CN111097063A

CN111097063A - Medical composite antibacterial wound surface coating product

Info

Publication number: CN111097063A
Application number: CN201911401450.0A
Authority: CN
Inventors: 谢友能; 肖宇群; 徐艳
Original assignee: Jiangxi Ganda Material Technology Research Co ltd
Current assignee: Jiangxi Ganda Material Technology Research Co ltd
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-05-05

Abstract

The invention relates to the technical field of wound surface coating, in particular to a medical composite antibacterial wound surface coating product which has the advantages of reasonable structure, convenient use, capability of promoting wound healing, broad-spectrum long-acting antibacterial effect, safety, reliability and low price; including medical adhesive tape layer, the layer that absorbs water, antibiotic functional layer and leave type paper layer, it is fixed that the layer that absorbs water passes through medical level hot melt adhesive bonding with antibiotic functional layer to it fixes through the non-setting adhesive layer to absorb water the layer medical adhesive tape layer upper surface to the area on the layer that absorbs water is less than medical adhesive tape layer, it is fixed to bond from type paper layer edge region and medical adhesive tape layer edge region, and from type paper layer central zone and antibiotic functional layer surface contact.

Description

Medical composite antibacterial wound surface coating product

Technical Field

The invention relates to the technical field of wound surface coating, in particular to a medical composite antibacterial wound surface coating product.

Background

As is well known, after a wound surface is produced, usually, a suitable coating product is selected to cover the wound surface sufficiently after a disinfection treatment, and then, the wound surface is fixed by a medical adhesive tape. The coating product has the main functions of protecting the wound surface, absorbing wound tissue fluid and stopping bleeding, thereby promoting the wound surface to heal. However, the traditional coating product does not contain effective antibacterial components, cannot eliminate complications such as wound secondary infection and the like caused by bacteria, and still has defects in the aspect of treating large wound patients such as large-area burns and the like. Meanwhile, although the traditional coating product can absorb wound tissue fluid and blood, thereby being beneficial to wound healing, the surface of the traditional coating product does not contain components for effectively promoting wound healing, and the traditional coating product is mainly repaired and healed by the body, so that the healing period is still longer, and the risk of wound infection is further increased. Therefore, the development of a coating product with antibacterial and wound healing promoting functions has urgent practical requirements.

In view of the above disadvantages, many companies and scientific research institutes have made many studies on the problems of the antibacterial property of the coated product. Korean laid-open patent publication No. 2010-0021108 discloses a silver nanoparticle-containing dressing, which is characterized in that a fiber having silver nanoparticles is prepared by mixing a silver salt with a fiber polymer and then electrospinning, to form a fiber member, and antibacterial effects are achieved by using the silver nanoparticles. Similarly, Xuyin leap et al (patent application No. 201680017038.7) uses water-soluble polymer to release silver by dissolving in water of wound exudate such as tissue fluid, etc. to realize the antibacterial action of dressing. The above two patents both use silver as an antibacterial component, which is relatively high in cost, but silver also has certain biological toxicity and environmental hazard, and is not approved by FDA. Meanwhile, both patents only mention the antibacterial property, and no report on the promotion of wound healing exists.

Patent [201720703863.4] adopts dressing layer containing arginine and hydrogel layer containing nitric oxide synthase as dressing, utilizes the body temperature of wound surface to activate the activity of nitric oxide synthase, catalyzes arginine to produce NO, and the hydrogel layer can rapidly absorb the exudate on the surface of wound after contacting with the wound surface, the absorbed exudate further promotes nitric oxide synthase to catalyze arginine, produce NO, and the pH value near the wound becomes low after reaction, and the created subacid environment promotes the secretion of wound growth factor. And the hydrogel layer can provide a slightly humid healing environment for the wound surface and promote the wound healing. Although the dressing described in the patent mentions antibacterial and wound healing promotion, the dressing needs to be stored at low temperature before use, and the raw material cost is expensive and the practicability is not strong.

Disclosure of Invention

In order to solve the technical problems, the invention provides a medical composite antibacterial wound surface coating product which has a reasonable structure, is convenient to use, can promote wound healing, has a broad-spectrum long-acting antibacterial effect, is safe and reliable, and is low in price.

The invention relates to a medical composite antibacterial wound surface coated product which comprises a medical adhesive tape layer, a water absorption layer, an antibacterial function layer and a release paper layer, wherein the water absorption layer and the antibacterial function layer are fixedly bonded through medical hot melt adhesive, the water absorption layer is fixedly arranged on the upper surface of the medical adhesive tape layer through an adhesive sticker layer, the area of the water absorption layer is smaller than that of the medical adhesive tape layer, the edge area of the release paper layer is fixedly bonded with the edge area of the medical adhesive tape layer, and the central area of the release paper layer is in contact with the surface of the antibacterial function layer.

The medical composite antibacterial wound surface coating product provided by the invention has the advantages that the antibacterial functional layer contains an antibacterial additive, the antibacterial additive is copper-doped zinc oxide nanoparticles, the size of the copper-doped zinc oxide nanoparticles is 20-800 nm, and the copper content is 0.2-20%.

The invention relates to a medical composite antibacterial wound surface coating product, and a preparation method of copper-doped zinc oxide nanoparticles comprises the following steps:

s1, weighing 50-80 parts by weight of copper salt and zinc salt according to the weight ratio of 0.2-20% of copper to zinc, and dissolving in deionized water to obtain a solution A;

s2, weighing 20-50 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;

s3, weighing 0.05-5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;

s4, mixing the solution B obtained from the solution A, S2 obtained from the S1 and the solution C obtained from the S3, and reacting at 60-100 ℃ to obtain a mixed solution D;

and S5, centrifuging the mixed solution D obtained in the step S4 at the speed of 3000-10000 r/min for centrifugal treatment, filtering and cleaning the precipitate obtained by centrifugation, and drying at the temperature of 50-120 ℃ for 6-24 hours to obtain the copper-doped zinc oxide particles.

Compared with the prior art, the invention has the beneficial effects that: the medical composite antibacterial wound surface coated product comprises a coated product such as common gauze and a composite antibacterial additive, wherein the composite antibacterial additive can be added in any link from the spinning of the coated product to a finished product, the dressing is endowed with excellent antibacterial performance mainly by adding copper-zinc composite antibacterial particles on the surface layer of the common coated product, and the existence of zinc ions can promote the rapid healing of the wound surface. The inorganic copper-zinc composite antibacterial agent has lasting antibacterial performance and does not generate drug resistance, and under the premise of ensuring the functions of the traditional coating product, the antibacterial property and the ability of promoting wound healing are endowed, so that the infection of the wound is reduced, the treatment course is shortened, and the inorganic copper-zinc composite antibacterial agent has the advantages of broad-spectrum long-acting antibacterial property, safety, reliability, low price, capability of promoting wound healing, no generation of drug resistance of bacteria and the like.

Drawings

FIG. 1 is a schematic structural view of a medical composite antimicrobial wound dressing article of the present invention;

FIG. 2 is an XRD spectrum of the ZnO-1% Cu nano-antibacterial composite obtained in example 1;

FIG. 3 is an SEM photograph of the ZnO-1% Cu nano antibacterial composite obtained in example 1;

FIG. 4 is an SEM photograph of the ZnO-10% Cu nano antibacterial composite obtained in example 2;

FIG. 5 is an SEM photograph of the ZnO-20% Cu nano antibacterial composite obtained in example 3;

in the drawings, the reference numbers: 1. a medical rubberized fabric layer; 2. a water-absorbing layer; 3. an antimicrobial functional layer; 4. and (7) a release paper layer.

Detailed Description

The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

Example 1

Aligning a second water absorption layer 2 and a third antibacterial functional layer 3 which have the same shape and size, and bonding the two layers by using medical-grade hot melt adhesive to bond the two layers together; the water absorption layer 2 is formed by compounding high-power water absorption fibers with a nano antibacterial material by methods of spraying, padding, dipping and the like, the antibacterial function layer 3 is formed by compounding a porous PE film with the nano antibacterial material by methods of spraying, padding, dipping and the like, the water absorption layer 2 and the antibacterial function layer 3 are fixed in the middle of the first medical rubberized fabric layer 1 through a non-setting adhesive layer on the first layer (the area of the first layer is larger than that of the second layer and the third layer), and the adhesive layer on the periphery of the first medical rubberized fabric layer 1 is exposed; the periphery of the fourth release paper layer 4 is bonded and fixed with the adhesive layer exposed at the periphery of the first layer, and the middle part of the fourth release paper layer covers the upper surface of the third antibacterial function layer 3. Thus, the four layers of materials are bonded together according to the specification requirement to prepare the multilayer medical dressing which has the advantages of broad-spectrum antibiosis, high moisture absorption, strong air permeability, no drug resistance and convenient use.

The preparation method of the copper-doped zinc oxide nano antibacterial material comprises the following steps:

s1, weighing 65 parts by weight of copper salt and zinc salt according to the weight ratio of 1% of copper to zinc, and dissolving in deionized water to obtain a solution A;

s2, weighing 34.75 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;

s3, weighing 0.25 part by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;

s4, reacting the solution B obtained from the solution A, S2 obtained from S1 and the solution C obtained from S3 at 80 ℃ to obtain a mixed solution D;

s5, centrifuging the mixed solution D obtained in the step S4 at 8000 rpm, cleaning the precipitate obtained by centrifugation, and drying at 80 ℃ for 12 hours to obtain copper-doped zinc oxide particles.

The XRD pattern of the finally obtained ZnO-1% Cu nano antibacterial composite material is shown in figure 2, and the average grain size is 23 nm; the SEM photograph is shown in FIG. 3 and is a flower shape composed of nanosheets; the prepared medical nano antibacterial composite dressing shows good antibacterial performance through antibacterial experiments.

Example 2

s1, weighing 64.5 parts by weight of copper salt and zinc salt according to the weight ratio of 10% of copper to zinc, and dissolving in deionized water to obtain a solution A;

s2, weighing 33 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;

s3, weighing 2.5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;

s5, centrifuging the mixed solution D obtained in the step S4 at 8000 rpm, cleaning the precipitate obtained by centrifugation, and drying at 80 ℃ for 12 hours to obtain the copper-doped zinc oxide nanoparticles.

The SEM photograph of the ZnO-10% Cu nano antibacterial composite material is shown in FIG. 4, which is a sea urchin structure composed of nano rods; the results of antibacterial experiments show that the content of the granules for the escherichia coli and the staphylococcus aureus is more than 99.99 percent.

Example 3

The preparation method of the copper-doped zinc oxide antibacterial material comprises the following steps:

s1, weighing 63 parts by weight of copper salt and zinc salt according to the weight ratio of 20% of copper to zinc, and dissolving in deionized water to obtain a solution A;

s2, weighing 32 parts by weight of sodium hydroxide, and dissolving in deionized water to obtain a solution B;

s3, weighing 5 parts by weight of sodium borohydride, and dissolving the sodium borohydride in deionized water to obtain a solution C;

The SEM photograph of the finally obtained ZnO-20% Cu nano antibacterial composite material is shown in FIG. 5, and is a sea urchin structure consisting of nano rods; the results of antibacterial experiments show that the content of the granules for the escherichia coli and the staphylococcus aureus is more than 99.99 percent.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims

1. The utility model provides a medical compound antibiotic surface of a wound cladding goods, its characterized in that, includes medical adhesive tape layer, absorbs water the layer, antibiotic functional layer and leaves the type paper layer, it is fixed through medical level hot melt adhesive bonding with antibiotic functional layer to absorb water the layer and pass through the non-setting adhesive layer to be fixed medical adhesive tape layer upper surface to the area on layer that absorbs water is less than medical adhesive tape layer, it is fixed with medical adhesive tape layer edge region bonding from type paper layer edge region to it contacts with antibiotic functional layer surface from type paper layer central zone.

2. The medical composite antibacterial wound surface covering product of claim 1, wherein the antibacterial functional layer contains an antibacterial additive, the antibacterial additive is copper-doped zinc oxide nanoparticles, the size of the copper-doped zinc oxide nanoparticles is 20-800 nm, and the copper content is 0.2-20%.

3. The medical composite antibacterial wound-surface-coating product of claim 2, wherein the preparation method of the copper-doped zinc oxide nanoparticles comprises the following steps: