CN110893225A - Combined traditional Chinese medicine formula for treating Parkinson's disease - Google Patents
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Abstract
The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a combined traditional Chinese medicine formula for treating Parkinson's disease, which comprises sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, astragalus root, red-rooted salvia root, peach seed, common diaphragma, stir-fried jujube seed, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root, safflower and radix rehmanniae, and the weight ratio is as follows: 330 parts of sharpleaf galangal fruit, 330 parts of platycladi seed, 330 parts of thinleaf milkwort root-bark, 550 parts of astragalus root, 220 parts of salvia miltiorrhiza bunge, 220 parts of peach kernel, 270 parts of diaphragma juglandis, 90-110 parts of stir-fried spina date seed, 330 parts of bupleurum root, 330 parts of baical skullcap root, 270 parts of white paeony root, 330 parts of red paeony root, 330 parts of divaricate saposhnikovia root, 180 parts of safflower and 330 parts of rehmannia root. The combined traditional Chinese medicine formula for treating the Parkinson disease can effectively treat the Parkinson disease through the curative effect comprehensively generated by a plurality of medicines, has the functions of tonifying liver blood and removing liver wind, can treat symptoms of the Parkinson disease caused by encephalatrophy, has no side effect, and has no toxic medicine.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a combined traditional Chinese medicine formula for treating Parkinson's disease.
Background
Parkinsonism is a disease difficult to diagnose clearly, is manifested by four limbs concussion, and seriously affects the whole life.
Brain atrophy with multiple causes, caused by cerebral ischemia due to hereditary cerebral trauma, toxic sequelae, cerebral congestion, anoxia, cerebrovascular malformation, brain tumor, cerebral apoplexy, epileptic long-term attack, excessive smoking and drinking, malnutrition, thyroid gland function diseases, cerebral arteriosclerosis, coal gas poisoning, and supply and demand in alcohol
The existing Parkinson's disease is clinically proved to have no brain atrophy in Western medicine examination and Parkinson's disease after the brain atrophy, but no good traditional Chinese medicine can be solved when the Parkinson's disease is treated at present.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a combined traditional Chinese medicine formula for treating Parkinson's disease, and solves the problems mentioned in the background technology.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a combined traditional Chinese medicine formula for treating Parkinson's disease comprises sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, membranous milkvetch root, danshen root, peach seed, common diaphragma herb, stir-fried date seed, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root, safflower and rehmannia root, and the weight ratio is as follows: 330 parts of sharpleaf galangal fruit, 330 parts of platycladi seed, 330 parts of thinleaf milkwort root-bark, 550 parts of astragalus root, 220 parts of salvia miltiorrhiza bunge, 220 parts of peach kernel, 270 parts of diaphragma juglandis, 90-110 parts of stir-fried spina date seed, 330 parts of bupleurum root, 330 parts of baical skullcap root, 270 parts of white paeony root, 330 parts of red paeony root, 330 parts of divaricate saposhnikovia root, 180 parts of safflower and 330 parts of rehmannia root.
Preferably, the optimal weight ratio is as follows: 300 parts of sharpleaf galangal fruit, 300 parts of platycladi seed, 300 parts of thinleaf milkwort root-bark, 500 parts of astragalus root, 200 parts of red-rooted salvia root, 200 parts of peach seed, 300 parts of diaphragma juglandis, 100 parts of fried date seed, 300 parts of Chinese thorowax root, 300 parts of baical skullcap root, 300 parts of white paeony root, 300 parts of red paeony root, 300 parts of divaricate saposhnikovia root, 200 parts of safflower and 300 parts of.
Preferably, the method further comprises the following steps:
s1, grinding fructus Alpinae Oxyphyllae, semen Platycladi, cortex et radix Polygalae, radix astragali, lignum seu radix Schisandrae chinensis, radix bupleuri, Scutellariae radix, radix Paeoniae alba, radix Paeoniae Rubra, radix Saposhnikoviae, and radix rehmanniae into powder with a particle size of 40-60 mesh to obtain powdery raw materials for later use;
s2, pulverizing radix Salviae Miltiorrhizae, semen Persicae, semen Ziziphi Spinosae, and flos Carthami to powder with a particle size of 30-50 meshes to obtain powdered materials for use;
s3, mixing S1 and S2, adding purified water in an amount which is 3 times the weight of the mixture, and stirring the mixture to fully mix the mixture;
s4, adding 4 times and 8 times of water into the mixture in the S3, respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
s5, mixing the two dry extracts of S4, pulverizing into fine powder, or adding flour binder, and making into watered pill or tablet.
Preferably, the stirring time of the S1, the S2 and the S3 is 10 to 15 minutes.
Preferably, the composition obtained in S5 is filtered by a centrifuge, cooled to room temperature, sterilized by irradiation with ultraviolet light for 20 minutes, and packaged.
The efficacy is as follows:
fructus Alpinae Oxyphyllae has effects of warming spleen, relieving diarrhea, warming kidney, arresting polyuria, and stopping nocturnal emission, and is used for treating spleen and stomach deficiency cold, emesis, diarrhea, abdominal psychroalgia, excessive saliva, kidney deficiency, enuresis, pollakisuria, nocturnal emission, and whitish and turbid urine.
Semen Platycladi has effects of nourishing heart, tranquilizing mind, loosening bowel to relieve constipation, and arresting sweating. Can be used for treating yin and blood deficiency, vexation, insomnia, palpitation, constipation due to intestinal dryness, and night sweat due to yin deficiency.
Polygala tenuifolia has the functions of soothing nerves, benefiting intelligence, eliminating phlegm and reducing swelling, and is used for treating insomnia, dreaminess, amnesia, palpitation, absent mind, cough with phlegm, sore and ulcer, swelling and pain of breasts caused by imbalance between heart-yang and kidney-yin.
Radix astragali is sweet in flavor and slightly warm in nature, has the effects of invigorating qi, consolidating exterior, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, enhancing capillary resistance, arresting sweating and sex hormone, and can be used for treating exterior deficiency spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency diarrhea, edema, carbuncle, cellulitis, etc.
The salvia miltiorrhiza has the effects of activating blood and dissolving stasis, stimulating menstrual flow and relieving pain, clearing away heart fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Peach kernel has the functions of promoting blood circulation to disperse blood clots, relaxing bowels, relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma.
Diaphragma juglandis has the effects of controlling nocturnal emission, reducing urination, stopping bleeding, stopping leucorrhea and stopping diarrhea and dysentery. Can be used for treating spermatorrhea, frequent micturition, enuresis, metrorrhagia, leukorrhagia, diarrhea, and dysentery.
The stir-fried jujube kernels have the effects of calming the heart and tranquilizing the mind, can play a role in calming and hypnotizing, and can also play a role in protecting the cardiovascular system.
Bupleurum root, radix bupleuri has the functions of harmonizing exterior and interior, soothing liver and raising yang.
The scutellaria baicalensis can effectively relieve the emotions of tension, uneasiness, mental allergy, hysteria, neurasthenia, depression, crisis and the like.
White peony root, radix Paeoniae alba has effects of tonifying deficiency, and strengthening spleen and stomach.
Radix Paeoniae Rubra has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis.
Radix Saposhnikoviae can be used for treating common cold, headache, arthralgia, and neuralgia.
Safflower, blood circulation promoting and meridian dredging, stasis removing and pain relieving.
Radix rehmanniae has effects of clearing heat, cooling blood, nourishing yin and promoting fluid production.
(III) advantageous effects
Compared with the prior art, the invention provides a combined traditional Chinese medicine formula for treating Parkinson's disease, which has the following beneficial effects:
1. the combined traditional Chinese medicine formula for treating the Parkinson disease can effectively treat the Parkinson disease through the curative effect comprehensively generated by a plurality of medicines, has the functions of tonifying liver blood and removing liver wind, can treat symptoms of the Parkinson disease caused by encephalatrophy, has no side effect, and has no toxic medicine.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
a combined traditional Chinese medicine formula for treating Parkinson's disease comprises sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, membranous milkvetch root, danshen root, peach seed, common diaphragma herb, stir-fried date seed, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root, safflower and rehmannia root, and the weight ratio is as follows: 330 parts of sharpleaf galangal fruit, 330 parts of platycladi seed, 330 parts of thinleaf milkwort root-bark, 550 parts of astragalus mongholicus, 220 parts of salvia miltiorrhiza, 220 parts of peach kernel, 330 parts of diaphragma juglandis, 110 parts of fried jujube kernel, 330 parts of radix bupleuri, 330 parts of baical skullcap root, 330 parts of white paeony root, 330 parts of red paeony root, 330 parts of divaricate saposhnikovia root, 220 parts of safflower carthamus and 330 parts of radix.
The method also comprises the following steps:
s1, grinding fructus Alpinae Oxyphyllae, semen Platycladi, cortex et radix Polygalae, radix astragali, lignum seu radix Schisandrae chinensis, radix bupleuri, Scutellariae radix, radix Paeoniae alba, radix Paeoniae Rubra, radix Saposhnikoviae, and radix rehmanniae into powder with particle size of 60 mesh to obtain powdery raw materials for later use;
s2, pulverizing radix Salviae Miltiorrhizae, semen Persicae, semen Ziziphi Spinosae, and flos Carthami to powder with a particle size of 50 mesh to obtain powdered raw materials for use;
s3, mixing S1 and S2, adding purified water in an amount which is 3 times the weight of the mixture, and stirring the mixture to fully mix the mixture;
s4, adding 4 times and 8 times of water into the mixture in the S3, respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
s5, mixing the two dry extracts of S4, pulverizing into fine powder, or adding flour binder, and making into watered pill or tablet.
The stirring time of S1, S2 and S3 is 10-15 minutes.
The composition obtained in S5 was filtered using a centrifuge, cooled to room temperature, sterilized by irradiation with an ultraviolet lamp for 20 minutes, and packaged.
Example two:
a combined traditional Chinese medicine formula for treating Parkinson's disease comprises sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, membranous milkvetch root, danshen root, peach seed, common diaphragma herb, stir-fried date seed, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root, safflower and rehmannia root, and the weight ratio is as follows: 270 parts of sharpleaf galangal fruit, 270 parts of platycladi seed, 270 parts of thinleaf milkwort root-bark, 450 parts of astragalus root, 180 parts of red-rooted salvia root, 180 parts of peach kernel, 270 parts of diaphragma juglandis, 90 parts of fried date seed, 270 parts of Chinese thorowax root, 270 parts of baical skullcap root, 270 parts of white paeony root, 270 parts of red paeony root, 270 parts of divaricate saposhnikovia root, 180 parts of safflower and 270 parts of raw.
The method also comprises the following steps:
s1, grinding fructus Alpinae Oxyphyllae, semen Platycladi, cortex et radix Polygalae, radix astragali, lignum seu radix Schisandrae chinensis, radix bupleuri, Scutellariae radix, radix Paeoniae alba, radix Paeoniae Rubra, radix Saposhnikoviae, and radix rehmanniae into powder with a particle size of 40 mesh to obtain powdery raw materials for later use;
s2, pulverizing radix Salviae Miltiorrhizae, semen Persicae, semen Ziziphi Spinosae, and flos Carthami to powder with a particle size of 30 meshes to obtain powdered materials for use;
s3, mixing S1 and S2, adding purified water in an amount which is 3 times the weight of the mixture, and stirring the mixture to fully mix the mixture;
s4, adding 4 times and 8 times of water into the mixture in the S3, respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
s5, mixing the two dry extracts of S4, pulverizing into fine powder, or adding flour binder, and making into watered pill or tablet.
The stirring time of S1, S2 and S3 is 10-15 minutes.
The composition obtained in S5 was filtered using a centrifuge, cooled to room temperature, sterilized by irradiation with an ultraviolet lamp for 20 minutes, and packaged.
Example three:
a combined traditional Chinese medicine formula for treating Parkinson's disease comprises sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, membranous milkvetch root, danshen root, peach seed, common diaphragma herb, stir-fried date seed, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root, safflower and rehmannia root, and the weight ratio is as follows: 300 parts of sharpleaf galangal fruit, 300 parts of platycladi seed, 300 parts of thinleaf milkwort root-bark, 500 parts of astragalus root, 200 parts of red-rooted salvia root, 200 parts of peach seed, 300 parts of diaphragma juglandis, 100 parts of fried date seed, 300 parts of Chinese thorowax root, 300 parts of baical skullcap root, 300 parts of white paeony root, 300 parts of red paeony root, 300 parts of divaricate saposhnikovia root, 200 parts of safflower and 300 parts of.
The method also comprises the following steps:
s1, grinding fructus Alpinae Oxyphyllae, semen Platycladi, cortex et radix Polygalae, radix astragali, lignum seu radix Schisandrae chinensis, radix bupleuri, Scutellariae radix, radix Paeoniae alba, radix Paeoniae Rubra, radix Saposhnikoviae, and radix rehmanniae into powder with a particle size of 40-60 mesh to obtain powdery raw materials for later use;
s2, pulverizing radix Salviae Miltiorrhizae, semen Persicae, semen Ziziphi Spinosae, and flos Carthami to powder with a particle size of 30-50 meshes to obtain powdered materials for use;
s3, mixing S1 and S2, adding purified water in an amount which is 3 times the weight of the mixture, and stirring the mixture to fully mix the mixture;
s4, adding 4 times and 8 times of water into the mixture in the S3, respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
s5, mixing the two dry extracts of S4, pulverizing into fine powder, or adding flour binder, and making into watered pill or tablet.
The stirring time of S1, S2 and S3 is 10-15 minutes.
The composition obtained in S5 was filtered using a centrifuge, cooled to room temperature, sterilized by irradiation with an ultraviolet lamp for 20 minutes, and packaged.
Experimental example:
the effect was observed for the combined traditional Chinese medicine formulation for treating Parkinson's disease provided in examples 1-3, as shown in the following table:
and (4) judging the standard:
the invention has the beneficial effects that:
the combined traditional Chinese medicine formula for treating the Parkinson disease can effectively treat the Parkinson disease through the curative effect comprehensively generated by a plurality of medicines, has the functions of tonifying liver blood and removing liver wind, can treat symptoms of the Parkinson disease caused by encephalatrophy, has no side effect, and has no toxic medicine.
The experimental method comprises the following steps:
firstly, grinding sharpleaf galangal fruit, platycladi seed, thinleaf milkwort root-bark, astragalus root, diaphragma juglandis, Chinese thorowax root, baical skullcap root, white paeony root, red paeony root, divaricate saposhnikovia root and dried rehmannia root into powder with the granularity of 40-60 meshes to obtain powdery raw materials for later use;
step two, grinding the salvia miltiorrhiza, the peach kernels, the fried jujube kernels and the safflower into powder with the granularity of 30-50 meshes to obtain powdery raw materials for later use;
step three, mixing the step one and the step two, adding purified water in an amount which is 3 times of the weight of the mixture, and stirring the mixture to fully mix the mixture;
step four, adding 4 times and 8 times of water into the mixture obtained in the step three respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
step five, mixing the dry pastes obtained in the two times of the step four, crushing the dry pastes into fine powder, or adding a proper amount of flour adhesive, and preparing the fine powder into water-bindered pills or tablets.
The efficacy is as follows:
fructus Alpinae Oxyphyllae has effects of warming spleen, relieving diarrhea, warming kidney, arresting polyuria, and stopping nocturnal emission, and is used for treating spleen and stomach deficiency cold, emesis, diarrhea, abdominal psychroalgia, excessive saliva, kidney deficiency, enuresis, pollakisuria, nocturnal emission, and whitish and turbid urine.
Semen Platycladi has effects of nourishing heart, tranquilizing mind, loosening bowel to relieve constipation, and arresting sweating. Can be used for treating yin and blood deficiency, vexation, insomnia, palpitation, constipation due to intestinal dryness, and night sweat due to yin deficiency.
Polygala tenuifolia has the functions of soothing nerves, benefiting intelligence, eliminating phlegm and reducing swelling, and is used for treating insomnia, dreaminess, amnesia, palpitation, absent mind, cough with phlegm, sore and ulcer, swelling and pain of breasts caused by imbalance between heart-yang and kidney-yin.
Radix astragali is sweet in flavor and slightly warm in nature, has the effects of invigorating qi, consolidating exterior, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, expelling toxin, expelling pus, promoting granulation, enhancing capillary resistance, arresting sweating and sex hormone, and can be used for treating exterior deficiency spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency diarrhea, edema, carbuncle, cellulitis, etc.
The salvia miltiorrhiza has the effects of activating blood and dissolving stasis, stimulating menstrual flow and relieving pain, clearing away heart fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Peach kernel has the functions of promoting blood circulation to disperse blood clots, relaxing bowels, relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma.
Diaphragma juglandis has the effects of controlling nocturnal emission, reducing urination, stopping bleeding, stopping leucorrhea and stopping diarrhea and dysentery. Can be used for treating spermatorrhea, frequent micturition, enuresis, metrorrhagia, leukorrhagia, diarrhea, and dysentery.
The stir-fried jujube kernels have the effects of calming the heart and tranquilizing the mind, can play a role in calming and hypnotizing, and can also play a role in protecting the cardiovascular system.
Bupleurum root, radix bupleuri has the functions of harmonizing exterior and interior, soothing liver and raising yang.
The scutellaria baicalensis can effectively relieve the emotions of tension, uneasiness, mental allergy, hysteria, neurasthenia, depression, crisis and the like.
White peony root, radix Paeoniae alba has effects of tonifying deficiency, and strengthening spleen and stomach.
Radix Paeoniae Rubra has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis.
Radix Saposhnikoviae can be used for treating common cold, headache, arthralgia, and neuralgia.
Safflower, blood circulation promoting and meridian dredging, stasis removing and pain relieving.
Radix rehmanniae has effects of clearing heat, cooling blood, nourishing yin and promoting fluid production.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A combined traditional Chinese medicine formula for treating Parkinson's disease is characterized by comprising fructus alpiniae oxyphyllae, semen boitae, polygala tenuifolia, radix astragali, salvia miltiorrhiza, peach kernel, diaphragma juglandis, fried jujube kernel, radix bupleuri, radix scutellariae, radix paeoniae alba, radix paeoniae rubra, radix sileris, safflower and radix rehmanniae, and the weight ratio is as follows: 330 parts of sharpleaf galangal fruit, 330 parts of platycladi seed, 330 parts of thinleaf milkwort root-bark, 550 parts of astragalus root, 220 parts of salvia miltiorrhiza bunge, 220 parts of peach kernel, 270 parts of diaphragma juglandis, 90-110 parts of stir-fried spina date seed, 330 parts of bupleurum root, 330 parts of baical skullcap root, 270 parts of white paeony root, 330 parts of red paeony root, 330 parts of divaricate saposhnikovia root, 180 parts of safflower and 330 parts of rehmannia root.
2. The combined traditional Chinese medicine formula for treating Parkinson's disease according to claim 1, wherein the optimal weight ratio is as follows: 300 parts of sharpleaf galangal fruit, 300 parts of platycladi seed, 300 parts of thinleaf milkwort root-bark, 500 parts of astragalus root, 200 parts of red-rooted salvia root, 200 parts of peach seed, 300 parts of diaphragma juglandis, 100 parts of fried date seed, 300 parts of Chinese thorowax root, 300 parts of baical skullcap root, 300 parts of white paeony root, 300 parts of red paeony root, 300 parts of divaricate saposhnikovia root, 200 parts of safflower and 300 parts of.
3. The combined traditional Chinese medicine formulation for treating Parkinson's disease according to claim 1, further comprising the following methods:
s1, grinding fructus Alpinae Oxyphyllae, semen Platycladi, cortex et radix Polygalae, radix astragali, lignum seu radix Schisandrae chinensis, radix bupleuri, Scutellariae radix, radix Paeoniae alba, radix Paeoniae Rubra, radix Saposhnikoviae, and radix rehmanniae into powder with a particle size of 40-60 mesh to obtain powdery raw materials for later use;
s2, pulverizing radix Salviae Miltiorrhizae, semen Persicae, semen Ziziphi Spinosae, and flos Carthami to powder with a particle size of 30-50 meshes to obtain powdered materials for use;
s3, mixing S1 and S2, adding purified water in an amount which is 3 times the weight of the mixture, and stirring the mixture to fully mix the mixture;
s4, adding 4 times and 8 times of water into the mixture in the S3, respectively, decocting and extracting for two times, each time for 4 hours, combining the extracting solutions, concentrating, and drying to prepare dry paste;
s5, mixing the two dry extracts of S4, pulverizing into fine powder, or adding flour binder, and making into watered pill or tablet.
4. The combined traditional Chinese medicine formulation for treating Parkinson' S disease according to claim 3, wherein the stirring time of S1, S2 and S3 is 10-15 minutes.
5. The combination Chinese medicinal formulation for treating Parkinson' S disease according to claim 1, wherein the composition obtained in S5 is filtered by a centrifuge, cooled to room temperature, sterilized by irradiation with ultraviolet lamp for 20 min, and packaged.
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