CN110946786A - Mouthwash with polyaspartic acid active ingredient and preparation method - Google Patents
Mouthwash with polyaspartic acid active ingredient and preparation method Download PDFInfo
- Publication number
- CN110946786A CN110946786A CN201911389147.3A CN201911389147A CN110946786A CN 110946786 A CN110946786 A CN 110946786A CN 201911389147 A CN201911389147 A CN 201911389147A CN 110946786 A CN110946786 A CN 110946786A
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- CN
- China
- Prior art keywords
- polyaspartic acid
- mouthwash
- preparation
- acid sodium
- sodium salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The mouthwash with the polyaspartic acid active ingredient comprises high-molecular-weight polyaspartic acid sodium salt, chlorhexidine gluconate, essence, spice and pure water, and the finished product mouthwash is obtained by a preparation method, so that the advantages of the polyaspartic acid molecule such as moisture retention, surface activity, biological friendliness and the like are fully exerted, the components such as cosolvent, humectant and the like in the mouthwash are replaced, and the formula of the mouthwash is greatly simplified; meanwhile, a large number of carboxylate radicals carried by the polyaspartic acid molecules have good affinity with acid substances generated by decomposing oral food residues and calcium substances in tartar and tartar, and the prepared mouthwash has the effects and characteristics of efficiently removing halitosis, removing tartar, inhibiting generation of tartar and having mild taste.
Description
Technical Field
The invention relates to a formula and a preparation method of mouthwash, in particular to mouthwash containing polyaspartic acid active ingredients and a preparation method of the mouthwash.
Background
Polyaspartic Acid (PASP) is a high molecular polymer formed by condensation polymerization of L-aspartic acid, and experiments show that sodium polyaspartate can be used for reducing the formation of tartar, effectively controlling the development of dental plaque and culturing a bacterial biofilm outside teeth. Meanwhile, the cleaning of stains and artificial pigments on teeth is increased, and the staining of teeth is reduced. However, due to the lack of suitable carriers, there is currently little on the market regarding the use of polyaspartic acid for dental care.
The existing mouthwash formula has the disadvantages of various materials, complex preparation and higher production cost.
Disclosure of Invention
The invention aims to provide a mouthwash formula with a polyaspartic acid active ingredient and a preparation method thereof, wherein the mouthwash formula is loaded with a high-molecular-weight polyaspartic acid sodium salt active ingredient.
The invention relates to a mouthwash with polyaspartic acid active ingredients and a preparation method thereof, wherein the mouthwash comprises high-molecular-weight polyaspartic acid sodium salt, chlorhexidine gluconate, essence, spice and pure water, and the preparation method comprises the following steps:
step 1) purification of aqueous solution of polyaspartic acid sodium: selecting a polyaspartic acid sodium salt aqueous solution with the molecular weight of 10000-30000D and the dispersion coefficient of 2.1-2.5, and carrying out ultrafiltration concentration by an ultrafiltration membrane with the molecular weight of 3500-5000 to obtain a refined polyaspartic acid sodium salt aqueous solution with the concentration of 20-30%;
step 2) taking 5-10 parts of concentrated sodium polyaspartate aqueous solution, adding 0.2-2 parts of chlorhexidine gluconate, and stirring for 1-2 hours at the temperature of 30-40 ℃;
step 3), adding 0.5-2 parts of menthol, and continuously stirring for 2-4 hours;
step 4), cooling to room temperature, adding a proper amount of edible sodium dihydrogen phosphate to adjust the pH value to 6.5-7.5;
and 5) complementing the balance to 100 parts by pure water.
Further, the finished mouthwash comprises: 5 to 10 percent of polyaspartic acid sodium salt, 0.2 to 2 percent of chlorhexidine gluconate, 0.5 to 2 percent of menthol crystal and 86 to 94.3 percent of pure water.
The mouthwash with the polyaspartic acid active ingredient and the preparation method of the mouthwash with the polyaspartic acid active ingredient fully exert the advantages of polyaspartic acid molecules such as moisture retention, surface activity and biological friendliness, and further replace components such as a cosolvent and a humectant in mouthwash, so that the formula of the mouthwash is greatly simplified; meanwhile, a large number of carboxylate radicals carried by the polyaspartic acid molecules have good affinity with acid substances generated by decomposing oral food residues and calcium substances in tartar and tartar, and the prepared mouthwash has the effects and characteristics of efficiently removing halitosis, removing tartar, inhibiting generation of tartar and having mild taste.
Detailed Description
The technical scheme of the invention is as follows:
the invention relates to a mouthwash with polyaspartic acid active ingredients and a preparation method thereof, wherein the mouthwash comprises high-molecular-weight polyaspartic acid sodium salt, chlorhexidine gluconate, essence, spice and pure water, and the preparation method comprises the following steps:
step 1) purification of aqueous solution of polyaspartic acid sodium: selecting a polyaspartic acid sodium salt aqueous solution with the molecular weight of 10000-30000D and the dispersion coefficient of 2.1-2.5, and carrying out ultrafiltration concentration by an ultrafiltration membrane with the molecular weight of 3500-5000 to obtain a refined polyaspartic acid sodium salt aqueous solution with the concentration of 20-30%;
step 2) taking 5-10 parts of concentrated sodium polyaspartate aqueous solution, adding 0.2-2 parts of chlorhexidine gluconate, and stirring for 1-2 hours at the temperature of 30-40 ℃;
step 3), adding 0.5-2 parts of menthol, and continuously stirring for 2-4 hours;
step 4), cooling to room temperature, adding a proper amount of edible sodium dihydrogen phosphate to adjust the pH value to 6.5-7.5;
and 5) complementing the balance to 100 parts by pure water.
Further, the finished mouthwash comprises: 5 to 10 percent of polyaspartic acid sodium salt, 0.2 to 2 percent of chlorhexidine gluconate, 0.5 to 2 percent of menthol crystal and 86 to 94.3 percent of pure water.
The mouthwash composition table is as follows:
| components | Function of | Content (wt.) |
| Polyaspartic acid sodium salt (pure) | Dissolving aid, moisture keeping, scale inhibiting and deodorizing | 5％～10％ |
| Chlorhexidine glucose | Preservative | 0.2％～2％ |
| Menthol crystal | Essence | 0.5％～2％ |
| Sodium dihydrogen phosphate | pH regulator | Proper amount of |
| Pure water | Solvent(s) | Balance of |
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention relates, several simple deductions or substitutions may be made without departing from the spirit of the invention, and all shall be considered as belonging to the scope of the invention.
Claims (2)
1. A mouth wash with polyaspartic acid active ingredients and a preparation method thereof are characterized in that: the mouthwash comprises high molecular weight polyaspartic acid sodium salt, chlorhexidine gluconate, essence and perfume and pure water, and the preparation method comprises the following steps:
step 1) purification of aqueous solution of polyaspartic acid sodium: selecting a polyaspartic acid sodium salt aqueous solution with the molecular weight of 10000-30000D and the dispersion coefficient of 2.1-2.5, and carrying out ultrafiltration concentration by an ultrafiltration membrane with the molecular weight of 3500-5000 to obtain a refined polyaspartic acid sodium salt aqueous solution with the concentration of 20-30%;
step 2) taking 5-10 parts of concentrated sodium polyaspartate aqueous solution, adding 0.2-2 parts of chlorhexidine gluconate, and stirring for 1-2 hours at the temperature of 30-40 ℃;
step 3), adding 0.5-2 parts of menthol, and continuously stirring for 2-4 hours;
step 4), cooling to room temperature, adding a proper amount of edible sodium dihydrogen phosphate to adjust the pH value to 6.5-7.5;
and 5) complementing the balance to 100 parts by pure water.
2. The dental care material and the preparation process according to claim 1, characterized in that: the finished mouthwash comprises: 5 to 10 percent of polyaspartic acid sodium salt, 0.2 to 2 percent of chlorhexidine gluconate, 0.5 to 2 percent of menthol crystal and 86 to 94.3 percent of pure water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911389147.3A CN110946786A (en) | 2019-12-30 | 2019-12-30 | Mouthwash with polyaspartic acid active ingredient and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911389147.3A CN110946786A (en) | 2019-12-30 | 2019-12-30 | Mouthwash with polyaspartic acid active ingredient and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110946786A true CN110946786A (en) | 2020-04-03 |
Family
ID=69984831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911389147.3A Pending CN110946786A (en) | 2019-12-30 | 2019-12-30 | Mouthwash with polyaspartic acid active ingredient and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110946786A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005094765A1 (en) * | 2004-03-31 | 2005-10-13 | The Boots Company Plc | Oral care compositions comprising polyaspartate |
| CN106341977A (en) * | 2015-05-08 | 2017-01-18 | 库拉赛普特诶蒂艾斯有限公司 | Improved mouthwash preparation |
-
2019
- 2019-12-30 CN CN201911389147.3A patent/CN110946786A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005094765A1 (en) * | 2004-03-31 | 2005-10-13 | The Boots Company Plc | Oral care compositions comprising polyaspartate |
| CN106341977A (en) * | 2015-05-08 | 2017-01-18 | 库拉赛普特诶蒂艾斯有限公司 | Improved mouthwash preparation |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200403 |
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| RJ01 | Rejection of invention patent application after publication |