CN111035583A - 一种改善真表皮连接层的护肤品组合物 - Google Patents
一种改善真表皮连接层的护肤品组合物 Download PDFInfo
- Publication number
- CN111035583A CN111035583A CN201911340043.3A CN201911340043A CN111035583A CN 111035583 A CN111035583 A CN 111035583A CN 201911340043 A CN201911340043 A CN 201911340043A CN 111035583 A CN111035583 A CN 111035583A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin care
- improving
- junction layer
- epidermis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及化工技术领域,且公开了一种改善真表皮连接层的护肤品组合物,包括以下份数的原料:第一组分40份、第二组分40份、PEG/PPG/聚丁二醇‑8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份。该改善真表皮连接层的护肤品组合物,通过将PEG/PPG/聚丁二醇‑8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2‑戊二醇2份和1,3丙二醇7份以200‑300rpm低速搅拌,制得的护肤品组合物可以改善真表皮连接层,藉由增加层粘连蛋白‑5的表达使真表皮连接层与提高胶原蛋白合成与结构稳定达到了好的抗衰老效果,藉由改善真表皮连接层的状态,进而增加皮肤营养吸收,增加表皮层厚度,改善表皮对外界机械力的耐受性。
Description
技术领域
本发明涉及化工技术领域,具体为一种改善真表皮连接层的护肤品组合物。
背景技术
护肤品,即保护皮肤的产品,随着社会经济的不断进步和物质生活的丰富,护肤品,不再是过去只有富人才用的起的东西,现如今护肤品已走进了平常百姓家,它对人们的精神和形象提升起到了极大的作用。
在个人护理品中有针对于抗衰老研究相当广泛,但其中改善真表皮连接层(DEJ)的相关研究并不多,大多是朝向胶原蛋白与弹力蛋白增生的相关研究,然而要使皮肤外观回复饱满平滑状态,皮肤厚度是一个重要的关键,所以藉由改善真表皮连接层的状态,进而增加皮肤营养吸收,增加表皮层厚度,改善表皮对外界机械力的耐受性,以达到抗衰老之功效是一个抗衰老重要的方向,故而提出一种改善真表皮连接层的护肤品组合物。
发明内容
(一)解决的技术问题
针对现有技术的不足,本发明提供了一种改善真表皮连接层的护肤品组合物,具备可以藉由增加层粘连蛋白-5的表达使真表皮连接层与提高胶原蛋白合成与结构稳定来达到抗衰老功效等优点,解决了传统护肤品使皮肤外观回复饱满平滑状态效果较差的问题。
(二)技术方案
为实现上述藉由增加层粘连蛋白-5的表达使真表皮连接层与提高胶原蛋白合成与结构稳定来达到抗衰老功效的目的,本发明提供如下技术方案:一种改善真表皮连接层的护肤品组合物,包括以下份数的原料:第一组分40份、第二组分40份、PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份。
优选的,所述第一组分40份为[水/丙二醇/植物甾醇类],所述第二组分40份为[水/卵磷脂/二棕榈酰羟脯氨酸/苯氧乙醇/妥尔油甾醇/亚油酸/生育酚/抗坏血酸钠/羟苯甲酯/羟苯丁酯/羟苯乙酯/羟苯丙酯/羟苯异丁酯]。
优选的,所述一种改善真表皮连接层的护肤品组合物,其制备方法包括以下步骤:
1)先将PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份以200-300rpm低速搅拌,并置于超声波震荡器中,搅拌分散完全;
2)再加入第一组分40份和第二组分40份持续震荡搅拌30分钟,待分散均匀后,使用均质机以8500rpm均质180秒,即完成,制得所求一种改善真表皮连接层的护肤品组合物。
(三)有益效果
与现有技术相比,本发明提供了一种改善真表皮连接层的护肤品组合物,具备以下有益效果:
该改善真表皮连接层的护肤品组合物,通过将PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份以200-300rpm低速搅拌,并置于超声波震荡器中,搅拌分散完全,再加入第一组分40份和第二组分40份持续震荡搅拌30分钟,待分散均匀后,使用均质机以8500rpm均质180秒,制得的护肤品组合物可以改善真表皮连接层,藉由增加层粘连蛋白-5的表达使真表皮连接层与提高胶原蛋白合成与结构稳定达到了好的抗衰老效果,藉由改善真表皮连接层的状态,进而增加皮肤营养吸收,增加表皮层厚度,改善表皮对外界机械力的耐受性。
具体实施方式
下面将结合本发明的实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例:一种改善真表皮连接层的护肤品组合物,包括以下份数的原料:第一组分40份、第二组分40份、PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份。
第一组分40份为[水/丙二醇/植物甾醇类],第二组分40份为[水/卵磷脂/二棕榈酰羟脯氨酸/苯氧乙醇/妥尔油甾醇/亚油酸/生育酚/抗坏血酸钠/羟苯甲酯/羟苯丁酯/羟苯乙酯/羟苯丙酯/羟苯异丁酯]。
一种改善真表皮连接层的护肤品组合物,其制备方法包括以下步骤:
1)先将PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份以200-300rpm低速搅拌,并置于超声波震荡器中,搅拌分散完全;
2)再加入第一组分40份和第二组分40份持续震荡搅拌30分钟,待分散均匀后,使用均质机以8500rpm均质180秒,即完成,制得所求一种改善真表皮连接层的护肤品组合物。
[水/丙二醇/植物甾醇类]为GreenTech公司的REVERSKI N。
[水/卵磷脂/二棕榈酰羟脯氨酸/苯氧乙醇/妥尔油甾醇/亚油酸/生育酚/抗坏血酸钠/羟苯甲酯/羟苯丁酯/羟苯乙酯/羟苯丙酯/羟苯异丁酯]为MERCK公司的RonaCare ASCⅢ。
本发明可添入护肤品中的面膜精华液、精华液、乳液或膏霜之抗衰老功效物的添加,添加量2-6%。
试验例:44岁女性,未使用本发明的一种改善真表皮连接层的护肤品组合物前真表皮连接处(DEJ)为平坦,使用后发现DEJ重新连接,恢复表皮层营养供给,使肌肤回复弹性。
本发明的有益效果是:一种改善真表皮连接层的护肤品组合物,通过将PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份以200-300rpm低速搅拌,并置于超声波震荡器中,搅拌分散完全,再加入第一组分40份和第二组分40份持续震荡搅拌30分钟,待分散均匀后,使用均质机以8500rpm均质180秒,制得的护肤品组合物可以改善真表皮连接层,藉由增加层粘连蛋白-5的表达使真表皮连接层与提高胶原蛋白合成与结构稳定达到了好的抗衰老效果,藉由改善真表皮连接层的状态,进而增加皮肤营养吸收,增加表皮层厚度,改善表皮对外界机械力的耐受性,解决了传统护肤品使皮肤外观回复饱满平滑状态效果较差的问题。
尽管已经示出和描述了本发明的实施例,对于本领域的普通技术人员而言,可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型,本发明的范围由所附权利要求及其等同物限定。
Claims (3)
1.一种改善真表皮连接层的护肤品组合物,其特征在于,包括以下份数的原料:第一组分40份、第二组分40份、PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份。
2.根据权利要求1所述的一种改善真表皮连接层的护肤品组合物,其特征在于:所述第一组分40份为[水/丙二醇/植物甾醇类],所述第二组分40份为[水/卵磷脂/二棕榈酰羟脯氨酸/苯氧乙醇/妥尔油甾醇/亚油酸/生育酚/抗坏血酸钠/羟苯甲酯/羟苯丁酯/羟苯乙酯/羟苯丙酯/羟苯异丁酯]。
3.根据权利要求1所述的一种改善真表皮连接层的护肤品组合物,其特征在于:所述一种改善真表皮连接层的护肤品组合物,其制备方法包括以下步骤:
1)先将PEG/PPG/聚丁二醇-8/5/3甘油10份、二(月桂酰胺谷氨酰胺)赖氨酸钠1份、1,2-戊二醇2份和1,3丙二醇7份以200-300rpm低速搅拌,并置于超声波震荡器中,搅拌分散完全;
2)再加入第一组分40份和第二组分40份持续震荡搅拌30分钟,待分散均匀后,使用均质机以8500rpm均质180秒,即完成,制得所求一种改善真表皮连接层的护肤品组合物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911340043.3A CN111035583A (zh) | 2019-12-23 | 2019-12-23 | 一种改善真表皮连接层的护肤品组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911340043.3A CN111035583A (zh) | 2019-12-23 | 2019-12-23 | 一种改善真表皮连接层的护肤品组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111035583A true CN111035583A (zh) | 2020-04-21 |
Family
ID=70238733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911340043.3A Pending CN111035583A (zh) | 2019-12-23 | 2019-12-23 | 一种改善真表皮连接层的护肤品组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111035583A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113350311A (zh) * | 2021-06-23 | 2021-09-07 | 浙江宜格企业管理集团有限公司 | 一种水飞蓟素纳米结构脂质载体及其制备方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040053860A1 (en) * | 2002-09-02 | 2004-03-18 | Merck Patent Gmbh | Flavonoid derivatives for the treatment of eczema |
US20040081675A1 (en) * | 2001-03-02 | 2004-04-29 | Corinna Wirth | Cosmetic formulations containing flavonoid derivatives |
US20080319050A1 (en) * | 2004-11-19 | 2008-12-25 | Christophe Carola | Preparation Containing Oxidized Flavonoid Derivatives |
WO2013003465A2 (en) * | 2011-06-28 | 2013-01-03 | Avicena Group, Inc. | Methods and compositions for treating skin |
WO2014098254A1 (en) * | 2012-12-19 | 2014-06-26 | L'oreal | Anhydrous cosmetic composition |
US20180116927A1 (en) * | 2016-10-31 | 2018-05-03 | Sytheon Limited | Skin enhancing compositions and methods |
CN108186479A (zh) * | 2018-03-31 | 2018-06-22 | 佛山文森特知识产权服务有限公司 | 一种有助于改善肤质的护肤组合物及其在化妆品中的应用 |
CN109316368A (zh) * | 2018-11-28 | 2019-02-12 | 韩艳辉 | 抗衰老护肤品及其制备方法 |
CN109350591A (zh) * | 2018-10-24 | 2019-02-19 | 广州艾蓓生物科技有限公司 | 一种美颜干面膜及其制备方法 |
-
2019
- 2019-12-23 CN CN201911340043.3A patent/CN111035583A/zh active Pending
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040081675A1 (en) * | 2001-03-02 | 2004-04-29 | Corinna Wirth | Cosmetic formulations containing flavonoid derivatives |
US20040053860A1 (en) * | 2002-09-02 | 2004-03-18 | Merck Patent Gmbh | Flavonoid derivatives for the treatment of eczema |
US20080319050A1 (en) * | 2004-11-19 | 2008-12-25 | Christophe Carola | Preparation Containing Oxidized Flavonoid Derivatives |
WO2013003465A2 (en) * | 2011-06-28 | 2013-01-03 | Avicena Group, Inc. | Methods and compositions for treating skin |
WO2014098254A1 (en) * | 2012-12-19 | 2014-06-26 | L'oreal | Anhydrous cosmetic composition |
US20180116927A1 (en) * | 2016-10-31 | 2018-05-03 | Sytheon Limited | Skin enhancing compositions and methods |
CN108186479A (zh) * | 2018-03-31 | 2018-06-22 | 佛山文森特知识产权服务有限公司 | 一种有助于改善肤质的护肤组合物及其在化妆品中的应用 |
CN109350591A (zh) * | 2018-10-24 | 2019-02-19 | 广州艾蓓生物科技有限公司 | 一种美颜干面膜及其制备方法 |
CN109316368A (zh) * | 2018-11-28 | 2019-02-12 | 韩艳辉 | 抗衰老护肤品及其制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113350311A (zh) * | 2021-06-23 | 2021-09-07 | 浙江宜格企业管理集团有限公司 | 一种水飞蓟素纳米结构脂质载体及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110269814A (zh) | 一种含有乙酰基六肽-8的抗皱护肤品组合物的制备方法 | |
CN113616566B (zh) | 一种紧致肌肤的护肤精华液及其制备方法 | |
CN102939083A (zh) | 层粘连蛋白332生成促进组合物 | |
CN104644507B (zh) | 一种护理类膏霜组合物 | |
FR2802413A1 (fr) | Compositions cosmetiques ou dermopharmaceutiques contenant le tripeptide n-palmytoyl-gly-hys-lys, pour eliminer, reduire ou prevenir l'apparition de rides quelles qu'en soient la localisation et la cause | |
CN105250184A (zh) | 一种美白抗衰老精华液及其制备方法 | |
CN109481373B (zh) | 提拉紧致抗初老功效的美白v脸面膜贴及其制备方法 | |
CN111035583A (zh) | 一种改善真表皮连接层的护肤品组合物 | |
CN105395443A (zh) | 一种抗衰老眼霜及其制备方法 | |
CN109771311A (zh) | 一种美白祛斑霜及其制备方法 | |
CN107149583A (zh) | 一种抗皱化妆品组合物及其配制方法 | |
CN108852969B (zh) | 一种抗皱抗衰老美白面膜及其制备方法 | |
CN102657592B (zh) | 一种抗衰老的精华液组合物及其制备方法 | |
CN104784092A (zh) | 一种皮肤即时修复营养液 | |
CN108888531A (zh) | 一种喷雾剂 | |
KR101770556B1 (ko) | 사용 시 유화기능이 부여되는 마스크 팩 조성물 | |
CN112451401A (zh) | 一种含有多肽成分的抗衰老精华液及其制备方法 | |
CN106511144A (zh) | 一种眼唇卸妆水及其制备方法 | |
CN105726392A (zh) | 一种新生活水因子及其制备方法和在化妆品中的应用 | |
WO2015154126A1 (en) | Liposomal compound and compositions containing the compound | |
US20090203654A1 (en) | Cosmetic and pharmaceutical compositions | |
CN106061486A (zh) | 护肤*** | |
CN107970169A (zh) | 一种美白组合物、其护肤品及制备方法 | |
CN106473989A (zh) | 一种舒润修护面霜及其制备方法 | |
CN112168771A (zh) | 一种具有抗衰老功效的组合物及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200421 |
|
RJ01 | Rejection of invention patent application after publication |