CN111060707A - Biochemical immunity all-in-one - Google Patents
Biochemical immunity all-in-one Download PDFInfo
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Abstract
The invention relates to the technical field of biochemical immunodetection, and provides a biochemical immunodetection all-in-one machine, which comprises a sample feeding device, a sample adding device and a plurality of groups of detection devices, wherein the sample feeding device comprises a sample feeding device body and a sample feeding device body; the multiple groups of detection devices are arranged side by side, and the sample feeding device and the sample adding device are arranged on the side surfaces of the multiple groups of detection devices; the multi-group detection device comprises an incubation unit and an optical detection unit; the incubation unit is including setting up application of sample station and the detection station in same direction, and the incubation unit carries out the incubation to the reagent card and handles to can transfer the reagent card, the application of sample station to the detection station, and application of sample device can move to injection device and carry out the reagent sample and remove to application of sample station and carry out the application of sample to the reagent card and handle, and optical detection unit can carry out optical detection to the reagent card that is located detection station. The invention realizes the technical effect that a biochemical and immune integrated machine can be formed by combining different detection devices for one sample so as to simultaneously detect a plurality of reagent cards; especially meeting the requirements of primary hospitals.
Description
Technical Field
The application relates to the technical field of biochemical immunodetection, in particular to a biochemical immunodetection all-in-one machine.
Background
At present, in the technical field of biochemical immunoassay, different physiological detection indexes of a human body need to be detected by different detection instruments according to different detection principles. For example, indexes of blood sugar and blood fat need to be detected by a biochemical detection method; human body hormone indexes need to be detected by adopting a detection method with high sensitivity; the indexes of respiratory diseases need to be detected by a dry immunoassay method. In actual life, when a patient detects physiological indexes, the patient often needs to go to different departments and use a plurality of different detection instruments for detection.
At present many basic level health units, because the restriction of financial resources material resources and place space, can't dispose a plurality of different kinds of detecting instrument simultaneously to the detection of each item index of patient often needs a plurality of different detecting instrument to detect, has caused the patient to need to go to different detection departments and has detected, causes detection inefficiency, the problem of mistake appears easily. The existing single detection instrument cannot be combined due to the huge difference of the self-construction, so that the integrated machine has huge market demand, but has not been successfully designed and manufactured.
Disclosure of Invention
The invention aims to solve the defects that a single detection instrument has low detection efficiency and high cost, and the existing immunoassay analyzers cannot be combined due to the huge difference of models and specifications.
In order to solve the technical problems, the invention provides a biochemical and immune integrated machine, which comprises:
a biochemical immunization integrated machine comprises a sample feeding device, a sample feeding device and a plurality of groups of detection devices; the multiple groups of detection devices are arranged side by side, and the sample feeding device and the sample adding device are arranged on the side surfaces of the multiple groups of detection devices; the multi-group detection device comprises an incubation unit and an optical detection unit; the incubation unit is including setting up application of sample station and the detection station in same direction, and the incubation unit carries out the incubation to the reagent card and handles to can transfer the reagent card, the application of sample station to the detection station, and application of sample device can move to injection device and carry out the reagent sample and remove to application of sample station and carry out the application of sample to the reagent card and handle, and optical detection unit can carry out optical detection to the reagent card that is located detection station.
Specifically, the plurality of detection devices may be a luminescence detection device, a biochemical detection device, a fluorescence detection device, and the like.
Specifically, the bottom of biochemical immune all-in-one machine is installed the bottom plate, and the whole shape of bottom plate is the quadrangle, installs sampling device, application of sample device and multiunit detection device on the bottom plate.
Specifically, the multiple groups of detection devices are mutually independent, and optical detection on different reagent cards can be realized.
The application of sample device includes application of sample needle and application of sample arm, and application of sample arm transversely installs in multiunit detection device's top, and application of sample needle is located application of sample arm, and application of sample needle is after application of sample device acquires the reagent, and application of sample needle moves the application of sample station in order to realize the application of sample to the reagent card from application of sample arm.
Specifically, the stand is installed to application of sample arm lower part, and the stand provides the support to application of sample arm to make application of sample arm violently in detection device's top.
The sample adding device also comprises a transverse transmission mechanism, a longitudinal transmission mechanism, a transverse driving unit and a longitudinal driving unit; the transverse driving unit drives the transverse transmission mechanism to rotate so as to drive the sample adding needle to move on the sample adding arm, and the longitudinal driving unit drives the longitudinal transmission mechanism to rotate so as to drive the sample adding needle to move longitudinally.
Specifically, the transverse driving unit and the longitudinal driving unit are both driving motors.
Specifically, the transverse transmission mechanism and the longitudinal transmission mechanism are both designed as transmission belts, and the transmission belts are driven by the driving motor to drive the transmission belts to move.
The sample introduction device comprises a sample storage unit, a driving unit and a supporting plate; install sample storage unit and actuating mechanism in the backup pad, the sample is deposited the unit and is deposited the sample, and actuating mechanism drive sample storage unit removes to application of sample needle side, and application of sample needle removes to the sample and deposits the unit inside in order to absorb the sample.
Specifically, the sample storage unit is a test tube rack and a test tube device, and the test tube is used for storing reaction reagents.
The sample adding device also comprises a liquid path component and a peristaltic device, wherein the liquid path component and the peristaltic device are arranged on one side of the sample adding arm, and the liquid path component and the peristaltic device enable the reagent needle to finish sample adding of the reagent and sucking of the reagent by adjusting the pressure inside the reagent needle.
The incubation unit comprises an incubation groove, a cover plate and an incubation driving mechanism; the upper part of the incubation groove is covered with a cover plate, the cover plate is provided with a sample adding station and a detection station, and the lower part of the incubation groove is provided with an incubation driving mechanism; the reagent card is subjected to an incubation process in the incubation tank, and the incubation driving mechanism drives the reagent card to move in the incubation tank.
In particular, the incubation drive mechanism may be a drive motor that drives the movement of the reagent card via a belt drive.
The optical detection unit comprises an optical driving unit and an optical detection instrument, the optical driving motor and the optical detection instrument are installed on the detection station, and the optical driving unit drives the optical detection instrument to move so as to realize optical detection of the reagent card.
Specifically, the optical driving unit comprises a driving unit in the X direction and a driving unit in the Y direction, so as to realize the movement of the optical detection instrument in the X direction and the Y direction, and realize the optical detection of the multi-channel reagent card.
The application of sample device still includes anticollision unit, and anticollision unit installs on the upper portion of application of sample needle, and anticollision unit is to the protection of application of sample needle in order to realize application of sample needle in the restriction of fore-and-aft movement distance.
The optical detection unit comprises an optical driving motor and an optical detection instrument; the optical drive motor is used for adjusting the movement of the optical detection instrument to realize the optical detection of the reagent card.
The multi-group detection device comprises a liquid suction station, the liquid suction station and the sample adding station are in the same direction with the detection station, a liquid suction unit and a liquid suction motor are installed on the liquid suction station, and the liquid suction motor drives the liquid suction unit to clean the reagent card.
The invention achieves the technical effects that: the biochemical and immune integrated machine can be used for simultaneously detecting various reagent cards, greatly improves the detection efficiency, and simultaneously reduces the waste and loss of raw materials.
Drawings
FIG. 1 is a schematic structural diagram of a bio-immune integrated machine according to an embodiment;
FIG. 2 is an exploded view of the integrated bio-immune device according to an embodiment;
FIG. 3 is a schematic view of an optical detection device of the integrated biochemical immunoassay device according to an embodiment;
fig. 4 is a schematic structural diagram of a sample injection device of the integrated biochemical immunoassay device according to an embodiment.
Fig. 5 is a schematic structural diagram of a sample adding device of the integrated biochemical-immune machine provided in an embodiment.
Fig. 6 is a schematic structural diagram of a biochemical detection device of the integrated biochemical immunoassay device according to an embodiment.
Fig. 7 is a schematic structural diagram of a fluorescence detection device of the bio-immune integrated machine according to an embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Furthermore, in the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral connections; can be mechanically or electrically connected; the two elements may be directly connected or indirectly connected through an intermediate medium, or may be communicated with each other inside the two elements, or may be wirelessly connected or wired connected. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Furthermore, the technical features mentioned in the different embodiments of the invention described later can be combined with each other as long as they do not conflict with each other.
Example (b):
referring to fig. 1 and 2, the three detection devices are a luminescence detection device 3, a biochemical detection device 4 and a fluorescence detection device 5, and the luminescence detection device 3, the biochemical detection device 4 and the fluorescence detection device 5 are independently arranged side by side. Three different reagent cards are respectively put into the luminescence detection device 3, the biochemical detection device 4 and the fluorescence detection device 5.
Referring to fig. 6, the sample application station and the detection station of the luminescence detection device 3 are both linearly installed on the incubation groove, the reagent card is placed in the luminescence detection device 3, the luminescence detection device 3 is installed on the supporting plate 10 and the supporting column 16, when the reagent card enters the incubation groove 9 for incubation treatment, the stepping motor 11 is installed under the incubation groove 9, the incubation groove 9 pushes the reagent card to move in the incubation groove 9 under the action of the stepping motor 11, and the incubation groove cover plate 12 is arranged on the upper part of the incubation groove 9 for incubation treatment of the reagent card for reaction.
Sample introduction device 2 sets up in above-mentioned detection device's side, provides the reagent of reaction for sampling device, and detection device 2's component is all installed on sample introduction device 2's riser 23, holds the reagent that is used for the reaction in the test tube 24, and driving motor 21 drive belt 22 rotates to drive test tube 24 and take place the motion, finally remove the side of application of sample needle 17.
Referring to fig. 4 and 5, during sampling, the transverse belt 20 is installed on the sample-adding arm 6, the sample-adding needle 17 firstly adjusts the sample-adding needle 17 to the inside of the test tube 24 to absorb the sample by the movement of the transverse belt 20 and the longitudinal belt 25, during absorption, the peristaltic assembly 8 and the liquid path assembly 1 adjust the pressure inside the sample-adding needle 17, so that the sample-adding needle 17 is in a negative pressure state for absorbing the reagent in the test tube 24, and the absorbed reagent is finally moved to the sample-adding station of the detection device by the movement on the sample-adding arm 6, and the sample-adding is carried out on the reagent card being incubated.
In the application of sample in-process, adjust the inside pressure of application of sample needle 17 through peristaltic subassembly 8 and liquid way subassembly 1, realize that application of sample needle 17 is inside to reach positive pressure to the application of sample to the realization reagent card.
The reagent card after the sample is added in fig. 3 continues to move in the incubation groove 9, when the incubation groove 9 moves to the detection station, the optical detection module 15 at the detection station optically detects the reagent card, and the optical detection module 15 optically detects the reagent card. After the optical detection is finished, the screw rod motor 14 and the liquid suction needle 13 are installed at the rear end of the incubation tank module 9, and the liquid suction needle 13 cleans the detected reagent card after sucking the cleaning liquid.
According to the above description, the sample loading and sampling processes of the fluorescence detection module 5 and the biochemical detection module 4 are consistent with those of the luminescence detection module 3. Only the difference is generated in the actual optical detection process, so the detection process of the fluorescence detection module 5 and the biochemical detection module 4 only needs to be described.
Referring to fig. 6, in the biochemical detecting device 4, the sample loading station and the detecting station of the biochemical detecting device 4 are linearly installed on the incubation chamber, the reagent card 27 is placed at the inlet end of the biochemical detecting module 4, the reagent card 27 is incubated in the incubation chamber 33, the cover plate 28 is placed on the incubation chamber 33, the thermal insulation plate 29 is placed on the side of the incubation chamber 33, the incubation treatment of the reagent card 27 is promoted by the cooperation of the heat insulation plate and the sample loading treatment of the reagent card 27 is carried out during the incubation treatment, so that the reagent card 27 is fully reacted. The reacted reagent card 27 continues the incubation process in the incubation tank 33 and the incubated reagent card 27 is tested in the optical test module 31. What the 43D motor is, what the puncture needle module is.
In the fluorescence detection device, the sample adding station and the detection station on the fluorescence detection device are both linearly installed on an incubation groove, firstly, the multi-channel reagent card 34 in the reagent card tray is selected according to the width of the reagent card and is put into the multi-channel reagent card tray 35, then the multi-channel reagent card tray 35 is put into the incubation groove for incubation treatment, the incubation groove is provided with an incubation cover plate 36, the multi-channel reagent card 34 is subjected to sample adding treatment in the incubation treatment process, when the multi-channel reagent card 34 moves to the sample adding station, the sample adding needle 17 carries out sample adding on the multi-channel reagent card 34, the multi-channel reagent card 34 after the sample adding treatment is subjected to reaction, and the driving motor 42 at the end of the incubation groove drives the multi-channel reagent card 34 to move in the incubation groove 43 through the crawler transmission device 43. When the multi-channel reagent card 34 enters the detection station, the fluorescence detector 37 installed on the detection station drives the length of the transverse screw 40 and the length of the longitudinal screw 44 to change through the transverse driving motor 38 and the longitudinal driving motor 39 under the action of the transverse driving motor 38 and the longitudinal driving motor 39, so that the fluorescence detector moves on the transverse guide rail 41 and the longitudinal guide rail 45, and the detection of the multi-channel reagent card 34 is sequentially completed.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (9)
1. A biochemical and immune integrated machine is characterized by comprising a sample feeding device, a sample adding device and a plurality of groups of detection devices; the multiple groups of detection devices are arranged side by side, and the sample feeding device and the sample adding device are arranged on the side surfaces of the multiple groups of detection devices; the multiple groups of detection devices comprise an incubation unit and an optical detection unit; the incubation unit is including setting up application of sample station and the detection station on same direction, the incubation unit carries out incubation to the reagent card and handles, and can with the reagent card, the application of sample station is transferred to the detection station, the application of sample device is followed the application of sample device carries out the reagent sample and moves to the application of sample station is right the reagent card carries out application of sample and handles, optical detection unit can be to lieing in detect the station reagent card carries out optical detection.
2. The integrated biochemical-immune machine according to claim 1, wherein the sample-adding device comprises a sample-adding needle and a sample-adding arm, the sample-adding arm is transversely installed above the plurality of sets of detection devices, the sample-adding needle is located on the sample-adding arm, and after the sample-adding device obtains the reagent, the sample-adding needle moves from the sample-adding arm to the sample-adding station to realize sample addition of the reagent card.
3. The integrated biochemical-immune machine according to claim 2, wherein the sample adding device further comprises a transverse transmission mechanism, a longitudinal transmission mechanism, a transverse driving unit and a longitudinal driving unit; the transverse driving unit drives the transverse transmission mechanism to drive the sample adding needle to move on the sample adding arm, and the longitudinal driving unit drives the longitudinal transmission mechanism to drive the sample adding needle to move longitudinally.
4. The integrated bio-chemical and immune machine according to claim 1, wherein the incubation unit comprises an incubation groove, a cover plate and an incubation driving mechanism; the cover plate is covered on the incubation groove, the sample adding station and the detection station are installed on the cover plate, and the incubation driving mechanism is installed at the lower part of the incubation groove; the reagent card is subjected to an incubation process in the incubation tank, and the incubation drive mechanism drives the reagent card to move in the incubation tank.
5. The integrated bio-chemical and immune machine according to claim 1, wherein the optical detection unit comprises an optical driving unit and an optical detection instrument, the optical driving unit and the optical detection instrument are installed on the detection station, and the optical driving unit drives the optical detection instrument to move so as to realize optical detection of the reagent card.
6. The integrated bio-chemical and immune machine according to claim 1, wherein the sample feeding device comprises a sample storage unit, a driving unit and a support plate; the sample storage unit and the driving mechanism are installed on the supporting plate, the sample storage unit stores the reagent, the driving mechanism drives the sample storage unit to move to the side face of the sample adding needle, and the sample adding needle moves to the inside of the sample storage unit to absorb the reagent.
7. The integrated biochemical-immune machine according to claim 3, wherein the sample adding device further comprises an anti-collision unit, the anti-collision unit is mounted on the upper portion of the sample adding needle, and the anti-collision unit limits the longitudinal movement distance of the sample adding needle so as to protect the sample adding needle.
8. The integrated bio-chemical and immune machine according to claim 1, wherein the optical detection unit comprises an optical driving motor and an optical detection instrument; the optical driving motor is used for adjusting the movement of the optical detection instrument to realize the optical detection of the reagent card.
9. The integrated biochemical-immune machine according to claim 1, wherein the plurality of sets of detection devices comprise a liquid suction station, the liquid suction station is in the same direction as the sample adding station and the detection station, a liquid suction unit and a liquid suction motor are installed on the liquid suction station, and the liquid suction motor drives the liquid suction unit to clean the reagent card.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010055059.6A CN111060707A (en) | 2020-01-17 | 2020-01-17 | Biochemical immunity all-in-one |
| CN202011066213.6A CN112230005B (en) | 2020-01-17 | 2020-09-30 | Physiological sample detection method and device |
| PCT/CN2020/128218 WO2022067984A1 (en) | 2020-01-17 | 2020-11-11 | Physiological sample detection method and equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010055059.6A CN111060707A (en) | 2020-01-17 | 2020-01-17 | Biochemical immunity all-in-one |
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| CN202011066213.6A Active CN112230005B (en) | 2020-01-17 | 2020-09-30 | Physiological sample detection method and device |
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| WO2022067984A1 (en) * | 2020-01-17 | 2022-04-07 | 深圳市活水床旁诊断仪器有限公司 | Physiological sample detection method and equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114167071A (en) * | 2022-02-10 | 2022-03-11 | 广州科方生物技术股份有限公司 | Multifunctional sample analysis system |
| CN114778877B (en) * | 2022-06-13 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sample adding assembly, sample adding method and sample detection device |
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| CN109100341A (en) * | 2018-08-27 | 2018-12-28 | 绿嘉图（北京）科技有限公司 | A kind of multi-functional dry type POCT equipment and detection method |
| CN111721948A (en) * | 2019-03-21 | 2020-09-29 | 深圳市活水床旁诊断仪器有限公司 | Biochemical and immune integrated analyzer and detection method |
| CN209858594U (en) * | 2019-03-21 | 2019-12-27 | 深圳市活水床旁诊断仪器有限公司 | Incubation groove component of biochemical analyzer and biochemical analyzer |
| CN111721955A (en) * | 2019-03-21 | 2020-09-29 | 深圳市活水床旁诊断仪器有限公司 | Chemiluminescence immunity analyzer and detection method |
| CN111721952A (en) * | 2019-03-21 | 2020-09-29 | 深圳市活水床旁诊断仪器有限公司 | Biochemical analyzer and biochemical analysis method |
| CN110187134A (en) * | 2019-05-22 | 2019-08-30 | 中山市创艺生化工程有限公司 | Blood cell analysis and POCT immunoassay automatic production line |
| CN111060707A (en) * | 2020-01-17 | 2020-04-24 | 深圳市活水床旁诊断仪器有限公司 | Biochemical immunity all-in-one |
-
2020
- 2020-01-17 CN CN202010055059.6A patent/CN111060707A/en active Pending
- 2020-09-30 CN CN202011066213.6A patent/CN112230005B/en active Active
- 2020-11-11 WO PCT/CN2020/128218 patent/WO2022067984A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022067984A1 (en) * | 2020-01-17 | 2022-04-07 | 深圳市活水床旁诊断仪器有限公司 | Physiological sample detection method and equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112230005B (en) | 2022-06-07 |
| WO2022067984A1 (en) | 2022-04-07 |
| CN112230005A (en) | 2021-01-15 |
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