CN110929379B - Topology optimization artificial vertebral body and design method thereof - Google Patents
Topology optimization artificial vertebral body and design method thereof Download PDFInfo
- Publication number
- CN110929379B CN110929379B CN201911022199.7A CN201911022199A CN110929379B CN 110929379 B CN110929379 B CN 110929379B CN 201911022199 A CN201911022199 A CN 201911022199A CN 110929379 B CN110929379 B CN 110929379B
- Authority
- CN
- China
- Prior art keywords
- vertebral body
- artificial vertebral
- topological
- optimization
- porous structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a topological optimization artificial vertebral body and a design method thereof, wherein the artificial vertebral body comprises a topological thin-wall structure with an opening and a porous structure arranged in the topological thin-wall structure with the opening, the topological thin-wall structure is designed in a light weight manner based on a topological optimization method under various motion gait mechanical environments, and on the basis of meeting the strength requirements of a prosthesis in different motion states, the porous structure is added to meet the bone ingrowth requirements, so that the later-stage biological fixation of the prosthesis is realized, and the good stability is ensured. The topologically optimized artificial vertebral body introduced by the invention can simultaneously ensure the instant stability and the medium-term stability of the implanted artificial vertebral body through the organic combination of the open-pore topological thin-wall structure and the porous structure, and is beneficial to the improvement of the recovery life quality of the spinal function of a patient.
Description
Technical Field
The invention belongs to the field of prosthesis design and manufacture, and particularly relates to a topology optimization artificial vertebral body and a design method thereof.
Background
The upper part of the spine bears the skull and the lower part is connected with the hip bone, which is an important component of the skeletal system of the human body and plays the physiological functions of maintaining the body, protecting the spinal cord, performing sports and the like. Since spinal tumors, tuberculosis, and severe fractures often cause spinal damage, which may result in spinal nerve damage, vertebrectomy and reconstruction are required.
Currently, for vertebral body reconstruction, there are three main methods in common use: bone graft reconstruction including autologous bone and allogeneic bone transplantation; rebuilding a titanium net; and (5) reconstructing an artificial vertebral body. For autologous bone grafting, secondary damage can be caused to a patient, and the allogeneic bone grafting has risks of immunological rejection reaction, non-fusion and the like, so that the clinical application of bone grafting reconstruction has more limitations; for titanium mesh reconstruction, the probability of loosening and collapse failure after implantation is high because the end surface of the titanium mesh can generate sharp thorn-shaped objects in the cutting process; for the reconstruction of the artificial vertebral body, the physiological curvature of the spine can be better recovered through reasonable design, the contact area between the artificial vertebral body and the adjacent segment end plate is increased, and the stability is improved, so the artificial vertebral body is gradually the preferred mode for the reconstruction of the vertebral body.
With the development of spinal vertebral body reconstruction and fusion technology, more and more biomechanical tests and clinical application researches show that the existing artificial vertebral body still has the following defects:
(1) the immediate stability and the medium-long-term stability are poor, and the artificial vertebral body is loosened in the early stage after being implanted due to unreasonable structural design or sinks and shifts due to no fusion;
(2) it is difficult to realize the unification of the lightweight design and the strength of the artificial vertebral body.
Therefore, aiming at the defects existing in the artificial vertebral body design, how to design the artificial vertebral body which can keep the instant stability and the medium-term stability after the artificial vertebral body is implanted and has the characteristics of light weight and high strength and uniformity still remains the problem which needs to be solved urgently in the field of spinal column reconstruction at present.
Disclosure of Invention
In order to solve the problems in the field of artificial vertebral body design, the invention provides a topological optimization artificial vertebral body and a design method thereof. The porous structure design is carried out according to the bone growth requirement so as to ensure good medium and long-term stability; the topology optimization method and the porous structure design realize the unification of the light weight and the high strength of the prosthesis.
In order to achieve the purpose, the invention adopts the following technical scheme:
a topological optimization artificial vertebral body comprises an open-pore topological thin-wall structure 1 and a porous structure 2 arranged in the open-pore topological thin-wall structure 1, wherein the open-pore topological thin-wall structure 1 is designed by a topological optimization method based on an initial solid model of the artificial vertebral body, and the light-weight and high-strength open-pore topological thin-wall structure provides reliable mechanical support; the porous structure 2 is designed according to the bone growth requirement so as to ensure the good stability of the artificial vertebral body;
the open-pore topological thin-wall structure 1 comprises two structures, wherein the first structure is as follows: the area in front of the human body is of a porous structure, and the area in back of the human body is of a solid thin-wall structure so as to avoid the neural friction between the open pore structure and the area in back of the human body; the second method is as follows: the area in front of the human body and the area behind the human body are both of open pore structures, and the holes of the open pore structures in the area behind the human body are coated to avoid the friction with nerves in the area behind the human body.
Preferably, the porous structure 2 is completely filled with the porous structure 2 or the bone grafting holes 3 are designed in the porous structure 2 according to the use requirement, and the diameter of the bone grafting holes 3 is more than 5mm, so that the bone grafting or the filling of the bioactive material in the operation is facilitated.
Preferably, the thickness of the open-pore topological thin-wall structure 1 is 0.5-3mm, and the thin wall is provided with a triangle, a strip, a circle, an ellipse, a ring, a polygon, a kidney, a fan and a hole formed by combining the above figures.
Preferably, the porous structure 2 is composed of an array of porous cells including, but not limited to, body centered cubic cells, diamond dodecahedral cells, and crisscrossed cells. The porosity of the porous structure is 70-90%, and the porous thickness is not less than 2 mm; and the holes in the porous structure are completely communicated, and the porous structure is a uniform porous structure or a porous structure with gradually changed hole diameters.
Preferably, the topology optimization artificial vertebral body can be designed into a personalized product according to the requirements of a patient, namely the height of the artificial vertebral body is designed to be in accordance with the height of a resection area of the patient, and the shape of the end face is completely fit with the shape of the residual bone of the patient; or the artificial vertebral body is designed into a series product, namely the artificial vertebral body is designed into a series height, and the end surface is planar, arched or vault-shaped so as to meet the requirements of different patients.
Preferably, the topology optimization artificial vertebral body is suitable for single-segment or multi-segment vertebral body resection reconstruction of cervical vertebra, thoracic vertebra and lumbar vertebra parts.
Preferably, the artificial vertebral body is made of medical metal materials and/or medical polymer materials by adopting an additive manufacturing technology.
The design method of the topology optimization artificial vertebral body comprises the following steps:
step 1: and (3) geometrical model reconstruction: the geometric model comprises a natural vertebral body segment geometric model, an artificial vertebral body initial model and an internal fixing system geometric model; the artificial vertebral body initial model needs to recover the intervertebral space height and physiological curvature of the excision area, the upper and lower surfaces of the artificial vertebral body are designed according to the shape and size of the vertebral body end plate of the adjacent segment of the excision vertebral body of a patient, the size of the upper and lower surfaces of the artificial vertebral body can be reduced by 3-4mm compared with the size of the vertebral body end plate of the healthy segment contacted with the artificial vertebral body, thereby ensuring larger contact area and being beneficial to the stability of the prosthesis after implantation; the three parts are assembled in three-dimensional mechanical design software according to the intraoperative implantation specification;
step 2: establishing a finite element model: importing the assembled geometric model into general commercial finite element analysis software, and carrying out material attribute assignment, grid division, contact condition setting, boundary condition and load application to complete the setting of finite element model pretreatment;
and step 3: and (3) artificial vertebral body topology optimization design: the artificial vertebral body initial model is taken as an optimization area, the combined action under various movement gait load conditions after the artificial vertebral body is implanted is considered in the optimization process, the optimization area strain energy is minimized as an optimization target, and the optimization target function is shown as the following formula:
in the formula (I), the compound is shown in the specification,
optimizing the strain energy of the region under each motion gait load condition;
withe weight coefficient of each movement gait is that Sigma W is 1;
in the optimization process, units with small strain energy in the optimization area are removed step by step through iterative calculation, the entity volume or the maximum stress value of the artificial vertebral body is reserved as a constraint condition, namely when the entity volume of the artificial vertebral body reaches a set target or the maximum stress value reaches the set target, the calculation is terminated, and the artificial vertebral body topology optimization model is output. Importing the topological optimization model into three-dimensional mechanical design software, reconstructing the topological optimization model according to the position, the form and the size of the opening on the topological optimization model, and designing the topological optimization model into a topological thin-wall structure model with the opening;
and 4, step 4: and (3) designing a porous structure: obtaining a porous structure area through Boolean subtraction operation according to the artificial vertebral body initial model and the open-pore topological thin-wall structure model, and selecting the space range of the bone grafting hole 3 in the porous structure according to the requirement;
and 5: checking the strength of the topology optimization artificial vertebral body: and (3) introducing the designed topological optimized artificial vertebral body into general commercial finite element analysis software to perform stress analysis on the artificial vertebral body under various motion gait load conditions, if the maximum stress on the artificial vertebral body is lower than the strength of the artificial vertebral body material under all motion gait load conditions, entering a manufacturing link, otherwise, changing topological optimization constraint condition parameters in the step (3), and repeating the step (3-4) until the strength of the prosthesis meets the requirements.
Step 6: and outputting the topology optimization artificial vertebral body model meeting the strength requirement for manufacturing.
Preferably, when the topological thin-wall structure model of the artificial vertebral body open pore in the topological optimization artificial vertebral body design step 3 is designed and the strength of the artificial vertebral body in the step 5 is checked, the adopted multi-motion gait considers the mechanical environments corresponding to all postures involved in daily activities, namely the spine anteflexion and extension, the left/right lateral bending and the left/right rotation activities.
Preferably, the porous structure design in the step 4 of designing the topology-optimized artificial vertebral body includes two conditions, the first condition is: filling a porous structure in all the areas obtained by the Boolean subtraction operation, and selecting whether to design bone grafting holes in the porous structure areas according to the use requirements; the second method is as follows: and filling the porous structure with the region obtained by the Boolean subtraction operation, and selecting whether to design bone grafting holes in the porous structure region according to the use requirement.
Compared with the prior art, the invention has the following advantages:
(1) the artificial vertebral body can restore the intervertebral space height and the physiological curvature of the spine excision area of the patient, and is beneficial to the improvement of the recovery life quality of the spine function of the patient.
(2) The topological thin-wall structure designed based on the topological optimization method can provide reliable mechanical support, and ensures the instant stability of the implanted artificial vertebral body. The porous structure design is carried out according to the bone growth requirement so as to ensure good medium and long-term stability;
(3) the topology optimization method and the porous structure design realize the unification of the light weight and the high strength of the prosthesis.
Drawings
FIG. 1 is a schematic view of a geometric model of a spinal system.
Fig. 2(a) is a schematic diagram of an initial model of an artificial vertebral body.
Fig. 2(b) is a schematic diagram of the three-dimensional model of the initial model of the artificial vertebral body.
Fig. 3(a) is a schematic diagram of a topology-optimized artificial vertebral body topology thin-wall structure.
FIG. 3(b) is a schematic diagram of a three-dimensional model of a topology thin-wall structure of a topology optimization artificial vertebral body.
Fig. 4(a) a schematic view of a topologically optimized artificial vertebral body (no bone graft hole).
Fig. 4(b) a schematic view of a topologically optimized artificial vertebral body (bone graft hole preserved).
Fig. 5 is a schematic view of other artificial vertebral body designs.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, but it should be noted that the embodiments described herein are only for illustrating and explaining the present invention and are not to be construed as limiting the present invention.
Taking the design of the artificial vertebral body for lumbar vertebra topology optimization as an example, the specific implementation mode is as follows:
step 1: and (5) reconstructing a geometric model of the vertebral body segment of the spine of the patient. Acquiring CT data of a spinal region of a patient, and establishing three-dimensional models of all fixed vertebral body segments (as shown in figure 1, the fixed segments are L1-L5 segments) of the patient according to preoperative planning through fault data processing software Mimics (Version 16.0, Materialise, Belgium);
step 2: and designing an internal fixing system. According to preoperative planning, designing an internal fixing system in three-dimensional mechanical design software Solidworks (Version 2014, Dassful systems S.A, France) software, wherein the fixing system consists of an internal fixing rod and a pedicle screw, the diameter of the fixing rod is 5.5mm, and the diameter of the pedicle screw is 6 mm;
and step 3: designing an artificial vertebral body initial model. The artificial vertebral body is designed according to the height of the area to be excised in the operation so as to restore the height of the intervertebral space in the reconstruction area. The contour of the upper surface and the lower surface of the artificial vertebral body are designed according to the forms of the end plates of the adjacent sections of the resection area contacted with the artificial vertebral body, and in order to keep the stability of the artificial vertebral body, the contour size of the upper surface and the lower surface of the artificial vertebral body is 3-4mm smaller than the contour size of the end plates of the healthy sections of the vertebral body contacted with the artificial vertebral body. The initial model of the finally designed artificial vertebral body is shown in fig. 2(a) and 2 (b);
and 4, step 4: and (5) reconstructing spinal geometrical model system assembly. According to the implantation specifications in clinical surgery, the patient vertebral body segment, the fixation system and the artificial vertebral body initial model are assembled in Solidworks (Version 2014, Dasssault systems s.a, france) software, and finally assembled as shown in fig. 1;
and 5: and reconstructing a finite element model of the spinal system. And (3) importing the assembled model into a finite element analysis software ABAQUS (6.12, Simulia, France), and performing material attribute assignment, meshing, contact condition setting, boundary condition and load application to complete the setting of finite element model pretreatment. The material properties of the vertebral body segments are divided into cortical bone and cancellous bone according to the bone morphology of the vertebral body, the material properties are respectively endowed to the cortical bone and the cancellous bone, the artificial vertebral body material is Ti-6Al-4V, the elastic modulus is 110GPa, and the Poisson ratio is 0.3; selecting a first-order tetrahedral unit by the grid; friction-free contact is used between the vertebral body and the vertebral body facet joint to simulate cartilage lubrication, binding contact is used between the screw and the vertebral body to simulate the screw fixation effect, and binding contact is used between the artificial vertebral body and the end plate contacting the vertebral body to simulate bone ingrowth; the boundary and load conditions are applied according to the physiological structure and the mechanical transmission mode of a human body, the lower surface of the model is completely fixed, the upper surface of the model is applied with a pressure which is vertically downward and has the size of 400N to simulate the weight of the upper half body of a human, the applied pressure has the size of 10 N.m, the directions of the applied pressure respectively extend in positive/negative directions of X, Y, Z, and the forward/backward extension, the left/right lateral bending and the left/right rotation of the human are simulated;
step 6: and (5) performing artificial vertebral body topology optimization design. And (3) performing topology Optimization design by using an Optimization module in ABAQUS software. The artificial vertebral body initial model is used as an optimization area, the minimum strain energy of the artificial vertebral body initial model is used as an optimization target, the combined effect of the artificial vertebral body after implantation under the conditions of forward flexion, backward extension, left and right lateral bending and left and right rotation loads is considered in the optimization process, the weighted strain energy of each unit on the artificial vertebral body initial model is calculated by setting a weight parameter for each motion posture, and the weight parameter of each motion posture is determined according to the frequency of each motion posture. Setting a constraint condition as that the final optimized volume is 7% of the original volume, gradually removing units with small strain energy in the artificial vertebral body initial model through iterative calculation, finally stopping calculation when the volume of the artificial vertebral body model is 7% of the initial model volume, and outputting a topology optimization artificial vertebral body model;
and 7: and (5) reconstructing a topological optimization artificial vertebral body geometric model. And importing the output topological optimization model file into Geomagic (2012, Geomagic, USA) software for geometric reconstruction, reconstructing the file into a thin-wall structure with the thickness of 1.2mm, and designing the opening on the thin wall according to the position, shape, size and shape of the opening in the topological optimization artificial vertebral body model. And the area behind the artificial vertebral body is designed into a smooth solid thin-wall structure to prevent friction with the posterior nerve, and finally the topological thin-wall structure model of the artificial vertebral body is obtained, as shown in fig. 3(a) and 3 (b);
and 8: and (4) designing a porous structure. The initial model of the artificial vertebral body and the topological optimization solid model are subjected to Boolean reduction operation to obtain a porous design area, and the porous design area is filled with multiple holes (figure 4(a)), or bone grafting holes are designed in the middle of the porous area (figure 4(b)), so that the bone grafting holes are larger than 5mm for facilitating bone grafting, and the minimum porous thickness is not smaller than 2mm for ensuring good bone growth effect. Wherein the porous units are rhombic dodecahedrons, the size of the porous cubic units is 2mm, and the porosity is 80%;
and step 9: and checking the strength of the topology optimization artificial vertebral body. The designed topological optimization artificial vertebral body is placed into a reconstructed spine finite element model, and mechanical analysis is carried out under the gait load conditions of anteflexion, postextension, left and right lateral bending and left and right rotation motion. If the maximum stress on the prosthesis is lower than the material strength of the artificial vertebral body in all the moving postures, outputting an artificial vertebral body data file capable of being printed in a 3D mode to enter a manufacturing link, if the maximum stress on the prosthesis is not lower than the material strength of the artificial vertebral body, changing the topological optimization constraint condition in the step 6, increasing the volume fraction ratio finally reserved by topological optimization, and repeating the steps 6-9 until the strength of the prosthesis meets the requirement;
and step 10, taking Ti-6Al-4V powder as a material, integrally preparing the designed topology optimization artificial vertebral body through an additive manufacturing technology, and performing subsequent processes such as powder blowing and heat treatment to finally obtain the topology optimization artificial vertebral body product. The topology optimization artificial vertebral body product comprises an open-pore topology thin-wall structure 1 and a porous structure 2 arranged in the open-pore topology thin-wall structure 1, wherein the porous structure 2 is completely filled with the porous structure 2 according to the use requirement or bone grafting holes 3 are designed in the porous structure 2, the diameter of each bone grafting hole 3 is larger than 5mm, and the bone grafting or the filling of bioactive materials in the operation is facilitated.
As for the design of the rest of topology-optimized artificial vertebral bodies, the design process is consistent with the process of the above topology-optimized artificial vertebral body design method, so that only schematic diagrams are given, and the design method is not described too much as shown in fig. 5(a), fig. 5(b) and fig. 5 (c).
Claims (9)
1. A design method of a topological optimization artificial vertebral body comprises an open-pore topological thin-wall structure (1) and a porous structure (2) arranged in the open-pore topological thin-wall structure (1), wherein the open-pore topological thin-wall structure (1) is designed by the topological optimization method based on an artificial vertebral body initial solid model, and the light-weight and high-strength open-pore topological thin-wall structure provides reliable mechanical support; the porous structure (2) is designed according to the bone growth requirement so as to ensure the good stability of the artificial vertebral body;
the topological thin-wall structure (1) with the holes comprises two structures, wherein the first structure is as follows: the area in front of the human body is of an open pore structure, and the area in back of the human body is of a solid thin-wall structure so as to avoid nerve friction between the open pore structure and the area in back of the human body; the second method is as follows: the area in front of the human body and the area behind the human body are both provided with the pore structures, and the pores of the pore structures in the area behind the human body are coated to avoid the friction with nerves in the area behind the human body;
the method is characterized in that: the design method comprises the following steps:
step 1: and (3) geometrical model reconstruction: the geometric model comprises a natural vertebral body segment geometric model, an artificial vertebral body initial model and an internal fixing system geometric model; the artificial vertebral body initial model needs to recover the intervertebral space height and physiological curvature of the resection area, the upper and lower surfaces of the artificial vertebral body are designed according to the shape and size of the vertebral body end plate of the adjacent section of the patient resected vertebral body, and the artificial vertebral body has larger contact area, thereby being beneficial to the stability of the prosthesis after implantation; the three parts are assembled in three-dimensional mechanical design software according to the intraoperative implantation specification;
step 2: establishing a finite element model: importing the assembled geometric model into general commercial finite element analysis software, and carrying out material attribute assignment, grid division, contact condition setting, boundary condition and load application to complete the setting of finite element model pretreatment;
and step 3: and (3) artificial vertebral body topology optimization design: the artificial vertebral body initial model is taken as an optimization area, the combined action under various movement gait load conditions after the artificial vertebral body is implanted is considered in the optimization process, the optimization area strain energy is minimized as an optimization target, and the optimization target function is shown as the following formula:
in the formula (I), the compound is shown in the specification,
optimizing the strain energy of the region under each motion gait load condition;
wiis a weight coefficient of each motion gait,
in the optimization process, units with small strain energy in the optimization area are removed step by step through iterative calculation, the entity volume or the maximum stress value of the artificial vertebral body is reserved as a constraint condition, namely when the entity volume of the artificial vertebral body reaches a set target or the maximum stress value reaches the set target, the calculation is terminated, and the artificial vertebral body topology optimization model is output; importing the topological optimization model into three-dimensional mechanical design software, reconstructing the topological optimization model according to the position, the form and the size of the opening on the topological optimization model, and designing the topological optimization model into a topological thin-wall structure model with the opening;
and 4, step 4: and (3) designing a porous structure: obtaining a porous structure area through Boolean subtraction operation according to the artificial vertebral body initial model and the open-pore topological thin-wall structure model, and selecting the space range of the bone grafting holes (3) in the porous structure according to the requirement;
and 5: checking the strength of the topology optimization artificial vertebral body: guiding the designed topological optimized artificial vertebral body into general commercial finite element analysis software to perform stress analysis on the artificial vertebral body under various motion gait load conditions, if the maximum stress on the artificial vertebral body is lower than the strength of the artificial vertebral body material under all motion gait load conditions, entering a manufacturing link, otherwise, changing the topological optimization constraint condition parameters in the step 3, and repeating the step 3-4 until the strength of the prosthesis meets the requirements;
step 6: and outputting the topology optimization artificial vertebral body model meeting the strength requirement for manufacturing.
2. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the porous structure (2) is completely filled with the porous structure (2) according to the use requirement or the bone grafting holes (3) are designed in the porous structure (2), the diameter of the bone grafting holes (3) is larger than 5mm, and the bone grafting or the filling of bioactive materials in the operation is facilitated.
3. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the thickness of the topology thin-wall structure (1) with the opening is 0.5-3mm, and the thin wall is provided with a triangle, a strip, a circle, an ellipse, a ring, a polygon, a kidney, a fan and holes formed by combining the figures.
4. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the porous structure (2) is composed of a porous unit array, the porous units are body-centered cubic units, diamond units, rhombic dodecahedron units or cross units, and the porosity is 70% -90%; and the holes in the porous structure are completely communicated, and the porous structure is a uniform porous structure or a porous structure with gradually changed hole diameters.
5. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the topology optimization artificial vertebral body can be designed into a personalized product according to the requirements of a patient, namely the height of the artificial vertebral body is designed to be in accordance with the height of a resection area of the patient, and the shape of the end face is completely attached to the shape of the residual bone of the patient; or the artificial vertebral body is designed into a series product, namely the artificial vertebral body is designed into a series height, and the end surface is planar, arched or vault-shaped so as to meet the requirements of different patients.
6. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the topology optimization artificial vertebral body is suitable for resection and reconstruction of single-segment or multi-segment vertebral bodies at cervical vertebra, thoracic vertebra and lumbar vertebra parts.
7. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: the artificial vertebral body is made of medical metal materials and/or medical polymer materials by adopting an additive manufacturing technology.
8. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: when the open-pore topological thin-wall structure model of the artificial vertebral body in the step 3 is designed and the strength of the artificial vertebral body in the step 5 is checked, the adopted multiple motion gaits consider the mechanical environments corresponding to all postures involved in daily activities, namely, the activities of spine anteflexion, extension backward, left and right lateral bending and left and right rotation.
9. The method for designing a topology-optimized artificial vertebral body according to claim 1, wherein: when the porous structure is designed in the step 4, two conditions are included, wherein the first condition is as follows: filling a porous structure in all the areas obtained by the Boolean subtraction operation, and selecting whether to design bone grafting holes in the porous structure areas according to the use requirements; the second method is as follows: and filling the porous structure with the region obtained by the Boolean subtraction operation, and selecting whether to design bone grafting holes in the porous structure region according to the use requirement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911022199.7A CN110929379B (en) | 2019-10-25 | 2019-10-25 | Topology optimization artificial vertebral body and design method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911022199.7A CN110929379B (en) | 2019-10-25 | 2019-10-25 | Topology optimization artificial vertebral body and design method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110929379A CN110929379A (en) | 2020-03-27 |
| CN110929379B true CN110929379B (en) | 2021-10-22 |
Family
ID=69849508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911022199.7A Active CN110929379B (en) | 2019-10-25 | 2019-10-25 | Topology optimization artificial vertebral body and design method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110929379B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111603280B (en) * | 2020-05-28 | 2022-10-14 | 北京市春立正达医疗器械股份有限公司 | Vertebral body prosthesis |
| CN112233801B (en) * | 2020-12-17 | 2021-03-26 | 季华实验室 | Construction method and topological optimization design method of topological optimization mathematical model of endoprosthesis |
| CN112690932B (en) * | 2020-12-25 | 2023-07-28 | 北京爱康宜诚医疗器材有限公司 | Method for processing vertebral prosthesis |
| CN113081405B (en) * | 2021-04-08 | 2023-11-03 | 新疆大学 | Artificial vertebral body and manufacturing method thereof |
| CN113408172B (en) * | 2021-06-28 | 2024-05-14 | 大连理工大学 | Manufacturing method and manufacturing system of interbody fusion cage |
| CN114429070A (en) * | 2022-01-26 | 2022-05-03 | 华侨大学 | Optimal design method for structure of molar prosthesis implant |
| CN114398799A (en) * | 2022-01-26 | 2022-04-26 | 华侨大学 | Optimization design method of variable gradient implant structure of molar prosthesis |
| CN116341336B (en) * | 2023-03-30 | 2024-02-20 | 之江实验室 | Topology reconstruction method and model for human-simulated robot calf |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8262737B2 (en) * | 2005-05-06 | 2012-09-11 | Titan Spine, Llc | Composite interbody spinal implant having openings of predetermined size and shape |
| CN102920537B (en) * | 2012-11-01 | 2014-12-17 | 上海理工大学 | Double safety and effectiveness inspection method of human lumbar bone and implant |
| CN104462723A (en) * | 2014-12-25 | 2015-03-25 | 北京航空航天大学 | Personalized interbody fusion cage design method based on topological optimization and bony reconstitution simulation |
| CN105740523B (en) * | 2016-01-26 | 2018-08-07 | 西安交通大学 | A kind of customization prosthese optimum design method based on host bone ambient stress |
| CN109091273B (en) * | 2018-06-13 | 2020-05-26 | 西安交通大学 | Personalized pelvis endoprosthesis design method based on topological structure optimization |
| CN109766599A (en) * | 2018-12-26 | 2019-05-17 | 国家康复辅具研究中心 | A kind of personalized anterior intervertebral fusion device design method based on bone remoulding principle |
| CN109481101A (en) * | 2018-12-28 | 2019-03-19 | 西安交通大学医学院第二附属医院 | A kind of anterior approach self-retaining artificial vertebral body |
| CN110353859B (en) * | 2019-07-31 | 2024-04-05 | 上海交通大学医学院附属第九人民医院 | 3D printing personalized rib replacement prosthesis and preparation method thereof |
-
2019
- 2019-10-25 CN CN201911022199.7A patent/CN110929379B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110929379A (en) | 2020-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110929379B (en) | Topology optimization artificial vertebral body and design method thereof | |
| CN109091273B (en) | Personalized pelvis endoprosthesis design method based on topological structure optimization | |
| CN102319129B (en) | Fusion prosthesis | |
| CN108348338B (en) | Medical device, method for producing a medical device and porous structure | |
| CN110226991B (en) | Method for producing a customized orthopaedic implant | |
| Wettergreen et al. | Creation of a unit block library of architectures for use in assembled scaffold engineering | |
| CN108635084B (en) | Polyether-ether-ketone variable-modulus artificial bone substitute prepared by fused deposition 3D printing and preparation method thereof | |
| CN112233801B (en) | Construction method and topological optimization design method of topological optimization mathematical model of endoprosthesis | |
| CN110236741A (en) | A kind of personalized condyle prosthesis design method and personalized condyle prosthesis with topological optimization fixed cell and porous condyle protruding head unit | |
| CN110840626A (en) | Femoral stem prosthesis design method | |
| CN109893302A (en) | Meniscus implant with Negative poisson's ratio | |
| Coogan et al. | Finite element study of a lumbar intervertebral disc nucleus replacement device | |
| CN112294502A (en) | Assembly type total intervertebral disc prosthesis based on 3D printing technology and manufacturing method thereof | |
| Karpiński et al. | Influence of patient position and implant material on the stress distribution in an artificial intervertebral disc of the lumbar vertebrae | |
| CN109009581A (en) | A kind of assembly type artificial vertebral body | |
| CN202342236U (en) | Fusion prosthesis | |
| Wang et al. | Multiscale design and biomechanical evaluation of porous spinal fusion cage to realize specified mechanical properties | |
| CN111986310B (en) | Design method of mandibular porous implant taking soft tissue attachment and bone growth into consideration and porous implant | |
| Cheng et al. | 3D-printed porous condylar prosthesis for temporomandibular joint replacement: Design and biomechanical analysis | |
| CN113633442A (en) | Individualized tantalum metal cervical vertebra interbody fusion cage and design method thereof | |
| CN202724045U (en) | Atlas fusion prosthesis | |
| Karuppudaiyan et al. | Finite element analysis of scaffold for large defect in femur bone | |
| CN210354993U (en) | Personalized condylar prosthesis with topology optimization fixing unit and porous condylar head unit | |
| Yahya et al. | Biomechanical Analysis of Spinal Fusion Cage for Lumbar Vertebrae | |
| Eldesouky et al. | Design and prototyping of a novel low stiffness cementless hip stem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20211019 Address after: 710300 building 4 in Caotang base standard workshop Park, No.8 West Qinling 4th Road, Caotang science and technology industrial base, high tech Zone, Xi'an City, Shaanxi Province Applicant after: WEIDU (XI'AN) BIOMEDICAL TECHNOLOGY Co.,Ltd. Address before: Beilin District Xianning West Road 710049, Shaanxi city of Xi'an province No. 28 Applicant before: XI'AN JIAOTONG University |