CN111122264B - Pathological section material comprehensive management system - Google Patents
Pathological section material comprehensive management system Download PDFInfo
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- CN111122264B CN111122264B CN201911312371.2A CN201911312371A CN111122264B CN 111122264 B CN111122264 B CN 111122264B CN 201911312371 A CN201911312371 A CN 201911312371A CN 111122264 B CN111122264 B CN 111122264B
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- 230000001575 pathological effect Effects 0.000 title claims abstract description 55
- 239000000463 material Substances 0.000 title claims abstract description 32
- 238000003860 storage Methods 0.000 claims abstract description 195
- 239000011521 glass Substances 0.000 claims abstract description 161
- 238000001035 drying Methods 0.000 claims abstract description 66
- 230000005540 biological transmission Effects 0.000 claims abstract description 25
- 238000010330 laser marking Methods 0.000 claims description 41
- 238000003825 pressing Methods 0.000 claims description 25
- 238000012546 transfer Methods 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000007664 blowing Methods 0.000 claims description 6
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- 238000009413 insulation Methods 0.000 claims description 4
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- 238000007648 laser printing Methods 0.000 claims description 3
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/30—Computing systems specially adapted for manufacturing
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Abstract
The invention relates to a pathological section material comprehensive management system, which mainly comprises an information management module, a slide glass storage marking module, a wax block storage module and a section drying module, wherein the information management module is fixed on the slide glass storage marking module, the lower end of the slide glass storage marking module is fixedly connected with the wax block storage module, the lower end of the wax block storage module is fixedly connected with the drying module, and the pathological section material comprehensive management system has the advantages that: through the mutual cooperation of each device hardware and unit spare in the system, guarantee the accuracy that whole section process information pairs, use automatic mechanism to reduce unnecessary manual operation, improve work efficiency, reduce its maloperation, the setting up of its data transmission interface can be used to monitor management device's state, with user interaction and control data transmission, can look over the section progress of sample at any time, every section operation history of digitization lets the section result traceable, has realized visual management.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a comprehensive management system for pathological section materials.
Background
The pathological technique is an important branch in pathology, is a methodology in pathological research and is the basis of pathological diagnosis. The current pathological techniques comprise conventional pathology, special staining, cell slice making, immunohistochemistry, molecular diagnosis technology, electron microscopy and the like, wherein the conventional pathology is the most basic and the most important part.
In conventional pathology, pathological sections of a certain size of lesion tissue are prepared by histopathology, and the lesion tissue is embedded in paraffin blocks, sliced by a microtome, stained, and further examined by a microscope. Finally making pathological diagnosis according to the occurrence and development process of the pathological changes. The rinsing, baking, staining and the like of pathological tissues are important processes before the pathological tissues are delivered to doctors for reading and diagnosis, and the treatment quality of the pathological tissues directly determines whether the doctors can make accurate judgment on diseases. During the preparation, the pathological tissues or organs with partial pathological changes are treated by various chemicals and embedding methods, are fixed and hardened, cut into slices on a slicer, adhered on a glass slide, dyed with various colors and examined under a microscope to observe pathological changes and make pathological diagnosis, thereby providing help for clinical diagnosis and treatment.
Chinese patent document CN: CN107640450B discloses a pathological section storage box, a box body and a cover body are movably connected through a flat cable installation rotary connecting frame, a cover body groove is arranged on the inner side of the cover body, a control key group is arranged in the cover body groove, a battery group is arranged at the bottom of the box body and is connected with a controller through a lead, a connecting wire is arranged in the winding displacement installation rotary connecting frame, one end of the connecting wire is connected with the controller, the other end of the connecting wire is connected with the control key group, a slice storage device is arranged in the box body at the upper part of the battery group, the device mainly solves the defect that the traditional pathological section storage box is inconvenient to store and take out, simultaneously changes the defect that the traditional pathological section storage box is fixedly arranged, however, the device is only a partial improvement on the box body, and cannot independently complete a whole set of automatic processing system for pathological section management.
In view of the above, a comprehensive management system for pathological section materials is invented to facilitate centralized management of pathological section manufacturing materials, simplify the preparation process of pathological sections, and improve the automation and informatization degree of pathological section management, and no report is found about the novel comprehensive management system for pathological section materials at present.
Disclosure of Invention
The invention aims to provide a comprehensive management system for pathological section materials aiming at the defects in the prior art, so as to facilitate the centralized management of pathological section manufacturing materials, simplify the preparation process of pathological sections and improve the automation and the informatization degree of pathological section management.
In order to achieve the purpose, the invention adopts the technical scheme that:
a comprehensive management system for pathological section materials mainly comprises an information management module, a glass slide storage marking module, a wax block storage module and a section drying module, wherein the information management module is fixed on the glass slide storage marking module, the lower end of the glass slide storage marking module is fixedly connected with the wax block storage module, and the lower end of the wax block storage module is fixedly connected with the drying module; the information management module comprises a shell A, a control panel, a display, a processor mainboard and a data transmission interface, wherein the display is arranged on the side of the shell, the control panel is arranged on the right side of the display, an operation key is arranged on the control panel, the display and the data transmission interface are both positioned on the processor mainboard, and the processor mainboard is positioned in the shell;
the glass slide storage and marking module comprises a laser marking module and a glass slide storage module, wherein the laser marking module mainly comprises a shell B, two guide slide rods, a laser marking head and a driving device, the driving device is positioned inside the laser marking module, the two guide slide rods are fixedly arranged in the shell, a rack is arranged between the two guide slide rods, the laser marking head is arranged on the rack, the contact end of the laser marking head is also provided with two connecting blocks, through holes penetrating through the connecting blocks vertically are formed in the connecting blocks, and the two guide slide rods penetrate through the two connecting blocks behind the laser marking head and are connected with the laser marking head;
the glass slide storage module consists of a glass slide storage rack conveying belt, a glass slide storage rack transfer area, a glass slide storage rack storage area, a glass slide loading rack, a glass slide propelling device and a glass slide loading rack ejecting device; the glass slide storage rack unloading area comprises a shell C, an ejection groove A, a bin door, a spring pressing block and limiting blocks, the ejection groove A is located at one end of the upper surface of the shell C, the glass slide loading rack is ejected out of the ejection groove A, grooves are formed in the periphery of one side inside the shell C, the limiting blocks and the spring pressing block are located in different grooves, the limiting blocks and the spring pressing block are located on the same horizontal line, the limiting blocks and the spring pressing block are arranged on two corresponding grooves in the front and at the back of one side inside the shell C, the spring pressing block and the limiting blocks are of symmetrical structures, the glass slide loading rack is located between the spring pressing block and the limiting blocks, a partition bar, a glass slide and a stop block are arranged on the glass slide loading rack, the partition bar is located at the left end and the right end of the glass slide loading rack, the number of the glass slides is 8-12, the number of the stop blocks is 16-24, an ejection groove B is further formed below the glass slide loading frame, a glass slide loading frame ejection device is arranged in the ejection groove B and comprises a base and an ejection block, the ejection block is located in the base, and the ejection groove B is arranged in a shell C; a glass slide storage rack is further arranged inside the shell C and used for containing a glass slide loading rack, a glass slide pushing device is arranged on the other side of the shell C and comprises a pushing block, an elastic push rod and a push plate, one end of the elastic push rod is connected with the push plate, an elastic push rod channel is arranged in the pushing block, a quadrilateral groove C is formed in the joint of the pushing block and the other end of the elastic push rod, a connecting hole is formed in the groove C, the other end of the elastic push rod enters the elastic push rod channel through the connecting hole in the groove C and is connected with the pushing block, the push plate is located in the glass slide storage rack inside the shell C, and a bin door is further arranged on one side face of the shell C; the storage area of the glass slide storage rack comprises a glass slide storage rack and glass slide storage rack conveying belts arranged at the upper end and the lower end of the glass slide storage rack, wherein rollers are arranged inside the glass slide storage rack conveying belts and are respectively positioned at the left side and the right side inside the glass slide storage rack conveying belts; the left and right sides of the storage area of the glass slide storage rack are respectively connected with the laser marking module and the glass slide propelling device, and the front and the back of the storage area of the glass slide storage rack are respectively connected with the transfer area of the glass slide storage rack and the sealing plate;
the wax block storage module comprises a wax block storage shell, a wax block storage cabinet, a wax block pushing device, a wax block storage groove and a bin gate, wherein the wax block storage shell is of a cubic structure, the front surface of the wax block storage shell is uniformly provided with slotted holes of the wax block storage groove, the number of the slotted holes is 12-20, one end of the wax block storage groove is connected with the bin gate, the bin gate is provided with a sliding rod, one end of the sliding rod is fixedly connected with the bin gate, the connecting part of the sliding rod at the other end of the sliding rod is also provided with a sliding rail, two sides of the sliding rail are provided with rails, and the size of the rails is matched with the connecting part of the sliding rod and is arranged on two sides of the wax block storage groove; the other end of the wax block storage tank is connected with a wax block propelling device, a rotating shaft is arranged in the wax block propelling device, rollers and rolling shafts which are equidistant are arranged on the rotating shaft, the rollers and the rolling shafts are fixedly connected together, 2-4cm intervals are reserved between each roller and the next roller, 4-6 rollers are arranged on each rotating shaft, the wax block propelling device is positioned on the rollers on the rotating shaft, the rotating shafts are arranged at the front and back positions in the wax block propelling device, the rotation is realized through the rollers and the rolling shafts, and the number of the wax block propelling device is respectively consistent with the number of the slotted holes and the number of the wax block storage tank;
the slice drying module comprises a slice drying bin, a drawing box, a heat transfer net, a drying bracket and a drying bin door, wherein a heat insulation layer is arranged between the outer wall and the inner wall of the slice drying bin, a heating panel is also arranged on the inner wall of the slice drying bin, an air blowing device is arranged in the slice drying bin, the heat transfer net is fixedly arranged on two side faces of the inner wall of the slice drying bin, a sliding groove is arranged on the heat transfer net, the drawing box is positioned in the slice drying bin, two sides of the drawing box are positioned on the sliding groove, the drying bracket is transversely arranged in the slice drying bin and is connected with the heat transfer net through the sliding groove, the drying brackets can be arranged into a plurality of parts as required, the drying brackets are positioned in the drawing box, one side face of the drying bin door is connected with the slice drying bin through a hinge, and an observation window and a handle are also arranged outside the drying bin door; the processor mainboard is also provided with a slice information management unit element, an infrared identification unit element, a heating device unit element, a refrigerating device unit element, a laser printing device unit element and a power control element.
In the above comprehensive pathological section material management system, as a preferred embodiment, the data transmission interface is configured to transmit all data information of the comprehensive pathological section material management system.
In the above comprehensive pathological section material management system, as a preferred scheme, the number of the elastic push rods is 2-4, and the number of the elastic push rod channels in the propulsion block is matched with the number of the elastic push rods.
In the above pathological section material comprehensive management system, as a preferable scheme, the slide storage rack conveyor belts are uniformly arranged with baffles, the number of the baffles on each slide storage rack conveyor belt is set to 8-12, the baffle spacing distance is greater than the width of one slide storage rack, and one slide storage rack is controlled between every two upper and lower baffles on the right opposite sides of the slide storage rack conveyor belts at the upper and lower ends.
In the pathological section material comprehensive management system, as a preferable scheme, the baffles on the upper slide storage rack conveying belt and the lower slide storage rack conveying belt are vertically symmetrical, and the number of the baffles on the slide storage rack conveying belts is kept consistent.
In the above comprehensive pathological section material management system, as a preferred solution, the slides loaded on the slide rack are arranged longitudinally in a single row, and each slide on the slide rack is separated by a stop block, and the stop block limits the movement direction of the slide to be only upward.
In the above comprehensive pathological section material management system, as a preferred embodiment, the wax block pushing device is composed of a conveyer belt with a baffle and a driving device, the driving device drives the conveyer belt to move to drive the baffle to push forward, and the baffle pushes forward the wax blocks in the wax block storage tank.
The invention has the advantages that:
1. the device has solved traditional pathological section save set and has accomodate and take out inconvenient defect, adopts electric control automatic giving, and its a plurality of wax stone storage device's setting makes things convenient for it to seek, and the device setting of the refrigeration that sets up and heating has satisfied some special pathological section and has needed to carry out the demand of preserving under specific temperature.
2. The invention integrates the storage of the pathological section glass slide and the wax block, the marking of the glass slide and the drying of the prepared pathological section, so that the whole preparation process of the pathological section is more uniform and ordered.
3. The invention adopts an information management technology, so that the information of each delivered slide glass after laser marking can be stored, and the operator, the operation time and the like of each pathological section can be traced from an information management system of the device, thereby facilitating the management of pathological information.
Drawings
FIG. 1 is a schematic structural diagram of a comprehensive management system for pathological section materials in the invention.
Fig. 2 is a schematic structural diagram of an information management module and a slide storage marking module according to the present invention.
Fig. 3 is a schematic structural view of a slide storage marking module according to the present invention.
Fig. 4 is a schematic structural diagram of a laser marking module on the slide storage marking module according to the present invention.
Fig. 5 is a schematic structural diagram of a laser marking head on the laser marking module of the present invention.
Fig. 6 is a schematic diagram of a motherboard structure inside the information management module according to the present invention.
Figure 7 is a schematic view of the slide storage rack staging area of the present invention.
Figure 8 is a schematic view of the structure of the slide carrier of the present invention.
Fig. 9 is a schematic view of the structure of the driving device of the present invention.
Figure 10 is a schematic view of the slide advancement device of the present invention.
Fig. 11 is a schematic structural view of a wax block storage module according to the present invention.
Fig. 12 is a schematic view of the internal structure of the wax block storage module of the present invention.
Fig. 13 is a schematic structural view of the bin gate B in the wax block storage module according to the present invention.
Fig. 14 is a schematic structural diagram of the slice drying module according to the present invention.
Fig. 15 is a schematic view of the internal structure of the slice drying module according to the present invention.
Fig. 16 is a schematic structural view of an internal blowing device of the chip drying module according to the present invention.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
The reference numerals and components referred to in the drawings are as follows:
Referring to fig. 1-16, fig. 1 is a schematic structural diagram of the comprehensive management system for pathological section materials in the present invention. Fig. 2 is a schematic structural diagram of an information management module and a slide storage marking module according to the present invention. Fig. 3 is a schematic structural view of a slide storage marking module according to the present invention. Fig. 4 is a schematic structural diagram of a laser marking module on the slide storage marking module according to the present invention. Fig. 5 is a schematic structural diagram of a laser marking head on the laser marking module according to the present invention. Fig. 6 is a schematic diagram of a motherboard structure inside the information management module according to the present invention. Figure 7 is a schematic view of the slide storage rack staging area of the present invention. Figure 8 is a schematic view of the structure of the slide carrier of the present invention. Fig. 9 is a schematic structural diagram of the driving module according to the present invention. Figure 10 is a schematic view of the slide advancement device of the present invention. Fig. 11 is a schematic structural view of a wax block storage module according to the present invention. Fig. 12 is a schematic view of the internal structure of the wax block storage module of the present invention. Fig. 13 is a schematic structural view of the bin gate B in the wax block storage module according to the present invention. Fig. 14 is a schematic structural view of the slice drying module of the present invention. Fig. 15 is a schematic view of the internal structure of the slice drying module according to the present invention. Fig. 16 is a schematic structural view of an internal blowing device of the chip drying module according to the present invention.
A pathological section material comprehensive management system is mainly composed of an information management module 1, a glass slide storage marking module 2, a wax block storage module 3 and a section drying module 4, wherein the information management module 1 is fixed on the glass slide storage marking module 2, the lower end of the glass slide storage marking module 2 is fixedly connected with the wax block storage module 3, and the lower end of the wax block storage module 3 is fixedly connected with the section drying module 4; the information management module 1 comprises five parts, namely a shell A55, a control panel 56, a display 57, a processor main board 58 and a data transmission interface 59, wherein the display 57 is arranged on the side of the shell A56, the control panel 56 is arranged on the right side of the display 57, an operation key 54 is arranged on the control panel 56, the display 57 and the operation key 54 are both connected with the processor main board 58 through wires, the display 57 and the data transmission interface 59 are both positioned on the processor main board 58, and the processor main board 58 is positioned in the shell A56.
The slide glass storage marking module 2 comprises a laser marking module 5 and a slide glass storage module 6, wherein the laser marking module 5 mainly comprises a shell B60, two guide sliding rods 61, a laser marking head 62 and a driving device 63, the driving device comprises a stepping motor 64 and a gear rack mechanism 65, and the working principle is as follows: the laser marking head 62 is placed on the driving device 63, a stepping motor 64 in the driving device 63 drives a gear, and the gear and the rack are meshed to enable the laser marking head 62 to move relative to the rack 66, namely the laser marking head 62 moves along the guide sliding rod 61 through the meshing of the gear and the rack, and the vertical position is adjusted to position a marking area; the two guide slide bars 61 are fixedly arranged in the shell B60, a rack 66 is arranged between the two guide slide bars 61, a laser marking head 62 is arranged on the rack, two connecting blocks 67 are further arranged at the contact end of the laser marking head 62, a through hole 68 which penetrates through the connecting blocks 67 up and down is formed in each connecting block 67, and the two guide slide bars 61 penetrate through the two connecting blocks 67 behind the laser marking head 62 and are connected with the laser marking head 62.
The slide glass storage module 6 consists of a slide glass storage rack conveying belt 7, a slide glass storage rack transfer area 8, a slide glass storage rack storage area 9, a slide glass loading rack 10, a slide glass pushing device 85 and a slide glass loading rack ejecting device 81; the slide glass storage rack transfer area 8 comprises a shell C71, an ejection groove A72, a bin door A73, a spring pressing block 74 and a limiting block 75, wherein when the slide glass storage rack transfer area 8 is formed by moving the slide glass storage marking module 2, the slide glass storage rack is in the transfer area after moving, and then the slide glass is loaded from the transfer area to the storage area, at the moment, the slide glass is loaded, the ejection groove A72 is positioned at one end of the upper surface of the shell C71, the slide glass loading rack 10 is ejected by the ejection groove A72, the ejection groove A72 at the outlet of the slide glass loading rack is arranged to be favorable for taking out the slide glass, grooves 76 are formed in the periphery of one side inside the shell C71, the limiting block 75 and the spring pressing block 74 are positioned in different grooves 76, the limiting block 75 and the spring pressing block 74 are positioned on the same horizontal line, the corresponding grooves 76 on two sides inside the shell C71 are provided with the limiting block 75 and the spring pressing block 74, and the bullet piece 74 and the stopper 75 of pressing be symmetrical structure, slide glass load carrier 10 be located and press between bullet piece 74 and the stopper 75, its theory of operation does: the slide glass loading rack 10 advances, the elastic pressing block 74 is pressed down until the elastic pressing block 74 completely passes through the slide glass loading rack, when the slide glass loading rack advances to a slot position between the limiting block 75 and the elastic pressing block 74, the elastic pressing block 74 is ejected out, the slide glass loading rack 10 is limited in the middle ejection slot A72 by matching with the limiting block 75, and at the moment, the subsequent slide glass loading rack 10 does not advance; the stopper 75 is used to limit the position of the slide holder 10. The slide glass loading frame 10 is provided with a parting strip 77, slide glasses 78 and stop blocks 79, the parting strip 77 is positioned at the left end and the right end of the slide glass loading frame 10, the length of the parting strip 77 is smaller than that of the slide glass loading frame 10, the number of the slide glasses 78 is 8-12, the number of the stop blocks 79 is 16-24, and the specific steps are as follows: when the slide 78 moves from bottom to top, the stopper 79 is pressed into the slot along the inclined angle of the stopper 79 to lift the slide 78, and the stopper 79 has one-way passing property, so that the slide 78 above cannot fall down. This ensures that all slides 78 move only upward. An ejection groove B80 is further arranged below the slide glass loading frame 10, a slide glass loading frame ejection device 81 is arranged in the ejection groove B80, the slide glass loading frame ejection device 81 is composed of a base 82 and an ejection block 83, the ejection block 83 is arranged in the ejection groove B80 at the bottom of the unloading area of the slide glass storage frame, and the ejection block 83 can be driven by a spring or a motor. The pop-up groove B80 is arranged in the shell C71, and the working principle is as follows: the ejection is realized by sending an ejection instruction to further control the spring drive or the motor drive to drive the slide loading rack 10 by a pre-programmed program; the slide glass storage rack 84 is further arranged inside the shell C71, the slide glass storage rack 84 is used for containing a plurality of slide glass loading racks 10, a slide glass pushing device 85 is arranged on the other side of the shell C71, the slide glass pushing device 85 comprises a pushing block 86, an elastic pushing rod 88 and a pushing plate 89, the elastic pushing rod 88 is a cylinder bent by 90-150 degrees, one end of the elastic pushing rod 88 is connected with the pushing plate 89, an elastic pushing rod channel 90 is further arranged inside the pushing block 86, and the elastic pushing rod channel 90 is matched with the elastic pushing rod 88 in number. The pushing block is connected with the other end of the elastic push rod through a quadrilateral groove C, a connecting hole is formed in the groove C, the other end of the elastic push rod 88 enters an elastic push rod channel through a connecting hole 92 in the groove C91 to be connected with the pushing block, the push plate 89 is positioned in the glass slide storage rack 84 in the shell C71, the advancing direction of the push plate 89 is pushed from the back to one side with an ejection groove B80, and the push plate 89 pushes the glass slide loading rack 84 in the glass slide storage rack 84 to a marking area along the direction, and the working principle of the pushing block is as follows: three elastic push rod channels 90 are arranged in the pushing block 86, the elastic push rod 88 moves along the elastic push rod channels under the pushing of a motor or other power devices, and compared with a straight push rod, the design of the elastic push rod 88 can change the motion direction of the push rod, so that the required space is reduced. And the three push rods are parallel, so that the motion stability of the push plate is improved. A door a73 is also provided on one side of the housing C71 and the system automatically pops open the door 73 to prompt removal of an empty slide storage rack 84 after the slide carriers in the slide storage rack have been ejected. The glass slide storage rack storage area 9 comprises glass slide storage racks 84 and glass slide storage rack conveying belts 93 arranged at the upper and lower ends of the glass slide storage racks, the number of the glass slide storage racks 84 is 4-6, rollers 95 are arranged inside the glass slide storage rack conveying belts 7, preferably, baffles 96 are uniformly arranged on the glass slide storage rack conveying belts 84, each baffle on the glass slide storage rack conveying belts is 8-12, the spacing distance between the baffles is slightly larger than the width of one glass slide storage rack, and one glass slide storage rack is controlled between every two upper and lower baffles on the right opposite surfaces of the glass slide storage rack conveying belts at the upper and lower ends. The rollers are respectively positioned on the left side and the right side inside the conveying belt of the glass slide storage rack, the conveying belt of the glass slide storage rack is divided into an upper conveying belt and a lower conveying belt, the upper conveying belt and the lower conveying belt move synchronously, and the glass slide storage rack is pushed to a transfer area of the glass slide storage rack. The working principle of the slide glass storage rack is as follows: when the slide storage standard reaching module is moved, the moved slide storage racks can automatically jump to the other side, the empty slide storage racks can be gathered together and used when the slide is reloaded next time, and the operation is sequentially circulated. The left and right sides of the storage area of the glass slide storage rack are respectively connected with the laser marking module and the glass slide propelling device, and the front and the back sides of the storage area of the glass slide storage rack are respectively connected with the transfer area of the glass slide storage rack and the sealing plate.
The wax block storage module 3 comprises a wax block storage shell 101, a wax block propelling device 103, a wax block storage tank 102 and a bin gate B108, wherein the wax block storage shell 101 is of a cubic structure, slotted holes 109 of the wax block storage tank are uniformly distributed on the front surface of the wax block storage shell, the number of the slotted holes is 12-20, one end of the wax block storage tank is connected with the bin gate B108, the bin gate B108 is provided with a sliding rod 110, one end of the sliding rod is fixedly connected with the bin gate B, a sliding rail 111 is further arranged at the connecting part of the sliding rod at the other end of the sliding rod, two sides of the sliding rail are provided with rails 112, the size of the rails is matched with the connecting part of the sliding rod and is arranged at two sides of the wax block storage tank 102, the sliding rails are fixedly connected with the wax block storage tank, the bin gate B is mainly controlled to open and close by the sliding rod and the sliding rail, and can be opened to the horizontal position, the pushed wax block is stopped at the position; the other end of wax stone hold up tank links together with wax stone advancing device 103, wax stone advancing device 103 be "L" shape setting, wax stone advancing device on be equipped with the baffle, the baffle promote the wax stone and advance under wax stone advancing device's drive, wax stone advancing device's inside still is provided with transmission shaft 113, be provided with equidistant gyro wheel 114 and roller 115 on the transmission shaft 113, gyro wheel 114 and roller 115 fixed connection together, and leave 2-4cm interval between each cylinder to the next gyro wheel, set up 4-6 cylinders on every transmission shaft, wax stone advancing device be located axis of rotation epaxial cylinder, and the inside front and back position of wax stone advancing device all is provided with the transmission shaft, realizes rotating through gyro wheel and roller for drive wax stone advancing device, wax stone advancing device respectively with slotted hole, The number of the bin gates B is consistent with that of the wax block storage grooves, the wax block storage grooves are used for placing wax blocks, and the width of the wax block storage grooves meets the requirement that the wax blocks are arranged in a single row.
The slice drying module 4 belongs to an electrothermal constant-temperature type drying box and comprises five parts, namely a slice drying cabin 141, a drawing box 142, a heat transfer net 143, a drying bracket 144 and a drying cabin door 145, wherein a heat insulation layer 146 is arranged between the outer wall and the inner wall of the slice drying cabin 141, the heat insulation layer is filled with heat insulation materials, a heating panel 147 is further arranged on the inner wall of the slice drying cabin, a blowing device 148 is arranged in the heating panel 147, and the heat of the heating panel 147 is transferred out of the drying bracket 144 and blown to the drying bracket 144 to dry a sample; fixed heat transfer net 143 that is provided with on the inner wall both sides face of stoving storehouse 141, be equipped with spout 149 on the heat transfer net 143, take out box 142 and be located the inside of stoving storehouse 141, and take out the box both sides and be located spout 149 on, stoving bracket 144 transversely put in stoving storehouse 141, and be connected with heat transfer net 143 through spout 149, stoving bracket 144 can set up as required to be a plurality ofly, stoving bracket 144 be located and take out box 142, a side of stoving door 145 is in the same place through hinge 150 with stoving storehouse 141, the outside of stoving door still is provided with observation window 151 and handle 152, observation window 151 can be used for observing inside sample stoving condition, the setting of its handle 152 provides convenience for the operator. The method mainly comprises the steps of storing the cut glass slide in a drying bracket, wherein the section drying module is relatively closed, and the temperature is controlled to be about 60 ℃ to dry paraffin on the glass slide. Generally, the baking is carried out at 60 degrees for more than 20 minutes.
In this embodiment, it is preferable that the processor main board 58 is further provided with a slice information management unit 520, an infrared identification unit 521, a heating device unit 522, a freezing device unit 523, a laser printing device unit 524 and a power control element 525, the units are respectively controlled by the operation keys 54 on the control panel for operation, the slice information management unit mainly controls the marking of the slide glass, records the system operation information, the operator information and the operation step record, records the warehousing and ex-warehousing information of the slide glass, the wax block and the dried slice, and all the data are uploaded to the server through the data transmission interface 59; the infrared identification unit element 521 controls the slide glass storage marking module and the wax block storage module, and intelligent identification is performed through pre-programmed matched software, so that the identification accuracy is improved, and the identification accuracy is higher compared with manual identification; the heating device unit element 552 controls the slice drying module, and the constant temperature of the slice drying bin is ensured by heating and drying the slice drying bin, so that the optimal temperature is kept when the slice drying bin is reused; the refrigerating unit 523 is used for refrigerating wax blocks during storage, mainly refrigerating through an externally connected compressor or a freezer, and controlling the temperature inside the refrigerating unit to be about minus 20 ℃; the laser marking device controls the laser marking head and the driving device, and the working principle is as follows: the laser marking head is placed on the driving device, a stepping motor in the driving device drives a gear to move relative to the rack through gear and rack meshing, namely the laser marking head moves along the guide sliding rod through gear and rack meshing, and the vertical position is adjusted to position a marking area; the power control element controls the master control switch of the system power supply and is controlled by the operation keys on the control panel to realize the operation of the whole system.
In this embodiment, the high-quality data transmission interface 59 is used for transmitting all data information of the pathological section material comprehensive management system, the data transmission interface can support an SSL (secure sockets layer) transmission protocol, and can also perform data transmission with upper computer software or a his system in a hospital, and the data transmission interface is used for monitoring the state of the management device, interacting with a user, and controlling data transmission through a pre-programmed software system, so as to realize visual management.
In this embodiment, it is preferable that the number of the elastic push rods 88 is 3, and the number of the elastic push rod channels in the propelling block is matched with the number of the elastic push rods. And three elastic push rod channels are arranged in the propelling block, the elastic push rod moves along the elastic push rod channels under the pushing of a motor or other power devices, and the design of the elastic push rod can change the moving direction of the push rod compared with a straight push rod, so that the required space is reduced. And the three push rods are parallel, so that the motion stability of the push plate is improved.
In this embodiment, it is preferred that the baffles 96 on the upper and lower slide storage rack conveyor belts 7 are vertically symmetrical and that the number of baffles on the slide storage rack conveyor belts remain consistent.
In this embodiment, it is preferable that the glass slides 78 on the glass slide loading rack 10 are arranged longitudinally in a single row, each glass slide 78 on the glass slide loading rack is spaced by a stop block, the stop block 79 limits the moving direction of the glass slide to be upward only, when the glass slide loading rack advances, the spring pressing block is pressed down until the spring pressing block completely passes through the glass slide loading rack, when the glass slide loading rack advances to a slot position between the limit block and the spring pressing block, the spring pressing block is ejected, the limit block is matched to limit the glass slide loading rack in the ejection slot position in the middle, and at this time, the subsequent glass slide loading rack does not advance.
In this embodiment, the wax block propelling device 103 preferably comprises a belt with a baffle and a driving device, and the working principle thereof is as follows: a stepping motor in the driving device drives a gear to move relative to the rack through gear-rack meshing, so that the baffle conveying belt moves to drive the baffle to push the wax blocks in the wax block storage tank forwards.
The using method of the invention comprises the following steps: firstly, when the device is started up in an earlier stage, the whole system can automatically operate, the freezing system and the drying module start to operate, cooling and heating treatment is carried out, enough glass slides are placed in a glass slide storage device, then wax blocks needing to be sliced are placed in a wax block storage device, slicing operation can be carried out after the temperature of the wax blocks is reduced (generally, the first starting up needs to wait, and the whole device can be kept to continuously operate later), and the drying module needs to be independently closed when the device is not used, wherein the operation flow of a matrix is as follows: firstly, loading glass slides, secondly loading wax blocks, thirdly setting marking information and drying information from a control panel, and fourthly connecting a network;
use of: firstly, verifying user authority, secondly, selecting functions:
1. the slide was removed.
1.1 confirm take back, laser marking head mark a set of slide, system record take information, time, take people, get amount, usage etc..
1.2 one set of slides will be ejected at a time, in units of slide carriers, such as: one slide rack can hold 9 slides.
1.3 the slide carriers can act as protective frames to ensure that the slides removed are safe to store when not in use.
2. And taking a wax block.
3. And (5) drying the sample.
It should be noted that: in the present invention, the blowing device and the driving device are disclosed in the prior art and are sold in the market, which is not described herein. The wax block storage module can be used only after the temperature of the wax block storage module reaches the specified temperature; the glass slide needs to be filled into a glass slide loading frame by a human tool; the slide loading frame needs to be filled into a slide storage frame by a human tool; after the bin door at the side of the storage rack slot position is automatically opened, the slide glass storage rack needs to be manually pulled out; the arrangement of the refrigerating device unit piece comprises the following steps: the temperature control function can be realized, and the temperature of the wax block can reach the required temperature of the slice in a short time; the wax block can realize an automatic ejection function according to a pre-programmed program, can be taken at any time, and constantly ensures that the temperature of the wax block is kept at the optimal temperature of the slice; the wax block storage module uses a heat insulation material to ensure the temperature of the wax block storage module to be constant; in the device, all the units on the processor mainboard are sequentially controlled by a pre-programmed program, the accuracy of information pairing in the whole slicing process is ensured, the labor is saved, unnecessary manual operation is reduced, the working efficiency is improved, the misoperation is reduced, the data transmission interface can be used for transmitting all data information of a pathological slice material comprehensive management system, the data transmission interface can support an SSL (secure sockets layer) transmission protocol and can also be used for transmitting data with upper computer software or a his system in a hospital, the state of the management device is monitored through a pre-programmed software system, the interaction with a user is realized, the data transmission is controlled, the slicing progress of a sample can be checked at any time, the operation history of each slice is digitized, the slicing result can be traced, the visual management is realized, and the accuracy of the operation safety is ensured, the application is widely popularized and used.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (7)
1. The comprehensive management system for pathological section materials is characterized by mainly comprising an information management module, a slide glass storage marking module, a wax block storage module and a section drying module, wherein the information management module is fixed on the slide glass storage marking module; the information management module comprises a shell A, a control panel, a display, a processor mainboard and a data transmission interface, wherein the display is arranged on the side of the shell, the control panel is arranged on the right side of the display, an operation key is arranged on the control panel, the display and the data transmission interface are both positioned on the processor mainboard, and the processor mainboard is positioned in the shell;
the slide glass storage and marking module comprises a laser marking module and a slide glass storage module, wherein the laser marking module mainly comprises a shell B, two guide slide rods, a laser marking head and a driving device, the driving device is positioned inside the laser marking module, the two guide slide rods are fixedly arranged in the shell, a rack is arranged between the two guide slide rods, the laser marking head is arranged on the rack, the contact end of the laser marking head is also provided with two connecting blocks, through holes penetrating up and down are formed in the connecting blocks, and the two guide slide rods penetrate through the two connecting blocks behind the laser marking head and are connected with the laser marking head;
the glass slide storage module consists of a glass slide storage rack conveying belt, a glass slide storage rack transfer area, a glass slide storage rack storage area, a glass slide loading rack, a glass slide propelling device and a glass slide loading rack ejecting device; the glass slide storage rack unloading area comprises a shell C, an ejection groove A, a bin door, a spring pressing block and limiting blocks, the ejection groove A is located at one end of the upper surface of the shell C, the glass slide loading rack is ejected out of the ejection groove A, grooves are formed in the periphery of one side inside the shell C, the limiting blocks and the spring pressing block are located in different grooves, the limiting blocks and the spring pressing block are located on the same horizontal line, the limiting blocks and the spring pressing block are arranged on two corresponding grooves in the front and at the back of one side inside the shell C, the spring pressing block and the limiting blocks are of symmetrical structures, the glass slide loading rack is located between the spring pressing block and the limiting blocks, a partition bar, a glass slide and a stop block are arranged on the glass slide loading rack, the partition bar is located at the left end and the right end of the glass slide loading rack, the number of the glass slides is 8-12, the number of the stop blocks is 16-24, an ejection groove B is further formed below the glass slide loading frame, a glass slide loading frame ejection device is arranged in the ejection groove B and comprises a base and an ejection block, the ejection block is located in the base, and the ejection groove B is arranged in a shell C; a glass slide storage rack is further arranged inside the shell C and used for containing a glass slide loading rack, a glass slide pushing device is arranged on the other side of the shell C and comprises a pushing block, an elastic push rod and a push plate, one end of the elastic push rod is connected with the push plate, an elastic push rod channel is arranged in the pushing block, a quadrilateral groove C is formed in the joint of the pushing block and the other end of the elastic push rod, a connecting hole is formed in the groove C, the other end of the elastic push rod enters the elastic push rod channel through the connecting hole in the groove C and is connected with the pushing block, the push plate is located in the glass slide storage rack inside the shell C, and a bin door is further arranged on one side face of the shell C; the storage area of the glass slide storage rack comprises a glass slide storage rack and glass slide storage rack conveying belts arranged at the upper end and the lower end of the glass slide storage rack, rollers are arranged inside the glass slide storage rack conveying belts, and the rollers are respectively positioned at the left side and the right side inside the glass slide storage rack conveying belts; the left and right sides of the storage area of the glass slide storage rack are respectively connected with the laser marking module and the glass slide propelling device, and the front and the back sides of the storage area of the glass slide storage rack are respectively connected with the transfer area of the glass slide storage rack and the sealing plate;
the wax block storage module comprises a wax block storage shell, a wax block storage cabinet, a wax block pushing device, a wax block storage groove and a bin gate, wherein the wax block storage shell is of a cubic structure, the front surface of the wax block storage shell is uniformly provided with slotted holes of the wax block storage groove, the number of the slotted holes is 12-20, one end of the wax block storage groove is connected with the bin gate, the bin gate is provided with a sliding rod, one end of the sliding rod is fixedly connected with the bin gate, the connecting part of the sliding rod at the other end of the sliding rod is also provided with a sliding rail, two sides of the sliding rail are provided with rails, and the size of the rails is matched with the connecting part of the sliding rod and is arranged on two sides of the wax block storage groove; the other end of the wax block storage tank is connected with a wax block propelling device, a rotating shaft is arranged in the wax block propelling device, rollers and rolling shafts which are equidistant are arranged on the rotating shaft, the rollers and the rolling shafts are fixedly connected together, a 2-4cm interval is reserved between each roller and the next roller, 4-6 rollers are arranged on each rotating shaft, the wax block propelling device is positioned on the rollers on the rotating shaft, the rotating shafts are arranged at the front and back positions in the wax block propelling device, the rotation is realized through the rollers and the rolling shafts, and the wax block propelling device is respectively kept consistent with the slotted holes and the wax block storage tank in number;
the slice drying module comprises a slice drying bin, a drawing box, a heat transfer net, a drying bracket and a drying bin door, wherein a heat insulation layer is arranged between the outer wall and the inner wall of the slice drying bin, a heating panel is also arranged on the inner wall of the slice drying bin, an air blowing device is arranged in the slice drying bin, the heat transfer net is fixedly arranged on two side faces of the inner wall of the slice drying bin, a sliding groove is formed in the heat transfer net, the drawing box is positioned in the slice drying bin, two sides of the drawing box are positioned on the sliding groove, the drying bracket is transversely arranged in the slice drying bin and is connected with the heat transfer net through the sliding groove, the drying brackets are arranged into a plurality of parts as required, the drying bracket is positioned in the drawing box, one side face of the drying bin door is connected with the slice drying bin through a hinge, and an observation window and a handle are also arranged outside the drying bin door; the processor mainboard is also provided with a slice information management unit element, an infrared identification unit element, a heating device unit element, a refrigerating device unit element, a laser printing device unit element and a power control element.
2. The integrated pathological section material management system according to claim 1, wherein the data transmission interface is configured to transmit all data information of the integrated pathological section material management system.
3. The comprehensive pathological section material management system of claim 1, wherein the number of the elastic push rods is 2-4, and the number of the elastic push rod channels in the propulsion block is matched with the number of the elastic push rods.
4. The integrated pathological section material management system according to claim 1, wherein the slide storage rack conveyors have baffles arranged uniformly, the number of baffles on each slide storage rack conveyor is 8-12, the distance between the baffles is greater than the width of one slide storage rack, and one slide storage rack is controlled between every two baffles on the opposite sides of the upper and lower slide storage rack conveyors.
5. The integrated pathological section material management system of claim 4, wherein the baffles on the upper and lower slide storage rack transport belts are symmetrical and the number of baffles on the slide storage rack transport belts is consistent.
6. The system for comprehensive management of pathological section materials according to claim 1, wherein the slides are loaded on the slide loading rack and are arranged in a single row and longitudinally, and each slide on the slide loading rack is separated by a stop block, and the stop block limits the movement direction of the slide to be only upward.
7. The system for comprehensively managing pathological section materials according to claim 1, wherein the wax block pushing device comprises a conveyor belt with a baffle and a driving device, the driving device drives the conveyor belt to move, the baffle is driven to be pushed forward, and the baffle pushes the wax blocks in the wax block storage tank forward.
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| CN113790940A (en) * | 2021-09-08 | 2021-12-14 | 深圳市森盈生物科技有限公司 | Serial-type waste liquid is clear away and automatic temperature control system |
| CN113558405B (en) * | 2021-09-26 | 2021-12-21 | 中国医学科学院北京协和医院 | Comprehensive intelligent management system and method based on wax block storage |
| CN114313552A (en) * | 2021-12-30 | 2022-04-12 | 福建瑞庚生物科技有限公司 | Intelligent slice storage mobile instrument |
| CN114963982B (en) * | 2022-05-17 | 2024-05-17 | 山东志盈医学科技有限公司 | Method and device for detecting slice position in digital pathological slice scanner |
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