CN111202066B - Nontoxic bait produced by coating technology and affecting digestive system of mice - Google Patents

Nontoxic bait produced by coating technology and affecting digestive system of mice Download PDF

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Publication number
CN111202066B
CN111202066B CN202010110776.4A CN202010110776A CN111202066B CN 111202066 B CN111202066 B CN 111202066B CN 202010110776 A CN202010110776 A CN 202010110776A CN 111202066 B CN111202066 B CN 111202066B
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bait
mice
peroxide
organic acid
digestive system
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CN202010110776.4A
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CN111202066A (en
Inventor
张华伟
王佳建
卢洪斌
葛迎春
王春磊
王英爽
刘丽颖
韩冰
于海龙
林文华
樊殿佐
关丽萍
吴爽
宋显全
安允龙
刘金霞
李万龙
张少龙
宋久栋
朱遵山
胡明慧
孙黎明
栾媛
高俊峰
卫鑫
安永一
闫金
刘世一
魏金龙
陈保胜
朱遵福
孙志权
张鹏
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Heilongjiang Forest Industry Agrochemical Co ltd
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Heilongjiang Forest Industry Agrochemical Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
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  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
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  • Birds (AREA)
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Abstract

The invention discloses a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials at least comprise organic acid, peroxide and bait; the organic acid and the peroxide are respectively coated and treated by capsules. The bait adopts nontoxic raw materials, and the raw materials which are easy to cause mice to refuse to eat and eat less are wrapped by using capsules, after the mice eat the bait, digestion functions are destroyed, blockage and obstruction appear in intestinal tracts after taking the bait for multiple times, and then the mice die, the acute poisoning phenomenon can not appear in the death process, other mice in the population are not influenced, drug resistance can not be caused, the overall death rate is improved, and meanwhile, the bait has high safety to animals except mice, and can be popularized and used in various fields such as production, life and the like for a long time.

Description

Nontoxic bait produced by coating technology and affecting digestive system of mice
Technical Field
The invention relates to the field of rat damage prevention and control, in particular to a nontoxic bait which is produced by using a coating technology and affects the digestive system of rats.
Background
Mice are one of the fastest animals in mammals, have strong viability, often go to and from places with bacteria such as a sewer, a toilet, a kitchen and the like and clean places, spread pathogenic bacteria through mouse feet, body hair and gastric carryover, exist in any place where human beings live, and sometimes cause fire caused by biting wires; as a omnivorous animal with a very large population, mice also cause a large amount of grain loss every year, so that prevention and control of mice are particularly important.
Chemical deratization accounts for a large part in prevention and treatment of mice, acute bait has strong toxicity, mice have short death time, are easy to cause population alertness, and have poor overall deratization effect; chronic baits have reduced toxicity, but mice have strong reproductive ability, and after many generations, they have resistance to drugs, resulting in poor drug resistance, and in addition, such baits present a threat to animals other than mice.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides a nontoxic bait for influencing the digestive system of mice, which is produced by using a coating technique, wherein the preparation raw materials at least comprise organic acid, peroxide and bait; the organic acid and the peroxide are respectively coated and treated by capsules.
As a preferable technical scheme, the preparation raw materials at least comprise 1-50 parts by weight of organic acid, 1-50 parts by weight of peroxide and 100-500 parts by weight of bait.
As a preferred technical scheme, the organic acid is selected from one or more of citric acid, malic acid, oxalic acid, succinic acid, tartaric acid, ascorbic acid, quinic acid, shikimic acid, benzoic acid, salicylic acid, caffeic acid and chlorogenic acid.
As a preferable technical scheme, the peroxide is selected from one or more of sodium peroxide, potassium peroxide, calcium peroxide, barium peroxide, magnesium peroxide and zinc peroxide.
As a preferred embodiment, the bait comprises sugar; the sugar is selected from one or more of glucose, mannose, fructose, galactose, arabinose, xylose, starch, gum arabic, xanthan gum, dextran, mannan, galactan, and polyfructose.
As a preferred embodiment, the bait comprises oil; the oil is selected from one or more of adeps bovis seu Bubali, adeps Sus Domestica, adeps Caprae Seu Ovis, adeps Anas Domestica, oleum Angustifoliae, oleum gosling, oleum Rapae, oleum Arachidis Hypogaeae, oleum Sesami, oleum Olivarum, oleum Cocois, oleum Maydis, soybean oil, tea seed oil, palm oil, oleum Helianthi, oleum Juglandis, and oleum Ricini.
As a preferred embodiment, the bait comprises a high protein food; the high protein food is selected from one or more of livestock meat, fowl meat, eggs, fish, shrimp, beans, and nuts.
As a preferable technical scheme, the preparation raw material also comprises 0-10wt% of medicinal components in the total amount of the bait; the pharmaceutical ingredients are laxatives and/or cholinergic receptor blockers; the antidiarrheal is selected from loperamide hydrochloride, diphenoxylate and compound camphor tincture; the choline receptor blocking medicine is selected from one or more of atropine, scopolamine, anisodamine, procaine, belladonna tincture and mecamylamine.
As a preferable technical scheme, the preparation raw material also comprises water-absorbing substances, and the dosage of the water-absorbing substances accounts for 0 to 80 weight percent of the total weight of the bait.
The second aspect of the present invention provides a method for preparing the nontoxic bait which affects the digestive system of mice and is produced by using the coating technology, wherein the method comprises the steps of respectively coating organic acid and peroxide by capsules, and mixing raw materials.
The beneficial effects are that: the invention provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, which adopts nontoxic raw materials, and uses capsules to coat the raw materials which are easy to cause mice to refusal to eat and eat less, after the mice eat the bait, the digestive function is destroyed, the blockage and the obstruction appear in the intestinal tract after eating for multiple times, further the mice die, the acute poisoning phenomenon can not appear in the death process, the other mice in the population can not be affected, the drug resistance can not be caused, the overall death rate is improved, and meanwhile, the safety to animals except the mice is high, and the bait can be popularized and used in various fields such as production, life and the like for a long time.
Detailed Description
The disclosure of the present application will be further understood in conjunction with the following detailed description of the preferred embodiments of the application, including examples. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. If the definition of a particular term disclosed in the prior art is inconsistent with any definition provided in the present application, the definition of the term provided in the present application controls.
As used herein, unless the context clearly indicates otherwise, the absence of a limitation to a plurality of features is also intended to include the plurality of features. It will be further understood that the terms "made of …" and "comprising," as used herein, are synonymous with "including," "comprising," "having," "including," and/or "containing," and when used in this specification, mean the stated composition, step, method, article, or apparatus, but do not preclude the presence or addition of one or more other compositions, steps, methods, articles, or apparatus. Furthermore, when describing embodiments of the present application, the use of "preferred," "more preferred," etc. refers to embodiments of the present application that may provide certain benefits in some instances. However, other embodiments may be preferred under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the application.
In order to solve the above problems, a first aspect of the present invention provides a nontoxic bait for influencing the digestive system of mice, which is produced by using a coating technique, wherein the preparation raw materials at least comprise organic acid, peroxide and bait; the organic acid and the peroxide are respectively coated and treated by capsules.
The capsule coating treatment in the application refers to a treatment method for embedding and sealing solid, liquid or gas, and specifically can adopt a spray drying method, a spray congealing method, an air suspension method, a vacuum evaporation deposition method, a complex coacervation method, a multi-cavity centrifugation method, a water phase separation method, an oil phase separation method, a capsule core exchange method, an extrusion method, an interfacial polymerization method, an in-situ polymerization method and the like.
Since both the organic acid and the peroxide are water-soluble compounds, it is preferable to carry out capsule coating by an in-situ polymerization method, an oil phase separation method, an interfacial polymerization method, a spray drying method, and a spray congealing method.
Taking an in-situ polymerization method for preparing the organic acid capsule as an example, the preparation steps comprise mixing the organic acid and an initiator as capsule cores, dispersing the capsule cores in an oily solvent, dropwise adding a capsule shell resin monomer under the condition of heating and stirring, filtering, washing and drying after the reaction is finished, and obtaining the organic acid capsule. In the above method, the oily solvent may be vegetable oil, such as rapeseed oil, peanut oil, sesame oil, olive oil, coconut oil, corn oil, soybean oil, tea seed oil, palm oil, sunflower seed oil, walnut oil, castor oil, etc., and the shell resin monomer is preferably a mixture of methacrylic acid and methyl methacrylate, and a surfactant may be added appropriately to disperse the reaction system uniformly.
Taking a spray congealing method as an example, the preparation method comprises the steps of dispersing a peroxide capsule core in liquefied capsule shell resin, atomizing, and solidifying the capsule shell at a low temperature to form a capsule. In the above method, the liquefied shell resin may be a resin dissolved in an oily solvent or a heat-melted resin, and in order to reduce the use of the solvent, a heat-melted resin is preferable, wherein the resin is exemplified by Eudragit series products produced by Rohm Germany, and further preferable Eudragit S100; low temperature means not higher than 30 ℃.
The capsule isolates the organic acid from the peroxide, so that the stability and the safety of the bait in the storage and transportation process are ensured, the capsule can mask the smell of the active ingredients when in use, the capsule shell is stable under the acidic condition, the capsule core material can be slowly released under the alkaline condition, namely, the capsule can keep complete when passing through the stomach of a rat, the capsule can be gradually dissolved after entering the intestinal tract, the active ingredients have an effect in the intestinal tract, the death of the rat is delayed, and the alarm of the rat is avoided.
In some preferred embodiments, the preparation raw materials comprise at least 1 to 50 parts by weight of organic acid, 1 to 50 parts by weight of peroxide and 100 to 500 parts by weight of bait.
In some preferred embodiments, the preparation raw materials comprise at least 10-30 parts by weight of organic acid, 5-15 parts by weight of peroxide and 100-500 parts by weight of bait.
In some preferred embodiments, the organic acid is selected from the group consisting of citric acid, malic acid, oxalic acid, succinic acid, tartaric acid, ascorbic acid, quinic acid, shikimic acid, benzoic acid, salicylic acid, caffeic acid, chlorogenic acid; further preferably, the organic acid is selected from one or more of citric acid, malic acid, succinic acid and oxalic acid; still further, the organic acid is selected from one or more of citric acid, malic acid, oxalic acid.
In some preferred embodiments, the peroxide is selected from the group consisting of sodium peroxide, potassium peroxide, calcium peroxide, barium peroxide, magnesium peroxide, and zinc peroxide; further preferably, the peroxide is selected from one or more of sodium peroxide, potassium peroxide and calcium peroxide.
The weight parts of the organic acid and the peroxide in the application are calculated according to the dosage of the active ingredients before the capsule coating treatment.
In some preferred embodiments, the bait comprises sugar, oil, high protein foods.
In some preferred embodiments, the sugar is selected from the group consisting of glucose, mannose, fructose, galactose, arabinose, xylose, starch, gum arabic, xanthan gum, dextran, mannan, galactan, and polyfructose.
Examples of the sugar include white sugar, soft sugar, brown sugar, crystal sugar, brown sugar, yellow sugar, and powdered sugar, in addition to the above-mentioned types.
The oil in the present application refers to edible oil.
In some preferred embodiments, the oil is selected from the group consisting of tallow, lard, sheep oil, duck oil, goose oil, rapeseed oil, peanut oil, sesame oil, olive oil, coconut oil, corn oil, soybean oil, tea seed oil, palm oil, sunflower oil, walnut oil, castor oil; further preferably, the oil is selected from one or more of beef tallow, lard, mutton tallow, sesame oil, soybean oil, corn oil; still further, the oil is selected from lard and/or sesame oil.
In some preferred embodiments, the high protein food is selected from the group consisting of livestock meat, poultry meat, eggs, fish, shrimp, beans, nuts, and combinations thereof; further preferably, the high protein food is selected from one or more of chicken, duck, beef, pork, mutton, egg, duck egg, goose egg, fish meal, shrimp meal, soybean, mung bean, red bean, black bean, soybean, peanut, hazelnut, walnut, and almond; further, the high protein food is selected from one or more of chicken, egg, fish meal, and peanut.
In some preferred embodiments, the weight ratio of sugar, oil, high protein food is (4-12): (5-15): 1, a step of; further preferably, the weight ratio of sugar, oil and high protein food is 6:10:1.
Besides the effect of attracting mice to eat, the bait provided by the application can also cause constipation of mice because the ingredients of the bait have the characteristics of high sugar, high fat and high protein, the pH environment in the intestinal tract is destroyed after the organic acid in the bait is released, and the peroxide reacts with water in the intestinal tract to generate oxygen, so that the original anaerobic environment is changed, anaerobic flora in the intestinal tract is disordered, digestive function is disordered, intestinal obstruction is caused, and then intestinal necrosis, peritonitis and the like are developed, and finally the mice die, especially when the peroxide is used together with the reducing organic acid, the reaction for generating oxygen is accelerated, and the death time of the mice is shortened. In the production process, the dosage of the peroxide and the organic acid is controlled, so that extremely uncomfortable mice taking baits caused by excessive dosage are avoided, other mice in the population are further alerted to the extremely uncomfortable mice, and in addition, if the dosage of the peroxide relative to the organic acid is excessive, a large amount of alkali and the organic acid are generated to neutralize, and the effect of the organic acid is weakened.
The inventor finds that the ratio of sugar, oil and protein in the bait can adjust the feeding amount and death rate of mice, because the sugar can directly adjust the blood sugar content in the animal body, when the sugar is excessive, the mice are not easy to generate hunger sensation after feeding once, and the foods cannot be quickly accumulated in intestinal tracts; when the oil is excessive, insufficient absorption of grease by the intestinal tract can be discharged along with the excrement, the grease has a lubricating effect, intestinal obstruction is difficult to induce, and the death rate is reduced; when the protein is too much, it is not as fragrant as oil, and the attracting effect to mice is slightly low, and in addition, the production cost is increased.
In some preferred embodiments, the preparation raw material further comprises 0 to 10wt% of a pharmaceutical ingredient based on the total weight of the bait; the pharmaceutical ingredients are laxatives and/or cholinergic receptor blockers; the antidiarrheal is selected from loperamide hydrochloride, diphenoxylate and compound camphor tincture; the choline receptor blocking medicine is selected from one or more of atropine, scopolamine, anisodamine, procaine, belladonna tincture and mecamylamine.
The antidiarrheal or choline receptor blocking agent in the application can act on the positions of intestinal smooth muscle or ganglion, skeletal muscle nerve and the like, inhibit nerve receptors in intestinal tracts, weaken intestinal peristalsis, prolong the contact between intestinal contents and intestinal mucosa, promote the back absorption of moisture in the intestines, harden stool and further promote mice to produce intestinal blockage.
In some preferred embodiments, the preparation materials further comprise a water-absorbing material in an amount of 0 to 80wt% based on the total weight of the bait.
In some preferred embodiments, the water-absorbing substance is selected from the group consisting of acrylic resin, starch, magnesium aluminum silicate, xanthan gum, gum arabic, and a mixture of one or more of silica gel powders.
Because of the special structure, the water-absorbing substance can absorb water with high water absorption function which is hundreds to thousands times heavier than the water-absorbing substance, and has excellent water retention property, once the water-absorbing substance absorbs water and expands into hydrogel, the water-absorbing substance is difficult to separate out, when a rat eats the bait, the water-absorbing substance enters the rat body, the activity of hydrophilic groups is limited under an acidic environment, the expansion multiple is limited, the acting force between the acidic groups is weakened after the water-absorbing substance enters the intestinal tract, the molecular chains are spread, the expansion multiple is increased, food residues lose moisture and become dry and hard gradually, and the rat finally dies due to the intestinal block.
The second aspect of the present invention provides a method for preparing the nontoxic bait which affects the digestive system of mice and is produced by using the coating technology, wherein the method comprises the steps of respectively coating organic acid and peroxide by capsules, and mixing raw materials.
Examples
The technical scheme of the present invention is described in detail below by way of examples, but the scope of the present invention is not limited to the examples. The raw materials in the present invention are all commercially available unless otherwise specified.
Example 1
Example 1 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise 20 parts of organic acid, 10 parts of peroxide and 300 parts of bait in parts by weight.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
The invention also provides a preparation method of the nontoxic bait which is produced by using the coating technology and affects the digestive system of mice, and the preparation method comprises the steps of respectively coating organic acid and peroxide by capsules, and mixing the raw materials.
Deratization test: mice were dosed periodically and quantitatively with this example, 30 mice per group were tested, and the time to death and mortality were recorded, and the results are shown in Table 1.
TABLE 1
Example 2
Example 2 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise 20 parts of organic acid, 10 parts of peroxide, 0.5 part of antidiarrheal and 300 parts of bait according to parts by weight.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8; the antidiarrheal agent is diphenoxylate (CAS number 915-30-0).
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The present example was used for the deratization test, and the test method was the same as that of example 1, and the death rate was comparable to that of example 1, and the death time was slightly shortened.
Example 3
Example 3 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise, by weight, 20 parts of organic acid, 10 parts of peroxide, 0.5 part of antidiarrheal, 3 parts of water-absorbent resin and 300 parts of bait.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8; the antidiarrheal is diphenoxylate (CAS number 915-30-0); the water-absorbing resin is acrylic resin powder, and is purchased from Yibang environmental protection technology Co., ltd.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The present example was used for the deratization test, and the test method was the same as that of example 1, and the death rate was comparable to that of example 1, and the death time was slightly shortened.
Example 4
Example 4 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise, by weight, 20 parts of organic acid, 10 parts of peroxide, 3 parts of water-absorbent resin and 300 parts of bait.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8; the water-absorbing resin is acrylic resin powder, and is purchased from Yibang environmental protection technology Co., ltd.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The present example was used for the deratization test, and the test method was the same as that of example 1, and the death rate was comparable to that of example 1, and the death time was slightly shortened.
Example 5
Example 5 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise, by weight, 20 parts of organic acid, 10 parts of peroxide, 60 parts of xanthan gum and 300 parts of bait.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The present example was used for the deratization test, and the test method was the same as that of example 1, and the death rate was comparable to that of example 1, and the death time was slightly shortened.
Example 6
Example 6 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, wherein the preparation raw materials comprise 10 parts of organic acid, 5 parts of peroxide and 300 parts of bait in parts by weight.
The organic acid is oxalic acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The oxalic acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of oxalic acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The present example was used for the deratization test, and the test method was the same as that of example 1, and the death rate was comparable to that of example 1, and the death time was slightly shortened.
Comparative example 1
Comparative example 1 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, and the preparation raw materials comprise 20 parts of organic acid and 300 parts of bait in parts by weight.
The organic acid is citric acid; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The invention also provides a preparation method of the nontoxic bait which is produced by using the coating technology and affects the digestive system of mice, and the bait is mixed with organic acid after being coated by capsules.
The test method is the same as that of the example 1, the death time of 3 groups of test mice is more than 7 days, and the death rate is lower than 60%.
Comparative example 2
Comparative example 2 provides a nontoxic bait which affects the digestive system of mice produced using coating technology, wherein the preparation raw materials comprise 10 parts of peroxide and 300 parts of bait in parts by weight.
The peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
The invention also provides a preparation method of the nontoxic bait which is produced by using the coating technology and affects the digestive system of mice, and the bait is obtained by mixing peroxide after capsule coating treatment.
The test method is the same as that of the example 1, the death time of 3 groups of test mice is more than 7 days, and the death rate is lower than 60%.
Comparative example 3
Comparative example 3 provides a nontoxic bait which is produced by using a coating technology and affects the digestive system of mice, and the preparation raw materials comprise 20 parts of organic acid, 30 parts of peroxide and 300 parts of bait in parts by weight.
The organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8.
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, adding 40g of capsule shell resin monomer (the mixture of methacrylic acid and methyl methacrylate with the molar ratio of 1:2) under the stirring condition, continuously stirring for 8 hours under the constant temperature condition of 65 ℃, standing, cooling, filtering, washing with water, and drying to obtain the finished product.
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
This example also provides a method of preparing a non-toxic bait affecting the murine digestive system produced using the coating technique as described above, similar to example 1.
The test method is the same as that of the example 1, the death time of 3 groups of test mice is more than 7 days, and the death rate is lower than 60%.
Example 7
Example 7 provides a bait comprising white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanut is 6:10:0.2:0.8.
Comparative example 4
Comparative example 4 provides a bait comprising white granulated sugar, lard, fish meal and peanut, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanut is 15:10:0.2:0.8.
Comparative example 5
Comparative example 5 provides a bait comprising white granulated sugar, lard, fish meal and peanut, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanut is 6:20:0.2:0.8.
Example 1, example 6, comparative example 4, comparative example 5 were used for feeding 140g-160g of test mice, the observation time was 24 hours, 15g were dosed, 5 mice were tested for each example, the feeding amount and the defecation amount were recorded, and the average value is recorded in table 2.
TABLE 2
Examples Food intake Defecation amount
Example 1 8.0g/24h 5.1g/24h
Example 7 8.2g/24h 7.3g/24h
Comparative example 4 6.6g/24h 6.2g/24h
Comparative example 5 8.5g/24h 8.1g/24h
It can be seen from examples 1 to 6 that the non-toxic bait for influencing the digestive system of mice produced by using the coating technique provided by the application can effectively kill mice, and suitable baits can be selected according to the degree of the mice. According to comparison of the embodiment 1 and the embodiment 7, after the organic acid and the peroxide coated by the capsule are added into the bait, the mice are not suspicious, the digestion function of the mice is destroyed after the normal feeding, the defecation amount is reduced, intestinal obstruction is caused by accumulation of hard feces in intestinal tracts after a few days, the mice are further killed, the phenomena of acute poisoning and the like of the mice in the death process are avoided, the other mice in the population are not influenced, and the overall death rate is improved. In addition, the bait in the application adopts low-toxicity or nontoxic raw materials, has higher safety to animals except mice, can kill mice by acting on the digestive system of the mice, can not cause the mice to generate drug resistance, and can be popularized and used for a long time.
The foregoing examples are illustrative only and serve to explain some features of the method of the invention. The appended claims are intended to claim the broadest possible scope and the embodiments presented herein are merely illustrative of selected implementations based on combinations of all possible embodiments. It is, therefore, not the intention of the applicant that the appended claims be limited by the choice of examples illustrating the features of the invention. Some numerical ranges used in the claims also include sub-ranges within which variations in these ranges should also be construed as being covered by the appended claims where possible.

Claims (4)

1. The nontoxic bait which is produced by using a coating technology and affects the digestive system of mice is characterized in that the preparation raw materials comprise 20 parts of organic acid, 10 parts of peroxide and 300 parts of bait by weight;
the organic acid is citric acid; the peroxide is sodium peroxide; the bait comprises white granulated sugar, lard, fish meal and peanuts, wherein the weight ratio of the white granulated sugar to the lard to the fish meal to the peanuts is 6:10:0.2:0.8;
The citric acid is coated by capsules, and the method comprises the following steps: uniformly mixing 5g of citric acid, 0.2g of ammonium persulfate and 0.6g of sodium stearate, adding into 110g of rapeseed oil, heating to 65 ℃, and adding 40g of capsule shell resin monomer under stirring; the capsule shell resin monomer comprises the following components in percentage by mole: 2, mixing methacrylic acid with methyl methacrylate; continuously stirring at 65 ℃ for 8 hours, standing, cooling, filtering, washing with water, and drying to obtain the product;
The sodium peroxide is subjected to capsule coating treatment, and the method comprises the following steps of: 5g of sodium peroxide was dispersed in 40g of molten Eudragit S100, atomized by an atomizer and coagulated at 30℃to form capsules.
2. The non-toxic bait for influencing the digestive system of mice produced by using the coating technique according to claim 1, wherein the preparation raw material further comprises 0-10 wt% of pharmaceutical ingredients based on the total weight of the bait; the pharmaceutical ingredients are laxatives and/or cholinergic receptor blockers; the antidiarrheal is selected from loperamide hydrochloride, diphenoxylate and compound camphor tincture; the choline receptor blocking medicine is selected from one or more of atropine, scopolamine, anisodamine, procaine, belladonna tincture and mecamylamine.
3. The non-toxic bait for influencing the digestive system of mice produced by using the coating technique according to claim 1, wherein the preparation raw material further comprises a water-absorbing substance in an amount of 0 to 80wt% based on the total amount of the bait.
4. A method for preparing a nontoxic bait for influencing the digestive system of mice, which is produced by the coating technique as claimed in any one of claims 1 to 3, wherein the organic acid and the peroxide are respectively coated by capsules and then mixed with raw materials.
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