CN111202506A - Fluid detection device, preparation method thereof and blood detection device in blood vessel - Google Patents

Fluid detection device, preparation method thereof and blood detection device in blood vessel Download PDF

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CN111202506A
CN111202506A CN201811393947.8A CN201811393947A CN111202506A CN 111202506 A CN111202506 A CN 111202506A CN 201811393947 A CN201811393947 A CN 201811393947A CN 111202506 A CN111202506 A CN 111202506A
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shape memory
substrate
shape
detecting
detection device
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冯雪
张柏诚
刘兰兰
陈颖
蒋晔
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Tsinghua University
Institute of Flexible Electronics Technology of THU Zhejiang
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Tsinghua University
Institute of Flexible Electronics Technology of THU Zhejiang
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00

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  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

The invention relates to a fluid detection device, a preparation method thereof and a blood detection device in a blood vessel. The detection device includes: the material of the substrate is a shape memory material; a sensing unit comprising at least one electrode, the sensing unit for detecting an impedance of a directly contacted fluid, the sensing unit disposed on the substrate; wherein the substrate is capable of coordinating fluid detection by changing its shape. The substrate in the detection device has the shape memory function, so that a three-dimensional and refined detection device can be prepared by the preparation method of the two-dimensional device, when the detection device is used, the detection device with a preset shape can be obtained through the change of the shape of the substrate, the fixation of the detection device at a specified position is realized, the detection of the impedance of the fluid is completed through the sensing unit, the detection of various signals of the fluid by the single sensing unit is realized, the method is simple, and the effect is good.

Description

Fluid detection device, preparation method thereof and blood detection device in blood vessel
Technical Field
The invention relates to the technical field of detection, in particular to a fluid detection device, a preparation method thereof and a blood detection device in a blood vessel.
Background
At present, most of the measurement of human blood electrical signals is to pump blood out of a human body through a needle tube and then place the blood in an external measuring instrument for monitoring, and the accuracy is high. However, devices such as external meters are expensive and generally concentrated in large and medium-sized general hospitals.
For this reason, researchers have developed implantable blood test devices in succession. However, most of the currently used implantable blood detection devices are heat conduction devices, and there are relatively few devices that can be implanted inside a blood vessel to perform blood electrical signal analysis by measuring and analyzing partial properties of blood through changes in the heat conduction rate of blood. The difficulty in measuring and analyzing blood electrical signals mainly has the following three problems: 1. a fine electric signal detection device with a complex shape such as a tubular shape cannot be prepared, so that the measurement precision of the detection device is poor, and blood cannot be monitored with high precision; 2. the interior of the blood vessel is complex, the detection device cannot be completely attached to the inner wall of the blood vessel after being designed, and the detection device is fixed in the blood vessel with certain difficulty; 3. at present, the blood electrical signal measurement mode is single, and various properties in blood cannot be comprehensively measured.
Disclosure of Invention
In view of the above, it is necessary to provide a fluid detection device, a method for preparing the same, and a blood detection device in a blood vessel, for solving the above-mentioned problem of detecting an electrical signal in blood; the substrate in the detection device has a shape memory function, so that a three-dimensional and refined detection device can be prepared by a two-dimensional device preparation method, when the detection device is used, a detection device with a preset shape can be obtained through the change of the shape of the substrate, the detection device is fixed at an appointed position, the detection of the impedance of the fluid is completed through the sensing unit, the detection of various signals of the fluid by the single sensing unit is realized, the method is simple, and the effect is good.
A detection device for a fluid, the detection device comprising:
the material of the substrate is a shape memory material;
the sensing unit is used for being in contact with a fluid and detecting the impedance of the fluid, the sensing unit is formed on the substrate, and the sensing unit comprises an interdigital electrode;
wherein the substrate is capable of coordinating fluid detection by changing its shape.
In one embodiment, the electrodes comprise interdigitated electrodes.
In one embodiment, the material of the interdigital electrode comprises one of a conductive polymer, a metal material, a metal paste and a carbon-based conductive material.
In one embodiment, the number of pairs of electrode pairs of the interdigital electrodes is 3-4 pairs.
In one embodiment, the interdigital depth of the interdigital electrode is D, and the distance between two adjacent electrode lines is D, wherein D is D, and the offset distance is 0.
In one embodiment, the shape memory material comprises one of a shape memory alloy and a shape memory polymer.
In one embodiment, the shape memory material is a light-induced shape memory material, and the light-induced shape memory material changes shape in a wavelength range of 100nm to 450 nm; or
The shape memory material is a thermotropic shape memory material, and the thermotropic shape memory material changes shape within the temperature range of 0-200 ℃; or
The shape memory material is a chemical induction type shape memory material, and the shape of the chemical induction type shape memory material is changed within the pH value range of 1.0-12.0.
In one embodiment, the sensing unit is provided with an external port for connecting an external device.
The fluid detection device can be deeply inserted into complex environments such as blood vessels and the like, is fixed at a specified position through the change of the shape of the substrate, and detects different models of the impedance of the fluid through the sensing unit at the fixed position, so that the problem of high difficulty in fixing the detection device in the complex environments such as the blood vessels and the like at present is solved, and the detection of various signals of the fluid by a single sensing unit can be realized. Meanwhile, through the shape memory function of the substrate, a three-dimensional and fine detection device can be prepared on the basis of the substrate with a two-dimensional structure such as a sheet structure, and the like, and a detection device with a complex shape such as a tubular shape can be obtained through the change of the shape of the substrate, so that the defect that the detection device with the complex shape such as the tubular shape cannot be prepared is overcome.
A method for manufacturing a fluid detection device as described above, the method comprising:
providing a substrate, wherein the material of the substrate is a shape memory material;
and forming a sensing unit on the substrate, wherein the sensing unit comprises at least one electrode to obtain a detection device.
In one embodiment, the substrate is sheet-like.
In one embodiment, the method for forming the sensing unit includes one of a 3D printing method, a physical deposition method, a chemical deposition method, and a transfer method.
The preparation method can be used for preparing a refined detection device, is simple, has mature process and is suitable for large-scale production and manufacturing.
A device for detecting blood in a blood vessel comprising a device for detecting a fluid as described above.
In one embodiment, the detection device has a length of 3.14cm or less and a thickness of 200 μm or less when detecting blood in a blood vessel.
In one embodiment, the length L of the electrode line of the interdigital electrode is greater than 0 and less than or equal to 1cm, and the width W of the electrode line is 20-200 μm.
In one embodiment, the interdigital depth D of the interdigital electrode is 20 μm to 200 μm, and the distance D between two adjacent electrode wires is 20 μm to 200 μm, wherein D ═ D, and the offset distance is 0.
In one embodiment, the shape memory material changes shape in a wavelength range from 360nm to 450 nm;
the thermotropic shape memory material changes shape within the temperature range of 35-450 ℃;
the chemical induction type shape memory material is subjected to shape change within the pH value range of 2.0-5.0.
The detection device for the blood in the blood vessel can obtain indexes of a series of components such as plasma, red blood cells and the like in the blood and non-macroscopic indexes such as flow rate, blood fat, electrolytes and the like of local blood at a designated position.
Drawings
FIG. 1 is a schematic view of a detection device of the present invention;
FIG. 2 is a diagram of the distribution of the electric field equipotential lines when the pair of electrodes is 1;
FIG. 3 is a diagram of the distribution of the equipotential lines of the electric field when the number of the electrode pairs is 2;
FIG. 4 is a diagram of the distribution of the electric field equipotential lines when the number of electrode pairs is 3;
FIG. 5 is a schematic diagram of an interdigital electrode offset distance of 0;
FIG. 6 is a schematic diagram of an interdigital electrode offset distance of 3 mm;
FIG. 7 is a schematic diagram of an interdigital electrode offset distance of 6 mm;
FIG. 8 is a schematic structural diagram of an interdigital electrode with two interdigital electrodes;
FIG. 9 is a schematic structural diagram of an interdigital electrode with two interdigital electrodes;
figure 10 is a schematic view of a blood three-element model.
In the figure, 1, a substrate; 2. a sensing unit; 3. and (4) connecting an external port.
Detailed Description
The present invention provides a fluid detection device, a method for manufacturing the same, and a blood detection device in a blood vessel.
In a circuit having a resistor and a capacitor, the resistance acting on the current in the circuit is called impedance. As shown in fig. 1, the present invention provides a fluid detection device for detecting impedance characteristics of a fluid.
Specifically, the detection device includes:
the substrate 1, the material of the said substrate 1 is the shape memory material;
a sensing unit 2, the sensing unit 2 comprising at least one electrode, the sensing unit 2 being configured to detect an impedance of a fluid in direct contact, the sensing unit 2 being disposed on the substrate 1;
wherein the substrate 1 is capable of cooperating with fluid detection by changing its shape.
Specifically, in different fluid detection environments, the deformed shape of the substrate 1 is different. For example, in the case of detecting a fluid in various lumens such as blood in a blood vessel, a solution in an industrial hose, etc., the shape memorized in the substrate 1 may be a flat shape, a cylindrical shape, or other shapes adaptable to the lumen, depending on the shape of the lumen. When in application, the detection device is mechanically sent to a specified position of a tube cavity, and then the substrate 1 is stimulated by applying the condition from the outside according to the condition of deformation of the substrate 1, so that the substrate 1 changes the shape of the substrate 1 and is unfolded in the tube cavity, and the shape is changed. Thereby, the substrate 1 is attached to the inner wall of the tube cavity under a certain pressure. Therefore, the detection device is firmly fixed with the inner wall of the lumen in the lumen, and the detection device cannot be taken away due to factors such as the increase of the flow velocity of the fluid.
Preferably, the detection device is curved to reduce the cross-section of the entire detection device for better placement in the lumen.
It will be appreciated that after the detection device is introduced into the lumen, the surface of the substrate 1 on the side facing away from the sensing unit 2 is in contact with the inner wall of the lumen, so that the sensing unit 2 can be brought into contact with the fluid flowing through the substrate 1 and detect the impedance characteristics of the fluid, thereby obtaining the desired information by analyzing the characteristics of the fluid.
While the shape memorized by the substrate 1 can be cylindrical or other shape adaptable to the detection, when detecting gastric juice such as in the stomach. Therefore, when in use, the detection device is mechanically sent into the stomach, and then the substrate 1 is stimulated by applying the condition to the outside according to the condition of deformation of the substrate 1, so that the substrate 1 changes the shape of the substrate and is unfolded in the stomach to form a cylindrical shape, and the cylindrical shape is suspended in gastric juice, thereby detecting the impedance of the gastric acid solution in direct contact, and judging whether diseases such as gastric bleeding and gastric ulcer exist by analyzing the gastric acid components.
It is considered that the substrate 1 needs to change its shape in order to match the detection of the fluid, i.e. the substrate 1 has a certain flexibility. Therefore, the sensor unit 2 also needs to have a certain flexibility. And the flexibility of the interdigital electrode is controllable, and therefore, the electrode is preferably an interdigital electrode.
It is to be understood that the interdigital electrodes are not limited in shape, including rectangular, serpentine, and the like.
Specifically, the material of the interdigital electrode comprises a conductive polymer, a metal material, a metal paste, a carbon-based conductive material and the like. The conductive polymer comprises PEDOT and the like, the metal material comprises silver nanowires, platinum metal films and the like, the metal slurry comprises gold nanometer conductive slurry and the like, and the carbon-based conductive material comprises graphene, carbon nanowires and the like.
As shown in fig. 2 to 4, the pair number of pairs of the interdigital electrodes is 1 pair, and the detection function can be realized. However, in fig. 2, there is a build-up of charge at the plate edges of the electrodes, resulting in a large electric field gradient at the edges. The more uniform the electric field distribution as the number of electrode pairs increases. Therefore, considering the stability of measurement, the logarithm of the electrode pair is 3-4 pairs, which is more beneficial to signal detection.
In the interdigital electrode, the interdigital depth of the interdigital electrode is D, the distance between two adjacent electrode wires is D, and the interdigital depth D is the same as the distance D between the two adjacent electrode wires. At the moment, the distance between two adjacent electrode wires is always kept equal, the unit volume of the solution between the two adjacent electrode wires is kept consistent, and the measured result is most accurate. Therefore, the equal interdigital depth D and the equal distance D between two adjacent electrode wires are important factors influencing the detection accuracy.
The offset distance is the difference between the depth D of the interdigital and the distance D between two adjacent electrode wires, and is shown in fig. 5 to 7, the offset distances are respectively 0mm, 3mm and 6mm, and the capacitance values are shown in table 1.
Offset distance 0 3mm 6mm
Capacitance x 10-12F 4.5987 3.5181 2.449
As can be seen from table 1, when the offset distance is 0, the capacitance value of the interdigital electrode is large. Therefore, the offset distance of the interdigital electrode is preferably 0, the sensitivity is highest, and the measured result is most accurate.
Specifically, the electrode line length L, the electrode line width W, the electrode line thickness T, the distance D between two adjacent electrode lines, and the interdigital depth D of the interdigital electrode are controlled according to a specific detection environment and the precision of the detection device.
In addition, the interdigital electrode shown in fig. 1 is a single-interdigital electrode, and when the detection device detects the resistance characteristic of the fluid, the sensitivity of the single-interdigital electrode is the best, and therefore, the interdigital electrode is preferably a single-interdigital electrode. When the detection device detects the capacitance characteristic of the fluid, the area of the capacitor plate formed by the multi-interdigital electrode is large, and therefore, the interdigital electrode is preferably a double-interdigital electrode as shown in fig. 8 or a three-interdigital electrode as shown in fig. 9.
Specifically, the shape memory material comprises one of shape memory alloy and shape memory polymer.
Preferably, the shape memory material has multiple shape memory functions. Thus, the shape memory material can be deformed many times during use. For example, the detection device is in a shape with larger volume like a tubular shape or a cylindrical shape when in use, and the shape memory material can remember a shape with smaller volume, so that the detection device is conveniently implanted into a lumen to be detected such as a blood vessel.
Wherein the shape memory alloy comprises titanium alloy and the like, and the shape memory alloy has flexibility.
The shape memory polymer includes cross-linked polyethylene, cross-linked polyolefins, ethylenic copolymers, polyurethane, polyester, and the like. Preferably a biodegradable shape memory polymer material such as cross-linked polylactic acid and the like.
Specifically, the shape memory material is one of a photo-induced shape memory material, a thermal-induced shape memory material and a chemical-induced shape memory material.
Wherein the shape of the light-induced shape memory material is changed in the wavelength range of 100 nm-450 nm, such as 6Az10-PVA, TCE ((tris (cinnamyl oxymethylethylene) ethane) and the like.
The thermotropic shape memory material changes shape within the temperature range of 0-200 ℃, such as polylactic acid, copolyamide, polyurethane and the like.
The chemical induction type shape memory material has shape change within the pH value range of 1.0-12.0, such as polyampholyte hydrogel, polyacrylamide and the like.
Specifically, the sensing unit 2 is provided with an external port 3, and the external port 3 is used for connecting an external device. The external equipment comprises equipment for detecting matched detection devices such as a power supply, an RFID signal transmitter and the like.
The detection device can be used for detecting various fluids such as blood, urine, spinal fluid, gastric juice and the like in vivo, and can also be used for detecting solutions in micro-channels and hoses in industry.
The fluid detection device can be deeply inserted into complex environments such as blood vessels and the like, is fixed at a specified position through the change of the shape of the substrate, and detects different models of the impedance of the fluid through the sensing unit at the fixed position, so that the problem of high difficulty in fixing the detection device in the complex environments such as the blood vessels and the like at present is solved, and the detection of various signals of the fluid by a single sensing unit can be realized. Meanwhile, through the shape memory function of the substrate, a three-dimensional and fine detection device can be prepared on the basis of the substrate with a two-dimensional structure such as a sheet structure, and the like, and a detection device with a complex shape such as a tubular shape can be obtained through the change of the shape of the substrate, so that the defect that the detection device with the complex shape such as the tubular shape cannot be prepared is overcome.
The invention also provides a preparation method of the fluid detection device, which comprises the following steps:
s1, providing a substrate, wherein the substrate is made of shape memory materials;
and S2, forming a sensing unit on the substrate, wherein the sensing unit comprises at least one electrode, and obtaining the detection device.
Preferably, the substrate is in a sheet shape in step S1. The sheet-shaped substrate has a two-dimensional plane, and a refined sensing unit can be prepared on the two-dimensional plane, so that the method is suitable for large-scale production and manufacturing. Thus, a refined detection device can be prepared.
In step S2, the forming method of the sensing unit includes a 3D printing method, a physical deposition method, a chemical deposition method, a transfer method, and the like, and the process is mature and reliable.
Preferably, step S3 is further included after step S2, and an external connection port is provided on the sensing unit.
The preparation method of the invention can be used for preparing a refined detection device, is simple, has mature process and is suitable for large-scale production and manufacture.
The invention also provides a device for detecting blood in a blood vessel, which comprises the device for detecting the fluid shown in the figure 1.
As shown in FIG. 10, the blood resistance R is macroscopically related to the plasma resistance RpIntracellular fluid resistance R of red blood celltAnd the cell membrane capacitance C of red blood cellsmIt is related. I.e. the equivalent circuit of blood is the red blood intracellular fluid resistance RtCell membrane capacitance C with red blood cellsmSeries connection with the plasma resistance RpAnd (4) connecting in parallel. In a circuit having a resistor and a capacitor, the resistance acting on the current in the circuit is called impedance. Therefore, according to the principle model shown in fig. 10, the blood can be detected by distributing the sensing unit 2 in the blood vessel to be in contact with the blood, and by different power supply modes of direct current or alternating current.
For example, an increase or decrease in the flow velocity of blood in a blood vessel causes an increase or decrease in the moving speed of electrolytes in blood, and thus the resistance value of the blood resistance R decreases or increases. Therefore, when the flow rate of blood is detected, direct current can be supplied to the detection device. At this time, the sensing unit 2 of the detection device is used as a resistor, and the resistance value is fixed, and after blood flows through the detection device and contacts the sensing unit 2, the circuit is turned on and the current in the circuit is blocked, so that the resistance value of the blood resistor R is obtained according to the current in the circuit, and further the relative flow velocity of the blood is obtained.
The plasma content is reduced or increased by increasing or decreasing the proportion of red blood cells in the blood per unit volume, the electrolytes in the plasma are reduced or increased by the unit volume, and the resistance value of the blood resistance R is increased or decreased. Therefore, when the concentration of red blood cells in blood is measured, direct current can be supplied to the measuring device. At this time, the sensing unit 2 of the detection device is a resistor with a fixed resistance value, and after blood flows through the detection device and contacts the sensing unit 2, the circuit is turned on to block the current in the circuit, so that the resistance value of the blood resistor R is obtained from the current in the circuit, and the relative proportion of red blood cells in the blood is obtained.
In blood, red blood cells may undergo disease deformation, such as spherical, ellipsoidal, target, sickle, etc., and different shapes may result in different capacitance characteristics of the red blood cell membrane. Therefore, when the shape of red blood cells in blood is detected, an alternating current can be supplied to the detection device. In this case, the sensing unit 2 serves as a plate of a capacitor, and the capacitance C is different from the cell membranemThe size of the red blood cell block current in the circuit, and the larger the capacitance, the larger the current in the circuit, so that the shape and density of the red blood cell can be judged according to the current in the circuit.
In the present embodiment, considering that the thickest diameter of the blood vessel of the human body is 1cm, it is preferable that the electrode line length L of the interdigital electrode is greater than 0 and equal to or less than 1 cm. Meanwhile, in consideration of the precision control of a detection device, the width W of the electrode wire of the interdigital electrode is 20-200 μm, the thickness T of the electrode wire of the interdigital electrode is 20-200 μm, the distance D between two adjacent electrode wires in the interdigital electrode is 20-200 μm, the interdigital depth D of the interdigital electrode is 20-200 μm, and the interdigital depth D is equal to the distance D between two adjacent electrode wires.
In this embodiment, the detection device is used for detecting a signal of blood in a blood vessel. Therefore, in consideration of the application environment of the detection device, in the process of delivering the detection device to a specified position of a blood vessel and expanding the substrate 1 in the blood vessel by applying conditions from the outside, the conditions for deforming the substrate 1 applied from the outside cannot cause side effects on the blood vessel, the human body, and the like.
Preferably, the shape memory material of the light-induced type has a shape change in a wavelength range of 360nm to 450nm, such as 6Az 10-PVA.
Preferably, the thermotropic shape memory material undergoes a shape change in a temperature range of 35 ℃ to 60 ℃, such as polylactic acid.
Preferably, the chemically-induced shape memory material undergoes shape change in a pH range of 2.0-5.0, such as polyampholyte hydrogel.
Meanwhile, the detection device has a length of 3.14cm or less and a thickness of 200 μm or less when detecting blood in a blood vessel, taking into consideration the diameter of the blood vessel. I.e. the maximum size of the detection device after deployment inside the blood vessel.
Therefore, the detection device for blood in blood vessel can obtain indexes of a series of components such as plasma, red blood cells and the like in blood, and non-macroscopic indexes such as flow rate, blood fat, electrolyte and the like of local blood at a designated position.
Hereinafter, the detection device, the method for manufacturing the same, and the detection device for blood in blood vessel will be further described by the following specific examples.
Example 1:
providing a shape memory material with a length of 3.5cm and a width of 1cm and a shape memory temperature of 60 ℃, wherein the shape memory material is a composite material of polylactic acid and nano HAP, and the addition amount of the nano HAP in the composite material is 30%. Using the shape memory material as a substrate, the memory shape of the substrate at 60 ℃ is set to a flat surface.
And printing a snake-shaped interdigital electrode on the surface of the substrate in a 3D printing mode to serve as a sensing unit, and correspondingly arranging an external port to obtain the detection device. The interdigital electrode is made of gold nano slurry, 3 pairs of electrode pairs of the interdigital electrode are made of gold nano slurry, the length L of an electrode wire is 0.8cm, the width W of the electrode wire is 50 micrometers, the depth D of the interdigital electrode is 50 micrometers, the thickness T of the electrode wire is 50 micrometers, and the gap D between every two adjacent electrode wires is 50 micrometers.
At normal temperature, the detection device is bent, combined with a vascular stent and implanted into a blood vessel.
The interdigital electrode on the detection device is heated in a blood vessel through an external microwave source, the temperature of the interdigital electrode is controlled to be 60 ℃, the substrate reaches the deformation temperature after the temperature of the interdigital electrode is raised, the substrate is unfolded in the blood vessel, and the side of the substrate, which is far away from the sensing unit, is attached to the inner wall of the blood vessel, so that the impedance of the directly contacted blood can be detected, and the condition of the blood can be analyzed.
Example 2:
the shape memory material is styrene-butadiene copolymer, and has a fixed phase of 120 deg.c and a reversible phase of 60 deg.c. The shape memory material is made into a sheet-like substrate, and the memory shape of the substrate at 120 ℃ is set to be an expanded cylindrical shape and the memory shape of the substrate at 60 ℃ is set to be a collapsed shape.
Printing a rectangular interdigital electrode on the surface of the substrate in a spraying mode to serve as a sensing unit, and correspondingly arranging an external port to obtain the detection device. The interdigital electrode is made of PEDOT materials, the number of pairs of electrode pairs of the interdigital electrode is 3, the length L of an electrode wire is 1cm, the width W of the electrode wire is 200 micrometers, the depth D of the interdigital electrode is 200 micrometers, the thickness T of the electrode wire is 200 micrometers, and the gap D between every two adjacent electrode wires is 200 micrometers.
Heating to 60 ℃ causes the substrate to collapse and then to be implanted into a hose for the discharge of industrial contaminated liquids.
When the waste liquid in the hose is gradually heated to 120 ℃, the substrate reaches the deformation temperature again, the substrate is unfolded in the hose to form a cylindrical shape, and the side of the substrate, which is away from the sensing unit, is attached to the inner wall of the hose, so that the impedance of the waste liquid in direct contact can be detected, and the condition of the waste liquid can be analyzed.
Example 3:
the shape memory material is TCE material, the fixed phase of the shape memory material is visible spectrum range larger than 400nm, and the reversible phase is 280nm-400n range. The shape memory material is made into a sheet-shaped substrate, and the memory shape of the substrate under the condition of 350nm is set to be an expanded cylindrical shape and to be a collapsed shape in a visible light range.
And printing a snake-shaped interdigital electrode on the surface of the substrate in a 3D printing mode to serve as a sensing unit, and correspondingly arranging an external port to obtain the detection device. The interdigital electrode is made of graphene conductive slurry, the number of pairs of electrode pairs of the interdigital electrode is 4, the length L of an electrode wire is 1cm, the width W of the electrode wire is 200 micrometers, the depth D of the interdigital electrode is 200 micrometers, the thickness T of the electrode wire is 200 micrometers, and the gap D between every two adjacent electrode wires is 200 micrometers.
The substrate is collapsed under visible light and then placed in a hose where organic solvents are photochemically decomposed.
When the device moves to a 350nm photochemical catalytic decomposition area, the substrate reaches a deformation condition, the substrate is unfolded in the hose to form a cylindrical shape, and the side of the substrate, which is far away from the sensing unit, is attached to the inner wall of the hose, so that the impedance of the directly contacted organic solution can be detected, and the decomposition condition of the organic solvent and the organic matter can be analyzed.
Example 4:
the shape memory material is chemical shape memory polymer polyampholyte hydrogel, and the reversible phase of the shape memory material is in a pH value range of 2.0-5.0. The shape memory material is made into a sheet-shaped substrate, and the memory shape of the substrate under the environment condition of pH value of 2.0-5.0 is set to be an expanded cylinder shape, and the substrate is set to be a collapsed shape within the range of pH value of 7.0-12.0.
And printing a snake-shaped interdigital electrode on the surface of the substrate in a 3D printing mode to serve as a sensing unit, and correspondingly arranging an external port to obtain the detection device. The material of the interdigital electrode is gold nano conductive slurry, the number of pairs of electrode pairs of the interdigital electrode is 2, the length L of an electrode wire is 0.5cm, the width W of the electrode wire is 200 micrometers, the depth D of the interdigital electrode is 200 micrometers, the thickness T of the electrode wire is 200 micrometers, and the gap D between two adjacent electrode wires is 200 micrometers.
The substrate is collapsed under pH of 7.0, and then made into capsule for swallowing into animal or human body.
When the device moves to a gastric juice (pH value is less than 5.0) area, the substrate reaches a deformation condition and is unfolded in the stomach to form a cylindrical shape so as to be suspended in the gastric juice, thereby detecting the impedance of the directly contacted gastric acid solution, analyzing the gastric acid components and judging whether diseases such as gastric hemorrhage, gastric ulcer and the like exist.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (17)

1. A device for detecting a fluid, the device comprising:
the material of the substrate is a shape memory material;
a sensing unit comprising at least one electrode, the sensing unit for detecting an impedance of a directly contacted fluid, the sensing unit disposed on the substrate;
wherein the substrate is capable of coordinating fluid detection by changing its shape.
2. The device for detection of a fluid according to claim 1, characterized in that said electrodes comprise interdigitated electrodes.
3. The device for detecting fluid according to claim 2, wherein the material of the interdigital electrode comprises one of a conductive polymer, a metal material, a metal paste, and a carbon-based conductive material.
4. The device for detecting a fluid according to claim 2, wherein the number of pairs of the electrode pairs of the interdigital electrodes is 3 to 4 pairs.
5. The device for detecting fluid according to claim 2, wherein the interdigital electrode has an interdigital depth D and a distance D between two adjacent electrode wires, wherein D is D and the offset distance is 0.
6. The device for detecting fluid of claim 1, wherein the shape memory material comprises one of a shape memory alloy and a shape memory polymer.
7. The device for detecting a fluid according to claim 1, wherein the shape memory material is one of a photo-induced shape memory material, a thermal-induced shape memory material, and a chemical-induced shape memory material.
8. The device for detecting a fluid according to claim 7, wherein the light-induced shape memory material undergoes a shape change in a wavelength range of 100nm to 450 nm;
the thermotropic shape memory material changes shape within the temperature range of 0-200 ℃;
the chemical induction type shape memory material is subjected to shape change within a pH value range of 1.0-12.0.
9. The device for detecting fluid according to claim 1, wherein the sensing unit is provided with an external port for connecting an external device.
10. A method for preparing a device for detecting the presence of a fluid according to any one of claims 1 to 9, characterized in that it comprises:
providing a substrate, wherein the material of the substrate is a shape memory material;
and forming a sensing unit on the substrate, wherein the sensing unit comprises at least one electrode to obtain a detection device.
11. The method for manufacturing a detection device of a fluid according to claim 10, wherein the substrate is in a sheet shape.
12. The method of manufacturing a device for detecting a fluid according to claim 11, wherein the method of forming the sensing unit includes one of a 3D printing method, a physical deposition method, a chemical deposition method, and a transfer method.
13. A device for detecting blood in a blood vessel, comprising a device for detecting a fluid according to any one of claims 1 to 9.
14. The device for detecting blood in a blood vessel according to claim 13, wherein the device has a length of 3.14cm or less and a thickness of 200 μm or less when detecting blood in a blood vessel.
15. The device for detecting blood in blood vessels according to claim 13, wherein the length L of the electrode wire of the interdigital electrode is greater than 0 and less than or equal to 1cm, and the width W of the electrode wire is 20 μm to 200 μm.
16. The device according to claim 13, wherein the depth D of the interdigital electrode is 20 μm to 200 μm, and the distance D between two adjacent electrode wires is 20 μm to 200 μm, wherein D is D and the offset distance is 0.
17. The device of claim 13, wherein the shape memory material changes shape over a wavelength range of 360nm to 450 nm;
the thermotropic shape memory material changes shape within the temperature range of 35-450 ℃;
the chemical induction type shape memory material is subjected to shape change within the pH value range of 2.0-5.0.
CN201811393947.8A 2018-11-21 2018-11-21 Fluid detection device, preparation method thereof and blood detection device in blood vessel Pending CN111202506A (en)

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