CN110882363A - A pharmaceutical composition with itching relieving effect - Google Patents

A pharmaceutical composition with itching relieving effect Download PDF

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Publication number
CN110882363A
CN110882363A CN201911368065.0A CN201911368065A CN110882363A CN 110882363 A CN110882363 A CN 110882363A CN 201911368065 A CN201911368065 A CN 201911368065A CN 110882363 A CN110882363 A CN 110882363A
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parts
pharmaceutical composition
preparation
prepared
skin
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张林昊
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West China Hospital of Sichuan University
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West China Hospital of Sichuan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)
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Abstract

The invention discloses a pharmaceutical composition with an itch dispelling effect, which is prepared from the following raw materials in parts by weight: 7-13 parts of fructus cnidii, 7-13 parts of fructus kochiae, 7-13 parts of radix sophorae flavescentis, 7-13 parts of radix stemonae, 7-13 parts of rhizoma atractylodis, 7-13 parts of cortex cercis chinensis and 7-13 parts of paniculate swallowwort root. The invention also provides a preparation method and application of the composition. The pharmaceutical composition can effectively treat skin itch, and has high cure rate and good clinical application prospect.

Description

A pharmaceutical composition with itching relieving effect
Technical Field
The invention particularly relates to a pharmaceutical composition with an itch dispelling effect.
Background
Pruritus is a dermatological condition in which there is only itching of the skin and no primary skin lesions. Generally, the skin itch is classified into general and limited types according to the extent and location of the skin itch.
The external treatment and the systemic treatment are generally local anesthetics, antihistamines, calcium agents, vitamin C, sodium thiosulfate, sedative hypnotic and other medicines, and the medicines have obvious side effects on human bodies, but physical treatment phototherapy has high cost, inconvenient treatment and poor compliance of patients.
The traditional Chinese medicine is the traditional treasure of Chinese nationality, and is increasingly accepted and accepted by the international society because of the curative effect and the function in preventing and treating common diseases, frequently encountered diseases, chronic diseases and major diseases. At present, the traditional Chinese medicine achieves the purpose of dispelling itch mainly through cooling and reducing temperature, and cannot fundamentally improve the symptom of skin itch.
Disclosure of Invention
In order to solve the problems, the invention provides a pharmaceutical composition with an itch-dispelling effect, which is prepared from the following raw materials in parts by weight: 7-13 parts of fructus cnidii, 7-13 parts of fructus kochiae, 7-13 parts of radix sophorae flavescentis, 7-13 parts of radix stemonae, 7-13 parts of rhizoma atractylodis, 7-13 parts of cortex cercis chinensis and 7-13 parts of paniculate swallowwort root.
Further, the feed additive is prepared from the following raw materials in parts by weight: 10 parts of common cnidium fruit, 10 parts of belvedere fruit, 10 parts of lightyellow sophora root, 10 parts of sessile stemona root, 10 parts of swordlike atractylodes rhizome, 10 parts of Chinese redbud bark and 10 parts of paniculate swallowwort root.
Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
Further, the preparation is an external preparation.
Further, the external preparation is a patch, powder or solution, preferably a solution.
Furthermore, the solution is a preparation prepared by taking the raw material medicines as active ingredients and adding wine.
The invention provides a preparation method of the solution, which comprises the following steps:
weighing the raw materials according to the proportion, adding 6-8 times of alcohol to soak for 7-14 days, filtering, and taking the filtrate to obtain the traditional Chinese medicine composition.
Further, the mixture was soaked in 7 times of alcohol for 7 days.
The invention also provides application of the pharmaceutical composition in preparing a medicament for dispelling wind, relieving itching or treating tinea.
Further, the medicament is a medicament for treating skin itch.
In the medicinal composition, all the medicines have the effects of dispelling wind, arresting itching and treating tinea, wherein the belvedere fruit, the lightyellow sophora root, the common cnidium fruit, the sessile stemona root and the Chinese redbud bark are bitter in nature, and the swordlike atractylodes rhizome and the paniculate swallowwort root are warm in nature. Bitter with strong yin and warm with activating collaterals, the medicine soaked in pungent-heat collateral-dredging wine can be used for treating skin malnutrition due to deficiency of qi, blood and yin and yang, or skin pruritus due to meridian obstruction due to invasion of internal and external toxic turbidity.
Clinical tests prove that: the effective rate of the medicinal liquor prepared from the composition for treating skin itch reaches 92.2%, the effect is very obvious, and the clinical application prospect is excellent.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of the medicament of the invention
The formula is as follows: 10g of fructus cnidii, 10g of fructus kochiae, 10g of radix sophorae flavescentis, 10g of radix stemonae, 10g of rhizoma atractylodis, 10g of cortex cercis chinensis and 10g of paniculate swallowwort root.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, mixing uniformly, adding 500ml of alcohol, sealing, soaking in cold dark for 7 days, unsealing after 7 days, filtering, and placing the filtrate in cold dark for sealed storage;
the using method comprises the following steps: the cotton bud is dipped with appropriate amount of medicated liquor, and is directly applied to affected part for 3 times per day for 30 days.
Example 2 preparation of the inventive Agents
The formula is as follows: 7g of fructus cnidii, 7g of fructus kochiae, 7g of radix sophorae flavescentis, 7g of radix stemonae, 7g of rhizoma atractylodis, 7g of cortex cercis chinensis and 7g of paniculate swallowwort root.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, mixing uniformly, adding 350ml of alcohol, sealing, soaking in cold dark for 7 days, unsealing after 7 days, filtering, and placing the filtrate in cold dark for sealed storage;
the using method comprises the following steps: the cotton bud is dipped with appropriate amount of medicated liquor, and is directly applied to affected part for 3 times per day for 30 days.
Example 3 preparation of the inventive Agents
The formula is as follows: fructus cnidii 13g, fructus kochiae 13g, radix sophorae flavescentis 13g, radix stemonae 13g, rhizoma atractylodis 13g, cortex cercis chinensis 13g and paniculate swallowwort 13 g.
The preparation method comprises the following steps: weighing raw materials according to a ratio, mixing well, adding 650ml of alcohol, sealing, soaking in cold dark for 7 days, unsealing after 7 days, filtering, and storing the filtrate in cold dark in a sealed manner;
the using method comprises the following steps: the cotton bud is dipped with appropriate amount of medicated liquor, and is directly applied to affected part for 3 times per day for 30 days.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1 clinical test of the present invention
1. The acceptance and treatment standard is as follows: the symptoms of various patients with skin pruritus are mainly intolerable skin pruritus.
Skin itch: the symptoms refer to the abnormal sensory skin diseases which have no primary damage clinically and are mainly pruritus, and the patients can scratch by themselves to have secondary clinical symptoms such as scratch, blood crust and the like.
Patients were received 180 persons according to the criteria previously described.
2. The treatment method comprises the following steps:
the drug was prepared as in example 1 and the patient was treated as per the protocol for 30 days.
Before treatment, the skin pruritus parts of the patients and the frequency and subjective severity of pruritus are recorded in detail, and the skin damage of the skin pruritus parts is photographed for a long time.
After the treatment is finished, the skin pruritus part of the patient and the frequency and subjective severity of pruritus are inquired again in detail, and the skin condition of the same part before and after the treatment is compared.
3. The efficacy was evaluated as follows:
(1) the effect is shown: the skin itch disappears, and the patient does not feel the skin itch any more subjectively, and the skin of the patient does not have secondary skin damage caused by scratching, blood crusting and the like.
(2) The method has the following advantages: the skin itch is not completely relieved, and the skin itch is still felt by patients and is relieved compared with the skin itch before the medicine is taken; the skin of the patient still has scratch marks, blood scabs and other secondary skin damages caused by scratching, but the skin damage is reduced compared with the skin damage before medication.
(3) And (4) invalidation: the skin itch is not different before and after the application of the medicine.
4. Therapeutic effect
The total treatment rate of 180 patients is 97 cases with obvious effect (stopping skin pruritus), 69 cases with effective effect (relieving skin pruritus) and 14 cases with ineffective effect (no relieving skin pruritus), and the total effective rate is as follows: 92.2 percent.
From the above clinical trials it can be seen that: the medicinal liquor has the obvious effect of treating skin itch.
Test example 2A recipe screening test of the present invention
(1) Comparative group 1:
the formula is as follows: 15g of fructus cnidii, 10g of fructus kochiae, 10g of radix sophorae flavescentis, 5g of radix stemonae, 10g of rhizoma atractylodis, 10g of cortex cercis chinensis and 5g of cynanchum paniculatum;
the preparation and use method comprises the following steps: same as example 1
When 32 persons were treated with the formulations of example 1 and comparative group 1, respectively, it was found that: example 1 group 29 persons with cessation or alleviation of cutaneous pruritus; in comparative group 1, 21 people stopped or reduced skin itch.
(2) Comparative group 2:
the formula is as follows: fructus cnidii 15g fructus kochiae 15g radix sophorae flavescentis 10g radix stemonae 5g rhizoma atractylodis 10g cortex cercis chinensis 5g paniculate swallowwort 15g
The preparation and use method comprises the following steps: same as example 1
When 32 persons were treated with the formulations of example 1 and comparative group 2, respectively, it was found that: 29 persons with cessation or alleviation of cutaneous pruritus in the example 1 group; in comparative group 2, 20 persons had stopped or reduced skin itch.
(3) Comparative group 3:
the formula is as follows: 10g of fructus cnidii, 10g of fructus kochiae, 5g of radix sophorae flavescentis, 15g of radix stemonae, 5g of rhizoma atractylodis, 5g of cortex cercis chinensis and 15g of cynanchum paniculatum;
the preparation and use method comprises the following steps: same as example 1
When 32 persons were treated with the formulations of example 1 and comparative group 3, respectively, it was found that: 29 persons with cessation or alleviation of cutaneous pruritus in the example 1 group; in comparative group 3, 18 persons had stopped or reduced skin itch. .
From the above results it can be seen that: the efficacy of the composition can be changed by slight change of the proportion of the medicines in the composition, the medicines in the composition cannot be added, deleted, replaced and combined at will, and the dosage of the medicines cannot be changed at will.
In conclusion, the composition disclosed by the invention is precise and appropriate in compatibility, remarkable in skin itch treatment effect, convenient to use, free of toxic and side effects and has practical application and popularization values.

Claims (10)

1. A pharmaceutical composition with an itch-dispelling effect is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 7-13 parts of fructus cnidii, 7-13 parts of fructus kochiae, 7-13 parts of radix sophorae flavescentis, 7-13 parts of radix stemonae, 7-13 parts of rhizoma atractylodis, 7-13 parts of cortex cercis chinensis and 7-13 parts of paniculate swallowwort root.
2. The pharmaceutical composition of claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10 parts of common cnidium fruit, 10 parts of belvedere fruit, 10 parts of lightyellow sophora root, 10 parts of sessile stemona root, 10 parts of swordlike atractylodes rhizome, 10 parts of Chinese redbud bark and 10 parts of paniculate swallowwort root.
3. The pharmaceutical composition according to claim 1 or 2, characterized in that: the preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
4. The pharmaceutical composition according to any one of claims 1 to 3, wherein: the preparation is an external preparation.
5. The pharmaceutical composition of claim 4, wherein: the external preparation is emplastrum, powder or solution, preferably solution.
6. The pharmaceutical composition of claim 5, wherein: the solution is prepared by taking raw material medicines as effective components and adding wine.
7. A method for producing a solution according to claim 5 or 6, characterized in that: it comprises the following steps:
weighing the raw materials according to the weight ratio of claim 1, adding 6-8 times of alcohol, soaking for 7-14 days, and filtering to obtain filtrate.
8. The method of claim 7, wherein: and 7 times of alcohol is added for soaking for 7 days.
9. Use of the pharmaceutical composition of any one of claims 1 to 6 for the preparation of a medicament for expelling wind, relieving itching or treating tinea.
10. Use according to claim 9, characterized in that: the medicine is used for treating skin pruritus.
CN201911368065.0A 2019-12-26 2019-12-26 A pharmaceutical composition with itching relieving effect Pending CN110882363A (en)

Priority Applications (1)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101554463A (en) * 2009-05-26 2009-10-14 贵州本草堂药业有限公司 Drug for treating gynecologic and andrological diseases and preparation method thereof
CN103316266A (en) * 2013-06-28 2013-09-25 李时珍医药集团有限公司 Chinese herbal medicine antibacterial lotion and preparation technology thereof
CN105435033A (en) * 2015-12-04 2016-03-30 管遵信 Itching-relieving liniment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101554463A (en) * 2009-05-26 2009-10-14 贵州本草堂药业有限公司 Drug for treating gynecologic and andrological diseases and preparation method thereof
CN103316266A (en) * 2013-06-28 2013-09-25 李时珍医药集团有限公司 Chinese herbal medicine antibacterial lotion and preparation technology thereof
CN105435033A (en) * 2015-12-04 2016-03-30 管遵信 Itching-relieving liniment

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张青等: "蛇部汤浸泡治疗手足癣60例", 《山西中医》 *
柴承光: "中药坐浴治疗急性***湿疹80例 ", 《皖南医学院学报》 *
虞绍铸等: "复方止痒散的制备及临床应用", 《中国药业》 *

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Application publication date: 20200317