier rhizome, 10 g of sophora twig, 20 g of celandine, 5 g of catechu, 5 g of camphor, 5 g of borneol, 5 g of dragon's blood, 20 g of rhizoma corydalis, 10 g of ephedra, 10 g of cassia twig, 10 g of cassia bark, 10 g of dried ginger, 10 g of.

Example 3

The constant-temperature long-acting self-heating plaster for treating osteoarthritis comprises: 8 g of angelica, 10 g of prepared monkshood, 10 g of prepared kusnezoff monkshood root, 8 g of myrrh, 12 g of mulberry twig, 6 g of safflower, 4 g of liquorice, 10 g of frankincense, 9 g of dalbergia wood, 3 g of lithospermum, 10 g of sappan wood, 11 g of bungarus parvus, 12 g of cochinchina momordica seed, 4 g of glabrous greenbrier rhizome, 8 g of sophora twig, 22 g of celandine, 6 g of catechu, 4 g of camphor, 5 g of borneol, 4 g of dragon's blood, 20 g of rhizoma corydalis, 7 g of ephedra, 10 g of cassia twig, 12 g of cassia bark, 8 g of dried ginger, 8 g of.

Example 4

The constant-temperature long-acting self-heating plaster for treating osteoarthritis comprises: 12 g of angelica, 12 g of prepared monkshood, 10 g of prepared kusnezoff monkshood root, 12 g of myrrh, 8 g of mulberry twig, 7 g of safflower, 3 g of liquorice, 9 g of frankincense, 11 g of dalbergia wood, 5 g of lithospermum, 12 g of sappan wood, 9 g of bungarus parvus, 8 g of cochinchina momordica seed, 5 g of glabrous greenbrier rhizome, 10 g of sophora twig, 23 g of celandine, 6 g of catechu, 3 g of camphor, 4 g of borneol, 5 g of dragon's blood, 16 g of rhizoma corydalis, 13 g of ephedra, 8 g of cassia twig, 12 g of cassia bark, 10 g of dried ginger, 9 g of.

Example 5

The constant-temperature long-acting self-heating plaster for treating osteoarthritis comprises: 15 g of angelica, 8 g of prepared monkshood, 12 g of prepared kusnezoff monkshood root, 8 g of myrrh, 8 g of mulberry twig, 3 g of safflower, 7 g of liquorice, 11 g of frankincense, 11 g of dalbergia wood, 7 g of lithospermum, 8 g of sappan wood, 11 g of bungarus parvus, 12 g of cochinchina momordica seed, 4 g of glabrous greenbrier rhizome, 12 g of sophora twig, 18 g of celandine, 3 g of catechu, 6 g of camphor, 6 g of borneol, 4 g of dragon's blood, 22 g of rhizoma corydalis, 10 g of ephedra, 12 g of cassia twig, 10 g of cassia bark, 6 g of dried ginger, 9 g of za.

Test example

Clinical trial

1. General data

360 patients were selected and all patients were randomized into treatment groups 1-5 and control groups, 60/group.

Inclusion criteria were: the patients who met the diagnosis standard of osteoarthritis can be included in the study cases.

2. Method of treatment

Treatment groups 1-5: the plasters prepared in examples 1 to 5 were used respectively and applied directly to the affected parts. The plaster is applied 24 hours each time, one plaster is taken every day, and 7 days are a treatment course.

Control group: rheumatism plaster (approved article No.: Hubei food medicine monitor No. 2007 No. 2261041). The application method is the same as that of the treatment group. Patients in the treatment group and the control group do not use other medicines in the treatment process.

3. Criteria for efficacy assessment

The method is drawn up according to the clinical disease diagnosis standard of healing improvement, and the improvement conditions of pain, swelling, tenderness, joint mobility and muscle strength of the affected knee are taken as evaluation indexes.

And (3) healing: pain, swelling, tenderness disappeared, normal joint mobility, and constant muscle strength.

The effect is shown: the joint has basically no pain and tenderness, and the swelling disappears. The joint mobility is improved by more than 30 degrees, the knee bending degree is more than 120 degrees, and the muscle strength is more than IV grade.

The method has the following advantages: the pain, swelling and tenderness of joints are all relieved, the mobility of joints is improved by less than 30 degrees, and the muscle strength reaches more than grade III.

And (4) invalidation: all indexes are not improved.

4. Therapeutic results

The results of the above criteria after 2 courses of treatment with the two above treatments are shown in table 1.

TABLE 1

Group of	n	Recovery method	Show effect	Is effective	Invalidation	Total effective rate (%)
							Treatment group 1	60	21	18	18	3	95
Treatment group 2	60	20	23	16	1	98.3
							Treatment group 3	60	18	20	17	5	91.7
Treatment group 4	60	16	25	13	6	90
							Treatment group 5	60	17	20	19	4	93.3
Control group	60	12	14	18	16	73.3

The results show that the total effective rate of the treatment group is obviously better than that of the control group, and the difference between the two groups is obvious (PP < 0.05).

In order to evaluate the fever effect of the plaster of the embodiment of the invention, the number of people who have fever with a body temperature of 35-42 ℃ for 24 hours in the treatment process of 1-5 groups of patients was counted, and the results are shown in table 2.

TABLE 2

Group of	Number of people
		Treatment group 1	57
Treatment group 2	58
		Treatment group 3	55
Treatment group 4	54
		Treatment group 5	57

The result shows that when the plaster is applied to the affected part, the plaster plays a constant-temperature and long-time heating function, can increase local blood circulation, dredge channels and collaterals, and quickly decompose and disperse all wind, cold, dampness, phlegm, stasis and extravasated blood at the affected part to disappear under the action of heating, thereby accelerating the improvement of the state of an illness.

Side reaction of the medicine: none of the patients in the treatment group showed skin allergy in the treatment process, which indicates that the plaster provided by the embodiment of the invention has low side effect and high safety.

Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. A constant-temperature long-acting spontaneous heating plaster for treating osteoarthritis is characterized by comprising the following medicinal materials in parts by weight: 8-15 parts of angelica sinensis, 8-12 parts of prepared monkshood, 8-12 parts of prepared kusnezoff monkshood root, 8-12 parts of myrrh, 8-12 parts of mulberry twig, 3-7 parts of safflower, 3-7 parts of liquorice, 9-11 parts of frankincense, 9-11 parts of dalbergia wood, 3-7 parts of lithospermum, 8-12 parts of sappan wood, 9-11 parts of bungarus parvus, 8-12 parts of momordica cochinchinensis, 4-6 parts of glabrous greenbrier rhizome, 8-12 parts of sophora japonica branch, 18-23 parts of celandine, 3-6 parts of catechu, 3-6 parts of camphor, 4-6 parts of borneol, 4-7 parts of dragon's blood, 16-22 parts of rhizoma corydalis, 7-13 parts of ephedra, 8-12 parts of cassia twig, 8-12 parts of cassia bark, 6-10 parts of dried ginger, 8-10 parts of za.

2. The constant-temperature long-acting self-heating plaster for treating osteoarthritis according to claim 1, comprising the following medicinal materials in parts by weight: 10 parts of angelica, 10 parts of radix aconiti preparata, 10 parts of radix aconiti kusnezoffii preparata, 10 parts of myrrh, 10 parts of mulberry twig, 5 parts of safflower, 5 parts of liquorice, 10 parts of frankincense, 10 parts of dalbergia wood, 5 parts of lithospermum, 10 parts of sappan wood, 10 parts of bungarus parvus, 10 parts of cochinchina momordica seed, 5 parts of glabrous greenbrier rhizome, 10 parts of sophora japonica branch, 20 parts of celandine, 5 parts of catechu, 5 parts of camphor, 5 parts of borneol, 5 parts of dragon's blood, 20 parts of rhizoma corydalis, 10 parts of ephedra, 10 parts of cassia twig, 10 parts of cassia bark, 10 parts of dried ginger, 10 parts.

3. The constant-temperature long-acting self-heating plaster for treating osteoarthritis according to claim 1, wherein the preparation method of the plaster comprises:

1) preparing the raw materials according to the proportion;

4) pouring the paste into cold water, repeatedly stretching to obtain twist shape, pouring out water, adding new cold water, changing water every day, soaking for 15 days, putting all twist-shaped paste into a pot, heating, stirring to boil, coating, and cooling to obtain the plaster.

4. Use of a plaster according to claim 1 for the preparation of a medicament for the treatment of osteoarthritis.