CN111067830A

CN111067830A - Blueb extract for improving scalp and hair health and application thereof

Info

Publication number: CN111067830A
Application number: CN201911394870.0A
Authority: CN
Inventors: 李明
Original assignee: Hangzhou Kebei'an Biopharmaceutical Co Ltd
Current assignee: Hangzhou Kebei'an Biopharmaceutical Co Ltd
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-04-28

Abstract

A blue cloth extract for improving scalp and hair health and application thereof belong to the technical field of chemistry. It specifically comprises a hair washing, caring and/or growing product for improving scalp and hair health, which contains extract of herba Gei aleppici. Can be used for improving scalp and hair health including improving scalp microcirculation, removing dandruff, preventing alopecia and promoting hair growth. The invention provides a blue cloth extract and a hair washing, caring and/or growing product for improving scalp and hair health, which can improve scalp and hair health, promote microcirculation of scalp, promote regeneration of small blood vessels of scalp, substantially improve functions of scalp and hair follicles, nourish and prevent alopecia, and promote hair growth.

Description

Blueb extract for improving scalp and hair health and application thereof

Technical Field

The invention belongs to the technical field of chemistry, and particularly relates to a bluecloth extract for improving scalp and hair health and application thereof.

Background

The human hair is continuously metabolized, and as long as the normal metabolic activity of the human body is maintained, the hair can continuously fall off and grow in a balanced state, so that the balanced hair density of the human is maintained. Hair is a hair follicle that grows on the scalp of a human body, but it interacts with many human organs. For example, the spleen and stomach, liver and kidney are closely related, and are more directly related to the blood supply of scalp. If the blood supply to the scalp is improved, the hair is supplied with sufficient oxygen and nutrients, the hair grows naturally exuberantly and the growth of the hair is closely related to the general health of the body. However, due to the great pressure of modern people in living and working, the phenomena of dandruff, alopecia and hair loss become more and more serious. In asia including china, nearly 60-70% of people suffer from dandruff and hair loss, while the prior art has less than ideal effects of preventing hair loss and promoting hair growth.

The blue cloth is a common Chinese medicinal material, has the effects of tonifying qi and spleen, enriching blood and nourishing yin, moistening lung and reducing phlegm and the like, and is often used as a cardiovascular and cerebrovascular disease research product or a food health-care tea and the like. The effects of the traditional Chinese medicine in the fields of preventing alopecia, removing dandruff and growing hair are not relevant to research.

Disclosure of Invention

In view of the problems of the prior art, the present invention is directed to provide a cervus elaphus extract for improving scalp and hair health and use thereof. The bluecloth extract can improve the microcirculation of the scalp, promote the regeneration of small blood vessels of the scalp, essentially improve the function of the scalp, remove dandruff, nourish the scalp, prevent alopecia and promote hair growth, effectively meet the requirements of people on removing dandruff, preventing alopecia and promoting hair growth, and solve the problem of hair loss of people over 30 years old.

In order to achieve the purpose, the invention adopts the following technical scheme:

the hair washing, caring and/or growing product for improving scalp and hair health is characterized by comprising a blue-berry extract.

The hair washing, caring and/or growing product for improving scalp and hair health is characterized in that the content of the blue-cloth extract is 0.5-100%, preferably 1-70%, and more preferably 2-10%.

The hair washing, caring and/or growing product for improving scalp and hair health is characterized in that the blue-bluecloth normal extract is a blue-bluecloth normal alcohol extract or a blue-bluecloth normal water extract.

The hair washing, caring and/or growing product for improving scalp and hair health is characterized in that the blue-cloth extract is obtained by drying the whole plant of the blue-cloth or drying the overground part of the blue-cloth through ethanol or water, wherein the concentration of the ethanol is 30-80%, and preferably 50%.

The blue cloth extract for improving the health of the scalp and the hair is characterized by being prepared by drying the whole plant of the blue cloth or extracting and drying the overground part of the blue cloth through ethanol or water, wherein the concentration of the ethanol is 30-80%, and the preferable concentration is 50%.

The use of the aleppocampus japonicus selenka extract in the preparation of a hair washing, caring and/or growing product for improving scalp and hair health, wherein the improvement of scalp and hair health comprises the improvement of scalp microcirculation, the removal of dandruff, the prevention of hair loss and the promotion of hair growing capability.

The application of the herba Gei Piloselloidis extract in preparing medicine for treating folliculitis is described.

The application of the herba Gei extract in preparing antibacterial and anti-inflammatory medicines is described.

The application of the herba Gei extract in preparing medicines for preventing and improving scalp degeneration caused by insufficient scalp microcirculation due to old people is provided.

The application of the herba Gei extract in preparing medicine for preventing and improving alopecia caused by liver and kidney diseases is provided.

The invention has the following beneficial effects:

the invention provides a blue linen extract, application thereof and a hair washing, caring and/or growing product for improving scalp and hair health, which can improve the scalp and hair health, promote the microcirculation of the scalp, promote the regeneration of small blood vessels of the scalp, essentially improve the functions of the scalp and hair follicles, nourish and prevent hair loss and promote hair growth.

Drawings

FIG. 1 is a graph showing a comparison of scalp condition before and after shampooing of a 61-year-old male with a shampoo containing a positive extract of blue cloth, wherein b is before use, and A-1, A-2 and A-3 are effects after 2-3 months of use;

FIG. 2 is a comparison of scalp condition before and after shampooing of a 33-year-old female with a shampoo of the upright extract of blue cloth, wherein b is before use, and A-1, A-2 and A-3 are after 3 months of use;

FIG. 3 is a comparison of scalp condition before and after shampooing of a 45 year old female with a shampoo of the upright extract of blue cloth, wherein b is before use, and A-1, A-2 and A-3 are after 3 months of use;

FIG. 4 is a comparison of scalp condition before and after shampooing of a 49-year-old male with a shampoo of the extract of the positive bluecloth, wherein b is before use, and A-1, A-2 and A-3 are after 2 months of use;

FIG. 5 is a comparison of scalp condition before and after shampooing of a 68 year old male with a shampoo of the extract of Echinochloa, wherein b is before use, and A-1, A-2 and A-3 are after 3 months of use;

FIG. 6 is a comparison of scalp condition before and after shampooing of a 54-year-old male with a shampoo of the extract of Bluecloth, wherein b is before use, and A-1, A-2 and A-3 are after 3 months of use;

FIG. 7 is a comparison of scalp condition before and after shampooing of 200 male and female patients with severe hair loss of 35 years old and older with a shampoo of the upright extract of bluecloth, wherein b is before use, and A-1, A-2 and A-3 are after 3-4 months of use;

FIG. 8 is a graph of an experiment of inducing liver and kidney injury in rats by injecting carbon tetrachloride;

figure 9 is a graph of results of rat hair after carbon tetrachloride injection experiments.

Detailed Description

The invention will be further described with reference to specific embodiments and drawings.

Example 1:

a shampoo, hair conditioner and hair growth promoter for improving scalp and hair health comprises (by weight parts) shampoo/hair conditioner matrix 90-98%, and blue cloth extract (blue cloth normal alcohol extract) 2-10%. Specifically, the shampoo/hair conditioner matrix comprises the following components in percentage by weight: 50-65% of surfactant, 0.5-3.0% of smoothing agent, 1-2% of coconut oil amide monoethanolamine, 0.1-1.0% of conditioner, 0.1-0.2% of essence and the balance of water. Wherein the surfactant is selected from at least one of amino acid surfactant, lauroyl glutamic acid, sodium laureth sulfate, cocamidopropyl and betaine. The smoothing agent is at least one selected from polydimethylsiloxane, hydroxypropyl guar gum and amino silicon emulsion. The conditioning agent is selected from at least one of guar gum hydroxypropyl trimethyl ammonium chloride and polyammonium salt. The shampoo has strong antibacterial effect, so no antiseptic is required.

Example 2:

the method for preparing a sinomontanum extract in example 1 includes the following steps:

(1) preparing a blue-green-blue-green extract: drying and crushing the whole herb of the bluecloth, adding 50% ethanol with the weight 5-10 times of that of the dried medicinal herb of the bluecloth, leaching for 24 hours at room temperature, collecting extracting solution, repeating the extracting solution twice, mixing the extracting solution twice, concentrating the extracting solution at the low pressure of 65 ℃, filtering and performing spray drying to obtain the extract powder of the bluecloth.

(2) Based on the purpose of removing dandruff, preventing alopecia or promoting hair growth, the prepared powder of the extract of the blue linen is mixed with corresponding hair washing/caring components in different weight proportions, and products for improving scalp and hair follicle health, removing dandruff, preventing alopecia or promoting hair growth can be respectively obtained.

In the embodiment, the 30% ethanol, the 60% ethanol and the 80% ethanol are adopted, so that the bluecloth extract for removing dandruff, preventing alopecia or growing hair can be finally obtained.

The extract of Echinops tabacum in example 1 can also be obtained by the following preparation method:

drying and crushing the whole plant of the bluecloth, adding water with the weight 5-10 times of that of the dried bluecloth crude drug, leaching for 24 hours at room temperature, collecting the extracting solution, repeating the extracting solution twice, mixing the extracting solution twice, concentrating the extracting solution at the temperature of 65 ℃ under low pressure, filtering, and performing spray drying to obtain the bluecloth crude drug extract powder.

Example 3:

the medicinal function of the extract of aleppo avens is explained as follows:

(1) extract of aleppodamia bigelovii: the bluebeard extract is reported to have the functions of effectively increasing blood supply in ischemic tissues or organs, promoting new blood vessel regeneration, obviously improving blood supply of ischemic organs, promoting regeneration of local damaged cells, promoting wound healing, resisting bacteria and the like. In addition, the alexandrium vulgare extract can also obviously improve the liver and kidney functions of experimental animals and the degeneration of the liver and kidney of old animals, so that the health of animal fur is obviously improved, the depilation of the experimental animals is reduced, and the luster of the animal fur is obviously improved. In the experiments of human volunteers, it was fully shown that it has functions of remarkably improving dandruff, alopecia and promoting hair growth of users, and also remarkably improving the health of scalp, promoting repair of scalp injury, resisting scalp infection, remarkably improving microcirculation of scalp, and promoting regeneration of subcutaneous microvasculature.

(2) The alexandrium vulgare linn extract provided by the embodiment 2 of the invention can effectively aim at the physiological characteristics of all people, particularly middle-aged and elderly people, improve the microenvironment for hair growth by improving the blood supply of the scalp of a user, provide enough nutrients for hair follicles of the scalp, nourish hair follicles and hair root growth cells, promote the healthy growth of hair, and effectively solve the problems of dandruff, alopecia and the like of the user, particularly the user over 30 years old. In addition, the blue cloth extract provided by the embodiment 2 of the invention also has the functions of nourishing the scalp and hair follicles, enabling the hair to be healthy, strong and firm, and fixed and not easy to fall off, and can effectively solve the problems of withered and yellow hair, white hair, fragility, easy falling and easy breaking of the hair of a user and the like.

The blue cloth extract for improving scalp health, removing dandruff, preventing alopecia and promoting hair growth can be mixed in shampoo, hair care liquid or hair growth liquid product for use, or can be used independently, the use method is selected according to the specific situation of a user, and the purpose is to uniformly distribute the blue cloth extract on the wet scalp, massage for 2-5 minutes and enable the medicine to be fully contacted with and absorbed by the scalp. The shampoo, the hair conditioner or the hair tonic refers to a substrate with basic hair washing and caring functions commonly seen in the field, namely, the hair washing/caring/hair tonic substrate is the prior art in the field, and a person skilled in the art can use the hair washing/caring/hair tonic commonly seen in the market to be matched with the blue cloth positive extract provided by the invention in proportion, namely, the hair washing and caring product for improving scalp health, removing dandruff, preventing alopecia and promoting hair growth provided by the embodiment of the invention can be obtained by uniformly mixing the hair washing/caring/hair tonic substrate and the blue cloth positive extract.

In the specific examples, the raw materials used are conventional products commercially available from manufacturers and specifications.

Example 4:

a shampoo for improving scalp and hair health (dandruff removing, alopecia preventing and hair growth promoting) comprises the following components in parts by weight: 95% shampoo base and 5% n-alcohol extract of blue cloth provided in example 2. The shampoo matrix used in the embodiment comprises the following components in percentage by weight: sodium laureth sulfate 63% (the concentration of the active in sodium laureth sulfate is 25%), silica dimethyl silylate 2%, guar hydroxypropyltrimonium chloride 0.5%, cocamide monoethanolamine 3% (the concentration of the active in cocamide monoethanolamine is 95%), perfume 0.2%, and water 31.3%.

Example 5:

a shampoo for improving scalp and hair health (dandruff removing, alopecia preventing and hair growth promoting) comprises the following components in parts by weight: shampoo base 95% and blue cloth normal water extract 5% as provided in example 2. The shampoo matrix used in the embodiment comprises the following components in percentage by weight: sodium laureth sulfate 63% (the concentration of the active in sodium laureth sulfate is 25%), silica dimethyl silylate 2%, guar hydroxypropyltrimonium chloride 0.5%, cocamide monoethanolamine 3% (the concentration of the active in cocamide monoethanolamine is 95%), perfume 0.2%, and water 31.3%.

Example 6:

experiments were conducted on the indicated population and the results were examined using the orthoethanolic blue cloth extract shampoo provided in example 4. The method comprises the following specific steps:

(1) referring to fig. 1, Mr. Li, 60 years old, often staying up all night, busy work, heavy pressure, irregular life, very obvious dandruff, a layer of dandruff on shoulders and heads of clothes, very obvious alopecia, early awakening, a plurality of fallen hairs on the pillow for sleeping, and a plurality of fallen hairs during hair washing. And the hair was fine, withered and yellow, and split. After 2-3 times of using the shampoo containing the euonymus alatus extract provided in the embodiment 4 of the invention, dandruff is remarkably reduced, and after about 6-8 times of using, the dandruff is basically completely disappeared. The scalp became smooth and the scalp acne visible before use was completely eliminated. After about one month (8-10 times/month of hair washing), the hair falling off from the pillow after early awakening is remarkably reduced, and the hair falling off amount during hair washing is also reduced by more than 50%. In addition, many short new hairs are visible in the area of the hair. A significant increase in the number of hairs per high magnification field was also seen under the microscope, and an increased proportion of 2-3 hairs were produced from one follicle. After 2-3 months of use, the hair gradually becomes lustrous, and the smoothness and the hair density are obviously improved.

(2) As shown in figure 2, the female in king aged 33 years old is working tense, high in stress, frequent staying up all night, menstrual disorder and endocrine disturbance. Resulting in severe hair loss and dry, yellow and dry hair. After 3 months (10-12 times per month) of the shampoo containing the eupolyphaga sinensis extract provided by the embodiment 4 of the invention, withered, yellow and dry hair gradually turns black from the root of the hair, the ratio of white hair is obviously reduced, and the hair begins to be glossy and soft. Also when waking in the morning, it was found that there was a significant reduction in the amount of hair removed from the pillow and a significant reduction in the amount of hair removed from shampooing. In addition, the increase of the density of the hair per visual field is also seen under a microscope, and the proportion of 2-3 hairs grown from one hair follicle is increased, so that the density of the hairs is also obviously improved.

(3) As shown in fig. 3, female plum, age 45, had severe dandruff and alopecia, and dry and lusterless hair. After the shampoo containing the euonymus japonicus extractive provided by the embodiment 4 of the invention is used for washing hair for one week, dandruff is obviously reduced, and after the shampoo is used for about two weeks, the dandruff basically and completely disappears. After the persistent use for one month, the alopecia phenomenon is obviously reduced. After 3 months of use (10-12 times per month), the hair quality was found to become smooth, the scalp was found to become smooth, and the scalp acne that often appeared originally also disappeared completely. And the hair falling off from the pillow after early awakening is obviously reduced, and the hair falling off during hair washing is reduced by more than 50%. In addition, many short new hairs are visible in the receding hairline area of the forehead. The proportion of the original white hairs is also reduced, and the number of hairs per visual field is obviously increased under a microscope, and the proportion of 2-3 hairs grown from one hair follicle is increased.

(4) As shown in fig. 4, mr. wang, age 49, alopecia has been occurring for nearly a decade, and the scalp at the top of the head is already clearly visible. After the shampoo containing the bluecloth extract provided by the embodiment 4 of the invention is used for washing hair for 2 months, the scalp with the clear and sparse hair gradually grows new hair, and the new hair is soft and smooth. It was also seen microscopically that the number of hairs per field increased significantly and that an increased proportion of 2-3 hairs were produced from one follicle.

(5) As shown in fig. 5, the horse is born, and is 68 years old, heart disease, very much dandruff, severe alopecia, and dry and lusterless hair. Forehead hairline withdrawal is severe. After the shampoo containing the euonymus japonicus extractive provided by the embodiment 4 of the invention is used for 1-2 weeks, dandruff is obviously reduced, after about 1 month, dandruff basically disappears completely, and alopecia is obviously reduced. After 3 months of use, the original receding hairline was found, and new hair was clearly visible on the top of the scalp, which became black and smooth (fig. five).

(6) Referring to fig. 6, Mr. Liangsheng, age 54, irregular life, increased hair loss from 7 years ago, severely reduced hair at the top of the head, and clearly visible scalp. After 1 month of using the shampoo containing the extract of the bluecloth provided by the embodiment 4 of the invention, the alopecia phenomenon is obviously reduced. After 3 months of use, it was found that new hair gradually grows out from the top of the scalp and the area of the receding hairline, the hair becomes black, and the hair quality becomes smooth.

(7) Referring to fig. 7, the shampoo containing the orthoalcohol extract of blue cloth provided in example 4 of the present invention was used to treat 200 men and women over 35 years old with more dandruff and severe alopecia. After all 200 experimental participants used the orthoalcohol blue cloth extract shampoo provided by the invention in the example 4 to shampoo for 1-3 weeks, the dandruff problem is remarkably improved, even no dandruff is basically sensed, and the effective rate is more than 95%. After 2 months of application, the alopecia problem was also significantly improved in all 200 subjects. After the application for 3-4 months, 160 subjects in the traditional Chinese medicine composition can find that new hairs grow, the hair quality is obviously improved, the effective rate of the new hairs is 80%, the scalp health is improved, dandruff is removed, alopecia is prevented or reduced, and the effective rate is more than 95%.

Similarly, 200 men and women over 35 years old suffered from dandruff and severe alopecia, and were tested using the shampoo containing the blue-cloth upright water extract provided in example 4 of the present invention. After all 200 experimental participants used the blue cloth normal water extract shampoo provided by the invention in example 4 to shampoo for 1-3 weeks, the problem of dandruff is remarkably improved, even no dandruff is basically sensed, and the effective rate reaches more than 90%. After 2 months of application, the alopecia problem was also significantly improved in all 200 subjects. After the application for 3-4 months, 154 subjects in the traditional Chinese medicine composition can find that new hairs grow, the hair quality is obviously improved, the effective rate of the new hairs is 77%, the scalp health is improved, dandruff is removed, alopecia is prevented or reduced, and the effective rate is over 90%.

Example 7:

in real life, we have found that patients with severe liver disease often have symptoms of disengageable axillary hair, pubic hair and chest hair, diffuse hair loss, and hair malnutrition. Patients with chronic nephropathy have dry hair, easy breakage, and diffuse alopecia. According to the theory of traditional Chinese medicine, common alopecia in daily life, including alopecia areata and male pattern alopecia (namely seborrheic alopecia), is closely related to liver, kidney and spleen. Kidneys mainly promote hair growth, and kidney essence is sufficient, so that hair is thick and glossy, otherwise, hair loss is easy. The hair is the rest of blood, and the liver stores blood, stagnation of liver qi or stagnation of liver qi transforming into fire can consume yin and blood, so that the hair is lack of nutrition and the hair is alopecia.

It is known in the prior art that the application of carbon tetrachloride can cause the liver and kidney injury of experimental rats, and further affect the hair of experimental animals. Therefore, we applied this model to examine the protective effect of the active extract of the Chinese herbal medicine on hair damage of experimental animals. An animal model of liver cirrhosis, renal injury and fibrosis was induced by intraperitoneal injection of Wistar mice (160-180g) with carbon tetrachloride dissolved in vegetable oil to a concentration of 50% and 3 ml/kg body weight/time. The intraperitoneal injection frequency of carbon tetrachloride is twice per week, and the total injection time is 15 weeks. Each animal was given 1 ml of 30% ethanol intravenously 5 times a week for 4 weeks on a day without carbon tetrachloride injection. After 9 weeks of carbon tetrachloride injection, experimental animals were randomized into treatment with the traditional Chinese medicine composition (n = 15), and control (n = 15). Starting at week 10, the herbal active extract (450 mg/kg/day) obtained in example 2 was administered to the experimental animals of the herbal composition treatment group by gavage for 12 weeks. The control group of experimental animals was gavaged with the same volume of water for the same 12 weeks. During the experiment, especially until the last four weeks of the experiment, it was found that the control group of experimental animals underwent progressive and progressive depilation as shown in fig. 8. In contrast, the hair of the animal group treated with the Chinese medicinal composition exhibited nearly normal, and little depilation was observed, as shown in FIG. 9.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A hair washing, caring and/or growing product for improving scalp and hair health, characterized in that it contains extract of Blueb.

2. A hair washing, conditioning and/or growing product for improving scalp and hair health according to claim 1, characterized in that the content of the alexandrium japonicum extract is 0.5% to 100%, preferably 1% to 70%, more preferably 2% to 10%.

3. The hair washing, caring and/or growing product according to claim 1 or 2, characterized in that the blue berry positive extract is a blue berry positive alcohol extract or a blue berry positive water extract.

4. The hair washing, caring and/or growing product according to claim 3, characterized in that the extract of the bluecloth is obtained from the whole dry herb of bluecloth, or the overground part of bluecloth is dried by ethanol or water extraction, the concentration of ethanol is 30-80%, preferably 50%.

5. A herba Gei extract for improving scalp and hair health is prepared from dry whole plant of herba Gei, or aerial parts of herba Gei by extracting with ethanol or water, wherein the ethanol concentration is 30-80%, preferably 50%.

6. Use of a alepponica officinalis extract for the preparation of a hair washing, caring and/or growing product for improving scalp and hair health including improving scalp microcirculation, removing dandruff, preventing hair loss and promoting hair growth.

7. An application of herba Gei Piloselloidis extract in preparing medicine for treating folliculitis is provided.

8. An application of herba Gei Piloselloidis extract in preparing antibacterial and antiinflammatory medicine is provided.

9. Use of herba Gei Piloselloidis extract in preparing medicine for preventing and improving scalp degeneration caused by scalp microcirculation deficiency due to senile people is provided.

10. Application of herba Gei Piloselloidis extract in preparing medicine for preventing and improving alopecia caused by liver and kidney diseases is provided.