CN111084673B

CN111084673B - Intra-cavity isolation stent compatible with branch blood vessels and intra-cavity isolation system

Info

Publication number: CN111084673B
Application number: CN201911421718.7A
Authority: CN
Inventors: 李雷
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2023-03-21
Anticipated expiration: 2039-12-31
Also published as: CN111084673A

Abstract

The present disclosure relates to an endoluminal exclusion stent and an endoluminal exclusion system compatible with branch vessels, the endoluminal exclusion stent comprising: a main body support (1) which has elasticity and can be tightly attached to the inner wall of a blood vessel, wherein a plurality of through holes (11) are formed in the main body support (1), and the through holes are formed into a mesh-shaped structure for example; a hydrogel layer (2) provided at least at a plurality of the through holes (11) so as to be capable of expanding and blocking the corresponding through holes (11) when encountering water. Through the technical scheme, the intracavity isolation stent and the intracavity isolation system compatible with the branch blood vessel can solve the technical problems of poor universality and compatibility of the intracavity graft.

Description

Intra-cavity isolation stent compatible with branch blood vessels and intra-cavity isolation system

Technical Field

The present disclosure relates to the field of artificial blood vessels, and in particular, to an endoluminal isolation system and method of manufacture.

Background

The incidence of aortic dissection has risen dramatically in recent years and there is a trend towards younger aortic dissection. By Aortic Dissection (AD), a pathological change in the aorta is formed by partial tearing of the inner wall of the aorta, and blood in the aortic lumen enters the aortic media from the aortic intimal laceration, causing the media to tear apart and expand along the major axis of the aorta. The blood supply of important branches of the aorta is interrupted during the formation of the dissecting, so that the serious ischemic function of important organs is lost, and even serious complications or death are caused, and in addition, the direct rupture of a false cavity or the rupture after the formation of an aneurysm can also cause massive hemorrhage and death.

In order to solve the problem, aortic dissection endoluminal isolation has been developed, that is, a minimally invasive method is adopted to seal dissection lacerations by implanting a straight-tube or branched endoluminal graft into a blood vessel lumen, so as to achieve the purpose of treatment.

Because the position of aortic dissection is different for each patient, when the lesion part is close to an important blood vessel branch, the intracavity graft needs to form a branch opening at a specific part according to the difference of the lesion position so as to avoid covering the blood vessel branch, thereby ensuring the smooth blood flow of the blood vessel branch. This results in reduced versatility and poor compatibility of the endograft, which leads to increased treatment costs.

Disclosure of Invention

The purpose of this disclosure is to provide a branch vessel compatible endoluminal isolation stent and endoluminal isolation system to solve the technical problem of poor versatility and compatibility of endoluminal grafts.

In order to achieve the above objects, the present disclosure provides a branched vessel-compatible endoluminal isolation stent comprising: the main body support is elastic and can be tightly attached to the inner wall of a blood vessel, and a plurality of through holes are formed in the main body support; the hydrogel layer is at least arranged at the through holes and can expand and block the corresponding through holes when meeting water.

Optionally, the main body support is a tubular structure, and a plurality of through holes are randomly distributed on the tube wall of the tubular structure.

Optionally, the main body support is formed as a mesh-like structure, and the through holes are constituted by mesh holes in the mesh-like structure.

Optionally, the diameter of the through hole is 0.5-2.0mm.

Optionally, the main body scaffold is a polymer scaffold.

Optionally, the hydrogel layer integrally wraps a surface of the body mount.

On the basis of the technical scheme, the present disclosure further provides an endoluminal isolation system compatible with a branch vessel, comprising: the intracavity isolation bracket in the technical scheme is provided; and an anti-clogging member for being removably implanted into at least one of the through-holes to prevent clogging thereof with the hydrogel.

Optionally, the anti-clogging element is a balloon.

Optionally, the main body stent is used for being implanted into a main body vessel, and the endoluminal isolation system further comprises branch stents, which are used for being implanted into corresponding branch vessels through the through holes which are not blocked by the anti-blocking pieces.

Optionally, a fastener is included to secure the body scaffold in the body vessel.

Through the technical scheme, when the main body support in the intracavity isolation support compatible with the branch blood vessels is implanted into the pathological change position of the main body blood vessels, the hydrogel layer meeting blood can expand in a certain time and block the through holes on the main body support, so that the tube wall of the main body support and the hydrogel layer are combined into a whole and tightly attached to the inner wall of the main body blood vessels, and the pathological change position is completely isolated from blood. In the process of expanding the hydrogel layer, a removable filler can be placed in a through hole or through holes corresponding to the branch blood vessels on the main body bracket, so that the through hole is not blocked by the hydrogel layer, and blood can flow into the branch blood vessels through the through hole to ensure the smooth blood flow of the branch blood vessels. That is, the physician can avoid one or more through holes on the main stent during the expansion of the hydrogel layer as required, so that the endoluminal isolation stent provided by the present disclosure can adapt to different lesion sites to be compatible with different branch vessels.

The intracavity isolation system compatible with the branch blood vessel comprises the intracavity isolation stent in the technical scheme, and has the same technical effect as the intracavity isolation stent. In addition, the anti-blocking piece in the isolated system in intracavity that this disclosure provided can be implanted in one or more through-holes on the main part support as required to prevent this through-hole at the hydrogel layer inflation in-process blockked up, after the hydrogel layer inflation is accomplished and is combined as an organic whole with the pipe wall of main part support, should prevent that the piece can shift out, so that blood can flow into branch's blood vessel through the through-hole that is not blockked up by hydrogel. Therefore, the intracavity isolation system provided by the disclosure is convenient to use, has good universality and can control the treatment cost.

Additional features and advantages of the present disclosure will be set forth in the detailed description which follows.

Drawings

The accompanying drawings, which are included to provide a further understanding of the disclosure and are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure without limiting the disclosure. In the drawings:

FIG. 1 is a schematic diagram of a chamber isolation system according to an embodiment of the present disclosure.

FIG. 2 is a schematic diagram of a chamber insulation system according to another embodiment of the present disclosure.

Description of the reference numerals

1-main body support, 11-through hole, 2-hydrogel layer, 3-branch support, 4-main body blood vessel, 41-branch blood vessel, 5-anti-blocking piece and 6-guide wire.

Detailed Description

The following detailed description of specific embodiments of the present disclosure is provided in connection with the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present disclosure, are given by way of illustration and explanation only, not limitation.

In the present disclosure, the use of directional terms such as "inner and outer" means inner and outer with respect to the intrinsic contours of the respective components, unless otherwise specified. In addition, when the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated.

According to the specific embodiment of the present disclosure, an isolated endoluminal stent compatible with branched blood vessels is provided, referring to fig. 1 and 2, the isolated endoluminal stent provided by the present disclosure may include a main body stent 1 and a hydrogel layer 2, the main body stent 1 has elasticity so as to be able to cling to the inner wall of a blood vessel, and the main body stent 1 may further be provided with a plurality of through holes 11, and the hydrogel layer 2 is at least disposed at the plurality of through holes 11 so as to be able to swell and block the corresponding through holes 11 when encountering water. The hydrogel layer 2 on the main body frame 1 can be obtained in any suitable manner, for example, when the main body frame 1 is in vitro, the hydrogel layer can be soaked in the hydrogel, so that the hydrogel layer 2 is wrapped at the through holes 11 of the main body frame 1. The main body stent 1 can be reached to the lesion site by various existing stent implantation methods, for example, the main body stent 1 can be attached to a balloon and introduced into a blood vessel of a patient through a guide wire.

Through the technical scheme, when the main body support 1 in the intracavity isolation support compatible with the branch blood vessels is implanted into the pathological change position of the main body blood vessel 4, the hydrogel layer 2 meeting blood can expand and block the through hole 11 on the main body support 1 within a certain time, so that the tube wall of the main body support 1 and the hydrogel layer 2 are combined into a whole and tightly attached to the inner wall of the main body blood vessel 4, and the pathological change position is completely isolated from the blood. During the expansion of the hydrogel layer 2, the removable filler can be placed in some through hole 11 corresponding to the branch vessel 41 on the main body frame 1, so that the through hole 11 is not blocked by the hydrogel layer, and thus blood can flow into the branch vessel 41 through the through hole 11 to ensure the unobstructed blood flow of the branch vessel 41. That is, the physician can make the hydrogel layer 2 avoid one or more through holes on the main stent 1 during the expansion process as required, so that the endoluminal isolation stent provided by the present disclosure can adapt to different lesion positions to be compatible with different branch vessels.

In particular embodiments of the present disclosure, the subject support 1 may be configured in any suitable manner. Alternatively, as shown in fig. 1 and 2, the main body stent 1 may be constructed in a tubular structure so as to be capable of cooperating with a plurality of branch stents 3 placed in branch vessels 41 to form a complete endoluminal insulation system, which will be described in detail hereinafter in the present disclosure. In addition, a plurality of through holes 11 can be randomly distributed on the tube wall of the tubular structure to adapt to the branch vessels at different lesion positions, and the plurality of through holes 11 can also be uniformly distributed at intervals, for example, the tube wall of the main stent 1 can be configured into a mesh-shaped structure, and the through holes 11 are formed by meshes on the main stent 1, and the present disclosure is not limited to the specific distribution mode of the through holes 11.

In order to accommodate a plurality of different important vessel branches, the plurality of through holes 11 may have different diameters, and in particular, the diameters of the plurality of through holes 11 may be distributed between 0.5mm and 2.0mm.

In the embodiment of the present disclosure, the main body support 1 may be made of a medical polymer material, for example, the main body support 1 may be made of PVDF or PTFE material, so that the main body support 1 has good stability.

In addition, the hydrogel layer 2 can wholly wrap the surface of the main body support 1, and as shown in fig. 1 and fig. 2, the hydrogel layer 2 can wrap the outer surface of the main body support 1, so that the hydrogel layer 2 can wrap the outer side of the main body support 1 after expansion, blood and lesion positions are completely isolated, and the reliability of the isolated support in the cavity is improved.

On the basis of the technical scheme, the disclosure also provides a branch vessel compatible endoluminal insulation system, which can comprise the endoluminal insulation stent and an anti-blocking member 5 in the technical scheme, and the anti-blocking member 5 can be used for being removably implanted into at least one through hole 11 to prevent the blocking by hydrogel, as shown in fig. 1 and 2.

The lumen insulation system compatible with branch vessels provided by the disclosure has the same technical effect as the lumen insulation stent. In addition, the anti-blocking member 5 in the endoluminal isolation system provided by the present disclosure can be implanted into one or more through holes 11 of the main body stent 1 as needed to prevent the through holes 11 from being blocked during the expansion of the hydrogel layer 2, and after the expansion of the hydrogel layer 2 is completed and integrated with the wall of the main body stent 1, the anti-blocking member 5 can be removed to allow blood to flow into the branch vessels 41 through the through holes 11 that are not blocked by the hydrogel. Therefore, the intracavity isolation system provided by the disclosure is convenient to use, has good universality and can control the treatment cost.

In particular embodiments of the present disclosure, the anti-clog member 5 may be configured in any suitable manner. Alternatively, as shown with reference to fig. 1, the anti-blocking member 5 may be a balloon that can be introduced into the corresponding through hole 11 through the guide wire 6. The sacculus is the more commonly used adjunctie therapy instrument in the intervention operation, and the sacculus has different size, can select the sacculus of corresponding size according to the diameter size of the through-hole 11 that needs remain.

In addition, after the main body stent 1 is implanted into the main body vessel 4, in order to further ensure the smooth blood flow of the branch vessels 41, the endoluminal isolation system may further include branch stents 3, as shown in fig. 2, the branch stents 3 are implanted into the corresponding branch vessels 41 through the through holes 11 that are not blocked by the blocking prevention members 5, so that according to the disease condition, on one hand, the blocking at the connection between the main body stent 1 and the branch vessels 41 can be prevented, which results in the poor blood flow of the branch vessels 41, and also the disease of the branch vessels 41 can be treated.

In order to prevent the main body stent 1 from being displaced in the blood vessel, the lumen insulation system may further include a fastener, such as bio-gel, for fixing the main body stent 1 in the main body blood vessel 4, and both ends of the main body stent 1 may be fixedly connected with the main body blood vessel 4 by the fastener, respectively, so as to improve the safety and reliability of the lumen insulation system. Further, one end of the branch stent 3 may be positioned in the through hole 11 so that the main body stent 1 is compressed between the branch stent 3 and the blood vessel, and the other end of the branch stent 3 may be supported and pressed against the inner wall of the branch blood vessel 41, thereby preventing the branch stent 3 from being displaced.

In the embodiment of the present disclosure, the branch stent 3 may be made of a medical material, for example, the branch stent 3 may be made of a medical metal material, and the branch stent 3 may be implanted by a variety of existing stent implantation methods, for example, the branch stent 3 may be attached to a balloon and introduced into a blood vessel of a patient through a guide wire, and the branch stent is opened by inflation of the balloon so as to be attached to the branch blood vessel 41. The present disclosure does not limit the specific implantation manner of the branch stent 3. In various embodiments of the present disclosure, the provided endoluminal isolation stent and endoluminal system may be used in various arteries with branched vessels, such as aortic bifurcations, or other vessels, without limitation to the present disclosure.

The preferred embodiments of the present disclosure are described in detail with reference to the accompanying drawings, however, the present disclosure is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical idea of the present disclosure, and these simple modifications all belong to the protection scope of the present disclosure.

It should be noted that, in the foregoing embodiments, various features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various combinations that are possible in the present disclosure are not described again.

In addition, any combination of various embodiments of the present disclosure may be made, and the same should be considered as the disclosure of the present disclosure, as long as it does not depart from the spirit of the present disclosure.

Claims

1. A branched vessel compatible endoluminal isolation system comprising:

an endoluminal insulating stent comprising:

the main body support (1) is constructed into an elastic tubular structure so as to be capable of being tightly attached to the inner wall of a blood vessel, and a plurality of through holes (11) are formed in the main body support (1) so as to communicate the inner side and the outer side of the main body support; and

a hydrogel layer (2) provided at least at a plurality of said through holes (11) so as to be able to swell and block the corresponding said through holes (11) when it encounters water; and

an anti-clogging element (5), the anti-clogging element (5) being intended to be removably implanted in at least one of said through holes (11) to prevent clogging thereof by the hydrogel.

2. Endoluminal insulation system according to claim 1, characterized in that a plurality of said through holes (11) are randomly distributed on the wall of the tubular structure.

3. Endoluminal insulation system according to claim 1, wherein the body support (1) is formed as a mesh-like structure, the through holes (11) being constituted by mesh openings in the mesh-like structure.

4. Endoluminal insulation system according to any of claims 1-3, wherein the through-holes (11) have a diameter of 0.5-2.0mm.

5. Endoluminal insulation system according to claim 1, wherein the body support (1) is a polymeric support.

6. Endoluminal insulation system according to any of claims 1-3, characterized in that the hydrogel layer (2) wraps entirely the surface of the body support (1).

7. Endoluminal insulation system according to claim 1, wherein the anti-blocking member (5) is a balloon.

8. Endoluminal insulation system according to claim 1 or 7, wherein the main body stent (1) is intended to be implanted in a main body vessel (4), the endoluminal insulation system further comprising branch stents (3), the branch stents (3) being intended to be implanted in corresponding branch vessels (41) through the through holes (11) not blocked by the anti-blocking members (5).

9. Endoluminal insulation system according to claim 8, further comprising fasteners to fix the body stent (1) in the body vessel (4).