CN111051326A - 核苷磷酸类化合物及其制备方法和用途 - Google Patents
核苷磷酸类化合物及其制备方法和用途 Download PDFInfo
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- CN111051326A CN111051326A CN201880054417.2A CN201880054417A CN111051326A CN 111051326 A CN111051326 A CN 111051326A CN 201880054417 A CN201880054417 A CN 201880054417A CN 111051326 A CN111051326 A CN 111051326A
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- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- RXRGZNYSEHTMHC-BQBZGAKWSA-N troxacitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)OC1 RXRGZNYSEHTMHC-BQBZGAKWSA-N 0.000 description 1
- 229950010147 troxacitabine Drugs 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
本发明涉及核苷磷酸类化合物、包含其的药物组合物及其制备方法和用途，该类化合物可以在肝细胞内顺利代谢，生成具有活性的代谢产物三磷酸核苷，用于治疗或预防相关疾病，例如肝癌。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017109915531 | 2017-10-23 | ||
| CN201710991553 | 2017-10-23 | ||
| PCT/CN2018/109983 WO2019080724A1 (zh) | 2017-10-23 | 2018-10-12 | 核苷磷酸类化合物及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111051326A true CN111051326A (zh) | 2020-04-21 |
Family
ID=66247180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880054417.2A Pending CN111051326A (zh) | 2017-10-23 | 2018-10-12 | 核苷磷酸类化合物及其制备方法和用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111051326A (zh) |
| WO (1) | WO2019080724A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274516A (zh) * | 2020-10-26 | 2021-01-29 | 中山大学附属第三医院 | 一种新型含碘抗病毒药物 |
| CN114480568B (zh) * | 2020-12-30 | 2024-04-26 | 安诺优达基因科技(北京)有限公司 | 一种磷酸化反应的检测方法及试剂盒 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695513A (zh) * | 2008-12-23 | 2012-09-26 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| WO2015158913A1 (en) * | 2014-04-17 | 2015-10-22 | Katholieke Universiteit Leuven | Novel antiviral and antitumoral compounds |
| CN105246902A (zh) * | 2013-03-15 | 2016-01-13 | 加利福尼亚大学董事会 | 无环核苷膦酸二酯 |
| CN106554382A (zh) * | 2015-09-29 | 2017-04-05 | 四川科伦药物研究院有限公司 | 核苷磷酰胺类化合物及其制备方法和药物中的应用 |
| CN109863160A (zh) * | 2016-12-23 | 2019-06-07 | 四川科伦博泰生物医药股份有限公司 | 核苷磷酸类化合物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010135520A1 (en) * | 2009-05-20 | 2010-11-25 | Chimerix, Inc. | Compounds, compositions and methods for treating viral infection |
| CN104761604A (zh) * | 2014-01-02 | 2015-07-08 | 江苏豪森药业股份有限公司 | 尿嘧啶核苷酸类似物及其制备方法和应用 |
| WO2016015638A1 (zh) * | 2014-07-30 | 2016-02-04 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| CN105254695B (zh) * | 2014-11-10 | 2019-01-18 | 南京曼杰生物科技有限公司 | 核苷氨基磷酸酯衍生物及其应用 |
-
2018
- 2018-10-12 CN CN201880054417.2A patent/CN111051326A/zh active Pending
- 2018-10-12 WO PCT/CN2018/109983 patent/WO2019080724A1/zh active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695513A (zh) * | 2008-12-23 | 2012-09-26 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| CN105246902A (zh) * | 2013-03-15 | 2016-01-13 | 加利福尼亚大学董事会 | 无环核苷膦酸二酯 |
| WO2015158913A1 (en) * | 2014-04-17 | 2015-10-22 | Katholieke Universiteit Leuven | Novel antiviral and antitumoral compounds |
| CN106554382A (zh) * | 2015-09-29 | 2017-04-05 | 四川科伦药物研究院有限公司 | 核苷磷酰胺类化合物及其制备方法和药物中的应用 |
| CN109863160A (zh) * | 2016-12-23 | 2019-06-07 | 四川科伦博泰生物医药股份有限公司 | 核苷磷酸类化合物及其制备方法和用途 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274516A (zh) * | 2020-10-26 | 2021-01-29 | 中山大学附属第三医院 | 一种新型含碘抗病毒药物 |
| CN112274516B (zh) * | 2020-10-26 | 2022-08-05 | 中山大学附属第三医院 | 一种新型含碘抗病毒药物 |
| CN114480568B (zh) * | 2020-12-30 | 2024-04-26 | 安诺优达基因科技(北京)有限公司 | 一种磷酸化反应的检测方法及试剂盒 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019080724A1 (zh) | 2019-05-02 |
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