CN110946770A

CN110946770A - Acne-removing cream with liquid crystal structure and preparation method thereof

Info

Publication number: CN110946770A
Application number: CN202010048980.8A
Authority: CN
Inventors: 张英燕; 林仲潘
Original assignee: Xiamen Zeben Health Management Co Ltd
Current assignee: Xiamen Zeben Health Management Co Ltd
Priority date: 2020-01-16
Filing date: 2020-01-16
Publication date: 2020-04-03

Abstract

The invention discloses an acne-removing cream with a liquid crystal structure and a preparation method thereof, wherein salicylic acid, azalea acid and other mixed organic acids are matched with flavone and other active substances, and a nonionic surface active emulsifier compounded by an emulsifier MONTANOV L and a self-emulsifier ARLACEL 165 is combined, so that the obtained acne-removing cream has the effects of improving acne skin, removing acne, whitening, moisturizing and the like, is stable in quality, overcomes the influence caused by unstable factors such as low pH value, various plant extracts, strong electrolyte and the like in the conventional acne-removing cream, and has good market prospect.

Description

Acne-removing cream with liquid crystal structure and preparation method thereof

Technical Field

The invention belongs to the field of skin care products, and particularly relates to acne removing cream with a liquid crystal structure and a preparation method thereof.

Background

The modern competitive society has fast pace of life, which makes people more and more stressed in life, work and study and brings negative effects to human bodies. Modern cosmetics become daily consumer products which improve appearance skin, pursue fashion and increase quality in daily life. The acne-removing cream is a skin-care cosmetic capable of preventing and improving whelk. In the existing cosmetic acne-removing cream system on the market, the main active ingredients, namely salicylic acid, azalea acid and other mixed acids are acidic in the cream, and in addition, various plant-extracted active ingredients are added, so that the cosmetic acne-removing cream system is strong in ionicity, high in electrolyte content and complex in ingredients, easily causes the phenomena of instability of the system, coarse cream and the like, and affects the consumption experience.

In the preparation of the acne-removing cream, the function of the emulsifier is particularly important. According to the invention, the cream matrix containing effective active ingredients (flavone, salicylic acid, azalea acid and the like) and grease components is fixed, and a compound emulsifier mode is adopted, so that the acne-removing cream with stable quality, low irritation and certain efficacy is obtained, and the problems of layering, thickening of cream body, discoloration and the like easily occurring in the quality guarantee period of the acne-removing cream containing a complex system of various active ingredients are solved.

Disclosure of Invention

The invention aims to provide acne-removing cream with a liquid crystal structure and a preparation method thereof, wherein the acne-removing cream is stable in quality and has the effects of improving acne skin, removing acne, whitening skin, moisturizing skin and the like.

In order to achieve the purpose, the invention adopts the following technical scheme:

an acne removing cream with a liquid crystal structure comprises the following raw materials in percentage by weight, wherein the sum of the percentage by weight is 100 percent: carbomer 200.1-0.2%, glycerol 4.0-8.0%, 1, 3-butanediol 6.0-10.0%, salicylic acid 0.5-1.5%, azelaic acid 1.0-5.0%, menthol 0.2-0.5%, trimethylglycine 0.5-2.0%, allantoin 0.1-0.3%, baicalin 0.2-1.0%, potassium hydroxide 0.1-0.3%, dipotassium glycyrrhizinate 0.05-0.2%, xanthan gum 0.05-0.2%, GTCC 3.0-8.0%, IPM 3.0-8.0%, 16-18 alcohol 1.0-2.0%, 201 silicone oil 3.0-8.0%, stearic acid 1.0-4.0%, ARLACEL 1650.5-2.0%, MONTANOV L1.0-5.0%, aloe 0.1-0.3%, anti-poise 0.05-0.0%, BHT 0.01-4.0%, BHT 0.05-2.0%, and propyl hydroxybenzoate 0.05-0%, and 3.05-0.0% of aloe extract, 3.0-5.0% of centella asiatica extract, 1.0-3.0% of purslane extract, 0.05-0.15% of chamomile extract, 0.1-0.4% of diazolidinyl urea, 0.05-0.2% of lavender essential oil and the balance of water.

Preferably, the acne-removing cream with the liquid crystal structure comprises the following raw materials in percentage by weight: carbomer 200.15%, glycerin 5.0%, 1, 3-butylene glycol 8.0%, salicylic acid 1.0%, azelaic acid 3.5%, menthol 0.3%, trimethylglycine 1.0%, allantoin 0.2%, baicalin 0.5%, potassium hydroxide 0.15%, dipotassium glycyrrhizinate 0.1%, xanthan gum 0.1%, GTCC 5.0%, IPM5.0%, 16-18 alcohol 1.5%, 201 silicone oil 5.0%, stearic acid 2.5%, ARLACEL 1651.0%, MONTANOV L3.0%, VE0.15%, antiallergic agent 0.15%, BHT 0.03%, methyl paraben 0.15%, propylparaben 0.1%, aloe extract 5.0%, herba Centellae extract 4.0%, herba Portulacae extract 2.0%, flos Chrysanthemi extract 0.1%, diazolidinyl urea 0.3%, lavender 0.1%, water 44.92%.

The preparation method of the acne-removing cream with the liquid crystal structure comprises the following steps:

1) sequentially dissolving salicylic acid, azelaic acid and menthol with 1, 3-butanediol to obtain clear and transparent mixed solution;

2) adding water into a water phase pot, adding carbomer 20, glycerol, trimethylglycine, allantoin, baicalin, potassium hydroxide, dipotassium glycyrrhizinate and xanthan gum according to a proportion under the condition of stirring, then stirring and heating to 75-85 ℃, and adding the mixed solution dissolved in the step 1) to obtain a water phase solution;

3) adding GTCC, IPM (isopropyl myristate), 16-18 alcohol, 201 silicone oil, stearic acid, ARLACEL 165, MONTANOVL, VE, an anti-allergy agent, BHT (dibutyl hydroxy toluene), methyl paraben and propyl paraben into an oil phase pot according to a proportion, and heating to 75-85 ℃ to melt the materials to obtain an oil phase solution;

4) pumping the water phase solution into a main pot of a homogenizing and emulsifying machine in vacuum, pumping the oil phase solution into the main pot of the homogenizing and emulsifying machine in vacuum under stirring, opening the homogenizing and emulsifying machine, and homogenizing for 7-10 minutes at the rotating speed of 2800 r/min;

5) homogenizing, stirring at 40r/min, and keeping the temperature at 80 deg.C for 5 min;

6) keeping the temperature, opening cooling water, cooling the mixed material obtained in the step 5) to 40-45 ℃, adding the aloe extract, the centella extract, the purslane extract and the feverfew extract, and fully and uniformly stirring;

7) adding diazolidinyl urea and lavender essential oil into the material obtained in the step 6), uniformly stirring, continuing stirring for 5-10 minutes after the material is pasty, and adjusting the pH value to 6.0-6.5;

8) discharging, taking the semi-finished product for inspection, aging, filling after qualification, and packaging.

Salicylic acid is a multifunctional natural active ingredient, is present in many plants, such as willow bark, is a nonsteroidal anti-inflammatory substance, has anti-inflammatory, spectrum antibacterial, bidirectional regulation of keratinocytes at low concentrations, and relaxing and exfoliating the keratinocytes at high concentrations, and has whitening (tyrosinase activity inhibition) effects, thus making the skin smooth and fine and reducing fine lines, thus improving the appearance and texture of the skin overall. The salicylic acid has effects of exfoliating cutin, dissolving acne keratoplug, resisting inflammation, targeting Propionibacterium acnes, and reducing pigmentation after acne. The salicylic acid has fat-soluble property, can be mutually soluble with grease, can penetrate into the stratum corneum of the skin and the deep part of the pore to treat a patient in a mode of being fused with the lipid, does not stimulate the dermal tissue, and is favorable for treating the dissolution of the old accumulated stratum corneum in the pore, thereby preventing the formation of acne and reducing the enlarged pore.

Azelaic acid, also called azelaic acid, has antibacterial action on propionibacterium acnes and staphylococcus epidermidis, has obvious permeability on the surface layer of skin, has the permeability efficiency which is several times of that of dimethyl sulfoxide, has low toxicity, can be used as a penetrant to be used together with various active substances, is beneficial to promoting the penetration of the active substances such as salicylic acid, baicalin, asiaticoside and the like on the skin, can weaken the adhesion of keratinocytes, and can degranulate mast cells in dermis and dilate capillary vessels in the superficial dermis, thereby achieving the effects of moisturizing, accelerating the metabolism of the skin, reducing melanin, reducing wrinkles and the like. Therefore, the medicine also has an improvement effect on the pigmentation spots caused by the acne after inflammation.

Trimethylglycine, also known as betaine, has small molecules and is easy to absorb. The moisturizing property is about 12 times of that of glycerol and 3 times of that of sorbitol, so that the skin moisturizing cream has good stability, water solubility and moisturizing property, can quickly improve the moisture retention of skin, keep sufficient moisture of skin stratum corneum, stimulate cell activity, soften skin, keep the skin moist and smooth, reduce stimulation, prevent skin dryness and skin darkness, and is beneficial to the absorption of functional components in cosmetics.

The addition of Mentholum can promote drug permeation through skin, and has effects of regulating lipid secretion, inhibiting bacteria, sterilizing, relaxing nerve, refreshing skin, relieving itching, and relieving edema.

Baicalin is a flavonoid extracted and separated from the dried root of scutellaria baicalensis, and baicalein has the characteristics of metronidazole-style raw materials, plays a role of phytohormone, and has the effects of resisting inflammation, inhibiting bacteria, resisting allergy and the like. The baicalin has 2 times of metronidazole action of inhibiting propionibacterium acnes at the same concentration, has remarkable skin-whitening, freckle-removing and acne-removing skin-treating effects of inhibiting inflammation and allergy phenomena such as skin inflammation, cyst, reddening and the like caused by propionibacterium acnes, can effectively inhibit the formation of melanin and remove oxygen radicals, and is a good functional cosmetic raw material.

Asiatic acid and asiaticoside in herba Centellae extract have estrogen-like effect, and can be used for promoting wound healing, stimulating granulation growth, promoting epidermal keratinization or epidermal regeneration, promoting generation of new connective tissue, removing facial acne, promoting rapid healing of acne, repairing acne skin, and effectively preventing generation of dark scar.

Allantoin has anti-irritant, anti-allergic, and antioxidant effects, and can soften keratin, keep skin moisture, maintain physiological balance of skin moisture, and especially restore skin with chapped and rough skin to smooth and moisten; allantoin can promote the growth of cell tissue, accelerate wound healing, influence the rapid granulation of epidermis, accelerate renewal process, and is a good active agent for treating skin injury.

The aloe extract is a natural plant component with multiple effects of moisturizing, whitening, removing acne, resisting inflammation, relieving itching, promoting wound healing, repairing after sunburn and the like. The polysaccharide and vitamins in Aloe can also provide skin with moistening and nourishing effects, and has free radical scavenging and antioxidant effects.

The purslane extract is mainly used for resisting allergy, inflammation and inflammation, resisting various external irritation to the skin and has an acne removing function. Especially has obvious anti-allergic effect on skin allergy caused by long-term use of hormone cosmetics.

The chamomile has good anti-inflammatory, antibacterial and antiallergic effects, has the effects of relieving and calming the skin, can enhance the resistance of capillary vessels, can be used for treating eczema, oral ulcer, burn, bruise and the like, and is a good natural therapy. In addition, the antioxidant property of the chamomile helps to remove free radicals and relieve aging.

In a cream system, it is difficult to make the cream system in a stable state by simply using an anionic emulsifier, a cationic emulsifier, a general nonionic emulsifier and a complex emulsifier. According to the invention, through emulsifier test screening, the nonionic surfactant emulsifier is finally determined to be used for stabilizing the acne-removing cream system, and specifically, potassium stearate generated after neutralization of stearic acid and potassium hydroxide is compounded with the emulsifier MONTANOV L and the self-emulsifier ARLACEL 165, the emulsifier with a liquid crystal net structure can generate interactive lamellar liquid crystal, and the structure is extremely similar to the three-dimensional structure of lipid among skin stratum corneum cells, so that the acne-removing cream has the advantages of good emulsifying effect, good stability and excellent moisture retention. And the polymer emulsifying thickener carbome 20 and xanthan gum added in the formula are beneficial to further improving the stability of the system.

Salicylic acid and azelaic acid are likely to precipitate at a pH of > 3 and affect the use effect, and therefore, the pH of products containing salicylic acid and azelaic acid is often lower than 3, but this is likely to cause skin irritation and exfoliation of skin cutin. Meanwhile, most of active substances extracted from natural plants used in the cream contain strong electrolyte salt, which can affect an emulsification system to a certain extent, and when the system is emulsified by adopting an anionic emulsifier, the anionic emulsifier can be ionized in a solution and carry charges, so that the anionic emulsifier can be neutralized with electrolyte raw materials in the system to generate precipitation, and the emulsification capacity is lost. According to the pathogenesis of the acne, the invention not only enables the obtained acne removing cream to have the effects of improving the acne skin, removing acne and whitening, moisturizing and moistening the skin and the like by matching the mixed organic acid such as salicylic acid, azalea acid and the like with the active substances such as flavone and combining the compounded nonionic surfactant emulsifier, but also has stable quality, the pH value is controlled between 6.0 and 6.5, the influence caused by unstable factors such as low pH value, various plant extracts contained in the system, strong electrolyte and the like of the existing acne removing cream is overcome, and the acne removing cream has good market prospect.

Drawings

FIG. 1 is a micrograph of the liquid crystal structure formed by the emulsifier.

Detailed Description

In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.

The acne cream is prepared according to the formula of table 1, wherein the formula and the dosage of the emulsifier are shown in table 2.

Table 1 test matrix formulations

Table 2 experimental emulsifier formulations

The preparation method of the acne-removing cream comprises the following steps:

2) adding water into a water phase pot, adding carbomer 20, glycerol, trimethylglycine, allantoin, baicalin, dipotassium glycyrrhizinate and xanthan gum according to a proportion under the condition of stirring, then stirring and heating to 75-85 ℃, and adding the mixed solution dissolved in the step 1) to obtain a water phase solution;

3) adding GTCC, IPM, 16-18 alcohol, 201 silicone oil, VE, an anti-allergic agent, BHT, methyl paraben and propyl paraben into an oil phase pot in proportion, and heating to 75-85 ℃ to melt the materials to obtain an oil phase solution (the emulsifier is correspondingly added into the oil phase pot or the water phase pot according to the property);

4) pumping the water phase solution into a main pot of a homogenizing and emulsifying machine in vacuum, opening a scraper for stirring, pumping the oil phase solution into the main pot of the homogenizing and emulsifying machine in vacuum, opening the homogenizing and emulsifying machine, and homogenizing for 7-10 minutes at the rotating speed of 2800 r/min;

5) after homogenizing, slowly stirring at 40r/min, and keeping the temperature for 30 minutes at 75-85 ℃ under the vacuum degree of 0.03-0.06 mpa;

Firstly, testing the stability of the product

The stability of the samples obtained was tested according to the technical specifications for cosmetic safety (2015 edition) and the relevant physicochemical standards in QB/T1857 emollient cream and GB/T22965 skin care lotion, with the following relevant criteria:

1. skin appearance: the paste is uniform, bright and fine, has good spreadability when being smeared, does not whiten and has good moistening feeling.

2. And (3) measuring the pH value: the pH value is preferably 5.0-5.5 by detecting according to GB/T13531.1 (dilution method).

3. And (3) centrifugal test: 4000r/min, and 30min of centrifugation, and oil-water stratification should be avoided.

4. Heat resistance test: standing in a thermostat at 48 deg.C for 48h, and recovering to room temperature without discoloration and oil-water separation.

5. Cold resistance test: and (3) standing in a refrigerator at the temperature of-15 ℃ for 48 hours, and when the temperature is restored to the room temperature, the phenomena of color change and oil-water separation are avoided.

6. Cold-hot cycling test: the constant temperature box and the refrigerator are alternately placed for 24 hours and alternately circulated for 30 days, and the phenomena of color change, thickening and oil-water stratification do not occur.

The test results are shown in Table 3.

Table 3 stability test results

As can be seen from the table, the influence of the electrolyte in the No. 1-3 anionic emulsifier system is large, and the emulsifier is not suitable for being used as an emulsion stabilizer in an acne-removing cream system. 5. Although the No. 6 nonionic emulsifier system can resist acid and alkali, the stability test cannot be passed in the formula system of the acne-removing cream, which may be caused by that a polyoxyethylene chain in the emulsifier structure forms a complex with a hydroxyl group or a carboxyl group in the salicylic acid structure, so that the emulsifier loses emulsifying capacity, and an emulsion matrix is damaged, so that the emulsion is unstable. 10. The long-term stability of the No. 11 compound emulsifier system is superior to that of other emulsifiers, and the compounding of the No. 10 emulsifier SS and the No. 10 emulsifier SSE can form a liquid crystal structure and is beneficial to stabilizing the system. The No. 11 anionic emulsifier potassium stearate, the nonionic alkyl glycoside type emulsifier MONTANOV L and the self-emulsifier ARLACEL 165 are compounded, so that the synergistic emulsification effect is achieved, the emulsifiers are directionally arranged on the interface of two phases to form a bilayer, a layered liquid crystal structure (shown in figure 1) is generated, namely a multi-thin-layer structure is generated, the van der Waals force among emulsion liquid drops can be remarkably reduced, the thinning of an oil drop liquid film is delayed, the mutual attraction and aggregation among the oil drops are prevented, and the system is stable. The liquid crystal structure can promote the physiological integrity of the upper layer of the epidermis and enhance the integrity of the skin barrier function. In addition, the polymer emulsifying thickener carbome 20 and xanthan gum added in the formula of the acne cream are beneficial to improving the stability of the system.

On the basis of the stability test, the emulsion process and the active ingredient were determined according to the one-way test, with the amounts of stearic acid and potassium hydroxide fixed, and the self-emulsifying agents ARLACEL 165 and MONTANOV L set to five ratios of 1:1, 1:2, 1:3 and 2:3, 3:1 were tested. The results are shown in Table 4.

Table 4 stability test results for emulsifiers in different proportions

As can be seen from Table 4, the emulsions prepared by compounding according to different proportions have good stability and are basically consistent in other indexes except a small amount of separation layers in part of tests, and are further compared by skin-feel evaluation.

Skin feel evaluation criteria:

1. whiteness of the paste: the cream should be visually milky white or yellowish emulsion. The paste obviously has 0 minute of particles and 10 minutes of milky and fine paste;

2. gloss: the brightness and the uniform and fine degree of the surface of the cream body are visually observed. Dark and dull is 0 minutes, bright is 10 minutes;

3. the picking property: ease of lifting with a spoon in a sample container. The hand sticking is 0 minutes when the hand cannot be picked up, and the hand sticking is 10 minutes when the hand cannot be picked up easily;

4. spreadability: ease of spreading on the skin when applied three times. Dragging is 0min, and sliding is 10 min;

5. softness: ease of application to the skin. The hard coating is 0 minute, and the soft coating is 10 minutes;

6. absorbency: when the water sensation on the skin disappears, the speed at which the water has been absorbed by the skin smear is felt. 0 minutes for very slow speed and 10 minutes for very fast speed;

7. smooth feeling: ease of finger sliding on the skin. The feeling is 0 minutes and 10 minutes;

8. sticky feeling: the degree of blocking between fingers in the product. The very sticky between the two fingers is 0 minutes, and the non-sticky between the two fingers is 10 minutes;

9. residual feeling: how much residual amount is felt on the skin. The feeling was thick and the residue was 0 minutes at most, and the feeling was 10 minutes without residue.

The score criteria range is divided by 0 to 10. 25 volunteers, aged 18 to 45 years, were selected, of which 15 women and 10 men. About 0.2 g of sample was taken and tested on the inner side of the volunteer's forearm (the volunteer's forearm was cleaned and disinfected by alcohol wiping before trying), the area of 4.5cm diameter on the forearm was selected and applied with the index finger in a loop (clockwise application, about 1 second/time, generally about 15 times), and the skin feel after application was felt with the other index finger, the results are shown in table 5.

TABLE 5 skin feel assessment scoring results

As can be seen from the results in Table 5, when the components are compounded in a ratio of 3:1, the emulsified system has thick paste, poor spreadability, poor whiteness, gloss and absorptivity, obvious whitening after being applied and poor skin feel experience. With the opposite dosage of the proportion, the paste has moderate consistency, fine and smooth luster, smooth smearing and no whitening phenomenon. Along with the increase of the proportion, the effect is gradually obvious, the skin feel is better and better, the skin feel is basically consistent at 1:3 and 2:3, and in consideration of the application cost, the proportion of the selected emulsifiers ARLACEL 165 and MONTANOV L is the best at 1:3, so that the skin feel accords with the HLB theoretical requirement.

Secondly, selecting a formula and a process

Selecting four horizontal points with emulsification temperature of 70 deg.C, 75 deg.C, 80 deg.C and 85 deg.C according to L₁₆（4³) Orthogonal test design was performed at three-factor four levels, each factor level is shown in table 6, 16 tests were performed in total, and the optimum combination of emulsification temperature, emulsification time and stirring speed was screened through the tests without considering the interaction.

TABLE 6 influence factor level table L₁₆（4³）

So as to be able to distinguish clearly the test items of stable cream quality: appearance, heat resistance test and particle size were measured and compared. The scoring standard is as follows:

1. appearance: the factors of the glossiness, the fineness, the uniformity of the material body, the spreadability, the smoothness, the consistency, the whiteness and the like of the emulsion meet 10 minutes, and one of the defects is 1 minute.

2. Heat resistance test: the emulsion is uniform and not layered, and the surface is bright and has no impurities (9-10 min); separating a small amount of oil and water or impurities (7-8 min); obvious oil-water separation or impurity precipitation (5-6 min); separating out impurities (3-4 minutes) from the oil-water separation cargo with a scale; separating out impurities (1-2 min) from oil-water separation cargos with the scale of about 1 mL; impurities (0 min) were precipitated from the oil-water separation product in excess of 1 mL.

3. Granularity: the particle size is observed to be below 50 μm (9-10 min) under a microscope; 50-100 μm (7-8 min); 100-180 μm (5-6 min); coarse (5 min or less).

The results are shown in Table 7.

TABLE 7 results of orthogonal experiments

As can be seen from Table 7, the main and secondary sequence of the factors affecting emulsification is A > C > B, i.e. the emulsification temperature has a major effect on the system, followed by the stirring speed and finally the emulsification time. And (4) comprehensively considering the production process, and finally selecting the optimal combination of A3B2C 3. Namely the emulsifying temperature is 80 ℃, the stirring speed is 40r/min, and the emulsifying time is 5 min. The results of the verification test were shown in Table 9, and are shown in Table 8.

Table 8 verification of the test protocol

TABLE 9 comparison of optimum Process parameter test results

The test results show that the low temperature is not favorable for emulsification, the material body is easy to be rough and has bubbles, and the stability is poor; when the temperature is too high, jelly appears in the material body, and the surface of the emulsion is rough. Sample No. 5 is superior to the other four test results in material appearance, centrifugal test, cold and heat resistance test and granularity inspection, and proves the correctness of the optimal process combination.

Thirdly, investigating the stability of the product

Three batches of cream are prepared according to the formula in the table 10, the appearance, skin feel, pH value, viscosity, centrifugal test, cold resistance test, heat resistance test, cold and heat cycle test and the like of a sample are taken as investigation indexes to verify the emulsification effect and the cream stability, and the results are shown in the table 11.

TABLE 10 raw material formulation

TABLE 11 stability test results for three batches of creams

And (3) filling the three batches of samples into a PE (polyethylene) hose package, sealing and storing at room temperature to avoid direct irradiation of sunlight, and sampling and detecting the consistency, color, uniformity, skin-smearing feeling, pH value, centrifugal test, heat resistance test, cold resistance test and cold-heat cycle test after 6 months of storage. The results show that the appearance and the color of the cream are not changed; the paste is fine and uniform, and the skin feel is good when the paste is applied; there is an increase in viscosity, but the balance is moderate; the pH value is basically unchanged and meets the requirement; the centrifugal test, the heat resistance test, the cold resistance test and the cold and hot circulation test are all non-layered, and the cream has good stability and meets the requirements.

The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.

Claims

1. The acne-removing cream with the liquid crystal structure is characterized in that the sum of the weight percentages is 100%, and the weight percentages of the raw materials are as follows: carbomer 200.1-0.2%, glycerol 4.0-8.0%, 1, 3-butanediol 6.0-10.0%, salicylic acid 0.5-1.5%, azelaic acid 1.0-5.0%, menthol 0.2-0.5%, trimethylglycine 0.5-2.0%, allantoin 0.1-0.3%, baicalin 0.2-1.0%, potassium hydroxide 0.1-0.3%, dipotassium glycyrrhizinate 0.05-0.2%, xanthan gum 0.05-0.2%, GTCC 3.0-8.0%, IPM 3.0-8.0%, 16-18 alcohol 1.0-2.0%, 201 silicone oil 3.0-8.0%, stearic acid 1.0-4.0%, ARLACEL 1650.5-2.0%, MONTANOV L1.0-5.0%, aloe 0.1-0.3%, anti-poise 0.05-0.0%, BHT 0.01-4.0%, BHT 0.05-2.0%, and propyl hydroxybenzoate 0.05-0%, and 3.05-0.0% of aloe extract, 3.0-5.0% of centella asiatica extract, 1.0-3.0% of purslane extract, 0.05-0.15% of chamomile extract, 0.1-0.4% of diazolidinyl urea, 0.05-0.2% of lavender essential oil and the balance of water.

2. The acne-removing cream with the liquid crystal structure according to claim 1, which is characterized by comprising the following raw materials in percentage by weight: carbomer 200.15%, glycerin 5.0%, 1, 3-butylene glycol 8.0%, salicylic acid 1.0%, azelaic acid 3.5%, menthol 0.3%, trimethylglycine 1.0%, allantoin 0.2%, baicalin 0.5%, potassium hydroxide 0.15%, dipotassium glycyrrhizinate 0.1%, xanthan gum 0.1%, GTCC 5.0%, IPM5.0%, 16-18 alcohol 1.5%, 201 silicone oil 5.0%, stearic acid 2.5%, ARLACEL 1651.0%, MONTANOV L3.0%, VE0.15%, antiallergic agent 0.15%, BHT 0.03%, methyl paraben 0.15%, propylparaben 0.1%, aloe extract 5.0%, herba Centellae extract 4.0%, herba Portulacae extract 2.0%, flos Chrysanthemi extract 0.1%, diazolidinyl urea 0.3%, lavender 0.1%, water 44.92%.

3. The acne cream with liquid crystal structure according to claim 1 or 2, characterized in that the preparation method comprises the following steps:

3) adding GTCC, IPM, 16-18 alcohol, 201 silicone oil, stearic acid, ARLACEL 165, MONTANOV L, VE, an anti-allergy agent, BHT, methyl paraben and propyl paraben into an oil phase pot in proportion, and heating to 75-85 ℃ to melt the materials to obtain an oil phase solution;