CN110897996A - 可溶性利多卡因高聚物微针的制备方法 - Google Patents
可溶性利多卡因高聚物微针的制备方法 Download PDFInfo
- Publication number
- CN110897996A CN110897996A CN201911269839.4A CN201911269839A CN110897996A CN 110897996 A CN110897996 A CN 110897996A CN 201911269839 A CN201911269839 A CN 201911269839A CN 110897996 A CN110897996 A CN 110897996A
- Authority
- CN
- China
- Prior art keywords
- microneedle
- lidocaine
- solution
- polymer
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 43
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 229960004194 lidocaine Drugs 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000758 substrate Substances 0.000 claims abstract description 25
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 23
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 9
- -1 Polydimethylsiloxane Polymers 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 49
- 239000003814 drug Substances 0.000 claims description 26
- 238000007605 air drying Methods 0.000 claims description 11
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 10
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 9
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims description 8
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 8
- 238000005266 casting Methods 0.000 claims description 7
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- 238000000576 coating method Methods 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 4
- 239000004626 polylactic acid Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 102000004877 Insulin Human genes 0.000 claims description 2
- 108090001061 Insulin Proteins 0.000 claims description 2
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 238000007664 blowing Methods 0.000 claims description 2
- 238000004043 dyeing Methods 0.000 claims description 2
- 229940125396 insulin Drugs 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 239000004633 polyglycolic acid Substances 0.000 claims description 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 1
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 229940014041 hyaluronate Drugs 0.000 abstract 1
- 238000002690 local anesthesia Methods 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 20
- 239000010410 layer Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
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- 238000003825 pressing Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
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- 238000003491 array Methods 0.000 description 1
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- 239000011230 binding agent Substances 0.000 description 1
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- 238000009826 distribution Methods 0.000 description 1
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- 238000011068 loading method Methods 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201911269839.4A CN110897996B (zh) | 2019-12-11 | 2019-12-11 | 可溶性利多卡因高聚物微针的制备方法 |
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CN201911269839.4A CN110897996B (zh) | 2019-12-11 | 2019-12-11 | 可溶性利多卡因高聚物微针的制备方法 |
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CN110897996A true CN110897996A (zh) | 2020-03-24 |
CN110897996B CN110897996B (zh) | 2021-10-01 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111991344A (zh) * | 2020-09-28 | 2020-11-27 | 四川大学 | 一种适用于局部麻醉的微针贴片及其制备方法 |
CN113952318A (zh) * | 2021-09-08 | 2022-01-21 | 北京宝理泰科技有限公司 | 一种用于镇痛的多层微针贴片的制备方法 |
CN115430031A (zh) * | 2022-07-05 | 2022-12-06 | 哈尔滨工业大学 | 一种多功能美容微针贴片及其批量化制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN204767021U (zh) * | 2015-05-07 | 2015-11-18 | 苏州大学 | 一种空心丝素蛋白微针结构 |
CN106039552A (zh) * | 2016-05-30 | 2016-10-26 | 北京化工大学 | 一种气泡式微针及其制备方法 |
CN107412943A (zh) * | 2017-04-17 | 2017-12-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种可溶性微针贴片及其制备方法 |
-
2019
- 2019-12-11 CN CN201911269839.4A patent/CN110897996B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN204767021U (zh) * | 2015-05-07 | 2015-11-18 | 苏州大学 | 一种空心丝素蛋白微针结构 |
CN106039552A (zh) * | 2016-05-30 | 2016-10-26 | 北京化工大学 | 一种气泡式微针及其制备方法 |
CN107412943A (zh) * | 2017-04-17 | 2017-12-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种可溶性微针贴片及其制备方法 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111991344A (zh) * | 2020-09-28 | 2020-11-27 | 四川大学 | 一种适用于局部麻醉的微针贴片及其制备方法 |
CN113952318A (zh) * | 2021-09-08 | 2022-01-21 | 北京宝理泰科技有限公司 | 一种用于镇痛的多层微针贴片的制备方法 |
CN113952318B (zh) * | 2021-09-08 | 2023-12-15 | 北京宝理泰科技有限公司 | 一种用于镇痛的多层微针贴片的制备方法 |
CN115430031A (zh) * | 2022-07-05 | 2022-12-06 | 哈尔滨工业大学 | 一种多功能美容微针贴片及其批量化制备方法 |
CN115430031B (zh) * | 2022-07-05 | 2024-06-07 | 哈尔滨工业大学 | 一种多功能美容微针贴片及其批量化制备方法 |
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Inventor after: Zhuang Jian Inventor after: Gao Xiaolong Inventor after: Huang Yao Inventor after: Kang Tingting Inventor after: Lin Long Inventor after: Wu Daming Inventor after: Zhang Jiarong Inventor after: Yang Zhenzhou Inventor after: Sun Jingyao Inventor after: Fang Yile Inventor after: Du Weijia Inventor after: Xu Hong Inventor before: Zhuang Jian Inventor before: Huang Yao Inventor before: Kang Tingting Inventor before: Lin Long Inventor before: Wu Daming Inventor before: Yang Zhenzhou Inventor before: Sun Jingyao Inventor before: Fang Yile Inventor before: Du Weijia Inventor before: Xu Hong Inventor before: Gao Xiaolong |
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Effective date of registration: 20240627 Address after: 065000 Building 40-1, Phase 1, Jingnan Science and Technology Achievement Transformation Base, Daqinghe Park, Gu'an County, Langfang City, Hebei Province Patentee after: Huabo Jinggong (Hebei Province) Technology Co.,Ltd. Country or region after: China Address before: 100029, No. 15 East Third Ring Road, Chaoyang District, Beijing Patentee before: BEIJING University OF CHEMICAL TECHNOLOGY Country or region before: China |