CN111109606A - 一种增强免疫力食品组合物及其制备方法 - Google Patents
一种增强免疫力食品组合物及其制备方法 Download PDFInfo
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- CN111109606A CN111109606A CN202010080253.XA CN202010080253A CN111109606A CN 111109606 A CN111109606 A CN 111109606A CN 202010080253 A CN202010080253 A CN 202010080253A CN 111109606 A CN111109606 A CN 111109606A
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- calcium
- powder
- food composition
- vitamin
- composition
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- 235000013305 food Nutrition 0.000 title claims abstract description 44
- 230000036039 immunity Effects 0.000 title claims abstract description 34
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 18
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- 239000000843 powder Substances 0.000 claims description 37
- 239000003795 chemical substances by application Substances 0.000 claims description 20
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- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 4
- OENHQHLEOONYIE-UKMVMLAPSA-N beta-Carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 4
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
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Abstract
本发明涉及一种用于增强免疫力食品组合物及其制备方法，该组合物能够帮助人体建立免疫防线，对抗各种病毒及细菌。本发明以食品原料为基础，降低了药食同源的原料及保健品原料可能存在的风险性概率，减少了食品产品工业化生产及上市流通产品的风险性；通过控制β‑葡聚糖、蛋白组合物、其它填充组合物添加量及组合物的配比，提升现有工艺方法，制备的食品组合物能够增强人体自身抵抗力及免疫力。
Description
技术领域
本发明属于功能食品领域，具体涉及一种用于增强免疫力食品组合物及其制备方法。
背景技术
免疫***(immune system)是机体执行免疫应答及免疫功能的重要***。由免疫器官、免疫细胞和免疫分子组成。免疫***具有识别和排除抗原性异物、与机体其他***相互协调．共同维持机体内环境稳定和生理平衡的功能。人体共有三道防线：第一道防线是由皮肤和黏膜构成的，第二道防线是体液中的杀菌物质和吞噬细胞。第三道防线主要由免疫器官（胸腺、***和脾脏等）和免疫细胞（淋巴细胞）组成。
本发明从专业的角度，帮助人体建立第二道防线，同时通过补充多种营养物质及提供免疫球蛋白G（IgG）帮助第三道防线正常运转，对抗各种病毒或细菌。淋巴细胞在抗原刺激下转化为浆细胞，产生能与相应抗原发生特异性结合的抗体，称为免疫球蛋白。β-葡聚糖能识别并结合受体，激活免疫细胞，促进细胞因子的生成，提高并维持抗体水平，激活补体***，从而增强动物机体抵御外来病原、微生物的入侵及组织自身修复功能。β-葡聚糖能明显增加抗生素的效力，当其和抗生素联合使用的时候，其刺激巨噬细胞的作用能够增加药物的治疗效果。
目前，现有技术对提高免疫***的产品有多处不足之处。在配方上采用单一的原料，对人体免疫力的***的建立并不完善。而且现有没有提到使用β-葡聚糖及蛋白组合物联合配制，特别是在组合配方没有涉及比例。本发明经过大量实验，优化配方组合、原料参数、比例及工艺，制备增强免疫力食品组合物，能弥补市场对增强免疫力功能食品的需求。
发明内容
本发明涉及一种用于增强免疫力食品组合物及其制备方法，主要针对人体免疫***的特点，优化配方组合、原料参数、比例及工艺。本发明人基于从事此类产品研发及制造多年丰富的经验和专业知识，并配合理论的运用，积极加以研究创新，对配方及其生产技术工艺进行了改进。
本发明主要是通过以下技术方案得以实现的。
本发明提供了一种用于增强免疫力食品组合物及其制备方法，包含β-葡聚糖、蛋白组合物、其它填充组合物，所述食品组合物中乳铁蛋白含量＞0.049%，β-葡聚糖含量＞0.05%。
优选地，一种用于增强免疫力食品组合物及其制备方法，包含β-葡聚糖0.07-50份、蛋白组合物10-50份、其它填充组合物20-80份。
优选地，一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述β-葡聚糖选自燕麦β-葡聚糖、酵母β-葡聚糖中的一种或两种,其特征在于颗粒大小在25-200目。
优选地，一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述蛋白组合物选自乳铁蛋白、乳清蛋白粉、浓缩乳清蛋白、牛初乳中的一种或几种。
优选地，一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述乳清蛋白粉、浓缩乳清蛋白中乳铁蛋白含量＞0.049%。
优选地，一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述其它填充组合物包括L-谷氨酰胺、牛磺酸、γ-亚麻酸、鱼油粉、植物脂肪粉、亚麻籽油微囊粉、高油酸葵花籽油微囊粉、植物脂肪粉、植物甾醇、植物甾醇脂、DHA藻油粉末、花生四烯酸油脂粉末、牛磺酸、全脂奶粉、脱脂奶粉、燕麦粉、大豆分离蛋白、牛奶蛋白、乳白蛋白分、左旋肉碱、β-羟基-β-甲基丁酸盐、酪蛋白磷酸肽、大豆分离蛋白、燕麦粉、麦芽糊精、全脂奶粉、脱脂奶粉、脱盐乳清粉、聚葡萄糖、菊粉、葡萄糖、抗性糊精、低聚异麦芽糖、低聚果糖、低聚半乳糖、乳糖、固体玉米糖浆中的一种或几种。
优选地，一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述食品组合物还包含，选自牛磺酸、维生素A、β胡萝卜素、维生素D、维生素E、维生素K、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酸、叶酸、泛酸、生物素、胆碱、硒剂、钙剂、铁剂、锌剂、镁剂、铜剂、锰剂、钾剂、磷剂。所述硒剂选自***钠、硒酸钠、硒蛋白、富硒食用菌粉、L-硒-甲基硒代半胱氨酸中的一种或多种；钙剂选自碳酸钙、葡萄糖酸钙、柠檬酸钙、乳酸钙、L-乳酸钙、磷酸氢钙、L-苏糖酸钙、甘氨酸钙、天门冬氨酸钙、柠檬酸苹果酸钙、醋酸钙（乙酸钙）、氯化钙、磷酸三钙、维生素 E 琥珀酸钙、甘油磷酸钙、氧化钙、硫酸钙、骨粉中的一种或多种；铁剂选自硫酸亚铁、葡萄糖酸亚铁、柠檬酸铁铵、富马酸亚铁、柠檬酸铁、乳酸亚铁、氯化高铁血红素、焦磷酸铁、铁卟啉、甘氨酸亚铁、还原铁、乙二胺四乙酸铁钠、羰基铁粉、碳酸亚铁、柠檬酸亚铁、延胡索酸亚铁、琥珀酸亚铁、血红素铁、电解铁中的一种或多种；锌剂选自硫酸锌、葡萄糖酸锌、甘氨酸锌、氧化锌、乳酸锌、柠檬酸锌、氯化锌、乙酸锌、碳酸锌中的一种或多种；镁剂选自硫酸镁、氯化镁、氧化镁、碳酸镁、磷酸氢镁、葡萄糖酸镁中的一种或多种；铜剂选自硫酸铜、葡萄糖酸铜、柠檬酸铜、碳酸铜中的一种或多种；锰剂选自硫酸锰、氯化锰、碳酸锰、柠檬酸锰、葡萄糖酸锰中的一种或多种；钾剂选自氯化钾、碳酸钾、碳酸氢钾、乳酸钾、柠檬酸钾、葡萄糖酸钾、磷酸二氢钾、磷酸氢二钾；钾剂选自磷酸三钙、磷酸氢钙中的一种或多种。
本发明一种用于增强免疫力食品组合物及其制备方法，进一步提供了制备方法，包括如下
（1）原料配制：将上述原料按比例配制。
（2）混料：在混料机中混合，优选温度控制4-28℃，湿度17-68%，最优选为温度控制24℃，湿度45%。优选混合时间为0.1-2小时，最优选为混合时间为0.5小时。
（3）过筛网：筛网优选25-120目，最优选为30目。
本发明主要是以食品为β-葡聚糖、蛋白组合物、其它填充组合物的配比，通过以上工艺，以实现免疫成分与β-葡聚糖的优化组合，从而达到合适颗粒大小，同时具有提升免疫力食品组合物。
本发明的目的及相对于现有技术具有如下效果：
本发明的产品以食品原料配制而成，相对于药物，免除存在的风险性及副作用，显著提高安全性。本发明的食品组合物，大大提升现有技术，改进现有食品配方，对提升免疫力及抵抗力起到了很好作用。为功能食品的发展进一步提供了帮助。
具体实施方式
为使本发明的目的、技术方案及效果更加清楚、明确，以下参照具体实施例对本发明作进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明。
实施例1
一种增强免疫力食品组合物及其制备方法，包括组分β-葡聚糖5kg、蛋白组合物20kg、其它填充组合物74.9kg、维生素C为0.1kg；
所述β-葡聚糖选自酵母β-葡聚糖；
所述蛋白组合物选自乳清蛋白粉；
所述食品组合物还包含维生素C；
所述其它填充组合物L-谷氨酰胺、DHA藻油粉末、低聚果糖、麦芽糊精；
所述发明进一步的提供了制备方法，包括如下
（1）原料配制。
（2）在混料机中混合，温度控制24℃，湿度48%。
（3）混合时间为0.5小时，分装。
实施例2
一种增强免疫力食品组合物及其制备方法，包括组分β-葡聚糖4kg、蛋白组合物21kg、其它填充组合物74.9kg、维生素C为0.1kg；
所述β-葡聚糖选自酵母β-葡聚糖；
所述蛋白组合物选自乳清蛋白粉；
所述食品组合物还包含维生素C；
所述其它填充组合物L-谷氨酰胺、麦芽糊精；
所述发明进一步的提供了制备方法，包括如下
（1）原料配制。
（2）在混料机中混合，温度控制24℃，湿度48%。
（3）混合时间为0.5小时，分装。
对比实例1
一种增强免疫力食品组合物及其制备方法，包括组分β-葡聚糖3kg、大豆分离蛋白22kg、其它填充组合物74.9kg、碳酸钙为0.1kg；
所述其它填充组合物为麦芽糊精；
所述食品组合物还包碳酸钙；
所述发明进一步提供了制备方法，包括如下
（1）原料配制。
（2）在混料机中混合，温度控制29℃，湿度68%。
（3）混合时间为0.1小时，分装。
对比实例2
一种增强免疫力食品组合物及其制备方法，包括如下组分蛋白组合物21kg、其它填充组合物78.9kg、碳酸钙为0.1kg；
所述蛋白组合物为乳清蛋白粉；
所述食品组合物还包碳酸钙；
所述发明进一步提供了制备方法，包括如下
（1）原料配制。
（2）在混料机中混合，温度控制25℃，湿度58%。
（3）混合时间为0.5小时，分装。
增强免疫力功能研究。
将实例1、实例2 及对比实例1、对比实例2制备的样品，每组10只单一性别小鼠，30天实验。具体实验过程与评价标准参照《保健食品检验与评价技术规范》(2003年版)中第一部分“1 .增强免疫力功能检测方法”中的小鼠巨噬细胞吞噬鸡红细胞实验。
| 组别 | 吞噬率(%) | 吞噬指数 |
| 实例1样品 | 27.95±3.54 | 0.45±0.76 |
| 实例2样品 | 28.35±6.71 | 0.54±0.61 |
| 对比实例1样品 | 2.33±3.55 | 0.63±0.57 |
| 对比实例2样品 | 2.79±3.99 | 0.68±0.83 |
由表可知，实例1样品组、实例2样品组与对比实例1样品组、对比实例2样品组比较，本发明实例1样品组、实例2样品组对小鼠腹腔巨噬细胞吞噬鸡红细胞的吞噬率与吞噬指数均具有明显的升高作用(P＜0 .05)。说明本发明物具有促进小鼠吞噬细胞的吞噬作用，可增强其非特异性免疫功能。
样品人员试吃研究
本发明实施例1及实施例2制备得到的样品，每日食用10g,104人分4组.
组1食用实例1制得的样品26人食用6个月。
组2食用对比实例1制得的样品26人食用6个月。
组3食用实例2制得的样品26人食用6个月
组4食用对比实例2制得的样品26人食用6个月。
经过跟踪观察发现，实例组1、2在食用6个月过程中均无人发烧感冒，对比实例1，有3人发烧过，其中1人感冒；对比实例2有2人感冒。
由上述结果可以看到，通过采用本发明制备方法制备得到的增强免疫力食品组合物，其中的蛋白质，脂肪，碳水化合物等成分均符合国家标准的规定，同时能够提高人体抵抗力及免疫力；
以上具体实施方式部分对本发明所涉及的分析方法进行了具体的介绍。应当注意的是，上述介绍仅是为了帮助本领域技术人员更好地理解本发明的方法及思路，而不是对相关内容的限制。在不脱离本发明原理的情况下，本领域技术人员还可以对本发明进行适当的调整或修改，上述调整和修改也应当属于本发明的保护范围。
Claims (8)
1.一种用于增强免疫力食品组合物及其制备方法，包含β-葡聚糖、蛋白组合物、其它填充组合物，所述食品组合物中乳铁蛋白含量＞0.049%，β-葡聚糖含量＞0.05%。
2.根据权利要求1所述的一种用于增强免疫力食品组合物及其制备方法，包含β-葡聚糖0.07-50份、蛋白组合物10-50份、其它填充组合物20-80份。
3.根据权利要求1所述的一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述β-葡聚糖选自燕麦β-葡聚糖、酵母β-葡聚糖中的一种或两种,其特征在于颗粒大小在25-200目。
4.根据权利要求1-2所述的一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述蛋白组合物选自乳铁蛋白、乳清蛋白粉、浓缩乳清蛋白、牛初乳中的一种或几种。
5.根据权利要求4所述的一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述乳清蛋白粉、浓缩乳清蛋白中乳铁蛋白含量＞0.049%。
6.根据权利要求1所述的一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述其它填充组合物包括L-谷氨酰胺、牛磺酸、全脂奶粉、脱脂奶粉、燕麦粉、大豆分离蛋白、牛奶蛋白、乳白蛋白、γ-亚麻酸、鱼油粉、植物脂肪粉、亚麻籽油微囊粉、高油酸葵花籽油微囊粉、植物脂肪粉、植物甾醇、植物甾醇脂、DHA藻油粉末、花生四烯酸油脂粉末、牛磺酸、左旋肉碱、β-羟基-β-甲基丁酸盐、酪蛋白磷酸肽、大豆分离蛋白、蛋黄粉、燕麦粉、麦芽糊精、全脂奶粉、脱脂奶粉、脱盐乳清粉、聚葡萄糖、菊粉、葡萄糖、抗性糊精、低聚异麦芽糖、低聚果糖、低聚半乳糖、乳糖、固体玉米糖浆中的一种或几种。
7.根据权利要求1所述的一种用于增强免疫力食品组合物及其制备方法，其特征在于，所述食品组合物还包含，选自牛磺酸、维生素A、β胡萝卜素、维生素D、维生素E、维生素K、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酸、叶酸、泛酸、生物素、胆碱、硒剂、钙剂、铁剂、锌剂、镁剂、铜剂、锰剂、钾剂、磷剂。
8.所述硒剂选自***钠、硒酸钠、硒蛋白、富硒食用菌粉、L-硒-甲基硒代半胱氨酸中的一种或多种；钙剂选自碳酸钙、葡萄糖酸钙、柠檬酸钙、乳酸钙、L-乳酸钙、磷酸氢钙、L-苏糖酸钙、甘氨酸钙、天门冬氨酸钙、柠檬酸苹果酸钙、醋酸钙（乙酸钙）、氯化钙、磷酸三钙、维生素 E 琥珀酸钙、甘油磷酸钙、氧化钙、硫酸钙、骨粉中的一种或多种；铁剂选自硫酸亚铁、葡萄糖酸亚铁、柠檬酸铁铵、富马酸亚铁、柠檬酸铁、乳酸亚铁、氯化高铁血红素、焦磷酸铁、铁卟啉、甘氨酸亚铁、还原铁、乙二胺四乙酸铁钠、羰基铁粉、碳酸亚铁、柠檬酸亚铁、延胡索酸亚铁、琥珀酸亚铁、血红素铁、电解铁中的一种或多种；锌剂选自硫酸锌、葡萄糖酸锌、甘氨酸锌、氧化锌、乳酸锌、柠檬酸锌、氯化锌、乙酸锌、碳酸锌中的一种或多种；镁剂选自硫酸镁、氯化镁、氧化镁、碳酸镁、磷酸氢镁、葡萄糖酸镁中的一种或多种；铜剂选自硫酸铜、葡萄糖酸铜、柠檬酸铜、碳酸铜中的一种或多种；锰剂选自硫酸锰、氯化锰、碳酸锰、柠檬酸锰、葡萄糖酸锰中的一种或多种；钾剂选自氯化钾、碳酸钾、碳酸氢钾、乳酸钾、柠檬酸钾、葡萄糖酸钾、磷酸二氢钾、磷酸氢二钾；钾剂选自磷酸三钙、磷酸氢钙中的一种或多种。
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