CN111171955A - Water-soluble compound essential oil for livestock and poultry as well as preparation method and application thereof - Google Patents

Water-soluble compound essential oil for livestock and poultry as well as preparation method and application thereof Download PDF

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Publication number
CN111171955A
CN111171955A CN202010041050.XA CN202010041050A CN111171955A CN 111171955 A CN111171955 A CN 111171955A CN 202010041050 A CN202010041050 A CN 202010041050A CN 111171955 A CN111171955 A CN 111171955A
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parts
oil
livestock
poultry
water
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王占锋
方建军
张健
张晓波
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Kaifeng Jiajun Biotechnology Co Ltd
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Kaifeng Jiajun Biotechnology Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00Essential oils; Perfumes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/111Aromatic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses water-soluble compound essential oil for livestock and poultry, which relates to the technical field of livestock and poultry breeding and comprises 3-6 parts of oregano oil, 2-4 parts of cinnamaldehyde, 2-4 parts of peppermint oil, 1.5-3 parts of tea tree oil, 3-6 parts of eucalyptus oil, 3.5-7 parts of lemon oil, 25-45 parts of an emulsifier, 2-3 parts of a co-emulsifier, 2-3 parts of a surfactant and 5-10 parts of absolute ethyl alcohol. The water-soluble compound essential oil for livestock and poultry is a green and safe substitute of antibiotics, can improve the immunity and resistance of livestock and poultry, reduces the morbidity, improves the production performance, and has high absorption rate and utilization rate of the essential oil, safety, environmental protection and stable drug effect.

Description

Water-soluble compound essential oil for livestock and poultry as well as preparation method and application thereof
Technical Field
The invention relates to the technical field of livestock and poultry breeding, in particular to water-soluble compound essential oil for livestock and poultry and a preparation method and application thereof.
Background
With the improvement of the living standard of people and the enhancement of self-health care consciousness, when people select livestock and poultry products, the livestock and poultry products are required to be rich in nutrition and safe, sanitary and health-care, and the most fundamental one is no drug residue. In recent years, the abuse and overproof use of antibiotics become main causes of drug residues in animal products, and the food safety is seriously threatened.
The plant essential oil is concentrated essence obtained by extracting Chinese herbal medicine plants in nature, and has the advantages of resisting bacteria and viruses, enhancing the immune function of animal organisms, improving the anti-stress capability of animals, improving the production performance of animals and the like. The Chinese herbal medicine essential oil can effectively improve the immunity of livestock and poultry and prevent and treat diseases, can replace antibiotics, is green and environment-friendly, and is safe and harmless to human bodies.
Therefore, the water-soluble compound essential oil for livestock and poultry, which is green and environment-friendly, safe and harmless to human bodies and can replace antibiotics to be used, is developed to improve the immunity of livestock and poultry, and has important economic value and environmental protection significance in the modern society.
Disclosure of Invention
The invention aims to: the water-soluble compound essential oil for livestock and poultry, as well as the preparation method and the application thereof, is a green and safe substitute of antibiotics, can improve the immunity and the resistance of livestock and poultry, reduce the morbidity, improve the production performance, and has high absorptivity and utilization rate of the essential oil, safety, environmental protection and stable drug effect.
The technical scheme adopted by the invention is as follows:
in order to achieve the purpose, the invention provides water-soluble compound essential oil for livestock and poultry, which comprises 3-6 parts of oregano oil, 2-4 parts of cinnamaldehyde, 2-4 parts of peppermint oil, 1.5-3 parts of tea tree oil, 3-6 parts of eucalyptus oil, 3.5-7 parts of lemon oil, 25-45 parts of an emulsifier, 2-3 parts of a co-emulsifier, 2-3 parts of a surfactant and 5-10 parts of absolute ethyl alcohol.
The emulsifier used in the invention is polypropylene glycol 6000, the co-emulsifier is aluminum stearate, and the surfactant is a condensation product of alkylphenol and ethylene oxide.
Oregano oil has antibacterial and bacteriostatic effects and is effective in clearing heat, eliminating dampness, dispelling summerheat, relieving exterior syndrome, and regulating qi.
Cinnamaldehyde has antibacterial, disinfectant and antiviral effects, and can inhibit Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Staphylococcus albus, Shigella dysenteriae, typhoid fever, Bacillus paratyphi, pneumococcus, aerobacter, Proteus, Bacillus anthracis, Salmonella enteritidis, and Vibrio cholerae; the cinnamaldehyde is an aromatic stomach-invigorating and pathogenic-expelling agent, has mild stimulation effect on intestines and stomach, can promote secretion of saliva and gastric juice, and can enhance digestive function.
Peppermint oil has the functions of treating wind-heat type common cold, early warm disease, liver depression, qi stagnation, chest distress, hypochondriac pain and the like.
Tea tree oil is a natural disinfectant, and has antibacterial, antiinflammatory, anthelmintic, and refreshing effects.
Eucalyptus oil can effectively relieve nasal sinus infection, influenza, bronchitis, common cold nasal obstruction and other respiratory system diseases, and has good antibacterial and bactericidal properties.
The lemon oil has fragrant and pleasant smell, has the effects of relieving asthma, eliminating phlegm, relieving cough, relieving pain, resisting bacteria and diminishing inflammation, promoting gastrointestinal peristalsis, promoting secretion of digestive juice and the like, and after the lemon oil is added, the inherent fragrant substances of the lemon oil can blend the taste of the compound essential oil, so that the compound essential oil can be more easily accepted by livestock and poultry when in use.
Preferably, the water-soluble compound essential oil for livestock and poultry comprises 6 parts of oregano oil, 2 parts of cinnamaldehyde, 2 parts of peppermint oil, 3 parts of tea tree oil, 5 parts of eucalyptus oil, 7 parts of lemon oil, 40 parts of an emulsifier, 3 parts of a co-emulsifier, 3 parts of a surfactant and 10 parts of absolute ethyl alcohol.
The invention also provides a preparation method of the water-soluble compound essential oil for livestock and poultry, which comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, a co-emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing and packaging to obtain the water-soluble compound essential oil for livestock and poultry.
Preferably, adding absolute ethyl alcohol, emulsifying and shearing for 1-2 h, then adding purified water to a required volume, continuing emulsifying and shearing for 1-2 h, and then subpackaging.
The invention also provides application of the water-soluble compound essential oil for livestock and poultry in improving the immunity of the livestock and poultry.
Preferably, the water-soluble compound essential oil for livestock and poultry is applied by spraying, adding into drinking water or serving as a feed additive.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the water-soluble essential oil solves the problem of inconvenient administration of the essential oil, can be used as a feed additive in the conventional livestock and poultry breeding production process, and can be smoothly realized through two administration ways of drinking water and spraying, so that the administration is more convenient and quicker.
2. Compared with the prior art, the water-soluble essential oil has low absorptivity after oral administration due to the fact that the essential oil belongs to fat-soluble substances, the absorptivity and the utilization rate of the essential oil are obviously improved after the essential oil is emulsified by a special process, the usage amount and the cost are reduced, and meanwhile, the drug effect is obvious.
3. The water-soluble essential oil has scientific and reasonable formula and mutual synergistic effect, has the effects of resisting bacteria and diminishing inflammation, relieving pain and cough, promoting qi circulation and eliminating dampness, clearing heat and removing toxicity, and activating blood and regulating qi, can improve the immunity and resistance of livestock and poultry, reduces the morbidity and improves the production performance.
4. The water-soluble essential oil disclosed by the invention is safe and environment-friendly in components, stable in drug effect and harmless to a human body, and is a green and safe substitute of antibiotics.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A water-soluble compound essential oil for livestock and poultry comprises 3 parts of oregano oil, 3 parts of cinnamaldehyde, 2 parts of peppermint oil, 1.5 parts of tea tree oil, 4 parts of eucalyptus oil, 3.5 parts of lemon oil, 25 parts of an emulsifier, 2 parts of a co-emulsifier, 2 parts of a surfactant and 5 parts of absolute ethyl alcohol.
A preparation method of water-soluble compound essential oil for livestock and poultry comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, an auxiliary emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing for 1h, then adding purified water to a required volume, continuing to emulsify and shear for 1h, and then subpackaging to obtain the water-soluble compound essential oil for livestock and poultry.
Example 2
The water-soluble compound essential oil for livestock and poultry comprises 4 parts of oregano oil, 2 parts of cinnamaldehyde, 3 parts of peppermint oil, 2 parts of tea tree oil, 3 parts of eucalyptus oil, 5 parts of lemon oil, 30 parts of an emulsifier, 2 parts of a co-emulsifier, 2 parts of a surfactant and 5 parts of absolute ethyl alcohol.
A preparation method of water-soluble compound essential oil for livestock and poultry comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, an auxiliary emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing for 2 hours, then adding purified water to a required volume, continuing to emulsify and shear for 2 hours, and subpackaging to obtain the water-soluble compound essential oil for livestock and poultry.
Example 3
The water-soluble compound essential oil for livestock and poultry comprises 6 parts of oregano oil, 2 parts of cinnamaldehyde, 2 parts of peppermint oil, 3 parts of tea tree oil, 5 parts of eucalyptus oil, 7 parts of lemon oil, 40 parts of an emulsifier, 3 parts of a co-emulsifier, 3 parts of a surfactant and 10 parts of absolute ethyl alcohol.
A preparation method of water-soluble compound essential oil for livestock and poultry comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, an auxiliary emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing for 2 hours, then adding purified water to a required volume, continuing to emulsify and shear for 2 hours, and subpackaging to obtain the water-soluble compound essential oil for livestock and poultry.
Example 4
The water-soluble compound essential oil for livestock and poultry comprises 6 parts of oregano oil, 4 parts of cinnamaldehyde, 4 parts of peppermint oil, 3 parts of tea tree oil, 6 parts of eucalyptus oil, 6 parts of lemon oil, 45 parts of an emulsifier, 3 parts of a co-emulsifier, 3 parts of a surfactant and 8 parts of absolute ethyl alcohol.
A preparation method of water-soluble compound essential oil for livestock and poultry comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, an auxiliary emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing for 1.5h, then adding purified water to a required volume, continuing to emulsify and shear for 1.5h, and subpackaging to obtain the water-soluble composite essential oil for livestock and poultry.
Example 5
The water-soluble compound essential oil for livestock and poultry comprises 3 parts of oregano oil, 3 parts of cinnamaldehyde, 3 parts of peppermint oil, 2 parts of tea tree oil, 5 parts of eucalyptus oil, 5 parts of lemon oil, 35 parts of an emulsifier, 2 parts of an auxiliary emulsifier, 2 parts of a surfactant and 10 parts of absolute ethyl alcohol.
A preparation method of water-soluble compound essential oil for livestock and poultry comprises the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, an auxiliary emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing for 1.5h, then adding purified water to a required volume, continuing to emulsify and shear for 1.5h, and subpackaging to obtain the water-soluble composite essential oil for livestock and poultry.
Test examples
150 healthy pigs of three months of age were selected and randomly divided into 3 treatment groups, 50 pigs per treatment group. Wherein the treatment group 1 is a control group, and the water-soluble compound essential oil is not added into drinking water; treatment groups 2 and 3 were test groups to which 0.8% and 0.4% of the water-soluble complex essential oil of the present invention was added to drinking water, respectively. The same grain was fed, 20 days later, feces were taken aseptically, and escherichia coli and salmonella in the feces were detected, with the results shown in table 1.
TABLE 1 control results of bacteria detection in feces
Figure BDA0002367773000000041
As can be seen from Table 1, after the water-soluble compound essential oil disclosed by the invention is used, the number of escherichia coli and salmonella is obviously reduced compared with that of an unadditized control group, and the water-soluble compound essential oil is beneficial to growth and reproduction of beneficial bacteria in intestinal tracts, improvement of intestinal microecology, maintenance of intestinal health, effective inhibition of growth and reproduction of partial pathogenic bacteria in the intestinal tracts, improvement of immunity of livestock and poultry, resistance of virus and pathogenic bacteria and reduction of morbidity and mortality of the livestock and poultry.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; these modifications and substitutions do not cause the essence of the corresponding technical solution to depart from the scope of the technical solution of the embodiments of the present invention, and are intended to be covered by the claims and the specification of the present invention.

Claims (6)

1. The water-soluble compound essential oil for livestock and poultry is characterized by comprising 3-6 parts of oregano oil, 2-4 parts of cinnamaldehyde, 2-4 parts of peppermint oil, 1.5-3 parts of tea tree oil, 3-6 parts of eucalyptus oil, 3.5-7 parts of lemon oil, 25-45 parts of an emulsifier, 2-3 parts of a co-emulsifier, 2-3 parts of a surfactant and 5-10 parts of absolute ethyl alcohol.
2. The water-soluble composite essential oil for livestock and poultry according to claim 1, which comprises 6 parts of oregano oil, 2 parts of cinnamaldehyde, 2 parts of peppermint oil, 3 parts of tea tree oil, 5 parts of eucalyptus oil, 7 parts of lemon oil, 40 parts of an emulsifier, 3 parts of a co-emulsifier, 3 parts of a surfactant and 10 parts of absolute ethyl alcohol.
3. A preparation method of water-soluble compound essential oil for livestock and poultry is characterized by comprising the following steps: sequentially adding oregano oil, cinnamaldehyde, peppermint oil, tea tree oil, eucalyptus oil and lemon oil into a liquid preparation tank with an emulsifying head, stirring and mixing uniformly, then adding an emulsifier, a co-emulsifier and a surfactant into the tank, emulsifying, shearing and mixing uniformly, then adding absolute ethyl alcohol, emulsifying, shearing and packaging to obtain the water-soluble composite essential oil for livestock and poultry according to claim 1 or 2.
4. The preparation method of the water-soluble compound essential oil for livestock and poultry as claimed in claim 3, wherein the absolute ethyl alcohol is added, emulsification and shearing are carried out for 1-2 h, then the purified water is added to a required volume, and the emulsification and shearing are carried out for 1-2 h, and then the split charging is carried out.
5. Use of the water-soluble compound essential oil for livestock and poultry according to claim 1 or 2 or the water-soluble compound essential oil for livestock and poultry prepared by the method according to claim 3 or 4 for improving immunity of livestock and poultry.
6. The use of the water-soluble compound essential oil for livestock and poultry according to claim 1 or 2 or the water-soluble compound essential oil for livestock and poultry prepared by the method according to claim 3 or 4, wherein the water-soluble compound essential oil for livestock and poultry is used by spraying, adding into drinking water or serving as a feed additive.
CN202010041050.XA 2020-01-15 2020-01-15 Water-soluble compound essential oil for livestock and poultry as well as preparation method and application thereof Pending CN111171955A (en)

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Publication number Priority date Publication date Assignee Title
CN111513211A (en) * 2020-06-01 2020-08-11 广州市天朝生物科技有限公司 Water-soluble nutrient essential oil for livestock and poultry and aquaculture and preparation method and application thereof
CN114468129A (en) * 2021-12-31 2022-05-13 山西瑞象生物药业有限公司 Plant essential oil microemulsion feed additive and preparation method and application thereof
WO2024028179A1 (en) * 2022-08-04 2024-02-08 Juan Antonio Santisteban Ortiz Biocidal composition

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CN108014170A (en) * 2016-11-04 2018-05-11 珠海天凯生物科技有限公司 Wild marjoram oil emu and preparation method thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111513211A (en) * 2020-06-01 2020-08-11 广州市天朝生物科技有限公司 Water-soluble nutrient essential oil for livestock and poultry and aquaculture and preparation method and application thereof
CN114468129A (en) * 2021-12-31 2022-05-13 山西瑞象生物药业有限公司 Plant essential oil microemulsion feed additive and preparation method and application thereof
WO2024028179A1 (en) * 2022-08-04 2024-02-08 Juan Antonio Santisteban Ortiz Biocidal composition

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Application publication date: 20200519