CN111109446A - Special sulfate radical-free organic trace element feed additive for piglets and preparation method thereof - Google Patents
Special sulfate radical-free organic trace element feed additive for piglets and preparation method thereof Download PDFInfo
- Publication number
- CN111109446A CN111109446A CN201911418880.3A CN201911418880A CN111109446A CN 111109446 A CN111109446 A CN 111109446A CN 201911418880 A CN201911418880 A CN 201911418880A CN 111109446 A CN111109446 A CN 111109446A
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- Prior art keywords
- parts
- methionine
- sulfate
- piglets
- solution
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- 239000011573 trace mineral Substances 0.000 title claims abstract description 99
- 235000013619 trace mineral Nutrition 0.000 title claims abstract description 99
- 239000003674 animal food additive Substances 0.000 title claims abstract description 85
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract description 53
- 239000011773 ferrous fumarate Substances 0.000 claims abstract description 53
- 235000002332 ferrous fumarate Nutrition 0.000 claims abstract description 53
- 229960000225 ferrous fumarate Drugs 0.000 claims abstract description 53
- HJSYJHHRQVHHMQ-TYYBGVCCSA-L zinc;(e)-but-2-enedioate Chemical compound [Zn+2].[O-]C(=O)\C=C\C([O-])=O HJSYJHHRQVHHMQ-TYYBGVCCSA-L 0.000 claims abstract description 49
- OXWRXONHMTWKHV-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;cobalt Chemical compound [Co].CSCC[C@H](N)C(O)=O OXWRXONHMTWKHV-WCCKRBBISA-N 0.000 claims abstract description 47
- BZVFZBYIWNIHHL-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;manganese Chemical compound [Mn].CSCC[C@H](N)C(O)=O BZVFZBYIWNIHHL-WCCKRBBISA-N 0.000 claims abstract description 47
- JZCAHRHZFBBFRZ-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;copper Chemical compound [Cu].CSCC[C@H](N)C(O)=O JZCAHRHZFBBFRZ-WCCKRBBISA-N 0.000 claims abstract description 43
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Abstract
The invention relates to the technical field of feed additive production, in particular to a special feed additive containing no sulfate radical organic trace elements for piglets and a preparation method thereof, wherein the special feed additive comprises the following raw materials in parts by weight: 30-80 parts of ferrous fumarate; 10-40 parts of zinc fumarate and 5-15 parts of manganese methionine; 5-15 parts of copper methionine; 1-5 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.001-0.03 part of sodium selenite; 0.001-0.03 part of cobalt methionine; 0.01-0.05 part of vitamin complex. The special feed additive for the piglets, prepared by the method, is all organic trace elements, does not contain sulfate ions, inorganic anions and bitter, has high product purity, can maintain electrolyte balance of the piglets, has good palatability, effectively reduces diarrhea rate of the piglets and meets the growth requirements of the piglets.
Description
Technical Field
The invention relates to the technical field of feed additive production, and particularly relates to a special sulfate radical-free organic trace element feed additive for piglets and a preparation method thereof.
Background
The health degree of piglets is an important problem influencing the breeding benefit of the pig industry for many years, and among all factors influencing the health degree of piglets, diarrhea of the piglets can be in the top position, and the diarrhea can cause low feed conversion rate, slow growth, growth and development stagnation of the piglets, death and even death of serious piglets, thereby causing huge economic loss. The piglet has weak self resistance, is sensitive to external stimulation, is easily affected by pathogenic microorganism invasion and various stress factors due to the physiological characteristics of incomplete digestive tract development, incomplete digestive enzyme system, insufficient gastric acid secretion, easy change of intestinal microflora and the like, and is difficult to adapt to daily ration change from liquid to solid feed during the weaning period, thereby often causing diarrhea. The causes of weaning piglet diarrhea are mainly disease diarrhea, environmental diarrhea and nutritional diarrhea. Disease diarrhea can be divided into bacterial diarrhea and viral diarrhea, and environmental diarrhea is often the cause of viral diarrhea or nutritional diarrhea; the causes of the piglet nutritional diarrhea are very complex, and the main factors comprise daily ration antigenicity, overhigh crude protein content, lack of vitamins and mineral elements, daily ration acidity and PH overhigh and daily ration electrolyte imbalance and the like.
The microelement feed additive plays an important role in the growth and development of animals, and the microelement not only influences the utilization rate of the feed, but also directly influences the healthy growth of the livestock and poultry in the daily ration of the livestock and poultry. For many years, traditional inorganic salts have been used as sources of trace elements. As a lot of inorganic trace element additives are used in the diet of piglets by many feed enterprises, the anion SO of the inorganic trace element additives4 2-And the like, have attracted more and more attention and research of scholars. Because inorganic trace element additive such as Cl is often used in large amount in feed-、SO4 2-Increase in the amount of Na inevitably causes+The vigorous metabolism of ions causes the deviation of electrolyte balance (dEB) in the animal body, and the electrolyte balance plays an important role in the aspects of gastrointestinal osmotic pressure, acid-base balance, water and salt metabolism. If electrolytes are unbalanced, a large amount of body fluid and electrolytes in piglets are easily lost, exude from bodies and flow back to intestinal tracts, so that the change of the internal environment of the digestive tracts is caused, the fragile intestinal mucosa of the piglets is damaged, the risk of virus infection is increased, the water in excrement is increased, the excrement is softened, and the diarrhea phenomenon of the piglets is caused. And a large amount of SO is added into the basal ration of the piglets4 2-Because sulfate radicals have bitter and astringent tastes and are also salt for dumping, the palatability of the piglets is influenced, the feed intake and daily gain of the piglets are reduced, and the use amount of a sweetening agent and lactose in basic daily ration is increased, so that the feed cost is increased. High dosage of SO4 2-The activity of digestive enzyme of the piglets is reduced, the digestibility of nutrient substances is influenced, the weight gain and the feed utilization rate of the piglets are reduced, and the feed has destructive effect on vitamins in the feed and has oxidation effect on fat.
At present, in order to prevent and control the diarrhea problem of piglets, the addition of high-dose zinc oxide is a general behavior, but the long-term use of high-dose zinc oxide also causes extensive disputes in the industry, the addition of zinc oxide in the piglet feed generally reaches the level of 3000mg/kg, which is far more than nearly 30 times of the normal zinc demand of the piglets, so that the zinc oxide is not related to the nutritional function of the piglets, but is used as an astringent, but does not play a role in solving the problems of intestinal injury, nutrient digestion and absorption function reduction, electrolyte imbalance and the like which cause the diarrhea, the addition of high-dose zinc oxide in the piglet feed also causes a series of problems that the intestinal mucosa epithelial cells of the piglets are seriously dehydrated, the nutrient digestion and absorption function is reduced, the organism immunity is reduced, the result shows that the later growth inhibition is performed, the zinc oxide secretion is dependent, the diarrhea of the piglets once the piglets are stopped, the absorption of copper and iron is antagonistic action, the absorption of the copper and iron is reduced, the synthesis of red blood lead to the red blood, the skin protein synthesis is finally reduced, the absorption of red pig skin protein is reduced, the pig toxin secretion and the pig's toxin is caused by the pig's toxin, the pig's intestine is caused by the pig's toxin, the pig's toxin is caused by the pig's toxin, the pig's intestine, the pig's toxin is caused by the pig's toxin, the pig's.
The results of a large number of studies and practical applications in recent years have shown that the long-term use of inorganic trace element feed additives in animal production has presented the following disadvantages: the feed additive has the advantages of low absorption rate, poor palatability, potential heavy metal risk, influence on animal health, unstable chemical properties, environmental protection pressure caused by large-scale excretion, easiness in chemical reaction with active ingredients such as vitamins in the feed and the like, and the inorganic mineral substances have antagonistic competition effect and influence on digestion and absorption of various inorganic trace elements. The factors lead the biological value of the inorganic trace element feed additive in organisms to be lower, and the heavy metal content in the excrement discharged by livestock and poultry seriously exceeds the standard, thereby causing environmental pollution. Particularly, inorganic trace elements used in the feed industry are mostly sulfate, and the situation that the inorganic trace elements are used in an overdose mode is common.
Compared with inorganic trace elements, the organic trace elements serving as a green and environment-friendly feed additive have the advantages of stable chemical property, high utilization rate, small addition amount, good palatability, guarantee of food safety and the like, and are valued by the feed and breeding industries. At present, some enterprises have carried out related researches on organic trace element feed additives. For example, Chinese patent with patent application number CN201410063216.2 discloses a biological feed composition containing organic trace elements and application thereof, a compound premix special for piglets and a feed special for piglets; the biological feed comprises organic trace elements and yeast metabolites, wherein the organic trace elements comprise copper glycinate, ferrous fumarate, zinc lactate, manganese methionine, selenium yeast and chromium nicotinate. However, the patent has the following disadvantages: the glycine product cannot remove inorganic anions such as SO4 from the raw material2-、CI-And the like, the product purity is poor, the palatability of the feed is influenced, the metabolism of Na + ions in an animal body is vigorous, the deviation of electrolyte balance (dEB) in the animal body is low, the biological value of inorganic trace elements is low, and a large addition amount is needed. Therefore, the novel feed additive which can not cause electrolyte imbalance of piglets, can effectively reduce diarrhea rate of piglets, meets the growth demand of piglets, maintains intestinal health of piglets and improves the health degree of piglets and is safe and friendly to environment is found, and has an important effect on promoting the development of piglet breeding industry in China.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides the special feed additive for the organic trace element piglets, which has the advantages of reasonable formula, high biological value, no side effect and no sulfate radical, and the preparation method thereof. The special feed additive for the piglets, prepared by the method, is an all-organic trace element composite bag, does not contain sulfate ions or inorganic anions, has good palatability and high purity, can maintain the electrolyte balance of the piglets, effectively reduces the diarrhea rate of the piglets, meets the growth requirements of the piglets, maintains the intestinal health of the piglets, improves the health degree of the piglets, and is safe and environment-friendly.
In order to achieve the purpose, the invention adopts the following technical scheme:
a special sulfate radical-free organic trace element feed additive for piglets comprises the following raw materials in parts by weight: 30-80 parts of ferrous fumarate; 10-40 parts of zinc fumarate and 5-15 parts of manganese methionine; 5-15 parts of copper methionine; 1-5 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.001-0.03 part of sodium selenite; 0.001-0.03 part of cobalt methionine; 0.01-0.05 part of vitamin complex.
The special sulfate radical-free organic trace element feed additive for the piglets comprises 1-200 parts by weight of filler, wherein the filler can be lead-free medical stone powder, or can be starch or byproducts of grain processing, such as wheat bran, bean bran, bran coat and the like, and is prepared into finished feed.
According to the special feed additive for the piglet without the sulfate radical organic trace elements, the ferrous fumarate, the zinc fumarate, the manganese methionine, the copper methionine and the cobalt methionine do not contain sulfate radical ions, so that impurities such as sulfate radicals are removed, and the iron fumarate, the zinc fumarate, the manganese methionine, the copper methionine and the cobalt methionine are all organic chelates. Wherein the production method of the ferrous fumarate comprises the following steps: taking 20-40 parts of fumaric acid, 20-40 parts of soda ash and 50-80 parts of ferrous sulfate according to parts by weight for later use, respectively dissolving the soda ash with a proper amount of water to obtain a soda ash solution, dissolving the fumaric acid with water to obtain a fumaric acid solution, dissolving the ferrous sulfate with water of more than 60 ℃ to obtain a ferrous sulfate solution, slowly dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 5.0-10.0 to obtain a mixed solution, heating to 65-75 ℃, heating the ferrous sulfate solution to 75 ℃, then adding the ferrous sulfate solution into the mixed solution to perform a neutralization reaction, controlling the reaction temperature of the neutralization reaction to be 75-85 ℃, controlling the reaction time to be 2.5 hours to obtain ferrous fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100-110 ℃, and performing 20-mesh fine screening to obtain a qualified ferrous fumarate finished product.
The production method of the zinc fumarate comprises the following steps: taking 15-30 parts of fumaric acid, 15-30 parts of soda ash and 40-70 parts of zinc sulfate heptahydrate according to parts by weight for later use, respectively dissolving the soda ash with proper amount of water to obtain soda ash solution, dissolving the fumaric acid with water to obtain fumaric acid solution, dissolving the zinc sulfate heptahydrate with water of more than 80 ℃ to obtain zinc sulfate solution, dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 6.0-10.0 to obtain mixed solution, heating to 55-65 ℃, heating the zinc sulfate solution to 70 ℃, then adding the zinc sulfate solution into the mixed solution to perform neutralization reaction, wherein the reaction temperature of the neutralization reaction is 70-80 ℃, the reaction time is 1.5 hours to obtain zinc fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100-110 ℃, sieving with a 20-mesh fine sieve, and checking to be qualified to obtain a finished product of the zinc fumarate.
The production method of the copper methionine comprises the following steps: taking 40-70 parts of copper sulfate according to parts by weight; 20-40 parts of methionine; 5-15 parts of caustic soda flakes for later use, adding a proper amount of water into copper sulfate, heating to 60-70 ℃, dissolving to obtain a copper sulfate solution, adding methionine into the copper sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and inspecting to obtain high-purity methionine copper;
the production method of the manganese methionine comprises the following steps: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into manganese sulfate, heating to 50-60 ℃, dissolving to obtain a manganese sulfate solution, adding methionine into the manganese sulfate solution, heating to 70-80 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-10.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and inspecting to obtain the high-purity methionine manganese.
The production method of the cobalt methionine comprises the following steps: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into cobalt sulfate, heating to 50-60 ℃, dissolving to obtain a cobalt sulfate solution, adding methionine into the cobalt sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 140 ℃ by using an air flow drying method, screening, and inspecting to be qualified to obtain the high-purity cobalt methionine.
Preferably, the special sulfate-free organic trace element feed additive for piglets comprises the following raw materials in parts by weight: 40-60 parts of ferrous fumarate; 15-35 parts of zinc fumarate and 8-12 parts of manganese methionine; 7-13 parts of copper methionine; 2-4 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.001-0.02 part of sodium selenite; 0.001-0.02 parts of cobalt methionine; 0.01-0.03 part of compound vitamin.
Preferably, the special sulfate-free organic trace element feed additive for piglets comprises the following raw materials in parts by weight: 50-70 parts of ferrous fumarate; 20-30 parts of zinc fumarate and 6-11 parts of manganese methionine; 8-12 parts of copper methionine; 3-5 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.002-0.03 part of sodium selenite; 0.002-0.03 part of cobalt methionine; 0.02-0.04 parts of compound vitamin.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate, and removing sulfate radical and other impurities for later use;
(2) taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
The invention also provides application of the special sulfate radical-free organic trace element feed additive for the piglets in preparation of feeds.
The invention also provides application of the special sulfate radical-free organic trace element feed additive for the piglets in the preparation of a medicine for preventing diarrhea of the piglets and promoting the growth of the piglets.
The ferrous fumarate is one kind of anemia treating medicine, is one kind of safe and efficient organic nutritious iron replenishing agent, and belongs to ferric organic acid, and has ferrous organic content as high as 30%, and the ferrous fumarate is absorbed to decompose ferrous ion easily and to enter red blood cell without needing extra energy, so that the product has no irritation to intestine and stomach, can raise and maintain the normal level of heme and may be used as nutritious additive for long term use. The ferrous fumarate is applied to breeding production, can improve the anti-stress capability and disease resistance of animals, can prevent iron-deficiency anemia of various animals, reduce diarrhea and diarrhea, improve the survival rate of livestock and poultry, reduce dystocia, stillbirth and abortion, improve the immunity and disease resistance of the animals, promote the growth and development of the animals, make the physique strong, make the skin and napped hair ruddy and glossy, improve the daily gain and the laying rate, reduce broken and soft-shell eggs, improve the quality of animal products, and has the advantages of low cost, good effect and the like.
The manganese methionine is amino acid chelated organic manganese, and the manganese element is supplemented by the manganese methionine in the form of an organic manganese source, so that the manganese utilization rate can be greatly improved, manganese required by synthesis of various metabolic enzymes in an animal body is met, the manganese methionine can effectively prevent and treat manganese deficiency (ataxia, abnormal bones and the like) to promote the growth of the animal, the biological utilization rate of the reproductive performance of the animal is improved, a compound which obstructs absorption is not formed with cellulose, phytic acid and the like, antagonism is not generated with mineral substances in a digestive tract, the immune function of the animal body can be enhanced through the rumen of a ruminant, the disease resistance of the animal is improved, the manganese methionine can promote synthesis and secretion of insulin, and normal glucose metabolism and fat metabolism are maintained.
The cobalt methionine is an amino acid chelate, and can be absorbed by the amino acid pinocyst, so that the competitive antagonism during the absorption of trace elements can be relieved, the absorption utilization rate of cobalt ions is greatly improved, and the absorption of other trace elements is also improved. The cobalt methionine is a component of vitamin B12 in an animal body, plays a role in the health and growth of the animal through vitamin B12, and when the cobalt is deficient, the appetite of the ruminant is poor, the ruminant grows slowly, the ruminant is thin, the ruminant is pica, and the ruminant is extremely anaemic and fatal.
The pantothenic acid used in the invention is also called vitamin B5, is mainly used for medicines, foods and feed additives, is a component of coenzyme A, participates in the metabolism of carbohydrate, fat and protein, and is a trace substance indispensable for maintaining normal physiological functions of human bodies and animals. Pantothenic acid plays a very important role in the synthesis and breakdown of fats, and is strongly linked to the normal function of the skin and mucous membranes, the color of the fur and resistance to diseases. The produced antibody is also one of the functions of pantothenic acid, and can help human body resist infectious diseases, alleviate side effects and toxicity of various antibiotics, and relieve allergic symptoms.
The sodium selenite and the vitamins used by the invention are nutrients necessary for normal functional activities in the animal body, and can be mutually cooperated in the animal body, so that the sodium selenite and the vitamins have an antioxidation effect, and protect in-vivo histiocytes and certain active substances from being damaged by peroxide, thereby regulating the normal metabolism of the animal body; meanwhile, sodium selenite and vitamins are also important substances capable of improving the reproductive capacity and the productivity of animals. The compound vitamin used in the invention comprises eight vitamins of A, D3, E, B1, B2, B6, pantothenic acid and vitamin K3.
The ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine in the raw materials used by the organic trace element piglet special feed additive without sulfate radicals are produced into various chelated trace elements without sulfate radicals by chelating trace elements (copper, zinc, manganese, iron and cobalt) with several different ligands (organic acid and amino acid) respectively, removing sulfate radicals brought by production raw materials and removing impurities such as sulfate radicals by a purification chelating process; all the organic trace elements do not contain sulfate ions, so that impurities such as sulfate and the like are removed, and all the organic trace elements are organic chelates.
The invention relates to a special feed additive for piglets without sulfate radical organic trace elementsThe agent is scientifically prepared from the raw materials, has prominent effects of no bitterness and diarrhea, and improves the palatability of piglets; maintaining intestinal electrolyte balance of piglets and inhibiting Na+The ions are excessively vigorously metabolized, tissue fluid backflow is not generated, no water sample is generated, and a zinc oxide astringent is not required to be added.
When the special feed additive for the piglet, disclosed by the invention, is added into a feed, the blood osmotic pressure balance can be maintained, and the piglet can be promoted to grow rapidly.
The invention has the beneficial effects that:
1. the special feed additive for the organic trace element-free piglet is characterized in that a plurality of different ligands (organic acid and amino acid) are respectively chelated with trace elements (copper, zinc, manganese and iron), sulfate radicals brought by production raw materials are removed, all organic trace elements are formed by scientific compounding, and the special feed additive does not contain inorganic anion sulfate radicals.
2. The special feed additive product for the piglet containing no sulfate organic trace elements has good palatability, can obviously and effectively improve the feed intake of the piglet and improve the health degree of the piglet. In addition, the organic trace elements in the product exist in a complex form, have lipophilicity, can be rapidly and completely absorbed into cells through cell membranes, and then enter animal bodies to be completely absorbed, so that the product can effectively resist diarrhea, can provide efficient and safe trace elements for piglets, and effectively supplement copper, zinc, manganese and iron. The ligands such as fumaric acid and methionine are important nutrients in the biochemical reaction in the animal body, are not in vitro substances, form a complex with trace elements in vitro of the animal body to save the internal energy of the animal, have no antagonism completely, cannot interfere with each other, and cannot cause the animal to generate rejection reaction. The inorganic trace element additive is poor in lipophilicity, and can be absorbed and utilized through a cell membrane only after forming a coordination bond complex with a suitable ion carrying carrier. Compared with the inorganic trace element additive, the feed additive prepared from the ferrous fumarate, manganese methionine, copper methionine and other organic trace element raw materials has higher and more obvious biological efficacy. The special feed additive containing no sulfate radical organic trace elements for the piglets is used in the piglet teaching and maintaining feed, can completely achieve the effect of replacing zinc oxide to resist diarrhea, can provide trace elements required by the growth of the piglets, improves the palatability of the feed and the health degree of the piglets, and reduces the death rate of the piglets.
3. The organic copper, zinc, manganese, iron complex monomer and the like are adopted as raw materials, and a safe, efficient and convenient organic trace element compound package is scientifically prepared, the prepared sulfate radical-free organic trace element-free piglet special feed additive is a piglet special compound feed additive, has high product purity, does not contain inorganic anions, can maintain electrolyte balance of piglets, fundamentally solves the problem of diarrhea of piglets, meets the growth requirements of piglets and maintains intestinal health of the piglets, can effectively reduce the diarrhea rate under the condition of reducing the consumption of zinc oxide, is used in piglet special feed, has good palatability and high absorption rate, can obviously improve the average daily gain, reduces the feed conversion ratio, improves the growth performance of the piglets, reduces the excretion of trace elements, and is safe and friendly to the environment. The product prepared by the invention is used for feed or applied to preparation of feed for preventing piglet diarrhea and promoting piglet growth, can improve the animal growth level and improve the breeding industry benefit, can also protect resources and environment, has obvious social benefit, and plays a positive promoting role in promoting and accelerating the development of animal husbandry in China.
Drawings
FIG. 1 is a photograph of piglets in a test group fed with the special feed additive for piglets free of sulfate organic trace elements according to the present invention in a feeding value evaluation test;
FIG. 2 is a photograph of piglets in a control group fed with the special feed additive for piglets without containing organic trace elements of sulfate radical in a feeding value evaluation test;
comparing the photographs of the piglets in fig. 1 and fig. 2 at the same time period, it can be seen that the piglets in the test group fed with the feed additive of the present invention grow well, are strong, and have ruddy skin; the piglets of the control group fed without the feed additive of the invention grew leaner. During the feeding process, the piglets in the control group are found to have low food intake, not quiet sleep, easy diarrhea and the like.
Detailed Description
The invention will now be described in further detail with reference to the following examples, which are given for the purpose of illustration only and are not intended to limit the scope of the invention. The experimental methods used in the following examples are all conventional methods unless otherwise specified, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
Example 1
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 55 parts of ferrous fumarate; 25 parts of zinc fumarate and 10 parts of manganese methionine; 10 parts of copper methionine; 3 parts of pantothenic acid; 0.015 part of calcium iodate; 0.015 part of sodium selenite; 0.015 part of cobalt methionine; 0.03 part of composite vitamin and 120 parts of filler; the filler is lead-free medical stone powder.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate are prepared by a special chelate process, and are treated by a purification chelation process to remove sulfate radicals and other impurities, so that various chelated trace elements without sulfate radicals are produced for later use;
(2) taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate, are prepared in the step (1), wherein the production method of the ferrous fumarate comprises the following steps: taking 30 parts of fumaric acid, 30 parts of soda ash and 70 parts of ferrous sulfate according to parts by weight for later use, respectively dissolving the soda ash with a proper amount of water to obtain a soda ash solution, dissolving the fumaric acid with water to obtain a fumaric acid solution, dissolving the ferrous sulfate with water at a temperature of more than 60 ℃ to obtain a ferrous sulfate solution, slowly dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to 8.0 to obtain a mixed solution, heating to 65-75 ℃, heating the ferrous sulfate solution to 75 ℃, adding the ferrous sulfate solution into the mixed solution to perform a neutralization reaction, performing the neutralization reaction at a reaction temperature of 75-85 ℃ for 2.5 hours to obtain ferrous fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at a temperature of 100 ℃ and 110 ℃, and performing 20-mesh fine screening to obtain a qualified ferrous fumarate finished product.
The production method of the zinc fumarate comprises the following steps: 25 parts of fumaric acid, 25 parts of soda ash and 60 parts of zinc sulfate heptahydrate are taken according to the parts by weight for standby, the soda ash is dissolved by using a proper amount of water respectively to obtain soda ash solution, the fumaric acid is dissolved by using water to obtain fumaric acid solution, the zinc sulfate heptahydrate is dissolved by using water with the temperature of more than 80 ℃ to obtain zinc sulfate solution, the soda ash solution is dripped into the fumaric acid solution to adjust the pH value of the solution to be 8.0 to obtain mixed solution, then the mixed solution is heated to 55-65 ℃, the zinc sulfate solution is heated to 70 ℃ and then added into the mixed solution for neutralization reaction, the reaction temperature of the neutralization reaction is 70-80 ℃, the reaction time is 1.5 hours to obtain zinc fumarate, centrifugal dehydration is carried out when the solution is hot, primary screening is carried out, drying is carried out at the temperature of 100 ℃ and 110 ℃, and the zinc fumarate is sieved by.
The production method of the copper methionine comprises the following steps: taking 60 parts of copper sulfate according to parts by weight; 30 parts of methionine; 10 parts of caustic soda flakes for later use, adding a proper amount of water into copper sulfate, heating to 60-70 ℃, dissolving to obtain a copper sulfate solution, adding methionine into the copper sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 8.0 by using the sodium hydroxide solution, reacting for 50 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and checking to be qualified to obtain high-purity methionine copper;
the production method of the manganese methionine comprises the following steps: taking 60 parts of cobalt sulfate according to parts by weight; 30 parts of methionine; 25 parts of caustic soda flakes for later use, adding a proper amount of water into manganese sulfate, heating to 50-60 ℃, dissolving to obtain a manganese sulfate solution, adding methionine into the manganese sulfate solution, heating to 70-80 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 8.0 by using the sodium hydroxide solution, reacting for 55 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and checking to be qualified to obtain the high-purity methionine manganese.
The production method of the cobalt methionine comprises the following steps: taking 60 parts of cobalt sulfate according to parts by weight; 30 parts of methionine; 20 parts of caustic soda flakes for later use, adding a proper amount of water into cobalt sulfate, heating to 50-60 ℃, dissolving to obtain a cobalt sulfate solution, adding methionine into the cobalt sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 7.0 by using the sodium hydroxide solution, reacting for 50 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 140 ℃ by using an air flow drying method, screening, and inspecting to be qualified to obtain the high-purity cobalt methionine.
Example 2
The special feed additive for the organic trace element-free piglet comprises the following raw materials in parts by weight: 60 parts of ferrous fumarate; 30 parts of zinc fumarate and 11 parts of manganese methionine; 12 parts of copper methionine; 3 parts of pantothenic acid; 0.02 part of calcium iodate; 0.02 part of sodium selenite; 0.02 part of cobalt methionine; 0.03 part of composite vitamin and 150 parts of filler; the filler is lead-free medical stone powder.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 3
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 65 parts of ferrous fumarate; 31 parts of zinc fumarate and 12 parts of manganese methionine; 12 parts of copper methionine; 3.5 parts of pantothenic acid; 0.02 part of calcium iodate; 0.02 part of sodium selenite; 0.02 part of cobalt methionine; 0.04 part of composite vitamin and 180 parts of filler; the filler is lead-free medical stone powder.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 4
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 70 parts of ferrous fumarate; 35 parts of zinc fumarate and 12 parts of manganese methionine; 13 parts of copper methionine; 4 parts of pantothenic acid; 0.03 part of calcium iodate; 0.02 part of sodium selenite; 0.02 part of cobalt methionine; 0.04 part of composite vitamin and 190 parts of filler; the filler is lead-free medical stone powder.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 5
The special feed additive for the organic trace element-free piglet comprises the following raw materials in parts by weight: 40 parts of ferrous fumarate; 15 parts of zinc fumarate and 8 parts of manganese methionine; 7 parts of copper methionine; 2 parts of pantothenic acid; 0.002 part of calcium iodate; 0.001 part of sodium selenite; 0.001 part of cobalt methionine; 0.01 part of vitamin complex and 1 part of filler.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 6
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 50 parts of ferrous fumarate; 20 parts of zinc fumarate and 6 parts of manganese methionine; 8 parts of copper methionine; 3 parts of pantothenic acid; 0.002 part of calcium iodate; 0.002 part of sodium selenite; 0.002 part of cobalt methionine; 0.02 part of vitamin complex and 10 parts of filler.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 7
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 30 parts of ferrous fumarate; 10 parts of zinc fumarate and 5 parts of manganese methionine; 5 parts of copper methionine; 1 part of pantothenic acid; 0.002 part of calcium iodate; 0.001 part of sodium selenite; 0.001 part of cobalt methionine; 0.01 part of compound vitamin.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; wherein the ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate complexes are in accordance with the preparation method of example 1.
(2) Taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
Example 8
A special sulfate radical-free organic trace element feed additive for piglets is composed of the following raw materials in parts by weight: 80 parts of ferrous fumarate; 40 parts of zinc fumarate and 15 parts of manganese methionine; 15 parts of copper methionine; 5 parts of pantothenic acid; 0.03 part of calcium iodate; 0.03 part of sodium selenite; 0.03 part of cobalt methionine; 0.05 part of vitamin complex and 200 parts of filler.
The preparation method of the special sulfate radical-free organic trace element feed additive for the piglets comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use; the production method of the ferrous fumarate comprises the following steps: taking 20-40 parts of fumaric acid, 20-40 parts of soda ash and 50-80 parts of ferrous sulfate according to parts by weight for later use, respectively dissolving the soda ash with a proper amount of water to obtain a soda ash solution, dissolving the fumaric acid with water to obtain a fumaric acid solution, dissolving the ferrous sulfate with water of more than 60 ℃ to obtain a ferrous sulfate solution, slowly dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 5.0-10.0 to obtain a mixed solution, heating to 65-75 ℃, heating the ferrous sulfate solution to 75 ℃, then adding the ferrous sulfate solution into the mixed solution to perform a neutralization reaction, controlling the reaction temperature of the neutralization reaction to be 75-85 ℃, controlling the reaction time to be 2.5 hours to obtain ferrous fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100-110 ℃, and performing 20-mesh fine screening to obtain a qualified ferrous fumarate finished product;
the production method of the zinc fumarate comprises the following steps: taking 15-30 parts of fumaric acid, 15-30 parts of soda ash and 40-70 parts of zinc sulfate heptahydrate according to parts by weight for later use, respectively dissolving the soda ash with proper amount of water to obtain soda ash solution, dissolving the fumaric acid with water to obtain fumaric acid solution, dissolving the zinc sulfate heptahydrate with water of more than 80 ℃ to obtain zinc sulfate solution, dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 6.0-10.0 to obtain mixed solution, heating to 55-65 ℃, heating the zinc sulfate solution to 70 ℃, then adding the zinc sulfate solution into the mixed solution to perform neutralization reaction, wherein the reaction temperature of the neutralization reaction is 70-80 ℃, the reaction time is 1.5 hours to obtain zinc fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100 ℃ and 110 ℃, and screening with a 20-mesh fine screen to obtain a qualified zinc fumarate finished product;
the production method of the copper methionine comprises the following steps: taking 40-70 parts of copper sulfate according to parts by weight; 20-40 parts of methionine; 5-15 parts of caustic soda flakes for later use, adding a proper amount of water into copper sulfate, heating to 60-70 ℃, dissolving to obtain a copper sulfate solution, adding methionine into the copper sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and inspecting to obtain high-purity methionine copper;
the production method of the manganese methionine comprises the following steps: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into manganese sulfate, heating to 50-60 ℃, dissolving to obtain a manganese sulfate solution, adding methionine into the manganese sulfate solution, heating to 70-80 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-10.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and inspecting to obtain high-purity methionine manganese;
the production method of the cobalt methionine comprises the following steps: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into cobalt sulfate, heating to 50-60 ℃, dissolving to obtain a cobalt sulfate solution, adding methionine into the cobalt sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 140 ℃ by using an air flow drying method, screening, and inspecting to be qualified to obtain high-purity cobalt methionine;
(2) taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope defined by the claims.
Example 9
Feeding effect test
1. Preparation of piglet feed
(1) The formula of the special feed for the piglets is respectively shown in the following table 1 and table 2:
2. and (3) experimental setting:
the test is divided into a test group and a control group, the test group comprises a first test group and a second test group, and the control group comprises a first control group and a second control group. The test groups were fed with the piglet specialty feeds provided in tables 1 and 2, and the control groups were fed with the basal diets provided in tables 1 and 2.
480 ternary hybrid piglets with the average weight of 15kg are selected and randomly divided into 4 groups according to the weight consistency principle, and the treatment is repeated for 6 times, and each group is repeated for 20 pigs. The weight of the tested piglet reaches 35kg and the application is finished. The pen house was thoroughly cleaned before the test, rinsed with 2% NaOH solution, then fumigated with formalin and potassium permanganate at a ratio of 2:1 for several hours, and after one week of aeration cleaning, the test was started. Before the beginning of the formal test, a pre-test is carried out for 7 days, and the test pigs are subjected to insect expelling and epidemic prevention during the pre-test period. And (3) feeding powdery materials at a fixed time at 8:00 and 17:00 every day in the normal test period, freely eating and drinking water, observing and recording the health condition of the pigs, and recording the food consumption in the whole period. The test period determination indexes comprise: average daily gain, feed-weight ratio and copper, zinc and iron contents in pig manure.
The index calculation method comprises the following steps:
average daily gain = (end of test body weight-initial body weight)/number of test days
Material weight ratio = average daily material consumption (kg/d/head)/average daily gain (kg/d/head)
3. The results are shown in Table 3.
As can be seen from the test results in table 3, the average daily gain of the first test group and the second test group was increased by 6.7% and 5.6%, respectively (P < 0.05), the feed-to-weight ratio was decreased by 7.8% and 8.1%, respectively, the amount of discharged copper in pig manure was decreased by 21.3% and 26.9%, respectively, the amount of discharged zinc in pig manure was decreased by 30.3% and 32.3%, respectively, and the amount of discharged iron in pig manure was decreased by 15.3% and 16.2%, respectively, as compared to the first control group and the second control group. It can be seen that the daily gain, the material-weight ratio, the zinc manure and the iron manure of the first test group and the second test group are obviously better than those of the first control group and the second control group, and the indexes of the first control group and the second control group have no obvious difference. The results show that the special feed additive for the piglets can promote the synergistic effect of all the trace elements and improve the utilization rate of the trace elements; the feed (the special feed for piglets provided in tables 1 and 2) prepared by adopting the special feed additive for piglets provided by the invention can obviously improve the average daily gain and obviously reduce the feed-weight ratio and the content of trace elements in feces.
Example 10
Feeding value evaluation test of special feed additive product for piglets
1 materials and methods
1.1 test the feed additive special for the organic trace element piglet without sulfate prepared in the embodiment 3 of the invention has the use specification of 1 kg/t.
1.2 design of the experiment
120 weaned piglets of 23 days old are selected in the test and randomly divided into 2 treatment groups, each treatment group has 6 repetitions, and each repetition has 10 pigs. The grouping and treatment of the test animals is shown in table 4 below:
1.3 test daily ration
The test diets were designed according to NRC (2012) in conjunction with standard test pig farm enterprises, see table 5.
Note:*the premix comprises mildew preventive, antioxidant, sweetener, phytase, vitamin and the like; the trace mineral element addition level in the inorganic mineral element premix is designed according to the content of the feed additive product prepared in example 3 of the present invention.
1.4 Breeding management
The piglet is set with a 4-day transition period after weaning, and the period is 28 days from the 25-day age of the piglet. The experimental piglets are fed by adopting a high bed, the pigsty is semi-open, natural ventilation and mechanical ventilation are adopted, and the piglets are fed and drunk freely. Immunization and anthelmintic procedures were performed according to the routine pig farm procedures. The health condition and ingestion condition of the piglets are observed and recorded at 10:00, 14:00 and 17:00, and the piglets are fed with the feed appropriately.
1.5 sample Collection
(1) Feed and fecal samples
After the test feed is prepared, respectively collecting feed samples and storing at low temperature for later use. At 14 days the test was run, 2 pigs were selected per replicate and fresh stool samples were collected for use.
(2) Blood sample
At the end of the feeding test, test pigs with weights close to the average weight are repeatedly selected, 15mL of blood is collected from the anterior vena cava, 5mL of separated serum is used for measuring the hormone level, and 10mL of whole blood is used for measuring the blood biochemical index.
1.6 measurement index and method
(1) Growth performance:
weighing and recording the residual feed amount and the feed amount of each circle of test pigs by taking the repetition as a unit when the test is finished, and calculating the Average Daily Feed Intake (ADFI) of each piglet in the whole period; weighing test pig powder (FBW) by taking a repetition as a unit after fasting for 12h 1 d before the test is finished, and calculating the Average Daily Gain (ADG) of each piglet in the whole period; the feed-to-weight ratio (F/G) was calculated from the ADFI and ADG of the piglet at the experimental period.
Diarrhea rate (%) = [ number of diarrhea heads/(number of test days × number of test heads) in test period) ] × 100.
(2) Serum hormone levels:
growth Hormone (GH), insulin growth factor (IGF-1) were assayed by ELISA.
(3) Feed pH and electrolyte balance (dEB):
3 samples were taken per feed, 2 replicates per sample were set up.
pH value: 20g of feed is taken, 30mL of deionized water is added, the mixture is stirred uniformly, and the pH value of the mixture is measured.
dEB：Na+、K+The measurement was carried out by atomic absorption spectrophotometry, C1-By indirect atomic absorption spectroscopy, SO4 2-Measured by volumetric titration.
dEB(mEq/kg)＝[Na+×1000/23 + K+×1000/39-Cl-×1000/35.5- 2SO4 2-×1000/96]/kg
(4) Blood pH, electrolyte balance dEB:
respectively measuring pH value and Na by a Techni2conRA-1000 full-automatic biochemical analyzer+、K+、Cl-And (4) concentration.
dEB(mEq/kg)＝[Na+×1000/23 + K+×1000/39-Cl-×1000/35.5]/kg
(5) Osmotic pressure of plasma and feces
Respectively measuring Na in blood by adopting Techni2conRA-1000 full-automatic biochemical analyzer+、K+Blood sugar and urineConcentration of elemental nitrogen, Na in feces+、K+The concentration was determined by atomic absorption spectrophotometry.
Plasma osmolality =2 × (blood potassium + blood sodium) + blood glucose + urea nitrogen
Poor stool penetration = plasma osmolality-2 × (stool [ Na ]+]+ stool (K)+]）
1.7 data processing and analysis
The test data are analyzed by SPSS19.0 statistical software, multiple comparison and difference analysis are carried out by a Duncan type new repolarization method, the test result is expressed by Mean value plus or minus standard error (Mean plus or minus SE), and P <0.05 is used as a difference significance standard.
2 results and analysis
2.1 Effect of the feed additive product special for piglets on growth performance of weaned piglets
The results of the effect of the special feed additive product for piglets on the growth performance of weaned piglets are shown in table 6. As can be seen from Table 6, the differences in body weight of the test pigs between the treatment groups at the start of the test were not significant (P > 0.05). The experimental results show that compared with the feed added with the special feed additive product for the piglets in the control group, the feed can increase the daily weight gain and the feed intake of the weaned piglets, reduce the feed meat, reduce the diarrhea rate of the weaned piglets, improve the health degree of the piglets and improve the growth performance of the weaned piglets.
2.2 the influence of the feed additive product special for piglets on serum hormone of weaned piglets
The different diet treatments have only a numerical influence on the serum GH and IGF-I concentrations of the weaned pigs, and have no significant difference
Iso (P > 0.05). The specific results are shown in table 7 below:
2.3 the influence of the feed additive product special for the piglets on the pH value and dEB value in the feed of the weaned piglets
Different diet treatments had only a numerical effect on weaned piglet diet pH and dEB with no significant difference (P > 0.05); the test results are shown in the following table 8, and the replacement of inorganic mineral elements by the special feed additive product for the piglets improves the dEB value (P is more than 0.05) of the feed in numerical value, and the reduction of the use of the acidifier improves the dEB value of the feed for the weaned piglets in numerical value1The value (P > 0.05); the experimental group adopting the special feed additive product for the piglets to replace inorganic mineral elements obviously improves the feed dEB2Value (P)<0.05）。
2.4 influence of the feed additive product special for piglets on pH value and dEB value of blood of weaned piglets
Different diet treatments had only a numerical effect on weaned piglet blood pH and dEB with no significant difference (P > 0.05). The test results are shown in the following table 9, and the replacement of inorganic mineral elements by the special feed additive product for the piglets improves the blood pH and dEB values (P is more than 0.05) numerically, and the reduction of the use of the acidifier improves the blood pH and dEB values (P is more than 0.05) numerically.
2.5 the feed additive product special for the piglets has the osmotic pressure on the plasma and the osmotic pressure on the excrement of the weaned piglets
Influence different diet treatments had only a numerical influence on plasma and fecal osmotic pressure of weaned piglets, with no significant difference (P > 0.05). The test results are shown in table 10 below.
3 small knot
Tests show that the special feed additive product for the piglets, which is free of sulfate radical and contains organic trace elements, has the positive effect of improving the growth performance of the weaned piglets by replacing inorganic mineral elements, can obviously improve the average daily gain, reduce the feed conversion ratio, effectively maintain the electrolyte balance of the piglets, fundamentally solve the problem of diarrhea of the piglets, maintain the intestinal health of the piglets, effectively reduce the diarrhea rate, can replace antibiotic zinc oxide, and can reduce the dosage of an acidifier. The special feed additive product for the piglet, which is researched and developed by the invention, containing no sulfate radical organic trace elements is used in the piglet teaching and maintaining feed, can completely achieve the effect of replacing zinc oxide for resisting diarrhea, can provide trace elements required by the piglet growth, improves the feed palatability and the piglet health degree, and reduces the piglet mortality.
Claims (12)
1. The special sulfate radical-free organic trace element feed additive for the piglets is characterized by comprising the following raw materials in parts by weight: 30-80 parts of ferrous fumarate; 10-40 parts of zinc fumarate and 5-15 parts of manganese methionine; 5-15 parts of copper methionine; 1-5 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.001-0.03 part of sodium selenite; 0.001-0.03 part of cobalt methionine; 0.01-0.05 part of vitamin complex.
2. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the raw materials further comprise 1-200 parts by weight of filler.
3. The special feed additive for the piglet without sulfate organic trace elements as claimed in claim 1, wherein the ferrous fumarate, the zinc fumarate, the manganese methionine, the copper methionine and the cobalt methionine do not contain sulfate ions and are all organic chelates, and the production method of the ferrous fumarate comprises the following steps: taking 20-40 parts of fumaric acid, 20-40 parts of soda ash and 50-80 parts of ferrous sulfate according to parts by weight for later use, respectively dissolving the soda ash with a proper amount of water to obtain a soda ash solution, dissolving the fumaric acid with water to obtain a fumaric acid solution, dissolving the ferrous sulfate with water of more than 60 ℃ to obtain a ferrous sulfate solution, slowly dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 5.0-10.0 to obtain a mixed solution, heating to 65-75 ℃, heating the ferrous sulfate solution to 75 ℃, then adding the ferrous sulfate solution into the mixed solution to perform a neutralization reaction, controlling the reaction temperature of the neutralization reaction to be 75-85 ℃, controlling the reaction time to be 2.5 hours to obtain ferrous fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100-110 ℃, and performing 20-mesh fine screening to obtain a qualified ferrous fumarate finished product.
4. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the production method of zinc fumarate comprises: taking 15-30 parts of fumaric acid, 15-30 parts of soda ash and 40-70 parts of zinc sulfate heptahydrate according to parts by weight for later use, respectively dissolving the soda ash with proper amount of water to obtain soda ash solution, dissolving the fumaric acid with water to obtain fumaric acid solution, dissolving the zinc sulfate heptahydrate with water of more than 80 ℃ to obtain zinc sulfate solution, dropwise adding the soda ash solution into the fumaric acid solution to adjust the pH value of the solution to be 6.0-10.0 to obtain mixed solution, heating to 55-65 ℃, heating the zinc sulfate solution to 70 ℃, then adding the zinc sulfate solution into the mixed solution to perform neutralization reaction, wherein the reaction temperature of the neutralization reaction is 70-80 ℃, the reaction time is 1.5 hours to obtain zinc fumarate, performing centrifugal dehydration while hot, performing primary screening, drying at the temperature of 100-110 ℃, sieving with a 20-mesh fine sieve, and checking to be qualified to obtain a finished product of the zinc fumarate.
5. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the production method of copper methionine is as follows: taking 40-70 parts of copper sulfate according to parts by weight; 20-40 parts of methionine; 5-15 parts of caustic soda flakes for later use, adding a proper amount of water into copper sulfate, heating to 60-70 ℃, dissolving to obtain a copper sulfate solution, adding methionine into the copper sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and checking to be qualified to obtain the high-purity copper methionine.
6. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the production method of the manganese methionine comprises the following steps: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into manganese sulfate, heating to 50-60 ℃, dissolving to obtain a manganese sulfate solution, adding methionine into the manganese sulfate solution, heating to 70-80 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-10.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 120 ℃ by using an air flow drying method, screening, and inspecting to obtain the high-purity methionine manganese.
7. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the production method of the cobalt methionine is as follows: taking 40-70 parts of cobalt sulfate according to parts by weight; 20-40 parts of methionine; 15-30 parts of caustic soda flakes for later use, adding a proper amount of water into cobalt sulfate, heating to 50-60 ℃, dissolving to obtain a cobalt sulfate solution, adding methionine into the cobalt sulfate solution, heating to 70-75 ℃, dissolving the caustic soda flakes with a proper amount of water to obtain a sodium hydroxide solution, adjusting the pH value of the solution to 5.0-8.0 by using the sodium hydroxide solution, reacting for 30-60 minutes, standing, cooling, centrifugally dewatering, recovering filtrate, drying filter residues at 140 ℃ by using an air flow drying method, screening, and inspecting to be qualified to obtain the high-purity cobalt methionine.
8. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, which comprises the following raw materials in parts by weight: 40-60 parts of ferrous fumarate; 15-35 parts of zinc fumarate and 8-12 parts of manganese methionine; 7-13 parts of copper methionine; 2-4 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.001-0.02 part of sodium selenite; 0.001-0.02 parts of cobalt methionine; 0.01-0.03 part of compound vitamin.
9. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, which comprises the following raw materials in parts by weight: 50-70 parts of ferrous fumarate; 20-30 parts of zinc fumarate and 6-11 parts of manganese methionine; 8-12 parts of copper methionine; 3-5 parts of pantothenic acid; 0.002-0.03 part of calcium iodate; 0.002-0.03 part of sodium selenite; 0.002-0.03 part of cobalt methionine; 0.02-0.04 parts of compound vitamin.
10. The special sulfate radical-free organic trace element feed additive for piglets as claimed in claim 1, wherein the preparation method comprises the following steps:
(1) preparing various sulfate radical-free chelated trace elements, namely ferrous fumarate, zinc fumarate, manganese methionine, copper methionine and cobalt methionine chelate for later use;
(2) taking the raw materials according to the weight part ratio, and putting the raw materials into a stirrer to be uniformly mixed;
(3) detecting;
(4) and (7) packaging a finished product.
11. Use of the sulfate-free organic trace element-containing feed additive special for piglets, according to any one of claims 1 to 9, in the preparation of a feed.
12. Use of the special sulfate-free organic trace element feed additive for piglets, according to any one of claims 1 to 9, in the preparation of a medicament for preventing diarrhea in piglets and promoting the growth of piglets.
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