CN110974926A - Chinese herbal medicine additive for improving immunity and blood health of live pigs and preparation method thereof - Google Patents

Chinese herbal medicine additive for improving immunity and blood health of live pigs and preparation method thereof Download PDF

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Publication number
CN110974926A
CN110974926A CN201911418756.7A CN201911418756A CN110974926A CN 110974926 A CN110974926 A CN 110974926A CN 201911418756 A CN201911418756 A CN 201911418756A CN 110974926 A CN110974926 A CN 110974926A
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parts
live pigs
immunity
radix
ethanol
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吴东
于政
谢继奎
葛好林
王勇
徐邦伟
孟冉冉
蒋文强
郝金玲
王玉峰
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Shenya Agriculture And Animal Husbandry Technology Co ltd
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Shenya Agriculture And Animal Husbandry Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

The invention provides a Chinese herbal medicine additive for improving the immunity and blood health of live pigs and a preparation method thereof. The preparation method is simple, scientific and reasonable, and the prepared Chinese herbal medicine additive is rich in organic biological iron source chelate which can be efficiently absorbed by live pigs, so that the immunity and the efficient iron supplement of the live pigs are improved, the immunity and the hematopoietic function of the live pigs are improved, and the generation of autologous red blood cells is promoted; meanwhile, the pig feed can meet the iron requirement of piglets, accelerate the weight gain of piglets, improve the immunity and resistance of organisms, and has no toxic or side effect, thereby realizing ecological breeding.

Description

Chinese herbal medicine additive for improving immunity and blood health of live pigs and preparation method thereof
Technical Field
The invention belongs to the field of antibiotic-free ecological feeding of live pigs, and particularly relates to a Chinese herbal medicine additive for improving immunity and blood health of live pigs and a preparation method thereof.
Background
With the rapid development of the live pig breeding industry, the scale and industrialization degree is continuously improved, the breeding density is increased, the live pig activity space is reduced, and the long-term serious shortage of movement causes the live pig to be in a sub-health state; in addition, mycotoxin, heavy metal and antibiotic abuse exist in the feed frequently, the immunity and hematopoietic function of the live pigs are seriously damaged, anemia and unsmooth blood circulation are caused, qi and blood disharmony is caused, diseases are caused, and therefore the antibiotics are used in large quantities, the antibiotics are seriously remained in the meat, and a large amount of excrement is provided to pollute the environment.
In the pig industry, the existing immunity and blood sub-health of a swinery are the main reasons for poor resistance of the swinery, and at present, the antibiotics are mainly used for supplementing iron by injecting an iron injection; or the piggery is stacked with loam rich in iron, so that piglets can bite iron freely; the sow takes threonine iron supplement instead of iron supplement, and the like, and the iron supplement modes have stimulation effect on the gastrointestinal tract of the pig, have large side effect and low absorption and utilization rate, and the iron deficiency symptoms of the pig still frequently appear. In addition, exogenous iron supplement often has the problems of slow absorption and poor absorption effect. In addition, a large number of farms at the present stage generally adopt the method of injecting iron dextran into the piglets for preventing short-term iron deficiency at the delivery room stage of the piglets, but the iron demand is increased along with the increase of the daily age of the piglets, the iron supplementing effect by injection is not obvious, and a plurality of problems are brought to the operation. These approaches still result in the use of antibiotics in large quantities.
Generally speaking, the ingredients of the feed which do not pass immunity do not provide enough iron, and mainly comprise two types of heme iron and non-heme iron from animals, wherein the heme iron is heme iron, the absorption mechanism of the two types of iron in the intestinal tract of the animals is completely different, and the absorption efficiency of the non-heme iron is lower than that of the heme iron; the porphyrin iron as iron reinforcer can be used for resisting anemia and activating the activity of various heme-containing enzymes in the live pigs. In the prior art, a feed additive which can improve immunity and contains porphyrin iron is urgently needed, and the feed additive can effectively improve the immunity of live pigs, supplement organic iron, improve physique and blood health.
Disclosure of Invention
The invention provides a Chinese herbal medicine additive for improving immunity and blood health of live pigs and a preparation method thereof, which can improve immunity and self hematopoietic function of the live pigs, promote generation of self red blood cells, accelerate weight gain of young pigs and improve immunity and resistance of organisms.
The technical scheme of the invention is realized as follows:
a Chinese herbal medicine additive for improving immunity and blood health of live pigs comprises the following raw materials in percentage by weight:
15-17 parts of astragalus membranaceus, 3-6 parts of radix curcumae, 5-10 parts of angelica sinensis, 11-15 parts of radix rehmanniae preparata, 5-11 parts of scutellaria baicalensis, 11-12 parts of radix paeoniae alba, 13-15 parts of codonopsis pilosula and 1 part of ferric glycinate.
Further, the material comprises the following raw materials in percentage by weight:
15 parts of astragalus, 6 parts of radix curcumae, 10 parts of angelica, 11 parts of prepared rhizome of rehmannia, 11 parts of scutellaria, 11 parts of white peony root, 14 parts of codonopsis pilosula and 1 part of glycine iron.
The invention also provides a preparation method of the Chinese herbal medicine additive for improving the immunity and blood health of live pigs, which comprises the following steps:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, pulverizing respectively, mixing at a certain proportion, or mixing at a certain proportion and pulverizing together;
s2) adding water into the mixture obtained in the step S1) to soak for 30-50 min; the adding amount of water is 5-15 times of the total weight of the astragalus root, the curcuma aromatica, the angelica, the prepared rhizome of rehmannia, the scutellaria baicalensis, the white paeony root and the codonopsis pilosula;
s3), stirring and heating the step S2) under a stirring state, and keeping the boiling state for 30-50 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and then separating to obtain liquid medicine and dregs;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 8-16 h;
s6) centrifuging the solution obtained in the step S5) to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) under the atmospheric pressure of 0.7-1atm and at the temperature of 50-100 ℃ until the supernatant is distilled into paste;
s8) drying and grinding the paste obtained in the step S7) in sequence, adding ferrous glycinate, mixing and crushing to obtain the Chinese herbal medicine additive for improving the immunity and blood health of live pigs.
Further, in step S4), the separation method is screen filtration.
Further, the operation of the residue obtained in the step S4) is repeated 2 to 3 times according to the operation conditions of the steps S2 to S4), and the liquid medicines obtained each time are combined.
Further, before the step S5), the method further comprises the step of performing rotary evaporation on the liquid medicine to 1/2-1/8 of the original volume.
Further, adding ethanol into the precipitate obtained by centrifugation in the step S6) for washing for 2-3 times, and combining the filtrate obtained by washing each time with the supernatant;
the volume concentration of the ethanol is 50-60%, and the adding amount of the ethanol is 2-6 times of the weight of the precipitate.
Further, step S8), the drying treatment is spray drying treatment, the air inlet temperature of the spray dryer is 180-200 ℃, the air outlet temperature is 70-90 ℃, and the drying time is 40-80 min.
Further, step S8), before adding the glycine iron, the method further comprises sieving the ground material with a sieve of 80-160 meshes.
Further, in step S5), the volume concentration of ethanol is 80-90%, and the amount of ethanol added is 1-2 times of the weight of the liquid medicine.
The invention provides a Chinese herbal medicine additive for improving the immunity and blood health of live pigs and a preparation method thereof, and the Chinese herbal medicine additive has the following advantages:
1) the invention adopts a reasonable formula of astragalus, radix curcumae, angelica, prepared rhizome of rehmannia, scutellaria, white paeony root, codonopsis pilosula and ferric glycinate, wherein the radix curcumae has the effects of activating blood and relieving pain, promoting qi circulation and removing depression, clearing away heart-fire and cooling blood, and benefiting gallbladder and removing jaundice; the myrobalan and astragalus membranaceus have various pharmacological effects of resisting oxidation, reducing blood sugar, regulating blood fat, resisting pathogenic microorganisms, resisting inflammation, calming, resisting tumors and the like; radix Codonopsis has tranquilizing, antipyretic, antimicrobial, liver protecting, gallbladder promoting, and blood pressure lowering effects; the scutellaria baicalensis clears heat and purges fire to cool blood and stop bleeding, can be used for treating hematemesis, epistaxis and other bleeding syndromes caused by exuberance of fire toxin and blood forcing and bleeding, and has the pharmacological effects of relieving fever, resisting inflammation, bacteria, viruses and tumors, removing free radicals, regulating immunity, treating ischemic reperfusion injury and the like; radix Paeoniae alba has effects of replenishing blood, resisting pathogenic microorganism, resisting cancer, relieving fever and inflammation, promoting bile flow, promoting blood circulation, and stopping bleeding. The Chinese herbal medicine additive prepared from the raw materials can promote the growth and development of live pigs and improve the immunity and blood health of the live pigs.
2) The preparation method is simple, scientific and reasonable, and the prepared Chinese herbal medicine additive is rich in organic biological iron source chelate which can be efficiently absorbed by live pigs, so that the immunity and the efficient iron supplement of the live pigs are improved, the immunity and the hematopoietic function of the live pigs are improved, and the generation of autologous red blood cells is promoted; meanwhile, the pig feed can meet the iron requirement of piglets, accelerate the weight gain of piglets, improve the immunity and resistance of organisms, and has no toxic or side effect, thereby realizing ecological breeding.
Detailed Description
The invention provides a Chinese herbal medicine additive for improving immunity and blood health of live pigs, which comprises the following raw materials in percentage by weight:
15-17 parts of astragalus membranaceus, 3-6 parts of radix curcumae, 5-10 parts of angelica sinensis, 11-15 parts of radix rehmanniae preparata, 5-11 parts of scutellaria baicalensis, 11-12 parts of radix paeoniae alba, 13-15 parts of codonopsis pilosula and 1 part of ferric glycinate.
The invention adopts a reasonable formula of astragalus, radix curcumae, angelica, prepared rhizome of rehmannia, scutellaria, white paeony root, codonopsis pilosula and ferric glycinate, and can promote the growth and development of live pigs and improve the immunity and blood health of the live pigs.
Radix astragali has various pharmacological effects of resisting oxidation, lowering blood sugar, regulating blood lipid, resisting pathogenic microorganism, resisting inflammation, tranquilizing, and resisting tumor. In the embodiment of the invention, the astragalus is 15-17 parts by weight; in a preferred embodiment, the astragalus is 15 parts by weight.
Radix Curcumae has effects of promoting blood circulation, relieving pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and eliminating jaundice. In the embodiment of the invention, the turmeric root-tuber is 3-6 parts by weight; in a preferred embodiment, the parts by weight of turmeric root-tuber are 6 parts.
Radix Angelicae sinensis has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. In the embodiment of the invention, the weight portion of the angelica is 5-10; in a preferred embodiment, the weight portion of the angelica is 10 portions.
Radix rehmanniae Preparata has effects of replenishing blood and nourishing yin. In the embodiment of the invention, the weight portion of the prepared rhizome of rehmannia is 11 to 15 portions; in a preferred embodiment, the weight portion of the prepared rhizome of rehmannia is 11 portions.
The Scutellariae radix has antipyretic, antiinflammatory, antibacterial, antiviral, antitumor, free radical scavenging, immunity regulating, and ischemic reperfusion injury effects. In the embodiment of the invention, the weight part of the scutellaria baicalensis is 5-11 parts; in a preferred embodiment, the weight part of the scutellaria baicalensis is 11 parts.
Radix Paeoniae alba has effects of replenishing blood, resisting pathogenic microorganism, resisting cancer, relieving fever and inflammation, promoting bile flow, promoting blood circulation, and stopping bleeding. In the embodiment of the invention, the white paeony root is 11-12 parts by weight; in a preferred embodiment, the white peony root is 11 parts by weight.
Radix Codonopsis has tranquilizing, antipyretic, antimicrobial, liver protecting, gallbladder promoting, and blood pressure lowering effects. In the embodiment of the invention, the codonopsis pilosula accounts for 13-15 parts by weight; in a preferred embodiment, the weight portion of the codonopsis pilosula is 14 portions.
In the examples of the present invention, the weight part of glycine iron was 1 part.
The invention also provides a preparation method of the Chinese herbal medicine additive for improving the immunity and blood health of live pigs, which comprises the following steps:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, pulverizing respectively, mixing at a certain proportion, or mixing at a certain proportion and pulverizing together;
s2) adding water into the mixture obtained in the step S1) to soak for 30-50 min; the adding amount of water is 5-15 times of the total weight of the astragalus root, the curcuma aromatica, the angelica, the prepared rhizome of rehmannia, the scutellaria baicalensis, the white paeony root and the codonopsis pilosula;
s3), stirring and heating the step S2) under a stirring state, and keeping the boiling state for 30-50 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and then separating to obtain a liquid medicine;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 8-16 h;
s6) centrifuging the solution obtained in the step S5) to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) under the atmospheric pressure of 0.7-1atm and at the temperature of 50-100 ℃ until the supernatant is distilled into paste;
s8) drying and grinding the paste obtained in the step S6) in sequence, adding ferrous glycinate, mixing and crushing to obtain the Chinese herbal medicine additive for improving the immunity and blood health of live pigs.
Wherein, the astragalus root, the curcuma aromatica, the angelica, the prepared rhizome of rehmannia, the scutellaria root, the white peony root, the codonopsis pilosula and the ferrous glycinate are all the same as the above, and are not repeated.
The preparation method is simple, scientific and reasonable, and the prepared Chinese herbal medicine additive is rich in organic biological iron source chelate which can be efficiently absorbed by live pigs, so that the immunity and the efficient iron supplement of the live pigs are improved, the immunity and the hematopoietic function of the live pigs are improved, and the generation of autologous red blood cells is promoted; meanwhile, the pig feed can meet the iron requirement of piglets, accelerate the weight gain of piglets, improve the immunity and resistance of organisms, and has no toxic or side effect, thereby realizing ecological breeding.
In the invention, astragalus, radix curcumae, angelica, prepared rhizome of rehmannia, scutellaria, white paeony root and codonopsis pilosula are respectively crushed after being cleaned and dried in the sun, and are mixed in proportion, or are crushed together after being mixed in proportion; wherein, the crushing mode can be chopping or crushing in a crusher.
Soaking the pulverized mixture in water for 30-50 min; wherein the amount of water added is 5-15 times of the total weight of radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, Scutellariae radix, radix Paeoniae alba, and radix Codonopsis; in the embodiment of the invention, the adding amount of the water is 10 times of the total weight of the astragalus, the curcuma aromatica, the angelica, the prepared rhizome of rehmannia, the scutellaria baicalensis, the white paeony root and the codonopsis pilosula. It should be noted that the water may be purified water or ordinary tap water.
Stirring the soaked mixture, heating under stirring, and boiling for 30-50 min.
Cooling the feed liquid to room temperature, and separating to obtain medicinal liquid. Wherein the separation mode is filter screen filtration. Repeating the above steps for 2-3 times according to the operation conditions of steps S2-S4, and mixing the obtained medicinal liquids.
Adding ethanol into the medicinal liquid, mixing, and standing for 8-16 hr; wherein the volume concentration of ethanol is 80-90%, and the addition amount of ethanol is 1-2 times of the weight of the medicinal liquid. Wherein the method comprises rotary evaporating the medicinal liquid to 1/2-1/8 of original volume before adding ethanol. Before the ethanol with the volume concentration of 80-90% is added, the liquid medicine is evaporated and concentrated, so that the adding amount of the ethanol with the volume concentration of 80-90% can be effectively reduced, and the waste of the ethanol is avoided.
It should be noted that after the liquid medicine is subjected to rotary evaporation to 1/2-1/8 of the original volume, the amount of the added ethanol is 1-2 times of the weight of the liquid medicine after evaporation.
Centrifuging the solution to obtain supernatant, adding ethanol into the obtained precipitate, washing for 2-3 times, and mixing the filtrate obtained by each washing with the supernatant; wherein, the volume concentration of the ethanol is 50-60%, and the adding amount of the ethanol is 2-6 times of the weight of the precipitate; the centrifugal rotating speed is 12000 r/min-20000 r/min.
The volume concentration of ethanol is 80-90%, and the volume concentration of ethanol is 50-60%, which refers to the volume concentration formed by ethanol and water, wherein the volume concentration of ethanol is 80%, and the volume concentration of ethanol is 80% refers to 80 parts by volume of ethanol and 20 parts by volume of water.
Heating the supernatant at 50-100 deg.C under 0.7-1atm until the supernatant is distilled into paste.
And drying and grinding the paste in sequence, adding ferric glycinate, mixing and crushing to obtain the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs. In the embodiment of the invention, the drying treatment is spray drying treatment, the air inlet temperature of a spray dryer is 180-200 ℃, the air outlet temperature is 70-90 ℃, and the drying time is 40-80 min. Wherein, before adding the glycine iron, the grinding material is sieved by a sieve of 80-160 meshes.
It is to be noted that ethanol, astragalus, radix curcumae, angelica, prepared rhizome of rehmannia, 11 parts of scutellaria baicalensis, white paeony root, codonopsis pilosula and ferric glycinate in the invention are all common raw materials sold in the market and have no special requirements. The skilled person can use the relevant raw materials according to his own experience, which is not described in detail below.
For further illustration of the present invention, the following examples are provided to describe the Chinese herbal medicine additive for enhancing immunity and blood health of live pigs and the preparation method thereof in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
The Chinese herbal medicine additive for improving the immunity and blood health of the live pigs comprises the following raw materials in percentage by weight:
16 parts of astragalus, 3 parts of radix curcumae, 5 parts of angelica, 15 parts of prepared rhizome of rehmannia, 5 parts of scutellaria, 12 parts of white peony root, 13 parts of codonopsis pilosula and 1 part of ferric glycinate.
Example 2
The Chinese herbal medicine additive for improving the immunity and blood health of the live pigs comprises the following raw materials in percentage by weight:
17 parts of astragalus, 5 parts of radix curcumae, 7 parts of angelica, 12 parts of prepared rhizome of rehmannia, 8 parts of scutellaria, 11.5 parts of white peony root, 15 parts of codonopsis pilosula and 1 part of ferric glycinate.
Example 3
The Chinese herbal medicine additive for improving the immunity and blood health of the live pigs comprises the following raw materials in percentage by weight:
15 parts of astragalus, 6 parts of radix curcumae, 10 parts of angelica, 11 parts of prepared rhizome of rehmannia, 11 parts of scutellaria, 11 parts of white peony root, 14 parts of codonopsis pilosula and 1 part of glycine iron.
Example 4
The Chinese herbal medicine additive raw material formula for improving the immunity and blood health of the live pigs, which is provided by the embodiment 3, is used for preparing the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs, and comprises the following steps:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, and pulverizing respectively;
s2) adding water into the mixture obtained in the step S1) and soaking for 30 min; the adding amount of the water is 5 times of the total weight of the astragalus, the curcuma, the angelica, the prepared rhizome of rehmannia, the scutellaria, the white paeony root and the codonopsis pilosula;
s3), stirring and heating the step S2) under a stirring state, and keeping the boiling state for 30 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and filtering and separating the feed liquid by using a filter screen to obtain liquid medicine and dregs;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 8 h; the volume concentration of the ethanol is 80 percent, and the adding amount of the ethanol is 1 time of the weight of the liquid medicine;
s6) centrifuging the solution obtained in the step S5) at the centrifugal rotating speed of 12000r/min to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) at the atmospheric pressure of 0.7atm and the temperature of 50 ℃ until the supernatant is distilled into paste;
s8) putting the paste obtained in the step S6) into a spray dryer for drying, wherein the air inlet temperature of the spray dryer is 180 ℃, the air outlet temperature of the spray dryer is 70 ℃, and the drying time is 40 min; grinding, sieving with 80 mesh sieve, adding ferric glycinate, mixing, and pulverizing to obtain Chinese herbal medicine additive for improving immunity and blood health of live pig;
example 5
The Chinese herbal medicine additive raw material formula for improving the immunity and blood health of the live pigs, which is provided by the embodiment 3, is used for preparing the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs, and comprises the following steps:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, mixing at a certain proportion, and pulverizing;
s2) adding water into the mixture obtained in the step S1) and soaking for 40 min; the adding amount of the water is 10 times of the total weight of the astragalus, the curcuma, the angelica, the prepared rhizome of rehmannia, the scutellaria, the white paeony root and the codonopsis pilosula;
s3) stirring and heating the step S2) in a stirring state, and keeping the boiling state for 40 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and filtering and separating the feed liquid by using a filter screen to obtain liquid medicine and dregs;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 12 h; the volume concentration of the ethanol is 90 percent, and the adding amount of the ethanol is 1.5 times of the weight of the liquid medicine;
s6) centrifuging the solution obtained in the step S5) at the centrifugal speed of 16000r/min to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) at the atmospheric pressure of 0.8atm and the temperature of 70 ℃ until the supernatant is distilled into paste;
s8) putting the paste obtained in the step S6) into a spray dryer for drying, wherein the air inlet temperature of the spray dryer is 190 ℃, the air outlet temperature of the spray dryer is 80 ℃, and the drying time is 60 min; and grinding, sieving with a 120-mesh sieve, adding ferric glycinate, mixing, and pulverizing to obtain the Chinese herbal medicine additive for improving immunity and blood health of live pigs.
Example 6
The Chinese herbal medicine additive raw material formula for improving the immunity and blood health of the live pigs, which is provided by the embodiment 3, is used for preparing the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs, and comprises the following steps:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, mixing at a certain proportion, and pulverizing;
s2) adding water into the mixture obtained in the step S1) and soaking for 50 min; the adding amount of the water is 15 times of the total weight of the astragalus, the curcuma, the angelica, the prepared rhizome of rehmannia, the scutellaria, the white paeony root and the codonopsis pilosula;
s3), stirring and heating the step S2) under a stirring state, and keeping the boiling state for 50 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and filtering and separating the feed liquid by using a filter screen to obtain liquid medicine and dregs;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 16 h; the volume concentration of the ethanol is 90 percent, and the adding amount of the ethanol is 2 times of the weight of the liquid medicine;
s6) centrifuging the solution obtained in the step S5) at the centrifugal speed of 20000r/min to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) under the atmospheric pressure of 1atm and at the temperature of 100 ℃ until the supernatant is distilled into paste;
s8) putting the paste obtained in the step S6) into a spray dryer for drying, wherein the air inlet temperature of the spray dryer is 200 ℃, the air outlet temperature of the spray dryer is 90 ℃, and the drying time is 80 min; and grinding, sieving with a 160-mesh sieve, adding ferric glycinate, mixing, and pulverizing to obtain the Chinese herbal medicine additive for improving immunity and blood health of live pigs.
Example 7
The following steps are added on the basis of the embodiment 5:
step S4), filtering and separating by a filter screen to obtain liquid medicine and dregs, repeating the operation of the dregs for 2 times according to the operation conditions of the steps S2-S4, and merging the liquid medicine obtained each time;
the method specifically comprises the following steps:
soaking the residue in water for 40 min; the adding amount of the water is 10 times of the total weight of the astragalus, the curcuma, the angelica, the prepared rhizome of rehmannia, the scutellaria, the white paeony root and the codonopsis pilosula; stirring, heating under stirring, and boiling for 40 min; cooling to room temperature, and filtering with a filter screen to obtain medicinal liquid and medicinal residue; the residue was repeated 2 times according to this procedure.
Example 8
The following steps are added on the basis of the embodiment 6:
step S4), filtering and separating with a filter screen to obtain liquid medicine and dregs, repeating the operation of the dregs for 3 times according to the operation conditions of the steps S2-S4, and combining the liquid medicines obtained each time;
the method specifically comprises the following steps:
soaking the residue in water for 50 min; the adding amount of the water is 15 times of the total weight of the astragalus, the curcuma, the angelica, the prepared rhizome of rehmannia, the scutellaria, the white paeony root and the codonopsis pilosula; stirring, heating under stirring, and boiling for 50 min; cooling to room temperature, and filtering with a filter screen to obtain medicinal liquid and medicinal residue; the residue was repeated 3 times according to this procedure.
Example 9
The following steps are added on the basis of the embodiment 7:
step S5), before adding ethanol, the method also comprises the steps of carrying out rotary evaporation on the combined liquid medicine until the evaporated liquid medicine becomes 1/2 of the original volume, and then adding ethanol; the dosage of the ethanol is 2 times of the weight of the liquid medicine after evaporation and concentration.
Example 10
The following steps are added on the basis of the embodiment 8:
step S5), before adding ethanol, the method also comprises the steps of carrying out rotary evaporation on the combined liquid medicine until the evaporated liquid medicine becomes 1/5 of the original volume, and then adding ethanol; the dosage of the ethanol is 2 times of the weight of the liquid medicine after evaporation and concentration.
Example 11
The following steps are added on the basis of the embodiment 8:
step S5), before adding ethanol, the method also comprises the steps of carrying out rotary evaporation on the combined liquid medicine until the evaporated liquid medicine becomes 1/8 of the original volume, and then adding ethanol; the dosage of the ethanol is 2 times of the weight of the liquid medicine after evaporation and concentration.
Example 12
The following steps are added on the basis of the example 9:
step S6), centrifuging to obtain supernatant and precipitate, adding ethanol into the precipitate, wherein the volume concentration of the ethanol is 50%, and the adding amount of the ethanol is 2 times of the weight of the precipitate, and centrifuging again to obtain supernatant and precipitate;
the precipitate was washed 3 times with ethanol and the supernatants were combined.
Example 13
The following steps are added on the basis of the embodiment 10:
step S6), centrifuging to obtain supernatant and precipitate, adding ethanol into the precipitate, wherein the volume concentration of the ethanol is 60%, and the adding amount of the ethanol is 6 times of the weight of the precipitate, and centrifuging again to obtain supernatant and precipitate;
washing the precipitate with ethanol for 2 times, and mixing the supernatants.
Example 14
The following steps are added on the basis of the embodiment 11:
step S6), centrifuging to obtain supernatant and precipitate, adding ethanol into the precipitate, wherein the volume concentration of the ethanol is 55%, and the adding amount of the ethanol is 4 times of the weight of the precipitate, and centrifuging again to obtain supernatant and precipitate;
the precipitate was washed 3 times with ethanol and the supernatants were combined.
The piglets after 28 days of weaning are taken as test objects, the number of the piglets is 140, the piglets are randomly divided into two groups, namely a test group and a control group, each group comprises 70 piglets, the control group is fed with basic ration, the test group is added with the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs, which is prepared in the embodiment 14, and the dosage of the Chinese herbal medicine additive for improving the immunity and blood health of the live pigs in each ton of the basic ration is 2 kg; two groups were fed continuously for 30 days.
Measurement indexes are as follows: comparing the physiological indexes of the piglet blood such as the number of red blood cells, the number of white blood cells, the hematocrit and the hemoglobin content in 7 days and 14 days of feeding, and obtaining the results shown in the following table 1; and the average daily gain, feed conversion ratio, IgA, IgG, IgM, interleukin-2, interleukin-6 and interferon values of the test group and the control group were measured, and the results are shown in Table 2.
TABLE 1 comparison of blood physiological indices of two groups of piglets
Figure BDA0002351832750000111
Figure BDA0002351832750000112
TABLE 2 test results of the test group and the control group
Item Test group Control group
Average daily gain (g/d) 445±30.00 347±21.20
Meat ratio of materials 1.91:1 2.10:1
IgA(g/L) 0.41±0.02 0.36±0.02
IgG(g/L) 4.55±0.26 3.75±0.14
IgM(g/L) 0.56±0.03 0.47±0.03
Interleukin-2 (ng/L) 85.75±28.75 63.98±7.02
Interleukin-6 (ng/L) 29.02±2.51 27.80±2.05
Interferon (ng/L) 85.33±31.00 44.67±13.01
As can be seen from tables 1 and 2, the invention can improve the immunity and the hematopoietic function of piglets, promote the generation of autologous red blood cells, accelerate the weight increment of piglets and improve the immunity and the resistance of organisms.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in the embodiments without departing from the principles and spirit of the invention, and these embodiments are within the scope of the invention.

Claims (10)

1. A Chinese herbal medicine additive for improving immunity and blood health of live pigs is characterized by comprising the following raw materials in percentage by weight:
15-17 parts of astragalus membranaceus, 3-6 parts of radix curcumae, 5-10 parts of angelica sinensis, 11-15 parts of radix rehmanniae preparata, 5-11 parts of scutellaria baicalensis, 11-12 parts of radix paeoniae alba, 13-15 parts of codonopsis pilosula and 1 part of ferric glycinate.
2. The Chinese herbal medicine additive for improving immunity and blood health of live pigs according to claim 1 is characterized by comprising the following raw materials in percentage by weight:
15 parts of astragalus, 6 parts of radix curcumae, 10 parts of angelica, 11 parts of prepared rhizome of rehmannia, 11 parts of scutellaria, 11 parts of white peony root, 14 parts of codonopsis pilosula and 1 part of glycine iron.
3. A method for preparing the herbal additive for enhancing immunity and blood health of live pigs according to claim 1 or 2, comprising the steps of:
s1) cleaning radix astragali, radix Curcumae, radix Angelicae sinensis, radix rehmanniae Preparata, radix Scutellariae, radix Paeoniae alba, and radix Codonopsis, sun drying, pulverizing respectively, mixing at a certain proportion, or mixing at a certain proportion and pulverizing together;
s2) adding water into the mixture obtained in the step S1) to soak for 30-50 min; the adding amount of water is 5-15 times of the total weight of the astragalus root, the curcuma aromatica, the angelica, the prepared rhizome of rehmannia, the scutellaria baicalensis, the white paeony root and the codonopsis pilosula;
s3), stirring and heating the step S2) under a stirring state, and keeping the boiling state for 30-50 min;
s4) cooling the feed liquid obtained in the step S3) to room temperature, and then separating to obtain liquid medicine and dregs;
s5) adding ethanol into the liquid medicine obtained in the step S4), fully mixing, and standing for 8-16 h;
s6) centrifuging the solution obtained in the step S5) to obtain a supernatant;
s7) heating the supernatant obtained in the step S6) under the atmospheric pressure of 0.7-1atm and at the temperature of 50-100 ℃ until the supernatant is distilled into paste;
s8) drying and grinding the paste obtained in the step S7) in sequence, adding ferrous glycinate, mixing and crushing to obtain the Chinese herbal medicine additive for improving the immunity and blood health of live pigs.
4. The method for preparing the herbal additive for improving immunity and blood health of live pigs according to claim 3, wherein in the step S4), the separation mode is filter screen filtration.
5. The method for preparing the herbal medicine additive for improving immunity and blood health of live pigs according to claim 3, wherein the herb residues obtained in the step S4) are repeatedly operated for 2-3 times according to the operation conditions of the steps S2-S4), and the herb solutions obtained each time are combined.
6. The method for preparing the herbal additive for enhancing immunity and blood health of live pigs according to any one of claims 3-5, wherein step S5) is preceded by rotary evaporation of the liquid medicine to 1/2-1/8 of the original volume.
7. The method for preparing the herbal additive for enhancing immunity and blood health of live pigs according to any one of claims 3-5, wherein the precipitate obtained by centrifugation in step S6) is washed with ethanol 2-3 times, and the filtrate obtained by each washing is combined with the supernatant;
the volume concentration of the ethanol is 50-60%, and the adding amount of the ethanol is 2-6 times of the weight of the precipitate.
8. The method for preparing the Chinese herbal medicine additive for improving the immunity and the blood health of the live pigs according to any one of claims 3 to 5, wherein the drying treatment in the step S8) is spray drying treatment, the air inlet temperature of a spray dryer is 180-200 ℃, the air outlet temperature is 70-90 ℃, and the drying time is 40-80 min.
9. The method for preparing herbal supplement for enhancing immunity and blood health of live pigs according to any of claims 3-5, wherein step S8), before adding glycine iron, further comprises sieving the ground material with 80-160 mesh sieve.
10. The method for preparing the herbal medicine additive for improving immunity and blood health of live pigs according to any one of claims 3 to 5, wherein in the step S5), the volume concentration of ethanol is 80 to 90%, and the adding amount of ethanol is 1 to 2 times of the weight of the liquid medicine.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114343057A (en) * 2022-01-11 2022-04-15 山东迅达康兽药有限公司 Feed additive for enriching blood and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114343057A (en) * 2022-01-11 2022-04-15 山东迅达康兽药有限公司 Feed additive for enriching blood and preparation method thereof
CN114343057B (en) * 2022-01-11 2023-08-29 山东迅达康兽药有限公司 Feed additive for enriching blood and preparation method thereof

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