CN110918574A - Sample cell belt cleaning device and solid phase extraction equipment - Google Patents

Sample cell belt cleaning device and solid phase extraction equipment Download PDF

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Publication number
CN110918574A
CN110918574A CN201911178963.XA CN201911178963A CN110918574A CN 110918574 A CN110918574 A CN 110918574A CN 201911178963 A CN201911178963 A CN 201911178963A CN 110918574 A CN110918574 A CN 110918574A
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CN
China
Prior art keywords
cleaning
sampling needle
sample tube
sample
cleaning device
Prior art date
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Pending
Application number
CN201911178963.XA
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Chinese (zh)
Inventor
张振方
王琦璞
***
徐渊
曲鹏
刘军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Xinyi Scientific Instrument Co Ltd
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Suzhou Xinyi Scientific Instrument Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Xinyi Scientific Instrument Co Ltd filed Critical Suzhou Xinyi Scientific Instrument Co Ltd
Priority to CN201911178963.XA priority Critical patent/CN110918574A/en
Publication of CN110918574A publication Critical patent/CN110918574A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08Cleaning containers, e.g. tanks
    • B08B9/0804Cleaning containers having tubular shape, e.g. casks, barrels, drums
    • B08B9/0813Cleaning containers having tubular shape, e.g. casks, barrels, drums by the force of jets or sprays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention provides a sample tube cleaning device and solid-phase extraction equipment, and relates to the technical field of solid-phase extraction devices. This sample cell belt cleaning device includes sampling needle and liquid pump, and the one end of sampling needle and the liquid outlet intercommunication of liquid pump, the purge hole has been seted up to the other end of sampling needle. When the sample tube cleaning device is used, one end of the sampling needle, which is provided with the cleaning hole, extends into the sample tube, and the cleaning hole is opposite to the side wall or the bottom wall of the sample tube; and the liquid pump works, a reagent for cleaning is pumped into the sampling needle, and the reagent is sprayed out of the cleaning hole to wash the inner wall of the sample tube. The pressure of the reagent sprayed out of the cleaning hole is high, so that the sample on the inner wall of the sample tube can be quickly cleaned, the cleaning time is effectively reduced, and the cleaning efficiency is improved.

Description

Sample cell belt cleaning device and solid phase extraction equipment
Technical Field
The invention relates to the technical field of solid-phase extraction devices, in particular to a sample tube cleaning device and solid-phase extraction equipment.
Background
Solid-Phase Extraction (SPE) is a sample pretreatment technology, is developed by combining liquid-Solid Extraction and column liquid chromatography, and is mainly used for separation, purification and concentration of samples. Compared with the traditional liquid-liquid extraction method, the solid-phase extraction method can improve the recovery rate of the target object, more effectively separate the target object from interfering components, reduce the steps of sample pretreatment, and has simple operation, time saving and labor saving, so the method is widely applied to the fields of medicine, food, environment, commercial inspection, chemical industry and the like.
In the solid phase extraction process, the sample loading rate of a sample directly influences the recovery rate of a target object. In the operation process, the sample is inevitably attached to the inner wall of the sample tube, so that the inner wall of the sample tube is required to be cleaned, and then a cleaning reagent containing the sample passes through the column, so that the sample loading rate of the sample is improved, and the purpose of completely loading the sample is even achieved.
The inner wall of the sample tube is mainly cleaned in two ways in the prior art: the first is manual cleaning; the second is that the solid phase extraction device adds a specific reagent with the same volume as the sample into the sample tube to clean the inner wall of the sample tube by soaking. However, in any of the above cleaning methods, there is a problem that the cleaning time is long and the cleaning efficiency is low.
Disclosure of Invention
The invention aims to provide a sample tube cleaning device and solid phase extraction equipment, which are used for solving the technical problems of long time for cleaning a sample tube and low cleaning efficiency in the prior art.
The invention provides a sample tube cleaning device which comprises a sampling needle and a liquid pump, wherein one end of the sampling needle is communicated with a liquid outlet of the liquid pump, and the other end of the sampling needle is provided with a cleaning hole.
Furthermore, the cleaning hole is arranged on the side wall of the sampling needle.
Further, the number of the cleaning holes is multiple.
Further, a plurality of the cleaning holes are uniformly distributed along the circumferential direction of the sampling needle.
Further, the axes of the plurality of cleaning holes are located in the same cross section of the sampling needle.
Furthermore, the sampling needle is linear, and the inner diameter of the sampling needle is unchanged from one end of the sampling needle to the other end of the sampling needle.
Further, the sampling needle is a seamless steel tube.
Furthermore, the sample tube cleaning device also comprises a pipeline, wherein one end of the pipeline is communicated with the sampling needle, and the other end of the pipeline is communicated with the liquid pump.
Further, the inner diameter of the pipe is consistent with the inner diameter of the sampling needle.
The sample tube cleaning device provided by the invention can produce the following beneficial effects:
in the sample tube cleaning device provided by the invention, one end of the sampling needle is communicated with the liquid outlet of the liquid pump, and the other end of the sampling needle is provided with a cleaning hole. When the sample tube cleaning device is used for cleaning the sample tube, one end of the sampling needle, which is provided with the cleaning hole, extends into the sample tube, and the cleaning hole is opposite to the side wall or the bottom wall of the sample tube; and the liquid pump works to pump a cleaning reagent into the sampling needle, and the cleaning reagent is sprayed out of the cleaning hole to wash the inner wall of the sample tube. Because the pressure of the cleaning reagent sprayed out of the cleaning hole is high, the sample remained on the inner wall of the sample tube can be quickly cleaned, so that the cleaning time is effectively reduced, and the cleaning efficiency is improved.
In addition, compared with a soaking cleaning mode, the sample tube cleaning device provided by the invention cleans the sample tube by means of the impact force generated when the cleaning reagent is sprayed out, and the used cleaning reagent is relatively less, so that the cleaning reagent can be saved, and the cost is reduced; after the washing is completed, the washing reagent containing the sample is loaded, and the waste liquid generated is also small.
The second objective of the present invention is to provide a solid phase extraction apparatus to alleviate the technical problems of long time for cleaning the sample tube and low cleaning efficiency in the prior art.
The solid phase extraction equipment provided by the invention comprises the sample tube cleaning device.
The solid phase extraction equipment provided by the invention has all the beneficial effects of the sample tube cleaning device, so that the details are not repeated herein.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic view of a portion of a sampling needle of a device for cleaning a sample tube according to an embodiment of the present invention inserted into the sample tube;
FIG. 2 is an enlarged schematic view at A in FIG. 1;
fig. 3 is a schematic partial structural diagram of a sample tube cleaning device provided in an embodiment of the present invention in a working state.
Icon:
100-a sampling needle; 110-cleaning holes; 200-sample tube; 300-a pipeline; 400-liquid pump.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the present invention conventionally place when used, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.
Fig. 1 is a schematic view of a partial structure of a sample tube 200 inserted into a sampling needle 100 of the sample tube cleaning apparatus provided in this embodiment, as shown in fig. 1, the sample tube cleaning apparatus includes the sampling needle 100 and a liquid pump 400, one end of the sampling needle 100 is communicated with a liquid outlet of the liquid pump 400, and a cleaning hole 110 is formed at the other end of the sampling needle 100.
When the sample tube cleaning device provided by the embodiment is used for cleaning the sample tube 200, one end of the sampling needle 100, which is provided with the cleaning hole 110, is extended into the sample tube 200, and the cleaning hole 110 is opposite to the side wall or the bottom wall of the sample tube 200; the liquid pump 400 operates to pump the cleaning reagent into the sampling needle 100, and the cleaning reagent is sprayed out of the cleaning hole 110 to wash the inner wall of the sampling tube 200. Because the pressure of the cleaning reagent sprayed from the cleaning hole 110 is high, the sample remained on the inner wall of the sample tube 200 can be quickly cleaned, so that the time for cleaning is effectively reduced, and the cleaning efficiency is improved.
In addition, compared with the soaking cleaning mode, the sample tube cleaning device provided by the embodiment cleans the sample tube 200 by means of the impact force generated when the cleaning reagent is sprayed out, and the used cleaning reagent is relatively less, so that the cleaning reagent can be saved, and the cost is reduced; after the washing is completed, the washing reagent containing the sample is loaded, and the waste liquid generated is also small.
In this embodiment, the shape of the cleaning hole 110 may be circular.
It should be noted that in other embodiments of the present application, the cleaning hole 110 may have other shapes, such as: the shape of the washing hole 110 is an ellipse, and the shape and size of the washing hole 110 are not particularly limited as long as the washing hole can spray a washing reagent to wash the inner wall of the sample tube 200.
Fig. 2 is an enlarged schematic view of a point a in fig. 1, and fig. 3 is a partial structural schematic view of the sample tube cleaning apparatus provided in this embodiment in a working state. In this embodiment, as shown in fig. 1 to 3, the cleaning hole 110 is opened on the side wall of the sampling needle 100. This kind of form that sets up, sampling needle 100 can stretch into sample cell 200's inside along sample cell 200's axial, and the lateral wall of sample cell 200 can directly be sprayed when washing reagent from cleaning hole 110 blowout, and flows to the washing reagent of sample cell 200 bottom and can soak the diapire of sample cell 200, sprays and soak and goes on simultaneously to this sample cell belt cleaning device can further accelerate the cleaning process, improves the cleaning efficiency.
In other embodiments of the present application, the cleaning hole 110 may be opened in the bottom wall of the sampling needle 100. In this arrangement, the sampling needle 100 is inserted into the sample tube 200 along the axial direction of the sample tube 200, the cleaning agent ejected from the cleaning hole 110 can directly wash the bottom wall of the sample tube 200, the sampling needle 100 is inserted into the sample tube 200 obliquely with respect to the axial direction of the sample tube 200, and the cleaning agent ejected from the cleaning hole 110 can spray on the side wall of the sample tube 200.
In addition, in other embodiments of the present application, the number of the washing holes 110 may be at least two, and one part of the washing holes is opened on the side wall of the sample tube 200, and the other part of the washing holes is opened on the bottom wall of the sample tube 200. In this arrangement, the cleaning reagent can be sprayed out from the cleaning holes on the bottom wall of the sampling needle 100 and the side wall of the sampling needle 100, and then the side wall and the bottom wall of the sample tube 200 can be cleaned simultaneously.
In this embodiment, the sampling needle 100 can be used for pipetting in addition to cleaning the inner wall of the sample tube 200, for example: the washing reagent containing the sample in the sample tube 200 is moved to the solid phase extraction column and loaded.
Specifically, a negative pressure may be formed inside the sampling needle 100, and the sample-containing washing reagent in the sample tube 200 may be sucked into the sampling needle 100 through the washing hole 110.
It should be noted that, since it is a well-established prior art to form a negative pressure inside the sampling needle 100 to suck the sample-containing wash reagent into the sampling needle 100, it is not described herein again.
When the sampling needle 100 in the sample tube cleaning device provided by this embodiment is used for pipetting, since the cleaning hole 110 is disposed on the sidewall of the sampling needle 100, when the sampling needle 100 extends to the bottom of the sample tube 200 and contacts with the bottom wall of the sample tube 200, the cleaning hole 110 as the liquid inlet is not blocked by the bottom wall of the sample tube 200, so as to facilitate the suction of all the liquids in the sample tube 200 to the inside of the sampling needle 100, thereby facilitating the complete sample loading of the sample and improving the recovery rate of the target object in the sample.
In this embodiment, as shown in fig. 2, the number of the cleaning holes 110 is plural. The plurality of cleaning holes 110 can increase the liquid outlet area of the sampling needle 100 and reduce the resistance of the cleaning reagent when the cleaning reagent is sprayed out of the cleaning holes 110; in addition, the cleaning agent sprayed from the plurality of cleaning holes 110 sprays the inner wall of the sample tube 200 at the same time, so that the cleaning speed of the sample tube 200 can be further increased, and the cleaning efficiency can be improved.
Specifically, the plurality of cleaning holes 110 may be uniformly distributed along the circumferential direction of the sampling needle 100.
Further, the axes of the plurality of cleaning holes 110 are located within the same cross-section of the sampling needle 100.
Preferably, when the inner wall of the sample tube 200 is cleaned by using the sample tube cleaning apparatus provided in this embodiment, the axis of the sampling needle 100 may coincide with the axis of the sample tube 200, so that the distances from the cleaning holes 110 to the sidewall of the sample tube 200 are equal, the pressure of the ejected cleaning reagent is the same, the impact force on the sidewall of the sample tube 200 is the same, and finally, the cleaning uniformity and the cleaning quality are improved.
It should be noted here that in other embodiments of the present application, the axes of the plurality of cleaning holes 110 may not be located in the same cross section of the sampling needle 100, for example: the plurality of cleaning holes 110 are arranged along the axial direction of the sampling needle 100 at intervals, and the axes of the plurality of cleaning holes 110 are positioned in the same longitudinal section of the sampling needle 100, or the plurality of cleaning holes 110 are arranged on the side wall of the sampling needle 100 along a spiral line. The arrangement of the cleaning holes 110 is not particularly limited as long as the cleaning holes 110 can spray a cleaning reagent to clean the inner wall of the sample tube 200.
Specifically, in the present embodiment, the number of the cleaning holes 110 may be three.
In this embodiment, the sampling needle 100 is linear, and the inner diameter of the sampling needle 100 is constant from one end of the sampling needle 100 to the other end of the sampling needle 100. In this arrangement, the flow rate of the cleaning reagent in the sampling needle 100 is more stable, so that the pressure stability of the cleaning reagent ejected from the cleaning hole 110 can be improved, and the cleaning quality can be improved.
In this embodiment, the sampling needle 100 is a seamless steel tube. In this arrangement, the inner wall of the sampling needle 100 is smooth, thereby facilitating the smooth and stable flow of the liquid in the sampling needle 100; in addition, in this arrangement, the value of the amount of liquid in the sampling needle 100 is more accurate every time the sampling needle 100 samples a sample, so that the sampling accuracy can be improved.
In this embodiment, the sampling needle 100 may be integrally formed.
In this embodiment, the sampling needle 100 may be a corrosion-resistant steel tube, for example: the sampling needle 100 may be a 316L steel tube.
The material of the sampling needle 100 is not particularly limited in the present application as long as the sampling needle 100 can suitably allow a cleaning reagent or the like to flow therein.
In this embodiment, as shown in fig. 1, the sample tube cleaning apparatus further includes a tube 300, one end of the tube 300 is communicated with the sampling needle 100, and the other end of the tube 300 is communicated with the liquid pump 400. The pipe 300 is used for connection, and the length of the pipe 300 can be selected according to actual needs. The pipeline 300 enlarges the application range of the sample tube cleaning device, thereby improving the convenience of the sample tube cleaning device.
In this embodiment, the inner diameter of the tube 300 is identical to the inner diameter of the sampling needle 100. In this arrangement, the flow cross section of the liquid in the pipe 300 and the sampling needle 100 is not changed, which is advantageous for improving the stability of the flow of the liquid in the pipe 300 and the sampling needle 100, and further, for improving the stability of the ejected liquid flow and the cleaning quality.
In the present embodiment, the liquid pump 400 is specifically a syringe pump.
It should be noted that in other embodiments of the present application, the liquid pump 400 may be other liquid pumps besides a syringe pump, for example: peristaltic pumps, metering pumps, and the like. The present application does not specifically limit the arrangement of the liquid pump 400 as long as it can pump the cleaning reagent into the sampling needle 100.
It should also be noted that the structures and working principles of the above injection pump, peristaltic pump, metering pump, etc. are well-established prior art, and no improvement is made to the structures and working principles, so that no further description is provided herein.
The embodiment also provides solid phase extraction equipment, and the solid phase extraction equipment comprises the sample tube cleaning device. The solid phase extraction equipment has all the beneficial effects of the sample tube cleaning device, so the details are not repeated herein.
In particular, the solid phase extraction device may be a solid phase extractor.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. The utility model provides a sample cell belt cleaning device, its characterized in that, includes sampling needle (100) and liquid pump (400), the one end of sampling needle (100) with the liquid outlet intercommunication of liquid pump (400), wash-out hole (110) have been seted up to the other end of sampling needle (100).
2. Sample tube cleaning device according to claim 1, characterized in that the cleaning aperture (110) opens into a side wall of the sampling needle (100).
3. Sample tube cleaning device according to claim 2, characterized in that the number of cleaning holes (110) is multiple.
4. Sample tube cleaning device according to claim 3, wherein a plurality of cleaning holes (110) are evenly distributed along the circumference of the sampling needle (100).
5. Sample tube cleaning device according to claim 4, characterized in that the axes of a plurality of cleaning holes (110) are located in one and the same cross section of the sampling needle (100).
6. The device for washing sample tubes according to any of claims 1-5, wherein the sampling needle (100) is linear and the inner diameter of the sampling needle (100) is constant from one end of the sampling needle (100) to the other end of the sampling needle (100).
7. The device for washing sample tubes according to any of claims 1 to 5, wherein the sampling needle (100) is a seamless steel tube.
8. The sample tube washing apparatus according to any of claims 1-5, further comprising a conduit (300), one end of the conduit (300) being in communication with the sampling needle (100) and the other end of the conduit (300) being in communication with the liquid pump (400).
9. Sample tube cleaning apparatus according to claim 8, wherein the inner diameter of the tubing (300) coincides with the inner diameter of the sampling needle (100).
10. A solid phase extraction apparatus comprising the sample tube washing device of any one of claims 1-9.
CN201911178963.XA 2019-11-27 2019-11-27 Sample cell belt cleaning device and solid phase extraction equipment Pending CN110918574A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911178963.XA CN110918574A (en) 2019-11-27 2019-11-27 Sample cell belt cleaning device and solid phase extraction equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911178963.XA CN110918574A (en) 2019-11-27 2019-11-27 Sample cell belt cleaning device and solid phase extraction equipment

Publications (1)

Publication Number Publication Date
CN110918574A true CN110918574A (en) 2020-03-27

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1008741A (en) * 1962-06-05 1965-11-03 Hamo S A Washing apparatus for test-tubes
US3849830A (en) * 1973-09-18 1974-11-26 W Wagner Test tube washer
JP2001353475A (en) * 2000-06-12 2001-12-25 Denso Corp Cleaning device and cleaning method
CN202427688U (en) * 2011-12-31 2012-09-12 泸州医学院附属医院 Fountain type multi-start test tube continuous cleaning device
CN106362999A (en) * 2016-08-29 2017-02-01 吉林大学 Handheld portable nuclear magnetic resonance sample tube high-pressure cleaning device
CN109926417A (en) * 2017-12-19 2019-06-25 西安思能网络科技有限公司 A kind of test tube cleaning device
CN211726856U (en) * 2019-11-27 2020-10-23 苏州新仪科学仪器有限公司 Sample cell belt cleaning device and solid phase extraction equipment

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1008741A (en) * 1962-06-05 1965-11-03 Hamo S A Washing apparatus for test-tubes
US3849830A (en) * 1973-09-18 1974-11-26 W Wagner Test tube washer
JP2001353475A (en) * 2000-06-12 2001-12-25 Denso Corp Cleaning device and cleaning method
CN202427688U (en) * 2011-12-31 2012-09-12 泸州医学院附属医院 Fountain type multi-start test tube continuous cleaning device
CN106362999A (en) * 2016-08-29 2017-02-01 吉林大学 Handheld portable nuclear magnetic resonance sample tube high-pressure cleaning device
CN109926417A (en) * 2017-12-19 2019-06-25 西安思能网络科技有限公司 A kind of test tube cleaning device
CN211726856U (en) * 2019-11-27 2020-10-23 苏州新仪科学仪器有限公司 Sample cell belt cleaning device and solid phase extraction equipment

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