CN110946930A - Formula for treating qi deficiency type diabetes and preparation method thereof - Google Patents

Formula for treating qi deficiency type diabetes and preparation method thereof Download PDF

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CN110946930A
CN110946930A CN201911052105.0A CN201911052105A CN110946930A CN 110946930 A CN110946930 A CN 110946930A CN 201911052105 A CN201911052105 A CN 201911052105A CN 110946930 A CN110946930 A CN 110946930A
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decoction
ginseng
deficiency type
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温玉波
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Xingren Hospital Of Traditional Chinese Medicine Guizhou Province
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention provides a prescription for treating qi deficiency type diabetes and a preparation method thereof, which comprises 25 to 40 g of astragalus root, 10 to 25 g of ginseng, 15 to 25 g of fried hawthorn, 10 to 30 g of cyclocarya paliurus, 10 to 20 g of yam rhizome, 8 to 15 g of bupleurum root and 8 to 16 g of cimicifuga foetida, and comprises the following raw materials by weight; 30 g of astragalus root, 20 g of ginseng, 25 g of fried hawthorn, 20 g of cyclocarya paliurus, 15 g of yam, 10 g of radix bupleuri and 10 g of rhizoma cimicifugae. The formula for treating qi-deficiency type diabetes and the preparation method thereof provided by the invention are prepared from medicinal materials such as astragalus, ginseng, fried hawthorn, cyclocarya paliurus, climbing entada, radix bupleuri, rhizoma cimicifugae and the like, the materials are easy to obtain, the preparation method is simple, the cost is low, the preparation process is simple and easy to learn, the formula can be directly taken, the utilization rate of the drug effect is improved, the formula can be used for treating the qi-deficiency type diabetes, the cure effect of the diabetes is improved, and the recurrence rate is low.

Description

Formula for treating qi deficiency type diabetes and preparation method thereof
Technical Field
The invention relates to the technical field of diabetes, in particular to a formula for treating qi deficiency type diabetes and a preparation method thereof.
Background
Diabetes is the disease name of traditional Chinese medicine, and refers to a comprehensive disease syndrome with polydipsia, diuresis, polyphagia, emaciation, fatigue and urine sweetness as main characteristics. If the test is performed, the main characteristics are hyperglycemia and urine glucose. The main pathological changes are in the lung, stomach and kidney, and the basic pathogenesis is yin and body fluid consumption and dryness-heat predominance. After long-term diabetes, the disease is out of control, yin deficiency affecting yang, heat burning fluid deficiency and blood stasis, which lead to qi and yin deficiency, yin and yang deficiency, collateral channel stasis, channel malnutrition, qi and blood disorder, viscera organ damage, and both symptoms of furuncle, carbuncle, vertigo, thoracic obstruction, deafness, blindness, limb numbness and pain, lower limb gangrene, renal failure edema, stroke coma and the like.
Diabetes is caused by various reasons, one of which is qi deficiency type, and the treatment effect of the diabetes with qi deficiency type is generally not ideal, the preparation is troublesome, the drug effect is poor, and the cure rate is low.
Therefore, there is a need to provide a new formula for treating qi deficiency type diabetes and a preparation method thereof to solve the above technical problems.
Disclosure of Invention
The invention provides a treatment formula for qi deficiency type diabetes and a preparation method thereof, and aims to improve the effect of treating the qi deficiency type diabetes.
In order to solve the technical problems, the formula for treating qi deficiency type diabetes provided by the invention comprises 25-40 g of astragalus, 10-25 g of ginseng, 15-25 g of fried hawthorn, 10-30 g of cyclocarya paliurus, 10-20 g of climbing entada, 8-15 g of radix bupleuri and 8-16 g of rhizoma cimicifugae.
Preferably, the raw materials comprise the following weight grams; 30 g of astragalus root, 20 g of ginseng, 25 g of fried hawthorn, 20 g of cyclocarya paliurus, 15 g of yam, 10 g of radix bupleuri and 10 g of rhizoma cimicifugae.
A method for preparing a treatment formula for qi-deficiency type diabetes, the treatment formula for qi-deficiency type diabetes according to any one of claims 1-2 comprising the steps of;
s1; the preparation method comprises the steps of obtaining raw materials, respectively preparing astragalus membranaceus, ginseng, fried hawthorn, cyclocarya paliurus, climbing entada, radix bupleuri, rhizoma cimicifugae and water, and preparing the prepared materials according to the weight ratio of 3:2:2.5:2:1.5:1:1 of the astragalus membranaceus, the ginseng, the fried hawthorn, the cyclocarya paliurus, the climbing entada, the radix bupleuri and the rhizoma cimicifugae for later use;
s2; decocting the raw materials of astragalus, ginseng, fried hawthorn, cyclocarya paliurus, climbing dragon, radix bupleuri and cimicifugae foetidae in a weight ratio of 3:2:2.5:2:1.5:1:1, adding water during decoction, and submerging the raw materials by one to two centimeters;
s201; decocting for thirty minutes for the first time to obtain 100 ml of decoction;
s202; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out second decoction for thirty minutes to obtain 100 milliliters of decoction;
s203; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out third decoction for thirty minutes to obtain 100 milliliters of decoction;
s3; mixing the decoction decocted for three times in the step S2;
s4; the decoction is taken three times, 100 ml each time.
Preferably, the decoction is carried out by a decoction device.
Compared with the related technology, the treatment formula for qi deficiency type diabetes and the preparation method thereof provided by the invention have the following beneficial effects:
the invention provides a formula for treating qi-deficiency type diabetes and a preparation method thereof, wherein the formula is prepared from medicinal materials such as astragalus, ginseng, fried hawthorn, cyclocarya paliurus, climbing dragon, radix bupleuri, cimicifugae foetidae and the like, the materials are easy to obtain, the preparation method is simple, the cost is lower, the preparation process is simple and easy to learn, the formula can be directly taken, the utilization rate of the drug effect is improved, the formula can be used for treating the qi-deficiency type diabetes, the cure effect of the diabetes is improved, and the recurrence rate is low.
Drawings
FIG. 1 is a schematic structural diagram of a preferred embodiment of the formula for treating diabetes with qi deficiency and the preparation method thereof according to the present invention;
FIG. 2 is a schematic view of the structure of the decocting chamber shown in FIG. 1;
fig. 3 is an enlarged schematic view of a point a shown in fig. 2.
Reference numbers in the figures: 100 decocting devices, 1, a decocting box, 2, a top cover, 3, a soup box, 4, a decocting pot, 5, a soup pipe, 6, a water tank, 7, a water pipe, 8, a three-way pipe, 9, a connecting piece, 10 and a groove.
Detailed Description
The invention is further described with reference to the following figures and embodiments.
Referring to fig. 1, fig. 2 and fig. 3, fig. 1 is a schematic structural diagram illustrating a preferred embodiment of a formula for treating qi-deficiency type diabetes and a preparation method thereof according to the present invention;
FIG. 2 is a schematic view of the structure of the decocting chamber shown in FIG. 1;
fig. 3 is an enlarged schematic view of a point a shown in fig. 2. The formula for treating qi-deficiency type diabetes is characterized by comprising 25-40 g of astragalus, 10-25 g of ginseng, 15-25 g of fried hawthorn, 10-30 g of cyclocarya paliurus, 10-20 g of yam rhizome, 8-15 g of radix bupleuri and 8-16 g of rhizoma cimicifugae.
Comprises the following raw materials by weight; 30 g of astragalus root, 20 g of ginseng, 25 g of fried hawthorn, 20 g of cyclocarya paliurus, 15 g of yam, 10 g of radix bupleuri and 10 g of rhizoma cimicifugae.
A method for preparing a treatment formulation for qi-deficiency type diabetes, characterized in that the treatment formulation for qi-deficiency type diabetes according to any one of claims 1-2 comprises the steps of;
s1; the preparation method comprises the steps of obtaining raw materials, respectively preparing astragalus membranaceus, ginseng, fried hawthorn, cyclocarya paliurus, climbing entada, radix bupleuri, rhizoma cimicifugae and water, and preparing the prepared materials according to the weight ratio of 3:2:2.5:2:1.5:1:1 of the astragalus membranaceus, the ginseng, the fried hawthorn, the cyclocarya paliurus, the climbing entada, the radix bupleuri and the rhizoma cimicifugae for later use;
s2; decocting the raw materials of astragalus, ginseng, fried hawthorn, cyclocarya paliurus, climbing dragon, radix bupleuri and cimicifugae foetidae in a weight ratio of 3:2:2.5:2:1.5:1:1, adding water during decoction, and submerging the raw materials by one to two centimeters;
s201; decocting for thirty minutes for the first time to obtain 100 ml of decoction;
s202; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out second decoction for thirty minutes to obtain 100 milliliters of decoction;
s203; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out third decoction for thirty minutes to obtain 100 milliliters of decoction;
s3; mixing the decoction decocted for three times in the step S2;
s4; the decoction is taken three times, 100 ml each time.
Wherein the decoction is carried out by using the decocting device 100.
The decocting device 100 comprises a decocting box 1, the upper part of the decocting box 1 is hinged with a top cover 2 for sealing, a soup box 3, a decocting pot 4 and a water tank 6 are respectively arranged in the decocting box 1, the soup box 3 and the water tank 6 are respectively arranged on two sides of the decocting pot 4, the water tank 6 is fixed on the inner side of the decocting box 1, and the bottom of the decocting pot 4 is fixed on the bottom side of the inner part of the decocting box 1 through a heating device.
The heating device is used for providing decoction for the decocting pot 4, is externally connected with a power supply through an electric wire, and is internally provided with a heating element capable of heating.
The inside water pipe 7 that is provided with of water tank 6, water pipe 7 communicate in boiling pan 4 to be provided with the booster pump on the water pipe 7, be used for pressurizeing when carrying out the moisturizing, water tank 6 communicates in external inlet tube, and external inlet tube is for can adding the water source department of carrying out the decocte.
The bottom of the boiling pot 4 is communicated with a medicine soup pipe 5, the medicine soup pipe 5 extends into a groove 10 arranged on the medicine soup box 3, the surface of the medicine soup pipe 5 is provided with external threads, the threads are connected with a connecting piece 9, the connecting piece 9 is communicated with a three-way pipe 8, the three-way pipe 8 is communicated with the medicine soup box 3,
when the medicine decocting pot is used, medicinal materials are placed in the decocting pot 4, then the pressurizing pump is started through the transparent shell which is arranged outside the decocting box 1 and provided with scales, so that the water pipe 7 stores an external water source through the water tank 6 and then sends the external water source into the decocting pot 4 until the water surface is one to two centimeters of the medicinal materials, then the external power supply is started to enable the heating device to be decocted, after the medicinal materials are decocted, medicinal soup is sent into the three-way pipe 8 in threaded connection with the medicinal soup pipe 5 through the pressurizing pump arranged on the medicinal soup pipe 5 and then sent into the medicinal soup box 3, and after the medicine is decocted, the medicinal soup box 3 can be rotated to enable the connecting piece 9 to be separated from the medicinal soup pipe 5;
the soup box 3 can be taken out by the handle arranged on the upper part of the soup box, the handle is connected with the soup box 3 by the soup box cover thread, the soup box cover can be unscrewed when the soup box is taken, the soup box can be taken, and the transparent part and the scale bar are arranged outside the soup box, so that the taking amount can be accurately taken.
The device of decocting medicinal herbs here can be very convenient decoct medicine, and it is very convenient to add water, has the storage department, can not appear the condition that interim lack of water leads to decocting medicinal herbs to fail, and after decocting medicinal herbs, the discharge of medicine soup is very convenient simultaneously, and it is all very convenient that medicine soup is deposited and is taken, need not connect alone at every turn, and subsequent taking is also comparatively good, can not run off.
Selecting a medical record: 100 patients with diabetes were selected for clinical observation, and patients were randomly divided into two groups, 50 treatment groups, wherein 28 men and 22 women were aged 40-75 years, the average age was 53 years, the course of disease was 1-5 years, and the average age was 3.5 years; the disease of 50 control groups, 30 men, 20 women, the age of 40-75 years, the average age of 54 years, 1-6 years of disease and the average age of 3.7 years are basically consistent and comparable, and the diet of two groups is controlled according to the requirements.
The test method comprises the following steps: the patients in the treatment group take the Chinese herbal preparation (prepared according to the formula) for oral administration, one dose of the Chinese herbal preparation is decocted with water for one time a day, 3 times a day, 14 days are a treatment course, the Chinese herbal preparation is continuously taken for 2-6 treatment courses, and the dosage is increased for patients with serious illness; the control group used the diabetes pill, as indicated.
And (3) judging the curative effect: (1) and curing: the symptoms of polydipsia, polyphagia, diuresis and emaciation of the diabetes disappear, and the blood sugar is normal.
(2) And (3) improvement: the symptoms of polydipsia, polyphagia, polyuria and emaciation of the thirst disease disappear or are slightly accurate, and the blood sugar does not fluctuate.
(3) And (3) invalidation: no change in clinical symptoms.
Test results treatment groups: 35 cases are cured, 12 cases are improved, 3 cases are invalid, the cure rate is 70%, and the total effective rate is 94%.
Control group: 32 cases are cured, 10 cases are improved, 8 cases are not effective, the cure rate is 64 percent, and the total effective rate is 84 percent.
The above results show that: the cure rate and the total effective rate of the treatment group are obviously higher than those of the control group.
Typical cases
Case one: in Sunzhi, male, age 51, suffered from diabetes for more than 1 year, orally taken antihypertensive drugs are used, blood sugar is unstable, high time and low time, nearly several days, thirst, polydipsia, emaciation, qi deficiency and no speaking desire, physical fatigue and hypodynamia, spontaneous perspiration, symptoms aggravated after activities, dizziness, pale complexion and 7.9mmol/L of blood sugar, diabetes is diagnosed, 4 courses of taking the traditional Chinese medicine preparation disclosed by the invention are used, symptoms disappear, blood sugar is normal, follow-up visits are carried out, no relapse is caused, and clinical cure is realized.
Case two: plum, female, age 48, suffering from diabetes for more than 2 years, orally taking antihypertensive drugs, unstable blood sugar, high time, low time, thirst, polydipsia, emaciation, qi deficiency, no speaking desire, tiredness, hypodynamia, spontaneous perspiration, aggravation of symptoms after activities, dizziness, pale complexion and 9.9mmol/L blood sugar, diagnosing the diabetes, taking the traditional Chinese medicine preparation of the invention for 4 courses of treatment, disappearance of symptoms, normal blood sugar, follow-up visit, no relapse and clinical cure.
Case three: yellow certain male, 57 years old, suffer from diabetes for more than 3 years, take hypotensor orally, blood sugar is unstable, the time is high, low, nearly several days, thirst, polydipsia, emaciation, qi deficiency and no speaking desire, tiredness and hypodynamia, spontaneous perspiration, symptoms aggravate after activity, dizziness, complexion are whitish, 10.2mmol/L of blood sugar, diagnose diabetes, 3 courses of taking the Chinese medicinal preparation of the invention, the symptoms disappear, the blood sugar is normal, after-visit, no recurrence, clinical cure.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (4)

1. A prescription for treating qi deficiency type diabetes is characterized by comprising 25-40 g of astragalus, 10-25 g of ginseng, 15-25 g of fried hawthorn, 10-30 g of cyclocarya paliurus, 10-20 g of yam rhizome, 8-15 g of radix bupleuri and 8-16 g of rhizoma cimicifugae.
2. The formula for treating qi deficiency type diabetes according to claim 1, comprising the following raw materials by weight; 30 g of astragalus root, 20 g of ginseng, 25 g of fried hawthorn, 20 g of cyclocarya paliurus, 15 g of yam, 10 g of radix bupleuri and 10 g of rhizoma cimicifugae.
3. A method for preparing a treatment formula for qi-deficiency type diabetes, wherein the treatment formula for qi-deficiency type diabetes according to any one of claims 1 to 2 comprises the following steps;
s1; the preparation method comprises the steps of obtaining raw materials, respectively preparing astragalus membranaceus, ginseng, fried hawthorn, cyclocarya paliurus, climbing entada, radix bupleuri, rhizoma cimicifugae and water, and preparing the prepared materials according to the weight ratio of 3:2:2.5:2:1.5:1:1 of the astragalus membranaceus, the ginseng, the fried hawthorn, the cyclocarya paliurus, the climbing entada, the radix bupleuri and the rhizoma cimicifugae for later use;
s2; decocting the raw materials of astragalus, ginseng, fried hawthorn, cyclocarya paliurus, climbing dragon, radix bupleuri and cimicifugae foetidae in a weight ratio of 3:2:2.5:2:1.5:1:1, adding water during decoction, and submerging the raw materials by one to two centimeters;
s201; decocting for thirty minutes for the first time to obtain 100 ml of decoction;
s202; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out second decoction for thirty minutes to obtain 100 milliliters of decoction;
s203; continuously adding water to submerge the medicinal materials for one to two centimeters, and carrying out third decoction for thirty minutes to obtain 100 milliliters of decoction;
s3; mixing the decoction decocted for three times in the step S2;
s4; the decoction is taken three times, 100 ml each time.
4. The method for preparing a formulation for treating diabetes mellitus due to qi deficiency according to claim 3, wherein the decoction is carried out by a decoction device.
CN201911052105.0A 2019-10-31 2019-10-31 Formula for treating qi deficiency type diabetes and preparation method thereof Pending CN110946930A (en)

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Application publication date: 20200403