CN111195259A - 一种氯化锶与d-泛醇复合制剂的制备方法及其抗敏修复的应用 - Google Patents
一种氯化锶与d-泛醇复合制剂的制备方法及其抗敏修复的应用 Download PDFInfo
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Abstract
本发明公开了一种氯化锶与D‑泛醇复合制剂的制备方法及其抗敏修复的应用,属于药品、化工以及个人护理品行业。基础配方,包括以下组分:去离子水50‑80份、氯化锶1‑5份、D‑泛醇2‑10份、辛酰羟肟酸0.1‑1份、1,2己二醇0.1‑1份。制备方法:A、准备原料:B、灭菌处理;C、制得类D‑泛醇水溶液;D、制得氯化锶水溶液;E、氯化锶水溶液抽入乳化锅中,搅拌均匀;F、将辛酰羟肟酸0.1‑1份、1,2己二醇0.1‑1份加入乳化锅中,搅拌均匀,送检复合理化指标后,出料。本发明本发明氯化锶与D‑泛醇的复配,能够起到更高的协同效果,针对敏感性皮肤的消费群体在使用过程中感觉到愉悦,更是一种能够完全发挥其作用的复配。
Description
技术领域
本发明涉及一种复合制剂,尤其涉及一种氯化锶与D-泛醇复合制剂的制备方法及其抗敏修复的应用,属于药品、化工以及个人护理品行业。
背景技术
化妆品使用不当会引起皮肤过敏、瘙痒、脱屑、红肿、红血丝等现象发生。***2003和2004年统计显示,接触性皮炎在六大类化妆品皮肤病中最常见,其发病率分别占化妆品皮肤总发病率的 82.6%和93.3%。化妆品接触性皮炎的常见致敏原主要比例如:30%-40%为防腐剂、20%-30%为香精香料、15%-20%为表面活性剂、还有防晒剂、抗氧化剂、抗菌剂等,而这些成分均为化妆品中常用添加剂。再加上部分商家为了追求利益,违规添加使部分人群的肤质越来越差,同时皮肤又经常暴露于紫外线、微生物、微粒的环境下,皮肤的敏感性愈来愈加重,皮肤敏感也越来越受到人们的重视。
防止皮肤过敏的途径有很多,主要大致分为;远离过敏原、使用抗组胺物质、清除自由基、抑制过敏因子、增加皮肤屏障功能这几大类。
专利CN 1864661A一种高效去渍增白牙膏及其制造方法中有提到采用氯化锶作为一种脱敏剂,可减少牙本质在酸、冷、热、甜刺激、刷牙、咬物时产生的酸痛,起脱敏镇痛作用;D-泛醇起到一种抗炎修复剂,主要起防止牙龈炎症,出血,增强牙周组织再生功效,令牙齿坚固,亮白。但专利CN 1864661A仅仅应用于牙膏行业,且氯化锶与D-泛醇在专利CN 1864661A里面仅仅起到辅助的效果。锶离子对皮肤有镇静抗敏的效果,D-泛醇能够修复上皮组织、消炎,起到修复皮肤屏障的功能。氯化锶与D-泛醇复配组合成制剂后应用于皮肤的抗敏测试起到的较好的效果,本发明阐述了氯化锶与D-泛醇复配成制剂后应用于皮肤,起到抗敏修复的效果。
发明内容
本发明的目的在于提供一种氯化锶与D-泛醇复合制剂的制备方法及其抗敏修复的应用,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
方案:
本发明的一种氯化锶与D-泛醇复合制剂的制备方法及其抗敏修复的应用的基础配方,按重量份计,包括以下组分:去离子水50-80份、氯化锶1-5份、D-泛醇2-10份、辛酰羟肟酸0.1-1 份、1,2己二醇0.1-1份
本发明的一种氯化锶、泛醇复合制剂的制备方法包括以下步骤:
A、按照以下组分及其重量准备原料:
去离子水50-80份、氯化锶1-5份、D-泛醇2-10份、辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份;
B、将去离子水50-80份加入乳化锅中,升温至85-90℃,保温20min做灭菌处理,制得灭菌水后降温室温待用;
C、将D-泛醇2-10份加入乳化锅中,加入制备好的灭菌水30-40份,抽真空至-0.1MPa,用4000rpm高速均质5min,制得类D-泛醇水溶液;
D、将氯化锶1-5份加入至水锅中,加入制备好的灭菌水30-40份,恒温控制在35℃-45℃,保温2H,制得氯化锶水溶液;
E、乳化锅抽真空至-0.1MPa,利用负压将锅中的氯化锶水溶液抽入乳化锅中,搅拌均匀;
F、将辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份加入乳化锅中,搅拌均匀,送检符合理化指标后,出料。
与现有技术相比,本发明的有益效果是:本发明氯化锶与D-泛醇的复配,能够起到更好的协同效果,不仅针对敏感性皮肤的消费群体在使用过程中感觉到愉悦,更是一种能够完全发挥其作用的复配制剂,不仅作用于人体皮肤表面,更能够保证在被皮肤吸收之后对人体不会产生危害。本发明可作用于直接涂抹,亦可作为药品、化工以及个人护理品行业的原料添加剂、制备方法简单,生产周期短、处方精简、适用人群。
具体实施方式
下面将结合本发明实施例对本发明的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
目前市场上的抗敏成分大可分为2种:中草药抗敏成分和化学合成抗敏成分,中草药抗敏需要添加量高,且容易出现析出、色差等问题,化学合成抗敏成分品种较多,效果优异的价格昂贵,且大部分都是通过抑制炎症因子的分泌。本发明从上皮组织与皮下组织展开了研究,通过锶离子对皮肤起到防护作用,且锶离子能够使皮肤的敏感度降低,通过作用于人体,减少人体钾离子通道的释放,并被皮肤吸收作用完之后能够随着血液循环补充体内的锶离子,起到保健品的功效;D-泛醇作为维生素B5的前体,不仅能够起到保湿,修复上皮组织之外,被皮肤少量吸收后能够转换为体内的营养物质,使人体的免疫力提高,达到保护皮肤及细胞粘膜的作用。氯化锶与D-泛醇的复配,能够起到更高的协同效果,不仅针对敏感性皮肤的消费群体在使用过程中感觉到愉悦,更是一种能够完全发挥其作用的复配制剂,不仅作用于人体皮肤表面,更能够保证在被皮肤吸收之后对人体不会产生危害。本发明可作用于直接涂抹,亦可作为药品、化工以及个人护理品行业的原料添加剂、制备方法简单,生产周期短、处方精简、适用人群广。
具体实施方式:
实施例1去离子水50-80份、氯化锶1份、D-泛醇2份、辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份;
实施例2去离子水50-80份、氯化锶2份、D-泛醇4份、辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份;
实施例3去离子水50-80份、氯化锶3份、D-泛醇8份、辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份;
实施例4去离子水50-80份、氯化锶5份、辛酰羟肟酸0.1-1份、1,2己二醇0.1-1份
实施案例1-4均通过以下步骤制备
将去离子水加入乳化锅中,升温至85℃,保温20min,做灭菌处理,降温至室温、分别加入 D-泛醇抽真空至-0.1MPa,用4000rpm高速均质5min,再将氯化锶加入乳化锅中搅拌均匀,最后将辛酰羟肟酸1,2己二醇加入乳化锅中,搅拌均匀,送检合格后出料
测试方法具体如下:
将中心装有100μL试验溶液的过滤器粘附在共20名受试者(每组5名)的皮肤上24小时,然后除去过滤器,测评皮肤反应的程度(具体的分组及测试敏感源如下所示)
表1
测试评价标记注解如下所示
标记 | 等级 | 评判准则 |
+ | 1 | 轻微红斑,无论是斑点状或弥漫性 |
++ | 2 | 中度均匀红斑 |
+++ | 3 | 强烈的红斑伴水肿 |
++++ | 4 | 强烈的红斑伴水肿和囊泡 |
- | 0 | 无刺激,无反应 |
表2
测试结果如下表
A组临床皮肤试验结果
表3
B组临床皮肤试验结果
表4
C组临床皮肤试验结果
表5
D组临床皮肤试验结果
表6
由上述结果所示,AB组的结果最佳,C组次之,D组效果较差,表明氯化锶与D-泛醇复配之后可以起到协同效果,使抗敏效果加强。
为了进一步验证氯化锶与D-泛醇的复配性能,故进行了二次试验,试验方法如下;随机抽取45位志愿者,年龄18-35岁,男女各15名,脸部皮肤均有相似的受损,其分为使用实施方案1、使用实施方案2和不使用任何修复产品的空白例。
使用方法:清水洁面后,将每组对应的产品均匀的涂抹在脸部上,轻轻按摩至吸收即可,每天早晚两次,连续使用7天,记录治疗效果。
疗效评价:利用红肿消退的情况来进行功效评价,分别为显著、有效与无效三个等级。其中显著是指红肿消退40%及以上,症状减轻;有效是指红肿消退15%-40%,症状改善;无效是指红肿消退小于15%,症状未改善。
具体疗效如下表所示:
表7
结果显示:本发明提供的抗敏修复皮肤损伤的复配制剂的治疗效果显著。由侧面反馈氯化锶的添加量过高,容易导致离子的渗透性过快,引起不适感;反应了没有氯化锶的复配下D-泛醇的抗敏性能几乎没有;但当氯化锶与D-泛醇复配之后,对于皮肤的红肿情况的消退效果显著,由表3可得出当氯化锶与D-泛醇按实施案例2复配时的性能得到最佳,氯化锶与D-泛醇的复配,能够起到更高的协同效果,不仅针对敏感性皮肤的消费群体在使用过程中感觉到愉悦,更是一种能够完全发挥其作用的复配制剂,不仅作用于人体皮肤表面,更能够保证在被皮肤吸收之后对人体不会产生危害。
Claims (1)
1.一种氯化锶与D-泛醇复合制剂的制备方法及其抗敏修复的应用,其特征在于基础配方和制备方法,的基础配方,按重量份计,包括以下组分:
去离子水 50-80份、氯化锶 1-5份 、D-泛醇 2-10份、辛酰羟肟酸 0.1-1份、1,2己二醇0.1-1份;
制备方法,包括以下步骤:
A、按照以下组分及其重量准备原料:
去离子水 50-80份、氯化锶 1-5份 、D-泛醇 2-10份、辛酰羟肟酸 0.1-1份、1,2己二醇0.1-1份;
B、将去离子水 50-80份加入乳化锅中,升温至85-90℃,保温20min做灭菌处理,制得灭菌水后降温室温待用;
C、将D-泛醇 2-10份加入乳化锅中,加入制备好的灭菌水30-40份,抽真空至-0.1MPa,用4000rpm高速均质5min,制得类D-泛醇水溶液;
D、将氯化锶1-5份加入至水锅中,加入制备好的灭菌水30-40份,恒温控制在35℃-45℃,保温2H,制得氯化锶水溶液;
E、乳化锅抽真空至-0.1MPa,利用负压将锅中的氯化锶水溶液抽入乳化锅中,搅拌均匀;
F、将辛酰羟肟酸 0.1-1份、1,2己二醇 0.1-1份加入乳化锅中,搅拌均匀,送检符合理化指标后,出料。
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