CN110960502A

CN110960502A - Substance for treating metabolic syndrome and application thereof

Info

Publication number: CN110960502A
Application number: CN201811134717.XA
Authority: CN
Inventors: 朱义鑫; 王蕊; 王云祥; 杨卫美; 陈芳琼; 王云
Original assignee: Xishuangbanna Hua Kun Biotechnology Co ltd
Current assignee: Xishuangbanna Hua Kun Biotechnology Co ltd
Priority date: 2018-09-28
Filing date: 2018-09-28
Publication date: 2020-04-07

Abstract

The invention discloses a substance for treating metabolic syndrome and application thereof. The substance is inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule, can be applied to medicine, health food, and can be used for treating and recovering metabolic syndrome patients. The metabolic syndrome patients can obtain good treatment and rehabilitation effects by directly taking or eating the medicine, health food and food added with the substance every day.

Description

Substance for treating metabolic syndrome and application thereof

Technical Field

The invention belongs to the field of biological medicines, and particularly relates to a substance (inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule) for treating metabolic syndrome and application thereof.

Background

The metabolic syndrome refers to a pathological state of metabolic disorder of substances such as protein, fat, carbohydrate and the like in a human body, is a complex metabolic disorder syndrome, and is a risk factor for causing diabetic cardiovascular and cerebrovascular diseases. Metabolic syndrome is a collection of various metabolic disorders including obesity, hyperglycemia, hypertension, dyslipidemia, high blood viscosity, hyperuricemia, high fatty liver incidence, and hyperinsulinemia; it can cause an increase in a number of diseases such as hypertension, coronary heart disease, stroke, and even certain cancers including sex hormone-related breast, endometrial, and prostate cancers, as well as pancreatic, liver and gall bladder, and colon cancers of the digestive system.

The metabolic syndrome seriously harms the health of people, but at present, no good solution exists in medicine. The existing medicines and treatment methods are basically limited to the stages of symptomatic treatment by special medicines aiming at different symptoms, such as blood pressure lowering medicines, blood sugar lowering medicines, blood fat lowering medicines and the like, and medicines and methods for integrally and comprehensively treating metabolic syndrome are lacked.

Disclosure of Invention

The invention aims to provide a substance (inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule) for treating and recovering metabolic syndrome patients, which is not available in the prior art, and an application thereof in pharmacy. The substance is inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule, can be directly eaten or applied to medicines, health foods and foods, and is used for treating and recovering metabolic syndrome patients. The metabolic syndrome patients can obtain good treatment and rehabilitation effects by directly taking or eating the medicine, health food and food added with the substance every day.

In order to achieve the above purpose of the present invention, the present invention provides the following technical solutions:

the main components are rubber tree seed oil and inulin or fructo-oligosaccharide; and embedding the rubber tree seed oil into a microcapsule form by adopting a micro-embedding technology and taking inulin or fructo-oligosaccharide as a wall material. The preparation method is technically characterized by comprising the following steps:

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (10-70% of dry weight of material); (2) wall material: inulin or fructo-oligosaccharide (type 75 syrup or 95% content powder) accounts for 20-85% of dry weight of the material; skimmed milk powder (0.03-0.08%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 5-10% of dry weight, mono-or di-glycerin fatty acid ester, sodium stearyl lactate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of mixing → emulsification → homogenization → spray drying → finished powder.

The invention also provides a pharmaceutical composition containing the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule with a therapeutically effective amount and a pharmaceutically acceptable carrier.

And the health food consists of the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule and a common carrier of the health food.

And food, which consists of the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule and a common food carrier.

The invention also provides application of the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule in preparing a medicament for treating or recovering metabolic syndrome.

Use as described, wherein inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules are used as the sole active ingredient.

The invention also provides application of the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule in preparing health-care food for treating or recovering metabolic syndrome.

And the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule is applied to preparing the food for rehabilitating metabolic syndrome.

According to the experimental data of the animal model of the metabolic syndrome and other experimental data, compared with the existing medicine for treating and recovering a specific disease of a patient with the metabolic syndrome, the medicine has the following advantages that:

1. provides a brand new substance for the treatment and rehabilitation of patients with metabolic syndrome;

2. has no side effect, and can be used for long term for patients with metabolic syndrome.

Detailed Description

The following examples are provided to further illustrate the essence of the present invention, but are not intended to limit the present invention.

Example 1

A substance for treating and recovering metabolic syndrome patients is characterized in that the main components are rubber tree seed oil and inulin or fructo-oligosaccharide; and embedding the rubber tree seed oil into a microcapsule form by adopting a micro-embedding technology and taking inulin or fructo-oligosaccharide as a wall material. The preparation method is technically characterized by comprising the following steps: the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (70% of dry weight material); (2) wall material: inulin (95% content powder) accounted for 25% of dry weight of the material; skimmed milk powder (0.05%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 5 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

the 50 successfully molded rats are randomly divided into 5 groups, namely a model group, a high, medium and low formula group (wherein the high, medium and low are calculated by the addition amount of rubber tree seed oil) of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules and a rosiglitazone group. Each group of rats was gavaged at 9:00 am every day, and the model group and the normal group were gavaged with double distilled water; intragastrically administering rosiglitazone 3mg/kg rosiglitazone hydrochloride suspension (preparation of rosiglitazone hydrochloride suspension, taking 3 and 4 mg/tablet of rosiglitazone hydrochloride, grinding into powder, dissolving in 12ml double distilled water, diluting to 1mg/ml, and using at present); the upper, middle and lower 3 formula groups of the invention are gavaged with 500mg/kg mixed solution every day (mixed solution preparation: 25g (10 g per bag) of the finished powder prepared in the embodiment is weighed and dissolved in 500ml of double distilled water to be diluted to 50mg/ml, and the mixed solution is used as it is). Rats were weighed 1 time per week, blood specimens and animal tissues were collected 8 weeks after intervention, and the corresponding index measurements were performed. The results are as follows:

1. general conditions given to groups of rats before and after

During the whole feeding process, rats in all groups do not die, and rats in normal groups have good state, normal activity, normal diet, sensitive reaction, glossy fur, plump muscles, long granular excrement and normal urine volume. During the 8-week drug intervention period, along with the treatment time, compared with the model group, the symptoms of polydipsia and diuresis of rats in each group are relieved, the activity, the hair color and the like are improved, the padding replacement frequency is reduced, and the symptoms of the rats in the rosiglitazone group are improved more remarkably;

2. comparison of fasting plasma glucose (FBG) levels in rats of various groups

No difference in FBG between the pre-administration model group and each treatment group: (P>0.05), but all are obviously increased compared with the normal group (P<0.05); after 4 weeks of administration, the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule high or low 3 formula groups and rosiglitazone FBG were all reduced compared with the model group, but the difference was not statistically significant (P>0.05) and the FBG in each treatment group model group is reduced after 6 weeks of administration (P<0.05), week 8, the FBG reduction of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule high dose formula group and rosiglitazone group was very significant compared to the model group (P<0.01), but the comparison between the two is not statistically significant (P>0.05）；

3. Comparison of fasting serum insulin (FINS) and insulin resistance Steady State model assessment (HOMA-IR) in rats of various groups

After 8 weeks of drug intervention, the rats in each treatment group had a reduction in FINS and HOMA-IR (P) compared to the model group<0.05), the dosage formula group and the rosiglitazone group in the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule have obvious effects (P<0.01) but the difference is not statisticalMeans (P>0.05）；

4. Change in Systolic Blood Pressure (SBP) in rats of each group

The difference of SBP between the pre-administration model and each treatment group has no statistical significance, but is obviously increased (P) compared with the normal group<0.05). After 6 weeks of administration, SBP of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule low dose formulation group was reduced compared to model group, and the difference was statistically significant (P)<0.05). After 8 weeks of administration, SBP was decreased in each treatment group compared with the model group (P)<0.05), significant in the 3:1 formulation group (P<0.01). Inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule low dose formula group has statistical significance compared with rosiglitazone group (P<0.05）；

5. Change in diastolic pressure (DBP) in rats in each group

The difference between DBP in the pre-administration model and each treatment group has no statistical significance, but is obviously increased compared with the normal group (P<0.05). After 8 weeks of administration, the DBP in each treatment group was decreased compared to that before administration, but the difference was not statistically significant (1)P>0.05）；

6. Comparison of lipid metabolism levels in rats of each group

After 8 weeks of treatment, inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule high dose formula group showed statistically significant reductions in TG, TC and LDL-C, increases in HDL-C and differences compared to the model group (1P<0.05); the differences in TC for the inulin-or fructooligosaccharide-encapsulated hevea brasiliensis seed oil microcapsule high dose formulation group compared to the rosiglitazone group are statistically significant ((P<0.05）。

Example 2

A substance for treating and recovering metabolic syndrome patients is characterized in that the main components are rubber tree seed oil and inulin or fructo-oligosaccharide; and embedding the rubber tree seed oil into a microcapsule form by adopting a micro-embedding technology and taking inulin or fructo-oligosaccharide as a wall material. The preparation method is technically characterized by comprising the following steps:

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (70% of dry weight material); (2) wall material: inulin (95% content powder) accounted for 25% of dry weight of the material; skimmed milk powder (0.05%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 5 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

mr. chen, 36 years old, ancestral nationality Shaanxi Ankang, works in all the adults, weighs 70 kilograms when young people enter, moves less after the people retreat, and needs more work to compensate, the weight reaches 95 kilograms, the body weight index is 31.3, mr. chen is found to be high before 2 years, 1 month in 2018 goes to a hospital for physical examination, triglyceride is 12.42mmol/L, the normal upper limit of triglyceride is 1.7mmol/L, the index of mr. chen is 7.3 times of the normal upper limit, and the index is very dangerous blood fat level;

by introduction of friends, mr. chen knows that the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule prepared in the embodiment is eaten after physical examination in 1 month, 15g (warm boiled water is taken) each time, twice a day, and 2 months continuously, namely 3 months in this year, mr. chen also goes to the same hospital for physical examination, triglyceride is reduced to 3.93mmol/L from 12.42mmol/L, foot is reduced by 70%, and is reduced to one third of original value, although the number is higher, the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule is no longer a terrorist number.

Example 3

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (60% of dry weight material); (2) wall material: inulin (95% content powder) accounted for 30% of the dry weight of the material; skimmed milk powder (0.05%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 10 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

mr. Shen, living in Yunnan Red river, age 46, has familial diabetes, high blood sugar, and high blood sugar value in 8 months physical examination in 2017, and is not qualified in various indexes; physical examination report of 8 months in 2017: fructosamine: 2.75 mmol/L; glycated hemoglobin: 11.6 percent; blood sugar 12.55 mmol/L;

when the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule prepared by the embodiment is continuously eaten for 4 months in the present year, 10g (warm boiled water is taken) is eaten before each meal, three times a day, and the patient goes to a hospital for secondary physical examination in 7 months in the present year, so that diabetes is improved a lot, and blood sugar is obviously reduced; examination report of 7 months in 2018: fructosamine: 1.52 mmol/L; glycated hemoglobin: 9.06 percent; glucose: 7.97 mmol/L.

Example 4

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (50% of dry weight material); (2) wall material: inulin (95% content powder) accounted for 40% of the dry weight of the material; skimmed milk powder (0.05%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 10 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

mr. Wang, living in Yunnan Red river, age 46, not only has familial diabetes, but also has high uric acid. The uric acid value in the physical examination report of 8 months in 2017 is 433 [ mu ] mol/L, the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule prepared in the embodiment is contacted in the next half year in 2017, but the eating is intermittent and not serious at that time, and the index of body 'floating' is not regarded as a new thing, and 15g (warm boiled water) is eaten at home for 2 times a day after 2018. In 2018, 7 months, the patient goes to the hospital again to be checked, the blood sugar is reduced, and the uric acid value is 425 mu mol/L and is reduced to the normal range.

Example 5

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (40% of dry weight material); (2) wall material: inulin (95% content powder) accounted for 50% of the dry weight of the material; skimmed milk powder (0.08%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 10 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

zheng Mr. 80 later, living in Yunnan, and after walking into the early years, the weight continuously rises, the physical quality is gradually improved, the user is often accompanied, the user can not eat or drink the wine, and the person can not be as young as staying late in the morning or late in the evening. Eating outside frequently, the physical condition is worse and worse, and the patient is in physical examination in 2015 with mild fatty liver; 2016, with fatty liver;

in 2018, 1 month, Zheng Mr. determines to change the current situation, and determines to reduce the body fat rate of the patient to eliminate fatty liver. Zheng Xiansheng starts eating the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule prepared by the embodiment 15g (warm boiled water for oral administration) each time, 2 times a day, and the period is kept without interruption. In 2018, in 3 months, the company organizes the workers to check, all indexes of Zheng Mr. are normal, and the fatty liver is not existed. After the physical indexes are good, the immunity is also good, and the cold is rarely caused.

Example 6

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (60% of dry weight material); (2) wall material: fructo-oligosaccharide (type 75 syrup) accounts for 30% of dry weight of the material; skimmed milk powder (0.08%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 10 percent of dry weight of the materials, (mono-glycerol and di-glycerol) fatty acid ester, sodium stearoyl lactylate, sodium hexametaphosphate, natural vitamin E and silicon dioxide. The production process comprises the steps of burdening → emulsification → homogenization → spray drying → finished powder;

mr. Cao, Shanxi, aged 55 years this year, had suffered from hypertension for more than twenty years, examined hyperglycemia and hyperlipidemia in 6 months in 2018, blood glucose value was 7.5mmol/L, blood lipid was 2.47mmol/L, uric acid was out of the normal range, uric acid value was 365.2. mu. mol/L, these let Mr. Cao find their own health problems more and more serious. The hypotensive drugs are taken before physical examination, and some people are not willing to take more drugs after the hyperglycemia and the hyperlipidemia are detected. Listening friends introduce the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule prepared by the embodiment, people can start to taste and eat by themselves, 15g (taking with boiled water) is eaten before each meal, 2 times a day is eaten, and after two months, physical examination is carried out again in 8 months in 2018, so that not only is uric acid reduced, blood sugar reduced to 6.84mmol/L from 7.5mmol/L, blood pressure reduced to 130/103Hg from 160/110Hg before, and blood fat reduced to 1.04mmol/L from 2.47 mmol/L.

Example 7

Inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules of the invention, prepared as in examples 2-6, can be used directly as a powder. The powder can be used as medicine, health food or food.

Example 8

Inulin or fructo-oligosaccharide-embedded hevea brasiliensis seed oil microcapsules of the present invention were prepared as in examples 2-6, and excipients were added in a ratio of 1:1 or 1:2 by weight of the fraction to excipients, and granulated and tabletted. The tablet can be used as medicine, health food or food.

Example 9

The inulin or fructo-oligosaccharide-embedded rubber tree seed oil microcapsules of the present invention were prepared in the same manner as in examples 2 to 6, and according to the portions, they were wrapped in the hard capsule wall material to prepare hard capsules by a conventional hard capsule preparation method. The hard capsule can be used as medicine, health food or food.

Example 10

Inulin or fructo-oligosaccharide embedded hevea brasiliensis seed oil microcapsules of the present invention were prepared as in examples 2-6, and then tableted as follows:

inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule 100mg

Proper amount of starch

Proper amount of corn steep liquor

Proper amount of magnesium stearate

The preparation method comprises the following steps: mixing inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule with adjuvant, sieving, mixing in suitable container, granulating, and tabletting.

Example 11

Inulin or fructo-oligosaccharide embedded hevea brasiliensis seed oil microcapsules of the present invention were prepared as in examples 2-6, and hard capsules were prepared from this fraction as follows:

inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule 1000mg

Appropriate amount of gelatin

Proper amount of glycerin

Proper amount of water

The preparation method comprises the following steps: soaking gelatin and glycerol in distilled water to make gelatin swell and soften, and stirring and mixing to obtain capsule wall material gelatin solution. Taking out the prepared capsule material glue solution, coating the glue solution in a hard capsule grinding tool to ensure that the thickness is uniform, and then heating the glue solution at the temperature of about 90 ℃ to evaporate the surface water to obtain the hard capsule tablet with certain toughness and certain elasticity. Finally, inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules (500 mg) are filled into hard capsule tablets to produce hard capsules.

Example 12

And (3) tablet preparation: inulin or fructo-oligosaccharide-embedded rubber tree seed oil microcapsules of the present invention were prepared in the same manner as in examples 2-6, containing 10mg of inulin or fructo-oligosaccharide, 180mg of lactose, 55mg of starch, and 5mg of magnesium stearate;

the preparation method comprises the following steps: inulin or fructo-oligosaccharide-embedded rubber tree seed oil microcapsules of the invention obtained as described in examples 2 to 6, lactose and starch were mixed, uniformly moistened with water, the moistened mixture was sieved and dried, sieved again, magnesium stearate was added, and the mixture was tabletted to a weight of 250mg per tablet, the content of inulin or fructo-oligosaccharide-embedded rubber tree seed oil microcapsules of the invention being 10 mg.

Example 13

And (3) capsule preparation: 2000g of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule, 1000g of gelatin, 500g of glycerol, 1000g of water according to the present invention were prepared as in examples 2 to 6;

the preparation method comprises the following steps: 1000g of gelatin and 500g of glycerol are put into 1000g of water to be soaked so as to swell and soften the gelatin, and then the gelatin and the glycerol are stirred and mixed uniformly to obtain capsule wall glue solution. Taking out the prepared capsule material glue solution, coating the glue solution in a hard capsule grinding tool to ensure that the thickness is uniform, and then heating the glue solution at the temperature of about 90 ℃ to evaporate the surface water to obtain the hard capsule tablet with certain toughness and certain elasticity. And finally, filling 500mg of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules into hard capsule tablets to produce hard capsules. Each soft capsule weighs 750mg, and the content of the inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsule is 500 mg.

Example 14

Food and health food: inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules of the present invention were prepared as described in examples 2-6 and were taken directly as a powder with hot water.

The preparation method comprises the following steps: 10g of inulin or fructo-oligosaccharide embedded hevea brasiliensis seed oil microcapsules of the present invention prepared as in examples 2-6 were added to 120ml of hot water at a temperature of 40-100 ℃ and melted to obtain a cup of milk-based drink. In the cup milk beverage, the content of inulin or fructo-oligosaccharide embedded rubber tree seed oil microcapsules is 10 g.

The foregoing is a more detailed description of the invention that is presented in conjunction with specific embodiments, and the practice of the invention is not to be considered limited to those descriptions. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.

Claims

1. A substance for treating and recovering metabolic syndrome patients is characterized in that the main components are rubber tree seed oil and inulin or fructo-oligosaccharide; embedding rubber tree seed oil into a microcapsule form by adopting a micro-embedding technology and taking inulin or fructo-oligosaccharide as a wall material; the preparation method is technically characterized by comprising the following steps:

the composition comprises the following components in parts by weight: (1) core material grease: rubber tree seed oil (10-70% of dry weight of material); (2) wall material: inulin or fructo-oligosaccharide (type 75 syrup or 95% content powder) accounts for 20-85% of dry weight of the material; skimmed milk powder (0.03-0.08%); (3) and (3) the rest auxiliary materials: glucose syrup, which accounts for 5-10% of dry weight, mono-or di-glycerin fatty acid ester, sodium stearyl lactate, sodium hexametaphosphate, natural vitamin E and silicon dioxide;

the production process comprises the steps of mixing → emulsification → homogenization → spray drying → finished powder.

2. A pharmaceutical composition comprising a therapeutically effective amount of inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules of claim 1 and a pharmaceutically acceptable carrier.

3. A health food comprising inulin or fructooligosaccharide-embedded rubber tree seed oil microcapsules of claim 1 and a carrier conventionally used in health foods.

4. A food product consisting of inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules of claim 1 and a food product common carrier.

5. Use of inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules according to claim 1 for the preparation of a medicament for the treatment or rehabilitation of metabolic syndrome.

6. Use according to claim 5, wherein inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules are used as the sole active ingredient in a medicament.

7. Use of inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules according to claim 1 for the preparation of a health food for the treatment or rehabilitation of metabolic syndrome.

8. Use according to claim 7, wherein inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules are used as the sole active ingredient.

9. Use of inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules according to claim 1 for the preparation of a foodstuff for rehabilitating metabolic syndrome.

10. The use according to claim 9, wherein inulin or fructooligosaccharide embedded hevea brasiliensis seed oil microcapsules are used as the sole active ingredient.