CN110976908A - Gold-platinum bimetallic nano-particles and preparation method thereof - Google Patents
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Abstract
The invention discloses a preparation method of gold-platinum bimetallic nanoparticles, which comprises the following steps: reacting chlorogenic acid aqueous solution with chloroplatinic acid aqueous solution and chloroauric acid aqueous solution at 80-100 ℃ to obtain the gold-platinum bimetallic nano-particles. The green preparation method of the Au @ Pt bimetallic nanoparticle is efficient and rapid, adopts chlorogenic acid as a reducing agent with bioactivity, avoids the use of reducing agents such as sodium borohydride and the like with high toxicity, does not need to add an additional stabilizing agent or a protective agent, has simple reaction conditions, is environment-friendly and short reaction time, and has good dispersibility, good scavenging effect on free radical DPPH, good oxidation resistance and potential medical application.
Description
Technical Field
The invention relates to a nano particle, in particular to a gold-platinum bimetallic nano particle and a preparation method thereof.
Background
Compared with single metal nano material, the bimetal nano material is a novel advanced material with unique charm, and two or more than two different functional nano materials can be integrated into a whole, so that more excellent performance or even new performance is obtained.
Bimetallic NPs are commonly in the form of core-shell, heterostructure and alloy nanostructures, and the most common bimetallic nanoparticles are made of noble metals, such as Au @ Ag, Au @ Pd, Au @ Pt, etc., whose properties are closely related to the structure and size of the nanoparticles.
Platinum nanostructures with high surface area in combination with other metal nanoparticles have been used as anti-tumor drugs in biomedical applications. The development of bimetallic nanomaterials based on platinum materials is currently an area of research interest. Meanwhile, the gold nanoparticles are easy to realize surface modification or biological coupling reaction, so that antibodies, polypeptides, ligands, drugs and genes can be introduced, and the targeting property and specificity of the nano-drugs are improved. The synthesis, composition and structure of the Au @ Pt bimetallic nanoparticles and the properties of the Au @ Pt bimetallic nanoparticles, such as biological activity, synergistic effect, catalysis and the like, are researched, and the Au @ Pt bimetallic nanoparticles are beneficial to developing important applications of the Au @ Pt bimetallic nanoparticles in aspects of biosensing, cell imaging, antitumor drugs and the like.
The common chemical reduction method of noble metal nano-particles often uses toxic and harmful chemical reducing agents, has long reaction time, is easy to agglomerate, and needs to add a stabilizing agent additionally. Poor biocompatibility and unfavorable application in biomedical field.
Disclosure of Invention
Based on the above, the present invention aims to overcome the disadvantages of the prior art and provide a preparation method of gold-platinum bimetallic nanoparticles. The green synthesis method uses plant extracts or biological active substances such as microorganisms and the like as reactants to synthesize NPs structure, replaces chemical reagents such as sodium borohydride and the like to eliminate harm to human and environment, can improve the biocompatibility of products, and simplifies reaction steps.
The choice of green reducing agent is a key issue in the green synthesis of noble metal nanoparticles. Chlorogenic acid (CGA), as a natural bioactive compound, is widely present in many plants, especially coffee beans, sea buckthorn berries and traditional Chinese herbal medicines, such as honeysuckle and eucommia ulmoides, with high content, and is also one of the main ingredients in many plant extracts. It is a depside, belongs to phenolic compounds, has the functions of resisting oxidation, bacteria, viruses and tumors, removing free radicals and the like, and is a potential green reducing agent.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a preparation method of gold-platinum bimetallic nanoparticles comprises the following steps: reacting chlorogenic acid aqueous solution with chloroplatinic acid aqueous solution and chloroauric acid aqueous solution at 80-100 ℃ to obtain the gold-platinum bimetallic nano-particles.
Preferably, the method is: mixing a chlorogenic acid aqueous solution, a chloroplatinic acid aqueous solution and water, heating and reacting in a constant-temperature water bath at 80-100 ℃ for 80-150 min, then stirring and heating to boil, and heating and reacting with a chloroauric acid aqueous solution to boil to obtain gold-platinum bimetallic nanoparticles;
or
The method comprises the following steps: mixing a chlorogenic acid aqueous solution, a chloroauric acid aqueous solution and water, heating and reacting in a constant-temperature water bath at 80-100 ℃ for 80-150 min, then stirring and heating to boil, and heating and reacting with a chloroplatinic acid aqueous solution to boil to obtain the gold-platinum bimetallic nanoparticles.
Preferably, the reaction concentration of the chloroauric acid is 0.06-0.9 mmol/L, the reaction concentration of the chloroplatinic acid is 0.06-0.9 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-5 mmol/L.
More preferably, the reaction concentration of the chloroauric acid is 0.1-0.9 mmol/L, the reaction concentration of the chloroplatinic acid is 0.1-0.9 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-2.8 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 9-9: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 28, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 28.
More preferably, the reaction concentration of the chloroauric acid is 0.1-0.8 mmol/L, the reaction concentration of the chloroplatinic acid is 0.1-0.8 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-2.5 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 8-8: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 25, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 25. The preferable reaction concentration and concentration ratio can avoid the agglomeration of the gold-platinum bimetallic nanoparticles, have good dispersibility and prepare nanoparticles with different morphologies.
Preferably, the reaction concentration ratio of the chlorogenic acid, the chloroauric acid and the chloroplatinic acid is as follows: gold chloride acid: chloroplatinic acid: chlorogenic acid is 1:1: a, and a is not less than 1.
Preferably, the method is: dripping mixed solution of chloroauric acid and chloroplatinic acid which are mixed in equal volume into preheated chlorogenic acid aqueous solution, controlling the reaction temperature to be 80-100 ℃, and cooling to room temperature after the reaction is finished to obtain the gold-platinum bimetallic nano-particles.
More preferably, after the hot plate is preheated for 30 minutes, the chlorogenic acid solution is placed in a sample bottle, the sample bottle is heated for 2 minutes without a cover on the hot plate, then a mixed solution of chloroauric acid and chloroplatinic acid with the same volume is dripped, the mixture is heated for 1 minute, the mixture is light brown immediately after the dripping is finished, the color is gradually deepened in the heating process, the reaction temperature is 80-100 ℃, the mixture is heated, and the mixture is cooled to room temperature, then the solution is clear and transparent and is brown.
Preferably, the concentration of the chloroauric acid is 0.1-3 mmol/L, the concentration of the chloroplatinic acid is 0.1-3 mmol/L, and the concentration of the chlorogenic acid is 0.1-10 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 9-9: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 10, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 10.
Preferably, the reaction temperature is 90-100 ℃. The bimetallic nano-particles with good dispersibility can be prepared by reaction in a preferred temperature range.
Meanwhile, the invention also provides the gold-platinum bimetallic nano-particles prepared by the preparation method.
Compared with the prior art, the invention has the beneficial effects that:
the green preparation method of the Au @ Pt bimetallic nanoparticle is efficient and rapid, adopts chlorogenic acid as a reducing agent with bioactivity, avoids the use of reducing agents such as sodium borohydride and the like with high toxicity, does not need to add an additional stabilizing agent or a protective agent, has simple reaction conditions, is environment-friendly and short reaction time, and has good dispersibility, good scavenging effect on free radical DPPH, good oxidation resistance and potential medical application.
Drawings
FIG. 1 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 1 of the present invention;
FIG. 2 is a transmission electron microscope image of the bimetallic Au-Pt nanoparticles obtained in example 1 of the present invention;
FIG. 3 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 1 of the present invention;
FIG. 4 is an infrared spectrum of the bimetallic gold-platinum nanoparticle obtained in example 1 of the present invention;
FIG. 5 is an EDS energy spectrum of bimetallic gold-platinum nanoparticles obtained in example 1 of the present invention;
FIG. 6 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 7 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 8 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 9 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 10 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 11 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 12 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 13 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 2 of the present invention;
FIG. 14 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 3 of the present invention;
FIG. 15 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 3 of the present invention;
FIG. 16 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 3 of the present invention;
FIG. 17 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 3 of the present invention;
FIG. 18 is a transmission electron microscope image of bimetallic Au-Pt nanoparticles obtained in example 3 of the present invention;
FIG. 19 is a TEM image of Au-Pt bimetallic nanoparticles obtained in example 3 of the present invention;
fig. 20 is a graph showing the radical scavenging rate of the bimetal nanoparticles of au-pt according to example 4 of the present invention.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to the accompanying drawings and specific embodiments.
Example 1
In an embodiment of the present invention, the preparation process of the gold-platinum bimetallic nanoparticle is as follows:
experimental materials: 10mmol/l chlorogenic acid solution, 3mmol/l chloroauric acid solution and 2.718mmol/l chloroplatinic acid solution;
the experimental process comprises the following steps:
preheating a hot plate for 30 minutes, putting 600 mu l of chlorogenic acid solution into a sample bottle, heating the sample bottle for about 2 minutes without a cover on the hot plate, then dropwise adding 600 mu l of mixed solution of chloroauric acid and chloroplatinic acid with the same volume, heating the mixed solution for about 1 minute, wherein the color is changed (the mixed solution is light brown immediately after dropwise adding, and the color is gradually deepened in the heating process), the reaction temperature is 80-95 ℃, after heating, cooling the mixed solution to room temperature, and the solution is clear and transparent and brown; the actual reaction concentration ratio is: chlorogenic acid, namely chloroauric acid and chloroplatinic acid, in a ratio of 5:0.75:0.68, and preparing the gold-platinum bimetallic nanoparticles after the reaction is finished; the transmission electron microscope images are shown in attached figures 1-3, the infrared spectrogram is shown in figure 4, and the EDS energy spectrogram is shown in figure 5;
as can be seen from the attached drawings 1-3, the Au-Pt bimetallic nanoparticles are mainly spherical and have a Tyndall phenomenon, but the dispersibility is poor, which indicates that the reaction sequence and concentration of chlorogenic acid and chloroauric acid or chloroplatinic acid need to be further regulated and controlled. As can be seen from FIG. 4, the formation of chlorogenic acid-Au @ Pt bimetallic nanoparticles is illustrated by the characteristic peak of-OH, chlorogenic acid can act as both a reducing agent and a stabilizer; as can be seen from FIG. 5, the Au and Pt characteristic peaks of EDS are illustrated and synthesized as Au @ Pt bimetallic nanoparticles.
Example 2
In an embodiment of the gold-platinum bimetallic nanoparticle of the present invention, the reaction concentration of chlorogenic acid in the preparation process and the reaction sequence in the preparation process of the gold-platinum bimetallic nanoparticle are specifically analyzed.
Preparing 1mmol/L chlorogenic acid aqueous solution, 1mmol/L chloroauric acid aqueous solution and 1mmol/L chloroplatinic acid aqueous solution; mixing chlorogenic acid water solution, chloroplatinic acid water solution and water, heating in 95 deg.C constant temperature water bath for 150min, stirring and heating on a heater to boil, and heating to boil with chloroauric acid solution. Controlling the actual reaction concentration of the chloroauric acid to be 0.1 mmol/L; chloroplatinic acid is 0.1 mmol/L; chlorogenic acid is 0.1mmol/L, 0.2mmol/L, 0.3mmol/L, 0.4mmol/L, the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is 1:1: 1-1: 1: 4; TEM images of the prepared Au @ Pt bimetallic nanoparticles are shown in FIGS. 6-9; in fig. 6, the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) was 1:1: 1, the Au @ Pt bimetallic nanoparticles are mainly spherical, contain a small amount of irregular edges and have large irregular shapes; in fig. 7, the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) was 1:1: 2, the Au @ Pt bimetallic nanoparticles have regular edges and regular shapes, are mainly spherical or hemispherical, contain a small amount of flower-shaped particles stacked by small particles, and have good dispersibility and no agglomeration; in fig. 8, the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) was 1:1: 3, similar to fig. 7, the Au @ Pt bimetallic nanoparticles have regular edges and regular shapes, are mainly spherical or hemispherical, contain a small amount of flower-shaped particles stacked by small particles, and have good dispersibility and no agglomeration; in fig. 9, the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) was 1:1: 4, the Au @ Pt bimetallic nanoparticles are neat in edge and regular in shape, are mainly spherical or hemispherical, contain a small amount of flower-shaped particles stacked by small particles, are good in dispersity and do not agglomerate; due to the excessive chlorogenic acid, an organic phase coated around the Au @ Pt bimetallic nanoparticles is more obvious; the change of the concentration of the chlorogenic acid indicates that the reaction concentration ratio of the chlorogenic acid and the chloroauric acid or the chloroplatinic acid is equal and the chlorogenic acid is in proper excess when the Au @ Pt bimetallic nanoparticle is prepared.
Changing the reaction sequence, mixing the chlorogenic acid aqueous solution and water on a heater, stirring and heating to boil, heating to react with the chloroauric acid aqueous solution to boil, heating to react with the chloroplatinic acid solution to boil, and then placing in a 95 ℃ constant-temperature water bath for reaction for 150 min. The actual reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) was still adjusted to 1:1: 1-1: 1: 4, TEM images of the prepared Au @ Pt bimetallic nanoparticles are shown in FIGS. 10-13; FIG. 10 shows that the actual reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is still 1:1: 1, TEM images after changing the reaction sequence, in comparison with fig. 6, it can be seen that the Au @ Pt bimetallic nanoparticles are more uniform, mainly being single spherical nanoparticles. FIGS. 11 to 12 show that the actual reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is still 1:1: 2, when the reaction concentration ratio is the same, the shape of the Au @ Pt bimetallic nanoparticle is changed, mainly showing flower-shaped large particles stacked by small particles, and the Au @ Pt bimetallic nanoparticle has good dispersibility and no agglomeration. FIG. 13 shows that the actual reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is still 1:1: 4, TEM images after changing the reaction sequence also become mainly flower-like large particles in comparison with FIG. 9. The above experimental data indicate that the reaction sequence of chlorogenic acid and chloroauric acid or chloroplatinic acid can affect the morphology of the Au @ Pt bimetallic nanoparticles.
Example 3
In an embodiment of the gold-platinum bimetallic nanoparticle of the present invention, the reaction concentrations of chloroplatinic acid and chloroauric acid in the preparation process of the Au @ Pt bimetallic nanoparticle and the reaction sequence in the preparation process are specifically analyzed.
Mixing a chlorogenic acid solution, a chloroplatinic acid solution and water in a water bath at 95 ℃ for 80min, stirring and heating on a heater until boiling, then adding a chloroauric acid solution, heating until boiling, and controlling the actual reaction concentration of the chloroauric acid to be 0.1 mmol/L; the chloroplatinic acid is respectively 0.2mmol/L, 0.4mmol/L and 0.8 mmol/L; chlorogenic acid is 2.5 mmol/L. The reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is 1: 2: 25. 1: 4: 25. 1: 8: 25. the TEM images of the bimetallic nanoparticles are shown in fig. 14, 15 and 16, respectively, and it can be seen that the prepared bimetallic nanoparticles have good average dispersibility, but as the concentration of chloroplatinic acid increases, the morphology of the bimetallic nanoparticles changes from flower-like shape with small ball accumulation, with few single-grain balls, to flower-like shape with single-grain balls as the main part and with small ball accumulation, and the trend of changing from flower-like shape to spherical shape is shown.
Under the same experimental conditions, the reaction concentration of chloroplatinic acid is controlled to be 0.1 mmol/L; the concentration of the chloroauric acid is respectively 0.2mmol/L, 0.4mmol/L and 0.8 mmol/L; chlorogenic acid is 2.5 mmol/L. The reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is 2: 1: 25. 4: 1: 25. 8: 1: 25. the TEM images are shown in fig. 17, 18 and 19, respectively, and it can be seen that the prepared bimetallic nanoparticles have good dispersibility, and the morphology is more clear due to the flower shape of the bead accumulation with the increase of the concentration of the chloroauric acid.
Example 4
In an embodiment of the gold-platinum bimetallic nanoparticle of the present invention, the oxidation resistance of the gold-platinum bimetallic nanoparticle is specifically studied and analyzed.
Mixing and oscillating 1ml of prepared CGA-Au @ PtNPs sample and 1ml of DPPH.radical absolute ethyl alcohol solution (0.2mmol/L) in a sample bottle, placing the sample bottle in a dark environment for reaction for 30min, and measuring the absorbance of the sample bottle at 517nm As reference by using 1ml of distilled water and 1ml of absolute ethyl alcohol mixed solution; simultaneously, 1ml of sample is taken to be mixed with 1ml of absolute ethyl alcohol to obtain absorbance Ab, 1ml of DPPH-free radical absolute ethyl alcohol solution is taken to be mixed with 1ml of distilled water to obtain absorbance Ac, and the clearance rate is calculated according to the following formula:
the measured clearance of the CGA-Au @ PtNPs sample to DPPH.radical is shown in the attached FIG. 20: as can be seen from FIG. 20, the prepared CGA-Au @ PtNPs have a DPPH radical scavenging rate of more than 90% and higher than that of CGA, and the prepared CGA-Au @ PtNPs are centrifuged, the supernatant is discarded, and after being redispersed with water, the DPPH radical scavenging rate is reduced and still reaches more than 90%, which indicates that the prepared Au @ PtNPs have better oxidation resistance.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A preparation method of gold-platinum bimetallic nanoparticles is characterized by comprising the following steps: reacting chlorogenic acid aqueous solution with chloroplatinic acid aqueous solution and chloroauric acid aqueous solution at 80-100 ℃ to obtain the gold-platinum bimetallic nano-particles.
2. The method for preparing the gold-platinum bimetallic nanoparticles as claimed in claim 1, wherein the method comprises the following steps: mixing a chlorogenic acid aqueous solution, a chloroplatinic acid aqueous solution and water, heating and reacting in a constant-temperature water bath at 80-100 ℃ for 80-150 min, then stirring and heating to boil, and heating and reacting with a chloroauric acid aqueous solution to boil to obtain gold-platinum bimetallic nanoparticles;
or
The method comprises the following steps: mixing a chlorogenic acid aqueous solution, a chloroauric acid aqueous solution and water, heating and reacting in a constant-temperature water bath at 80-100 ℃ for 80-150 min, then stirring and heating to boil, and heating and reacting with a chloroplatinic acid aqueous solution to boil to obtain the gold-platinum bimetallic nanoparticles.
3. The method for preparing the Au-Pt bimetallic nanoparticle as claimed in claim 2, wherein the reaction concentration of the chloroauric acid is 0.06-0.9 mmol/L, the reaction concentration of the chloroplatinic acid is 0.06-0.9 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-5 mmol/L.
4. The preparation method of the Au-Pt bimetallic nanoparticle as claimed in claim 3, wherein the reaction concentration of the chloroauric acid is 0.1-0.9 mmol/L, the reaction concentration of the chloroplatinic acid is 0.1-0.9 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-2.8 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 9-9: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 28, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 28.
5. The preparation method of the Au-Pt bimetallic nanoparticle as claimed in claim 4, wherein the reaction concentration of the chloroauric acid is 0.1-0.8 mmol/L, the reaction concentration of the chloroplatinic acid is 0.1-0.8 mmol/L, and the reaction concentration of the chlorogenic acid is 0.1-2.5 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 8-8: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 25, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 25.
6. The method for preparing the Au-Pt bimetallic nanoparticle of any one of claims 3 to 5, wherein the reaction concentration ratio of the chlorogenic acid, the chloroauric acid and the chloroplatinic acid is as follows: gold chloride acid: chloroplatinic acid: chlorogenic acid is 1:1: a, and a is not less than 1.
7. The method for preparing the gold-platinum bimetallic nanoparticles as claimed in claim 1, wherein the method comprises the following steps:
dripping mixed solution of chloroauric acid and chloroplatinic acid which are mixed in equal volume into preheated chlorogenic acid aqueous solution, controlling the reaction temperature to be 80-100 ℃, and cooling to room temperature after the reaction is finished to obtain the gold-platinum bimetallic nano-particles.
8. The preparation method of the Au-Pt bimetallic nanoparticle as claimed in claim 7, wherein the concentration of the chloroauric acid is 0.1-3 mmol/L, the concentration of the chloroplatinic acid is 0.1-3 mmol/L, and the concentration of the chlorogenic acid is 0.1-10 mmol/L; the actual reaction concentration ratios are as follows: the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 9-9: 1, the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 10, and the weight ratio of the chloroplatinic acid to the chlorogenic acid is 1: 1-1: 10.
9. The method for preparing the Au-Pt bimetallic nanoparticle of claim 2 or 7, wherein the reaction temperature is 90-100 ℃.
10. The gold-platinum bimetallic nano-particles prepared by the preparation method of any one of claims 1 to 9.
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Cited By (2)
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| CN111438368A (en) * | 2020-04-29 | 2020-07-24 | 西南大学 | Gold-platinum bimetallic nano-enzyme prepared from silk fibroin solution and application thereof |
| CN112893863A (en) * | 2021-01-20 | 2021-06-04 | 山东省科学院菏泽分院 | Preparation method of gold platinum nano material |
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| CN111438368A (en) * | 2020-04-29 | 2020-07-24 | 西南大学 | Gold-platinum bimetallic nano-enzyme prepared from silk fibroin solution and application thereof |
| CN111438368B (en) * | 2020-04-29 | 2022-08-16 | 西南大学 | Gold-platinum bimetallic nanoenzyme prepared from silk fibroin solution and application thereof |
| CN112893863A (en) * | 2021-01-20 | 2021-06-04 | 山东省科学院菏泽分院 | Preparation method of gold platinum nano material |
| CN112893863B (en) * | 2021-01-20 | 2022-07-15 | 山东省科学院菏泽分院 | Preparation method of gold platinum nano material |
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