CN111175371A - Two-dimensional focusing scanning magnetic acoustic imaging device - Google Patents
Two-dimensional focusing scanning magnetic acoustic imaging device Download PDFInfo
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- CN111175371A CN111175371A CN202010028022.4A CN202010028022A CN111175371A CN 111175371 A CN111175371 A CN 111175371A CN 202010028022 A CN202010028022 A CN 202010028022A CN 111175371 A CN111175371 A CN 111175371A
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- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/725—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables by using magneto-acoustical effects or the Barkhausen effect
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Abstract
A magnetoacoustic imaging device for two-dimensional focusing scanning comprises an excitation source, a phase-locked amplifier, an acquisition card and a computer, wherein the excitation source, the phase-locked amplifier, the acquisition card and the computer are sequentially connected in series and used for storing measurement data acquired by the acquisition card and displaying a reconstructed magnetoacoustic image, a measured sample is arranged on a two-dimensional translation platform and used for realizing two-dimensional scanning of the measured sample, two corresponding sides of the measured sample are respectively provided with a magnet N pole and a magnet S pole, the other two corresponding sides of the measured sample are respectively provided with a positive electrode and a negative electrode, the positive electrode is connected with the excitation source, the negative electrode is grounded, the direction of the excitation electrode is perpendicular to the direction of a static magnetic field, a scanning assembly is arranged above the measured sample, and the output end of the scanning. The invention can realize the high-precision magnetoacoustic signal pickup from the surface of the sample by carrying out two-dimensional focusing scanning and weak signal detection on the magnetoacoustic signal generated by the laminar sample under the current excitation, improves the magnetoacoustic imaging image quality and has positive significance for realizing in-vivo imaging.
Description
Technical Field
The present invention relates to a magnetoacoustic imaging apparatus. In particular to a magnetoacoustic imaging device with two-dimensional focusing scanning.
Background
Magnetoacoustic imaging is a novel tissue electrical characteristic functional imaging method, and medical applications such as early diagnosis of tumors and the like are realized by converting electrical characteristic parameters of tissues into acoustic signal response. The method can realize the spatial resolution of the tissue function imaging at millimeter level and is beneficial to realizing the high-precision conductivity imaging of the tissue because the electromagnetic field is converted into the sound wave.
The circular scanning mode commonly used at present is relatively complex, and the signal lines applying excitation and the like can generate noise and influence the detection and imaging quality, particularly for lamellar tissues, circular scanning. Therefore, the research and design of the magnetoacoustic imaging device with a novel scanning mode has positive significance for improving the image quality and realizing in-vivo imaging.
Disclosure of Invention
The invention aims to provide a magnetoacoustic imaging device which can improve the image quality and realize two-dimensional focusing scanning of in-vivo imaging.
The technical scheme adopted by the invention is as follows: a magnetoacoustic imaging device for two-dimensional focusing scanning comprises an excitation source for providing continuous wave excitation signals, a phase-locked amplifier for detecting amplitude measurement data of weak magnetoacoustic signals of a measured sample, an acquisition card for acquiring the amplitude measurement data output by the phase-locked amplifier, and a computer for storing the measurement data acquired by the acquisition card and displaying a reconstructed magnetoacoustic image, wherein the measured sample is arranged on a two-dimensional translation stage and used for performing two-dimensional motion on the measured sample in x and y directions to realize the two-dimensional scanning of the measured sample, two sides corresponding to the measured sample are respectively provided with a magnet N pole and a magnet S pole for generating static magnetic fields, the other two corresponding sides of the measured sample are respectively provided with a positive electrode and a negative electrode, the positive electrode is connected with the excitation source and used for applying excitation signals of the excitation source to the measured sample, the negative electrode is grounded, the direction of the excitation electrode is vertical to the direction of the static magnetic field, a scanning assembly for performing two-dimensional scanning on the sample to be measured to obtain magnetoacoustic signals is arranged above the sample to be measured, and the output end of the scanning assembly is connected with the phase-locked amplifier.
The scanning component comprises an acoustic lens group which is arranged above the measured sample and used for focusing the acoustic beam at the position corresponding to the measured sample, an acoustic probe which is used for measuring the magnetoacoustic signal generated by the focus point at the position corresponding to the measured sample is arranged above the acoustic lens group, and the output end of the acoustic probe is connected with the phase-locked amplifier.
The acoustic lens group is provided with 2 from top to bottom.
The acoustic lens group and the acoustic probe are respectively fixed on an adjusting device which is used for adjusting the position of the acoustic probe and the z axis of each lens in the acoustic lens group so as to focus the acoustic beam on one point.
The control end of the adjusting device is connected with the computer, and the computer controls the adjustment of the adjusting device according to the received amplitude measurement data of the measured sample.
The two-dimensional translation bench is fixed and is provided with the base, the positive electrode and the negative electrode that are surveyed sample and are located two corresponding avris of surveyed sample set up the base on, the magnet N pole and the magnet S pole that are located two other corresponding avris of surveyed sample are fixed the two-dimensional translation bench on.
The magnetoacoustic imaging device for two-dimensional focusing scanning disclosed by the invention can realize the purpose of picking up high-precision magnetoacoustic signals from the surface of a sample by carrying out two-dimensional focusing scanning and weak signal detection on magnetoacoustic signals generated by a layered sample under the excitation of current, improves the magnetoacoustic imaging image quality and has positive significance for realizing in-vivo imaging.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a two-dimensional focused scanning magnetoacoustic imaging device according to the present invention;
fig. 2 is a schematic diagram of the scanning measurement process of the measured sample in the present invention.
In the drawings
1: excitation source 2: phase-locked amplifier
3: and (4) acquisition card: computer with a memory card
5: positive electrode 6: negative electrode
7: two-dimensional translation stage 8: base seat
9: magnet N pole 10: magnet S pole
11: acoustic lens group 12: acoustic probe
13: the adjusting device 14: sample to be measured
Detailed Description
The two-dimensional focus scanning magnetoacoustic imaging apparatus of the present invention will be described in detail with reference to the following embodiments and the accompanying drawings.
As shown in fig. 1, the magnetoacoustic imaging device of two-dimensional focused scanning of the present invention includes an excitation source 1 for providing continuous wave excitation signals, a lock-in amplifier 2 for detecting amplitude measurement data of weak magnetoacoustic signals of a sample 14 to be measured, an acquisition card 3 for acquiring the amplitude measurement data output by the lock-in amplifier 2, and a computer 4 for storing the measurement data acquired by the acquisition card 3 and displaying reconstructed magnetoacoustic images, which are connected in series in sequence, the sample 14 to be measured is disposed on a two-dimensional translation stage 7 for performing two-dimensional motion of the sample 14 to be measured in x and y directions to realize two-dimensional scanning of the sample 14 to be measured, two corresponding sides of the sample 14 to be measured are respectively provided with a magnet N pole 9 and a magnet S pole 10 for generating static magnetic fields, two other corresponding sides of the sample 14 to be measured are respectively provided with a positive electrode 5 and a negative electrode 6, the positive electrode 5 and the negative electrode 6 are rectangular strips and are matched with the size of a measured sample, the positive electrode 5 is connected with the excitation source 1 and is used for applying an excitation signal of the excitation source 1 to the measured sample 14, the negative electrode 6 is grounded, the direction of the excitation electrode is perpendicular to the direction of a static magnetic field, a scanning assembly used for performing two-dimensional scanning on the measured sample 14 to obtain a magnetoacoustic signal is arranged above the measured sample 14, and the output end of the scanning assembly is connected with the phase-locked amplifier 2.
As shown in fig. 1 and fig. 2, the scanning assembly includes an acoustic lens group 11 disposed above the measured sample 14 for focusing an acoustic beam at a position corresponding to the measured sample 14, an acoustic probe 12 for measuring a magnetoacoustic signal generated by a focus point at a position corresponding to the measured sample 14 is disposed above the acoustic lens group 11, and an output end of the acoustic probe 12 is connected to the lock-in amplifier 2. The acoustic lens assembly 11 is provided with more than 2 from top to bottom. The acoustic lens group 11 and the acoustic probe 12 are respectively fixed on an adjusting device 13 for adjusting the z-axis position of the acoustic probe 12 and each lens in the acoustic lens group 11 to focus the acoustic beam on one point.
The control end of the adjusting device 13 is connected to the computer 4, the computer 4 controls the adjusting device, the focal lengths of the two acoustic focusing lenses are F1 and F2, and the distance between the two lenses is D, so that the distance between the nearest lens and the sample is F1 × F2/(F1+ F2-D).
The two-dimensional translation platform 7 is fixedly provided with a base 8, the measured sample 14 and the positive electrode 5 and the negative electrode 6 which are positioned on two corresponding sides of the measured sample 14 are arranged on the base 8, and the magnet N pole 9 and the magnet S pole 10 which are positioned on the other two corresponding sides of the measured sample 14 are fixed on the two-dimensional translation platform 7.
As shown in fig. 2, when the magnetoacoustic imaging apparatus with two-dimensional focus scanning detects a sample 14 to be detected, the sample 14 to be detected is divided into several regions, and the adjusting device 13 controls the acoustic probe 12 and the acoustic lens assembly 11 to perform two-dimensional scanning on the surface of the sample 14 to be detected. The acoustic probe 12 is connected to the lock-in amplifier 2, while the lock-in amplifier 2 is synchronized with the driver 1. The phase-locked amplifier 2 detects the acoustic signals, the acquisition card 3 acquires data and transmits the data to the computer 4, and the computer 4 records the x and y two-dimensional position of the two-position translation stage 7 and the measured acoustic signal amplitude. And finally, reconstructing an image by the computer according to the amplitude of the acoustic signal at the x and y positions of each two-dimensional scan.
In the embodiment of the invention, the excitation source can be realized by adopting a WF1973 function generator of NF company. The lock-in amplifier can be realized by an LI5620 digital lock-in amplifier of NF company. The acquisition card can be implemented by PXI5122 from NI corporation. The acoustic probe can be implemented by A303SU from Panametrics, Inc., and the acoustic lens is implemented by CRYSTAL acoustic lens from STP, Inc. The adjusting device is realized by adopting large constant photoelectricity GCM-085820M, the two-dimensional translation table can be manufactured by adopting an MGN7C guide rail, the N pole and the S pole of the magnet can be realized by adopting an N35 strong magnet, the positive electrode and the negative electrode can be manufactured by adopting copper foils, and the base can be manufactured by adopting a polytetrafluoroethylene plate. The two-dimensional translation stage is realized by adopting a large constant photoelectric GCM120302 AM.
The working process of the magnetoacoustic imaging device of the two-dimensional focusing scanning of the invention is,
and horizontally placing a to-be-imaged sample on the base, placing the base between the N pole of the magnet and the S pole of the magnet, and fixing the base, the N pole of the magnet and the S pole of the magnet on the two-dimensional translation table. And applying an excitation signal of the excitation source to a sample to be tested through the positive electrode and the negative electrode, so that the direction of the excitation electrode is perpendicular to the direction of the static magnetic field. And adjusting the adjusting device to control the z-axis position of each lens in the acoustic probe and the acoustic lens group so as to focus the acoustic beam at one point. And the x and y positions are adjusted by the two-dimensional translation stage. And dividing the measured sample into a plurality of regions, and controlling the acoustic probe and the lens group to perform two-dimensional scanning on the surface of the measured sample by the two-position translation stage. The acoustic probe is connected with the phase-locked amplifier, and the phase-locked amplifier is synchronous with the excitation source. The phase-locked amplifier detects the acoustic signal, the acquisition card acquires data and transmits the data to the computer, and the computer records the x and y two-dimensional position of the two-position translation stage and the measured acoustic signal amplitude. And finally, reconstructing an image by the computer according to the amplitude of the acoustic signal at the x and y positions of each two-dimensional scan.
Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope and spirit of the invention as set forth in the claims that follow.
Claims (6)
1. A magnetoacoustic imaging device for two-dimensional focusing scanning comprises an excitation source (1) for providing continuous wave excitation signals, a phase-locked amplifier (2) for detecting amplitude measurement data of weak magnetoacoustic signals of a sample to be measured (14), an acquisition card (3) for acquiring the amplitude measurement data output by the phase-locked amplifier (2), and a computer (4) for storing the measurement data acquired by the acquisition card (3) and displaying reconstructed magnetoacoustic images, which are sequentially connected in series, wherein the sample to be measured (14) is arranged on a two-dimensional translation stage (7) and used for enabling the sample to be measured (14) to perform two-dimensional motion in x and y directions so as to realize two-dimensional scanning of the sample to be measured (14), and two corresponding static magnets of the sample to be measured (14) are respectively provided with a magnet N pole (9) and a magnet S pole (10) for generating a magnetic field, the other two corresponding sides of the sample (14) are respectively provided with a positive electrode (5) and a negative electrode (6), the positive electrode (5) is connected with the excitation source (1) and is used for applying an excitation signal of the excitation source (1) to the sample (14), the negative electrode (6) is grounded, the direction of the excitation electrode is perpendicular to the direction of a static magnetic field, a scanning assembly for performing two-dimensional scanning on the sample (14) to be measured to obtain a magnetoacoustic signal is arranged above the sample (14), and the output end of the scanning assembly is connected with the phase-locked amplifier (2).
2. The magnetoacoustic imaging device of claim 1, wherein the scanning assembly includes an acoustic lens assembly (11) disposed above the sample (14) for focusing an acoustic beam at a position corresponding to the sample (14), an acoustic probe (12) for measuring a magnetoacoustic signal generated by a focus point at a position corresponding to the sample (14) is disposed above the acoustic lens assembly (11), and an output end of the acoustic probe (12) is connected to the lock-in amplifier (2).
3. A two-dimensional focus-scanning magnetoacoustic imaging device according to claim 2, wherein said acoustic lens group (11) is provided with 2 from top to bottom.
4. A magnetoacoustic imaging device for two-dimensional focused scanning according to claim 2, wherein said acoustic lens assembly (11) and acoustic probe (12) are fixed to an adjusting device (13) for adjusting the z-axis position of the acoustic probe (12) and lenses of the acoustic lens assembly (11), respectively, to focus the acoustic beam at a point.
5. A magnetoacoustic imaging device with two-dimensional focused scanning according to claim 4, characterized in that the control terminal of the adjusting device (13) is connected to the computer (4), and the computer (4) controls the adjustment of the adjusting device according to the received amplitude measurement data of the measured sample (14).
6. The magnetoacoustic imaging device of two-dimensional focused scanning according to claim 1, wherein a base (8) is fixedly arranged on the two-dimensional translation stage (7), the sample (14) to be measured and the positive electrode (5) and the negative electrode (6) which are positioned at two corresponding sides of the sample (14) to be measured are arranged on the base (8), and the magnet N pole (9) and the magnet S pole (10) which are positioned at the other two corresponding sides of the sample (14) to be measured are fixed on the two-dimensional translation stage (7).
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| CN202010028022.4A CN111175371A (en) | 2020-01-10 | 2020-01-10 | Two-dimensional focusing scanning magnetic acoustic imaging device |
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Cited By (2)
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| CN112683992A (en) * | 2020-12-22 | 2021-04-20 | 中国医学科学院生物医学工程研究所 | Positioning device and method capable of simultaneously detecting magnetic acoustic signals and electric field by noise-containing shielding |
| CN113729716A (en) * | 2021-09-30 | 2021-12-03 | 中国医学科学院生物医学工程研究所 | Magnetic-acoustic imaging device for brain of small animal |
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