CN110934812A - 一种美白亮肤冻干片及其制备方法 - Google Patents
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Abstract
本发明公开了一种美白亮肤冻干片,由抗坏血酸、白藜芦醇、β‑葡聚糖、透明质酸钠、海藻糖、肌肽、脱乙酰壳多糖、水解胶原、柠檬酸、柠檬酸钠、甘草酸二钾、贻贝提取物和水组成;本发明通过将各原料分散溶胀之后在GMP标准环境下,采用双层铝箔泡罩片作为包装进行冷冻干燥制的美白亮肤冻干片;本发明能够使黑色素还原,从而使肤色变白;同时能够抑制酪氨酸酶活性,进一步减缓黑色素形成,达到美白亮肤的效果。本发明利用冷冻干燥技术,将配液冻干成片状颗粒,能有效保护功效成分活性,降低其变质失活的风险,提高经济效益。
Description
技术领域
本发明涉及日用化妆品技术领域,具体的说涉及一种美白亮肤冻干片及其制备方法。
背景技术
如今化妆品广泛采用活性物质,尤其是功能性化妆品,这些活性成分往往见效快,却易失活,高温、光照、氧化、水解,都有可能让其失去活性,从而导致产品失去原本功效,甚至产品发生变质、变色、有异味等等现象。
近几年冷冻干燥技术逐渐受到化妆品研发人员的关注,于是出现了通过冻干技术保护功效成分活性,使用时再溶解使用的冻干粉化妆品。传统冻干粉是通过将配液灌装到西林瓶中进行冻干,由于西林瓶本身占用空间较大,因此在同一规格冻干设备中,空间利用率较低;此外,西林瓶为玻璃制品,在运输储存甚至使用过程中容易破碎伤人,存在一定安全隐患。
因此提供一种新型的、占用空间低、有效成分活性高、美白效果好的美白亮肤冻干片及其制备方法是本领域技术人员亟需解决的技术问题。
发明内容
有鉴于此,本发明提供了一种美白亮肤冻干片;
为了实现上述目的,本发明采用如下技术方案:
美白亮肤冻干片,由以下质量百分数原料组成:抗坏血酸5-30%、白藜芦醇1-5%、β-葡聚糖0.3-8%、透明质酸钠0.1-3%、海藻糖5-10%、肌肽0.5-5%、脱乙酰壳多糖0.1-2%、水解胶原2-3%、柠檬酸0.1-2%、柠檬酸钠0.1-2%、甘草酸二钾0.1-2%、贻贝提取物0.1-2.1%、余量为水。
优选的,由以下质量百分数原料组成:抗坏血酸15-30%、白藜芦醇1.8-4.7%、β-葡聚糖2-5%、透明质酸钠0.1-3%、海藻糖7-10%、肌肽0.8-3%、脱乙酰壳多糖0.4-1%、水解胶原2-2.5%、柠檬酸0.2-0.7%、柠檬酸钠0.3-0.7%、甘草酸二钾0.5-1%、贻贝提取物1.5-2%、余量为水。
更优选的,由以下质量百分数原料组成:抗坏血酸30%、白藜芦醇4.7%、β-葡聚糖5%、透明质酸钠0.2%、海藻糖10%、肌肽3%、脱乙酰壳多糖0.8%、水解胶原2%、柠檬酸0.2%、柠檬酸钠0.7%、甘草酸二钾0.8%、贻贝提取物1.5%、余量为水。
本发明的有益效果在于:本发明中采用的抗坏血酸和白藜芦醇是主要美白成分,抗坏血酸能够使黑色素还原,从而使肤色变白;白藜芦醇能够抑制酪氨酸酶活性,进一步减缓黑色素形成,同时白藜芦醇具有抗衰老功效,能够强化肌肤天然保护机制,是受损肌肤更好修复。β-葡聚糖、透明质酸钠、海藻糖在本发明配方体系中除了充当保湿剂,还有作为赋型剂和保护剂,对美白活性成分和多肽进行保护防止冻干过程被破坏。肌肽可清除在氧化应激过程中使细胞膜的脂肪酸过度氧化而形成的活性自由基以及不饱和醛,在本发明中可以防止肌肤衰老和增白皮肤。脱乙酰壳多糖是自然界中唯一的阳离子生物多糖,具有良好的生物相容性、黏附性、抑菌性,可促进伤口愈合和组织再生。水解胶原可以提亮肤色、促进皮肤恢复饱满弹性。柠檬酸、柠檬酸钠作为缓冲剂,对本发明体系酸碱度进行调节,使产品维持在弱酸性,一方面活性成分能够在合适的PH范围内发挥功效,另一方面和皮肤酸碱度相匹配保护肌肤不受损。甘草酸二钾、贻贝提取物能够赋予本发明抗敏、消炎功效,降低体系对肌肤刺激感。
本发明还提供了上述美白亮肤冻干片的制备方法,包括以下步骤:
(1)按上述美白亮肤冻干片质量分数称取各原料;
(2)将步骤(1)称好的各原料放入反应釜中搅拌分散均匀,然后升温至40-45℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用滤布进行过滤得到配液,将配液置于无菌环境中保存备用;
(4)在GMP标准环境下,将配液灌入铝箔泡罩片凹槽中,并进行冷冻干燥;
(5)冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
与现有技术相比本发明的有益技术效果在于:本发明利用冷冻干燥技术,将配液冻干成片状颗粒,能有效保护功效成分活性,降低其变质失活的风险;同时本发明采用双层铝箔泡罩包装,本发明采用的不透光铝箔包材,可以避免冻干片光照变色;还能增加了冻干设备空间利用率,增大生产者产出量,具备经济效益;另外,本发明采用双层铝箔泡罩包装替换传统西林瓶包装,既方便携带又减少了玻璃西林瓶破损带来的危害。
进一步,上述步骤(2)中搅拌速率为15-25r/min,搅拌时间为30-60min。。
采用上述进一步的有益效果在于:在本发明的搅拌速率和搅拌时间条件下能够将各原料充分混合均匀,有利于保护活性成分。
进一步,上述步骤(3)中滤布过滤粒度为100-300目。
采用上述进一步的有益效果在于:本发明采用的粒度范围能够确保滤液中无不溶物,形成均匀配液
进一步,上述步骤(4)中铝箔泡罩片采用双层铝箔作为外部泡罩包装;每片铝箔泡罩片灌入配液的量为0.3-1.5ml。
进一步,上述步骤(5)中冷冻干燥采用真空冷冻干燥,冷冻干燥压强为25-60Pa。
更进一步,上述冷冷冻干燥温度为-50~-30℃,冷冻干燥时间为40-60h。。
采用上述进一步的有益效果在于:低温冷冻能够使配液冻结成型,在本发明中干燥时间长短视灌装量而定,可以保证冻干结束后,冻干片不融化即可
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
美白亮肤冻干片的制备方法,步骤如下:
(1)准确称取抗坏血酸15kg、白藜芦醇1kg、β-葡聚糖1kg、透明质酸钠0.5kg、海藻糖5kg、肌肽0.5kg、脱乙酰壳多糖0.4kg、水解胶原2kg、柠檬酸0.2kg、柠檬酸钠0.5kg、甘草酸二钾0.1kg、贻贝提取物0.1kg、去离子水73.7kg;
(2)将步骤(1)称好的各原料放入反应釜中在15r/min下搅拌分散30min,然后将反应釜升温至45℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用100目的滤布进行过滤得到配液,将配液放入无菌环境中保存备用;
(4)在GMP标准环境下,将步骤(3)得到的配液灌入铝箔泡罩片凹槽中,每片铝箔泡罩片灌入0.3-1.5ml配液,并将铝箔泡罩片放入冻干机中;
(5)开启冻干机进行真空冷冻干燥,冷冻干燥压强为60Pa,冷冻干燥温度为-50~℃,冷冻干燥时间为40h,冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
实施例2
(1)准确称取抗坏血酸20kg、白藜芦醇1.8kg、β-葡聚糖2kg、透明质酸钠0.1kg、海藻糖7kg、肌肽0.5kg、脱乙酰壳多糖0.5kg、水解胶原2.2kg、柠檬酸0.2kg、柠檬酸钠0.7kg、甘草酸二钾0.5kg、贻贝提取物0.1kg、去离子64.4kg;
(2)将步骤(1)称好的各原料放入反应釜中在25r/min下搅拌分散60min,然后将反应釜升温至40℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用300目的滤布进行过滤得到配液,将配液放入无菌环境中保存备用;
(4)在GMP标准环境下,将步骤(3)得到的配液灌入铝箔泡罩片凹槽中,每片铝箔泡罩片灌入0.3-1.5ml配液,并将铝箔泡罩片放入冻干机中;
(5)开启冻干机进行真空冷冻干燥,冷冻干燥压强为25Pa,冷冻干燥温度为-30℃,冷冻干燥时间为60h,冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
实施例3
(1)准确称取抗坏血酸5kg、白藜芦醇1.8kg、β-葡聚糖5kg、透明质酸钠1kg、海藻糖10kg、肌肽0.5kg、脱乙酰壳多糖0.9kg、水解胶原2.5kg、柠檬酸0.1kg、柠檬酸钠0.3kg、甘草酸二钾1kg、贻贝提取物2kg、去离子水69.9kg。;
(2)将步骤(1)称好的各原料放入反应釜中在20r/min下搅拌分散40min,然后将反应釜升温至45℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用200目的滤布进行过滤得到配液,将配液放入无菌环境中保存备用;
(4)在GMP标准环境下,将步骤(3)得到的配液灌入铝箔泡罩片凹槽中,每片铝箔泡罩片灌入0.3-1.5ml配液,并将铝箔泡罩片放入冻干机中;
(5)开启冻干机进行真空冷冻干燥,冷冻干燥压强为40Pa,冷冻干燥温度为-40℃,冷冻干燥时间为50h,冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
实施例4
(1)准确称抗坏血酸15kg、白藜芦醇3kg、β-葡聚糖2kg、透明质酸钠1kg、海藻糖7kg、肌肽0.8kg、脱乙酰壳多糖1kg、水解胶原3kg、柠檬酸0.1kg、柠檬酸钠0.3kg、甘草酸二钾0.5kg、贻贝提取物1.5kg、去离子水64.8kg;
(2)将步骤(1)称好的各原料放入反应釜中在25r/min下搅拌分散50min,然后将反应釜升温至45℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用250目的滤布进行过滤得到配液,将配液放入无菌环境中保存备用;
(4)在GMP标准环境下,将步骤(3)得到的配液灌入铝箔泡罩片凹槽中,每片铝箔泡罩片灌入0.3-1.5ml配液,并将铝箔泡罩片放入冻干机中;
(5)开启冻干机进行真空冷冻干燥,冷冻干燥压强为50Pa,冷冻干燥温度为-45℃,冷冻干燥时间为45h,冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
实施例5
(1)准确称取抗坏血酸30kg、白藜芦醇4.7kg、β-葡聚糖5kg、透明质酸钠0.2kg、海藻糖10kg、肌肽3kg、脱乙酰壳多糖0.8kg、水解胶原2kg、柠檬酸0.2kg、柠檬酸钠0.7kg、甘草酸二钾0.8kg、贻贝提取物1.5kg、去离子水41.1kg;
(2)将步骤(1)称好的各原料放入反应釜中在15r/min下搅拌分散45min,然后将反应釜升温至40℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用150目的滤布进行过滤得到配液,将配液放入无菌环境中保存备用;
(4)在GMP标准环境下,将步骤(3)得到的配液灌入铝箔泡罩片凹槽中,每片铝箔泡罩片灌入0.3-1.5ml配液,并将铝箔泡罩片放入冻干机中;
(5)开启冻干机进行真空冷冻干燥,冷冻干燥压强为55Pa,冷冻干燥温度为-35℃,冷冻干燥时间为55h,冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
试验例
美白功效测试:随机挑选60名受试者(生活在同一地域黄色肤色人种),分为6组,每组10人,在手臂相同位置划定一块“3cm*3cm”区域,将本发明实施例1-5制备的样品与市售一款“100mg”规格美白冻干粉进行对比试验,每组人对应一种样品进行使用测试,每次将1片冻干片/1瓶冻干粉溶解于3ml去离子水,分别均匀涂抹于划定区域,每日一次。用皮肤黑色素测试仪于涂抹前、第1周、第2周、第3周、第4周测试划定区域黑色素含量,记录平均结果,实验数据如表1所示:
表1实施例1-5及对比例实验结果
结论:由表1可以看出,本发明具有明显美白去黑效果,抗坏血酸(维生素C)与白藜芦醇添加量越高,美白效果体现得越快。
Claims (9)
1.一种美白亮肤冻干片,其特征在于,由以下质量百分数原料组成:抗坏血酸5-30%、白藜芦醇1-5%、β-葡聚糖0.3-8%、透明质酸钠0.1-3%、海藻糖5-10%、肌肽0.5-5%、脱乙酰壳多糖0.1-2%、水解胶原2-3%、柠檬酸0.1-2%、柠檬酸钠0.1-2%、甘草酸二钾0.1-2%、贻贝提取物0.1-2.1%、余量为水。
2.根据权利要求1所述一种美白亮肤冻干片,其特征在于,由以下质量百分数原料组成:抗坏血酸15-30%、白藜芦醇1.8-4.7%、β-葡聚糖2-5%、透明质酸钠0.1-3%、海藻糖7-10%、肌肽0.8-3%、脱乙酰壳多糖0.4-1%、水解胶原2-2.5%、柠檬酸0.2-0.7%、柠檬酸钠0.3-0.7%、甘草酸二钾0.5-1%、贻贝提取物1.5-2%、余量为水。
3.根据权利要求2所述一种美白亮肤冻干片,其特征在于,由以下质量百分数原料组成:抗坏血酸30%、白藜芦醇4.7%、β-葡聚糖5%、透明质酸钠0.2%、海藻糖10%、肌肽3%、脱乙酰壳多糖0.8%、水解胶原2%、柠檬酸0.2%、柠檬酸钠0.7%、甘草酸二钾0.8%、贻贝提取物1.5%、余量为水。
4.一种美白亮肤冻干片的制备方法,其特征在于,包括以下步骤:
(1)按权利要求1-3任一项所述美白亮肤冻干片称取各原料;
(2)将步骤(1)称好的各原料放入反应釜中搅拌分散均匀,然后升温至40-45℃并继续搅拌至所有原料充分分散溶胀均匀,得到精华状液体,将精华状液体放入无菌环境中保存备用;
(3)将精华状液体用滤布进行过滤得到配液,将配液置于无菌环境中保存备用;
(4)在GMP标准环境下,将配液灌入铝箔泡罩片凹槽中,并进行冷冻干燥;
(5)冻干结束后取出铝箔泡罩片即得美白亮肤冻干片。
5.根据权利要求4所述一种美白亮肤冻干片的制备方法,其特征在于,步骤(2)中所述搅拌速率为15-25r/min,搅拌时间为30-60min。
6.根据权利要求4所述一种美白亮肤冻干片的制备方法,其特征在于,步骤(3)中滤布过滤粒度为100-300目。
7.根据权利要求4所述一种美白亮肤冻干片的制备方法,其特征在于,步骤(4)中每片铝箔泡罩片灌入配液的量为0.3-1.5ml。
8.根据权利要求4所述一种美白亮肤冻干片的制备方法,其特征在于,步骤(4)中所述冷冻干燥采用真空冷冻干燥,冷冻干燥压强为25-60Pa。
9.根据权利要求4或8所述一种美白亮肤冻干片的制备方法,其特征在于,所述冷冻干燥温度为-50~-30℃,冷冻干燥时间为40-60h。
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