CN110887917A - Liquid chromatograph for cyclic preparation - Google Patents
Liquid chromatograph for cyclic preparation Download PDFInfo
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- CN110887917A CN110887917A CN201911394537.XA CN201911394537A CN110887917A CN 110887917 A CN110887917 A CN 110887917A CN 201911394537 A CN201911394537 A CN 201911394537A CN 110887917 A CN110887917 A CN 110887917A
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- 239000007788 liquid Substances 0.000 title claims abstract description 29
- 125000004122 cyclic group Chemical group 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 81
- 238000004140 cleaning Methods 0.000 claims abstract description 22
- 239000007791 liquid phase Substances 0.000 claims description 10
- 230000002000 scavenging effect Effects 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 15
- 238000007872 degassing Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 4
- 238000004237 preparative chromatography Methods 0.000 description 4
- 238000004811 liquid chromatography Methods 0.000 description 3
- 238000004262 preparative liquid chromatography Methods 0.000 description 3
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 238000003889 chemical engineering Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a cyclic preparation liquid chromatograph which comprises a first shell, a first cleaning pump and a first support plate, wherein a first solvent bottle is lapped on one side of the upper end of the first shell, a second solvent bottle which is lapped with the first shell is arranged on one side of the first solvent bottle, the inner bottom end of the first shell is connected with the first cleaning pump through a screw, a first solvent degasser is connected on one side wall of the first cleaning pump through a screw, a first high-pressure pump is arranged on one side of the first solvent degasser, and a first piston is arranged on one side of the first solvent degasser, which is far away from the first high-pressure pump. Has the advantages that: through setting up high-pressure pump one, high-pressure pump two, solvent degasser one, solvent degasser two, piston one, piston two, scavenging pump one, scavenging pump two and three way connection, make equipment accessible binary channels handle solution fast, the treatment effeciency is high, and high-pressure pump one and high-pressure pump two are efficient, can further improve equipment's work efficiency, and is very practical.
Description
Technical Field
The invention relates to the technical field of manufacturing of instrument and equipment, in particular to a circularly prepared liquid chromatograph.
Background
Liquid chromatography is a separation and analysis technique characterized by the use of liquid as the mobile phase and the stationary phase in various forms, such as paper, sheet and packed bed. In the development process of the chromatographic technology, in order to distinguish various methods, respective names are generated according to the forms of stationary phases, such as paper chromatography, thin-layer chromatography and column liquid chromatography. In recent years, with the development of biotechnology and fine chemical engineering, preparative liquid chromatography, which is a branch of liquid chromatography, has been increasingly emphasized and becomes an indispensable means in biotechnology products and research. The preparative liquid chromatography can be divided into 3 scales according to the amount of one-time sample injection, namely semi-preparative chromatography, preparative chromatography and industrial-grade chromatography, the preparative chromatography aims at producing pure substances, and the larger the scale is, the better the scale is on the premise of economy and reasonableness. At present, the preparative liquid chromatography technology is widely applied to the separation and purification of samples in the fields of pharmacy, chemical engineering, biological engineering and the like. The preparative liquid chromatograph is an instrument composed of a liquid storage bottle, a sample introduction system, a chromatographic column, a detector, a chromatographic workstation, a collector and the like, and in the preparative chromatography, in order to save investment and operation cost, the maximum amount of products need to be produced in the minimum time.
Current circulation preparation liquid chromatograph handles solution through the single channel more to separate and the analysis to solution, work efficiency is lower, is difficult to satisfy the user demand, and current circulation preparation liquid chromatograph's advance kind work moreover mostly is semi-automatization working method, needs the manual work to assist, and efficiency and precision are not enough, and the practicality is not enough.
Disclosure of Invention
The present invention has been made to solve the above problems, and an object of the present invention is to provide a preparative cycle liquid chromatograph.
The invention realizes the purpose through the following technical scheme:
a circularly prepared liquid chromatograph comprises a first shell, a first cleaning pump and a first support plate, wherein a first solvent bottle is lapped on one side of the upper end of the first shell, a second solvent bottle which is lapped with the first shell is arranged on one side of the solvent bottle, the inner bottom end of the first shell is connected with the first cleaning pump through a screw, a first solvent degasser is connected on one side wall of the cleaning pump through a screw, a first high-pressure pump is arranged on one side of the first solvent degasser, a first piston is arranged on one side of the first solvent degasser far away from the high-pressure pump, a three-way joint is arranged on one side above the first piston, the first support plate is arranged above the three-way joint, the upper end of the first support plate is connected with a second cleaning pump through a screw, and a second solvent degasser is connected to the side wall of the second cleaning pump through a screw, a second high-pressure pump is arranged on one side of the second solvent degasser, and a second piston is arranged on one side, far away from the second high-pressure pump, of the second solvent degasser.
Furthermore, the first high-pressure pump, the first piston and the three-way joint are all connected with the inner wall of the first shell through screws, the first high-pressure pump is connected with the first solvent bottle and the first solvent degasser through pipelines, and the first piston is connected with the first solvent degasser and the three-way joint through pipelines.
By adopting the technical scheme, when the first high-pressure pump works, the solution in the first solvent bottle can be conveyed to the first solvent degasser for degassing.
Furthermore, the first support plate is welded with the first shell, the second high-pressure pump and the second piston are connected with the inner wall of the first shell through screws, the second high-pressure pump is connected with the second solvent bottle and the second solvent degasser through pipelines, and the second piston is connected with the second solvent degasser and the tee joint through pipelines.
By adopting the technical scheme, when the second high-pressure pump works, the solution in the second solvent bottle can be conveyed to the second solvent degasser for degassing.
Furthermore, a first box door is connected to the side walls of the first shell through hinges, the number of the first box doors is two, a connecting shell is welded to the lower end of the other side wall of the first shell, and the end, far away from the first shell, of the connecting shell is provided with a second shell.
By adopting the technical scheme, the parts in the first shell can be conveniently maintained after the first box door is opened.
Furthermore, the second shell is welded with the connecting shell, a second box door is connected to the side wall of the second shell through a hinge, a second supporting plate is arranged in the second shell, a sample seat is connected to one side of the upper end of the second supporting plate through a screw, and a sample bottle is connected to the sample seat through a clamping groove.
By adopting the technical scheme, the parts in the second shell can be conveniently maintained after the second box door is opened.
Further, the sample bottle upper end is provided with the manipulator, manipulator one side is provided with the injector, injector one side is provided with the switching-over valve, the manipulator and injector upper end all with the top passes through the screw connection in the shell two, injector below be provided with the fixing base of screw connection is passed through to backup pad two.
By adopting the technical scheme, the manipulator can grab the sample bottle during working and move the sample bottle between the sample seat and the fixed seat as required.
Furthermore, an ultraviolet-visible detector is arranged below the second supporting plate, a liquid phase column connected with the reversing valve and the ultraviolet-visible detector through pipelines is arranged on one side, away from the connecting shell, of the second shell, and the ultraviolet-visible detector is connected with the inner wall of the second shell through screws.
By adopting the technical scheme, the ultraviolet-visible detector can detect the liquid in the liquid phase column and transmit the detection result to an external computer for analysis.
Furthermore, a third support plate is arranged below the ultraviolet-visible detector, the second support plate and the third support plate are welded to the inner wall of the second shell, a component collector is arranged at the lower end of the third support plate, and the upper end of the component collector is connected with the lower end of the third support plate through screws.
By adopting the technical scheme, the third support plate provides support for the component collector.
Furthermore, a component seat is arranged below the component collector, a component bottle is arranged at the upper end of the component seat, the lower end of the component seat is connected with the inner bottom end of the second outer shell through a screw, and the lower end of the component bottle is connected with the component bottle through a clamping groove.
Through adopting above-mentioned technical scheme, the component bottle can follow convenient the taking off on the component seat.
Furthermore, the reversing valve, the three-way joint and the sample injector are connected through pipelines, and the component collector and the ultraviolet-visible detector are connected through pipelines.
By adopting the technical scheme, the component collector can separate the liquid passing through the ultraviolet-visible detector according to components and then fill the liquid into different component bottles.
The specific working principle is as follows: the recycling preparation liquid chromatograph uses an external power supply to work and is controlled by external equipment, the equipment can convey the solution in the solvent bottle I to the solvent degasser I for degassing at high pressure by the high-pressure pump I when working, the solution in the solvent bottle II can be conveyed to the solvent degasser II for degassing by the high-pressure pump II when working, the high-pressure pump I and the high-pressure pump II can respectively work, thus the equipment can process the solution through double channels, the efficiency is high, the solution processed by the solvent degasser I and the solvent degasser II can enter the reversing valve through the three-way joint and the pipeline and then enter the sample injector and the liquid phase column, the manipulator can conveniently take and place the sample bottle when working, the automation degree is extremely high, and the ultraviolet visible detector can detect the liquid in the liquid phase column, and the detection result is transmitted to an external computer for analysis, and then the component collector can separate the liquid passing through the ultraviolet-visible detector according to components and fill the liquid into different component bottles.
The invention has the beneficial effects that:
1. the high-pressure pump I, the high-pressure pump II, the solvent degasser I, the solvent degasser II, the piston I, the piston II, the cleaning pump I, the cleaning pump II and the tee joint are arranged, so that the equipment can quickly process the solution through double channels, the processing efficiency is extremely high, the high-pressure pump I and the high-pressure pump II have high efficiency, the working efficiency of the equipment can be further improved, and the equipment is very practical;
2. through setting up the manipulator, make equipment can make manipulator cooperation injector automize according to the work needs and carry out work, improved the degree of automation of circulation preparation liquid chromatograph greatly, and the manipulator can be by external control equipment's program control, and is very high-efficient, and is more high-efficient accurate for manual work.
Drawings
FIG. 1 is a schematic diagram of a cyclic preparative liquid chromatograph according to the present invention;
FIG. 2 is a cross-sectional view of a first housing and a coupling housing of a cyclic preparative liquid chromatograph in accordance with the present invention;
fig. 3 is a cross-sectional view of a second housing of a cycler liquid chromatograph in accordance with the present invention.
The reference numerals are explained below:
1. a first shell; 2. a first solvent bottle; 3. a second solvent bottle; 4. cleaning a first pump; 5. a first solvent degasser; 6. a first high-pressure pump; 7. a first piston; 8. a three-way joint; 9. a first support plate; 10. cleaning a second pump; 11. a second solvent degasser; 12. a second high-pressure pump; 13. a second piston; 14. a first box door; 15. a connecting shell; 16. a second shell; 17. a second box door; 18. a second support plate; 19. a sample holder; 20. a sample bottle; 21. a manipulator; 22. a sample injector; 23. a diverter valve; 24. a fixed seat; 25. an ultraviolet-visible detector; 26. a liquid phase column; 27. a third support plate; 28. a component collector; 29. a component seat; 30. and (4) component bottles.
Detailed Description
The invention will be further described with reference to the accompanying drawings in which:
as shown in fig. 1-3, a preparative cycle liquid chromatograph comprises a first shell 1, a first cleaning pump 4 and a first support plate 9, wherein a first solvent bottle 2 is lapped on one side of the upper end of the first shell 1, a second solvent bottle 3 lapped with the first shell 1 is arranged on one side of the first solvent bottle 2, the first cleaning pump 4 is connected with the inner bottom end of the first shell 1 through screws, a first solvent degasser 5 is connected with the side wall of the first cleaning pump 4 through screws, a first high-pressure pump 6 is arranged on one side of the first solvent degasser 5, a first piston 7 is arranged on one side of the first solvent degasser 5 far away from the first high-pressure pump 6, a three-way joint 8 is arranged on one side above the first piston 7, the first support plate 9 is arranged above the three-way joint 8, a second cleaning pump 10 is connected with the upper end of the first support plate 9 through screws, and a second solvent degasser 11 is connected with one side wall, and a second high-pressure pump 12 is arranged on one side of the second solvent degasser 11, and a second piston 13 is arranged on one side of the second solvent degasser 11, which is far away from the second high-pressure pump 12.
In this embodiment, the high-pressure pump 6, the piston 7 and the three-way joint 8 are all connected with the inner wall of the housing 1 through screws, the high-pressure pump 6 is connected with the solvent bottle 2 and the solvent degasser 5 through pipes, the piston 7 is connected with the solvent degasser 5 and the three-way joint 8 through pipes, the high-pressure pump 6 can convey the solution in the solvent bottle 2 to the solvent degasser 5 for degassing at high pressure during operation, and the piston 7 can assist the operation of the solvent degasser 5.
In this embodiment, the support plate one 9 is welded to the housing one 1, the heads of the high-pressure pump two 12 and the piston two 13 are connected to the inner wall of the housing one 1 through screws, the heads of the high-pressure pump two 12 are connected to the solvent bottle two 3 and the solvent degasser two 11 through pipes, the heads of the piston two 13 are connected to the solvent degasser two 11 and the tee joint 8 through pipes, the high-pressure pump two 12 can convey the solution in the solvent bottle two 3 to the solvent degasser two 11 for degassing when in operation, and the piston two 13 can assist the operation of the solvent degasser two 11.
In this embodiment, there are first chamber doors 14 on one side wall of the first housing 1 through hinge connection, the number of the first chamber doors 14 is two, a connecting shell 15 is welded at the lower end of the other side wall of the first housing 1, the connecting shell 15 is far away from one end of the first housing 1 is provided with a second housing 16, and the parts in the first housing 1 can be conveniently maintained after the first chamber doors 14 are opened.
In this embodiment, the second housing 16 is welded to the connecting shell 15, a second box door 17 is connected to one side wall of the second housing 16 through a hinge, a second supporting plate 18 is arranged in the second housing 16, a sample holder 19 is connected to one side of the upper end of the second supporting plate 18 through a screw, a sample bottle 20 is connected to the sample holder 19 through a clamping groove, the second housing door 17 can be conveniently opened to conveniently maintain components in the second housing 16, the sample bottle 20 can be taken from the sample holder 19, and the sample holder 19 can prevent the sample bottle 20 from toppling over.
In this embodiment, 20 upper ends of sample bottles are provided with manipulator 21, 21 one side of manipulator is provided with injector 22, injector 22 one side is provided with switching-over valve 23, manipulator 21 and injector 22 upper end all with the top passes through screwed connection in two 16 shells, injector 22 below be provided with two 18 fixing bases 24 through screwed connection of backup pad, manipulator 21 can be right at the during operation sample bottles 20 snatchs, and will as required sample bottles 20 be in sample seat 19 with remove between the fixing base 24, when sample bottles 20 move to when on the fixing base 24, injector 22 can advance its sample fast.
In this embodiment, an ultraviolet-visible detector 25 is arranged below the second support plate 18, a liquid phase column 26 connected with the reversing valve 23 and the ultraviolet-visible detector 25 through pipes is arranged on one side, away from the connecting shell 15, of the second housing 16, the ultraviolet-visible detector 25 is connected with the inner wall of the second housing 16 through screws, and the ultraviolet-visible detector 25 can detect liquid in the liquid phase column 26 and transmit a detection result to an external computer for analysis.
In this embodiment, a third support plate 27 is disposed below the ultraviolet-visible detector 25, the second support plate 18 and the third support plate 27 are both welded to the inner wall of the second housing 16, a component collector 28 is disposed at the lower end of the third support plate 27, the upper end of the component collector 28 is connected to the lower end of the third support plate 27 through a screw, and the third support plate 27 provides support for the component collector 28.
In this embodiment, a component seat 29 is disposed below the component collector 28, a component bottle 30 is disposed at the upper end of the component seat 29, the lower end of the component seat 29 is connected with the inner bottom end of the second housing 16 through a screw, the lower end of the component bottle 30 is connected with the component bottle 30 through a clamping groove, the component bottle 30 can be conveniently taken down from the component seat 29, and the component seat 29 can prevent the component bottle 30 from toppling over.
In this embodiment, the reversing valve 23, the three-way joint 8 and the sample injector 22 are connected by pipelines, the component collector 28 and the uv-vis detector 25 are connected by pipelines, and the component collector 28 can separate the liquid passing through the uv-vis detector 25 into different component bottles 30 according to components.
The specific working principle is as follows: the recycling preparation liquid chromatograph works by using an external power supply and is controlled by an external device, the device works, the first high-pressure pump 6 can convey the solution in the first solvent bottle 2 to the first solvent degasser 5 for degassing, the second high-pressure pump 12 can convey the solution in the second solvent bottle 3 to the second solvent degasser 11 for degassing, the first high-pressure pump 6 and the second high-pressure pump 12 can work respectively, so that the device can process the solution through double channels, the efficiency is high, the solution processed by the first solvent degasser 5 and the second solvent degasser 11 can enter the reversing valve 23 through the three-way joint 8 and a pipeline and then enter the sample injector 22 and the liquid phase column 26, the manipulator 21 can conveniently take and place the sample bottle 20 during working, and the automation degree is very high, the uv-vis detector 25 may detect the liquid in the liquid phase column 26 and transmit the detection result to an external computer for analysis, and then the component collector 28 may separate the liquid passing through the uv-vis detector 25 into different component bottles 30.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (10)
1. A cyclic preparative liquid chromatograph is characterized in that: the cleaning device comprises a first shell (1), a first cleaning pump (4) and a first support plate (9), wherein a first solvent bottle (2) is lapped on one side of the upper end of the first shell (1), a second solvent bottle (3) lapped with the first shell (1) is arranged on one side of the first solvent bottle (2), the inner bottom end of the first shell (1) is connected with the first cleaning pump (4) through screws, a first solvent degasser (5) is connected onto the side wall of the first cleaning pump (4) through screws, a first high-pressure pump (6) is arranged on one side of the first solvent degasser (5), a first piston (7) is arranged on one side of the first solvent degasser (5) far away from the first high-pressure pump (6), a three-way joint (8) is arranged on one side above the first piston (7), the first support plate (9) is arranged above the three-way joint (8), and a second cleaning pump (10) is connected onto the, and a second solvent degasser (11) is connected to one side wall of the second cleaning pump (10) through a screw, a second high-pressure pump (12) is arranged on one side of the second solvent degasser (11), and a second piston (13) is arranged on one side, far away from the second high-pressure pump (12), of the second solvent degasser (11).
2. The chromatograph of claim 1, wherein: the high-pressure pump I (6), the piston I (7) and the three-way joint (8) are connected with the inner wall of the shell I (1) through screws, the high-pressure pump I (6), the solvent bottle I (2) and the solvent degasser I (5) are connected through pipelines, and the piston I (7), the solvent degasser I (5) and the three-way joint (8) are connected through pipelines.
3. The chromatograph of claim 2, wherein: the supporting plate I (9) is welded with the shell I (1), the heads of the high-pressure pump II (12) and the piston II (13) are connected with the inner wall of the shell I (1) through screws, the high-pressure pump II (12) is connected with the solvent bottle II (3) and the solvent degasser II (11) through pipelines, and the piston II (13) is connected with the solvent degasser II (11) and the tee joint (8) through pipelines.
4. The chromatograph of claim 3, wherein: the refrigerator door is characterized in that a first box door (14) is connected to one side wall of the first shell (1), the number of the first box door (14) is two, a connecting shell (15) is welded to the lower end of the other side wall of the first shell (1), and the connecting shell (15) is far away from one end of the first shell (1) and is provided with a second shell (16).
5. The chromatograph of claim 4, wherein: the second shell (16) is welded with the connecting shell (15), a second box door (17) is connected to one side wall of the second shell (16) through a hinge, a second supporting plate (18) is arranged in the second shell (16), one side of the upper end of the second supporting plate (18) is connected with a sample seat (19) through a screw, and the sample seat (19) is connected with a sample bottle (20) through a clamping groove.
6. The chromatograph of claim 5, wherein: sample bottle (20) upper end is provided with manipulator (21), manipulator (21) one side is provided with injector (22), injector (22) one side is provided with switching-over valve (23), manipulator (21) and injector (22) upper end all with the top passes through the screw connection in shell two (16), injector (22) below be provided with backup pad two (18) pass through screwed connection's fixing base (24).
7. The chromatograph of claim 6, wherein: an ultraviolet-visible detector (25) is arranged below the second support plate (18), one side, far away from the connecting shell (15), of the second shell (16) is provided with a liquid phase column (26) which is connected with the reversing valve (23) and the ultraviolet-visible detector (25) through pipelines, and the ultraviolet-visible detector (25) is connected with the inner wall of the second shell (16) through screws.
8. The chromatograph of claim 7, wherein: a third support plate (27) is arranged below the ultraviolet-visible detector (25), the second support plate (18) and the third support plate (27) are welded to the inner wall of the second shell (16), a component collector (28) is arranged at the lower end of the third support plate (27), and the upper end of the component collector (28) is connected with the lower end of the third support plate (27) through screws.
9. The chromatograph of claim 8, wherein: a component seat (29) is arranged below the component collector (28), a component bottle (30) is arranged at the upper end of the component seat (29), the lower end of the component seat (29) is connected with the inner bottom end of the second shell (16) through a screw, and the lower end of the component bottle (30) is connected with the component bottle (30) through a clamping groove.
10. The chromatograph of claim 9, wherein: the reversing valve (23) is connected with the three-way joint (8) and the sample injector (22) through pipelines, and the component collector (28) is connected with the ultraviolet-visible detector (25) through a pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201911394537.XA CN110887917A (en) | 2019-12-30 | 2019-12-30 | Liquid chromatograph for cyclic preparation |
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| CN201911394537.XA CN110887917A (en) | 2019-12-30 | 2019-12-30 | Liquid chromatograph for cyclic preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202022101211U1 (en) | 2022-03-04 | 2023-06-07 | Dionex Softron Gmbh | Washing an element in a chromatography system |
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