CN110876814A - Liquid band-aid rich in antibacterial peptide and preparation method thereof - Google Patents
Liquid band-aid rich in antibacterial peptide and preparation method thereof Download PDFInfo
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- CN110876814A CN110876814A CN201911296756.4A CN201911296756A CN110876814A CN 110876814 A CN110876814 A CN 110876814A CN 201911296756 A CN201911296756 A CN 201911296756A CN 110876814 A CN110876814 A CN 110876814A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
Abstract
The invention relates to a liquid band-aid rich in antibacterial peptide and a preparation method thereof. The preparation method comprises the following steps: adding a film forming agent into a solvent, maintaining the temperature at 25-30 ℃, stirring for dissolving, after the components are stable, sequentially adding antibacterial peptide, an anti-inflammatory component and a sterilizing disinfectant, and performing ultrasonic dispersion to completely dissolve each component to form a component I; adding a thickening agent into a solvent, heating to 80-90 ℃, and stirring for dissolving to form a second component; adding the component two into the component one, and mixing uniformly. The liquid band-aid is added with the antibacterial peptide, the antibacterial peptide is obtained by culturing the antibacterial peptide in human bone marrow cells through a process technology, the whole process has no chemical action and is naturally prepared, and the antibacterial and anti-inflammatory capability of the liquid band-aid can be effectively enhanced, pain is relieved, and wound healing is accelerated.
Description
Technical Field
The invention relates to the technical field of biological medicine and medical technology science, in particular to a liquid band-aid rich in antibacterial peptide and a preparation method thereof.
Background
In daily life of people, wounds often appear on the skin of people due to the influence of various factors. Tissue necrosis and vascular rupture bleeding occur to different degrees on the surface of the wound, so that the wound is red, swollen and hot, and inflammation is caused. Therefore, the rapid sterilization and disinfection of the wound surface are realized, the red swelling and hot pain caused by inflammation are eliminated, and the wound healing is promoted, which becomes a great important research topic in the field of wound surface repair.
Compared with the traditional adhesive tape band-aid, the liquid band-aid avoids the trouble of changing the medicine, and overcomes the defects of adhesion wound, water resistance or water and air impermeability, susceptibility to bacteria, whitening and allergy of wound skin and the like caused by long-time adhesion of the adhesive tape band-aid.
Patent CN 105999393 a discloses a liquid adhesive bandage and a preparation method thereof, which comprises the following raw material components: acrylic copolymer, polyvinyl alcohol and polyethylene glycol copolymer, polysorbate 80, glycerol, sodium bicarbonate, sodium hydroxide and purified water. However, the active ingredients of the invention are chemically synthesized, the synthesis method is complicated, and the sensitive skin can also have the problems of red swelling, pruritus and the like.
Therefore, a liquid band-aid which is simple in preparation method and rich in natural biological preparation components is urgently needed at present.
Disclosure of Invention
The invention aims to provide a liquid band-aid rich in antibacterial peptide aiming at the defects of the prior art, and aims to achieve the purposes of diminishing inflammation, inhibiting bacteria and accelerating wound healing by adopting self-bioactive substances.
The invention is realized by the following technical scheme:
the liquid band-aid rich in antibacterial peptide is characterized by comprising antibacterial peptide, an anti-inflammatory component, a bactericidal disinfectant, a film-forming agent, a thickening agent and a solvent, wherein the antibacterial peptide is obtained by fermenting, culturing, inducing, expressing and purifying the antibacterial peptide in human bone marrow cells through a biological engineering technology, has no chemical action in the whole process and is naturally prepared.
The further technical scheme is as follows: the antibacterial peptide-containing emulsion comprises, by weight, 0.001-1% of antibacterial peptide, 5-10% of an anti-inflammatory component, 0.1-2% of a bactericidal disinfectant, 4-8% of a film-forming agent, 0.1-0.2% of a thickening agent and 60-95% of a solvent.
The further technical scheme is as follows: the anti-inflammatory component is bioactive hyaluronic acid which is a substance for regulating human body immunity, and the small molecular hyaluronic acid formed by processing through a special enzymolysis process is lower in molecular weight, easier to permeate pores and absorbed by skin mucous membrane, and better in anti-inflammatory effect when matched with antibacterial peptide.
The further technical scheme is as follows: the disinfectant is one of benzalkonium chloride, polyhexamethylene biguanide and methyl p-hydroxybenzoate.
The further technical scheme is as follows: the film forming agent is one of polyvinylpyrrolidone and chitosan.
The further technical scheme is as follows: the thickening agent is one of sodium alginate and sodium carboxymethyl cellulose.
The further technical scheme is as follows: the solvent is ethanol water solution.
The further technical scheme is as follows: the preparation method of the liquid wound plaster rich in the antibacterial peptide comprises the following steps:
(1) adding a film forming agent into a solvent, heating to 25-30 ℃, stirring for dissolving, after the components are stable, sequentially adding antibacterial peptide, an anti-inflammatory component and a sterilizing disinfectant, and carrying out ultrasonic dispersion at 35-55 kHz to completely dissolve each component to form a component I;
(2) adding a thickening agent into a solvent, heating to 80-90 ℃ in a water bath, and stirring for dissolving to form a second component;
(3) and finally, adding the component two into the component one, and uniformly mixing.
Compared with the prior art, the liquid adhesive bandage rich in antibacterial peptide has the beneficial effects that:
the liquid band-aid rich in antibacterial peptide prepared by the invention achieves the purposes of promoting wound healing, inhibiting bacteria and diminishing inflammation by adopting bioactive substance antibacterial peptide, is prepared naturally, replaces the complexity of chemical synthesis, and avoids the problems of red swelling, pruritus and the like of sensitive skin.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example one
A liquid wound plaster rich in antibacterial peptide comprises the following components in percentage by weight: 0.001% of antibacterial peptide, 10% of bioactive hyaluronic acid, 0.1% of benzalkonium chloride, 4% of polyvinylpyrrolidone, 0.1% of sodium alginate and the balance of solvent. The antibacterial peptide is in a powder shape. Adding polyvinylpyrrolidone in the proportion into a solvent, heating to 25-30 ℃, stirring for dissolving, adding antibacterial peptide, bioactive hyaluronic acid and benzalkonium chloride after the components are stable, and ultrasonically dispersing at 35kHz to completely dissolve each component to form a component I; heating sodium alginate in water bath to 80-90 ℃, stirring and dissolving to form a second component; adding the component two into the component one, stirring uniformly, and standing for 1 hour to obtain the liquid wound plaster.
Example two
A liquid wound plaster rich in antibacterial peptide comprises the following components in percentage by weight: 0.5% of antibacterial peptide, 7% of bioactive hyaluronic acid, 1% of polyhexamethylene biguanide, 6% of chitosan, 0.15% of sodium carboxymethylcellulose and the balance of solvent. The antibacterial peptide is in a powder shape. Dissolving chitosan in the proportion with 1% acetic acid, adding the dissolved chitosan into a solvent, heating the mixture to 25-30 ℃, stirring the mixture for dissolving, adding antibacterial peptide, bioactive hyaluronic acid and polyhexamethylene biguanide after the components are stabilized, and ultrasonically dispersing the mixture at 45kHz to completely dissolve each component to form a component I; heating sodium carboxymethylcellulose to 80-90 ℃ in a water bath, and stirring to dissolve to form a second component; adding the component two into the component one, stirring uniformly, and standing for 1 hour to obtain the liquid wound plaster.
EXAMPLE III
A liquid wound plaster rich in antibacterial peptide comprises the following components in percentage by weight: 1% of antibacterial peptide, 5% of bioactive hyaluronic acid, 2% of methyl p-hydroxybenzoate, 8% of polyvinylpyrrolidone, 0.2% of sodium alginate and the balance of solvent. The antibacterial peptide is in a powder shape. Adding polyvinylpyrrolidone in the proportion into a solvent, heating to 25-30 ℃, stirring for dissolving, adding antibacterial peptide, bioactive hyaluronic acid and methyl p-hydroxybenzoate after the components are stable, and ultrasonically dispersing at 55kHz to completely dissolve each component to form a component I; heating sodium alginate in water bath to 80-90 ℃, stirring and dissolving to form a second component; adding the component two into the component one, stirring uniformly, and standing for 1 hour to obtain the liquid wound plaster.
Control group
A common liquid band-aid without antibacterial peptide comprises the following components in percentage by weight: 10% of bioactive hyaluronic acid, 2% of methyl p-hydroxybenzoate, 8% of polyvinylpyrrolidone, 0.2% of sodium alginate and the balance of solvent. The antibacterial peptide is in a powder shape. Adding polyvinylpyrrolidone in the proportion into a solvent, heating to 25-30 ℃, stirring for dissolving, adding antibacterial peptide, bioactive hyaluronic acid and methyl p-hydroxybenzoate after the components are stable, and ultrasonically dispersing at 55kHz to completely dissolve each component to form a component I; heating sodium alginate in water bath to 80-90 ℃, stirring and dissolving to form a second component; adding the component two into the component one, stirring uniformly, and standing for 1 hour to obtain the liquid wound plaster.
The following tests were made on the antimicrobial peptide-rich liquid wound dressings of the present invention:
clinical trial
1. Method of treatment
Clinical trials were conducted on all 80 patients with different wounds, and 60 groups of 3 groups of the experimental group were subjected to wound treatment using the liquid wound dressings described in examples one, two and three, respectively, and 20 groups of the control group were subjected to wound treatment using the liquid wound dressings containing no antimicrobial peptide.
2. Assessment of efficacy
The healing speed of the wound surfaces of each group is observed, and the states of the wound surfaces in the process of repairing are compared.
3. Results
(1) By counting the number of people that healed the wound surface over time, the wound surface healing speed was compared for each group:
the healing speed of the wound surface is compared (the healing time is respectively 12h, 24h, 36h and 48 h)
Statistical data show that the main core component of the invention, namely the antibacterial peptide, can obviously accelerate the healing speed of the wound surface, the content of the antibacterial peptide is gradually increased from the first embodiment to the third embodiment, the number of people cured in a short time is gradually increased, the wound surface of an experimental group using the liquid band-aid containing the antibacterial peptide is basically healed within 48h, the content of the antibacterial peptide is high, the cost is correspondingly increased, and the content can be determined according to actual conditions; the cure rate of the control group is obviously reduced, and the cure rate within 48h is only 45%.
(2) Through counting the number of people who have red, swollen and itching on the wound surfaces of the tested groups of liquid woundplasts within 48 hours, the wound surface repairing conditions of the groups are compared:
comparison of wound repair Process states
Statistical data show that the wounds of all experimental groups have no red swelling or itching phenomenon in the healing process, no wound infection occurs within 48 hours, and the total effective rate is 100%; in the healing process of the control group, 6 cases of wounds have obvious red and swollen phenomena and are accompanied by itching feeling, and the total effective rate is only 70 percent.
In conclusion, the liquid wound plaster rich in the antibacterial peptide is added with the naturally prepared antibacterial peptide to replace a chemically synthesized component, so that the wound healing can be effectively accelerated, and the problems of red swelling, pruritus and the like caused by the allergy of sensitive skin to chemical drugs are solved.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention in the specification or directly or indirectly applied to the related technical field are included in the scope of the present invention.
Claims (8)
1. The liquid band-aid rich in antibacterial peptide is characterized by comprising antibacterial peptide, an anti-inflammatory component, a bactericidal disinfectant, a film-forming agent, a thickening agent and a solvent, wherein the antibacterial peptide is obtained by fermenting, culturing, inducing, expressing and purifying the antibacterial peptide in human bone marrow cells through a biological engineering technology.
2. The liquid band-aid rich in antibacterial peptide according to claim 1, wherein the raw material components comprise, by weight, 0.001-1% of antibacterial peptide, 5% -10% of anti-inflammatory component, 0.1-2% of bactericidal disinfectant, 4-8% of film-forming agent, 0.1-0.2% of thickening agent and 60-95% of solvent.
3. The liquid band-aid rich in antibacterial peptides according to claim 2, wherein said anti-inflammatory component is bioactive hyaluronic acid.
4. The liquid woundplast rich in antibacterial peptide of claim 2, wherein the bactericidal disinfectant is one of benzalkonium chloride, polyhexamethylene biguanide, and methyl paraben.
5. The liquid woundplast rich in antibacterial peptide of claim 2, wherein the film forming agent is one of polyvinylpyrrolidone and chitosan.
6. The liquid woundplast rich in antibacterial peptide of claim 2, wherein the thickener is one of sodium alginate and sodium carboxymethylcellulose.
7. The liquid woundplast rich in antibacterial peptide of claim 2, wherein the solvent is an aqueous ethanol solution.
8. The method for preparing the liquid woundplast rich in antibacterial peptide of any one of claims 1 to 7, characterized by comprising the following steps:
(1) adding a film forming agent into a solvent, heating to 25-30 ℃, stirring for dissolving, after the components are stable, sequentially adding antibacterial peptide, an anti-inflammatory component and a sterilizing disinfectant, and carrying out ultrasonic dispersion at 35-55 kHz to completely dissolve each component to form a component I;
(2) adding a thickening agent into a solvent, heating to 80-90 ℃ in a water bath, and stirring for dissolving to form a second component;
(3) and finally, adding the component two into the component one, and uniformly mixing.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910607213 | 2019-07-07 | ||
| CN2019106072133 | 2019-07-07 |
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| CN110876814A true CN110876814A (en) | 2020-03-13 |
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| CN201911296756.4A Pending CN110876814A (en) | 2019-07-07 | 2019-12-16 | Liquid band-aid rich in antibacterial peptide and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111569145A (en) * | 2020-06-08 | 2020-08-25 | 浙江博纳生物科技有限公司 | Liquid dressing for body surface wound antibacterial repair and preparation method and application thereof |
| CN112891615A (en) * | 2021-01-14 | 2021-06-04 | 广州贝奥吉因生物科技股份有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN116473949A (en) * | 2023-06-20 | 2023-07-25 | 山东利尔康医疗科技股份有限公司 | Disinfectant containing antibacterial peptide and capable of forming film rapidly and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111569145A (en) * | 2020-06-08 | 2020-08-25 | 浙江博纳生物科技有限公司 | Liquid dressing for body surface wound antibacterial repair and preparation method and application thereof |
| CN112891615A (en) * | 2021-01-14 | 2021-06-04 | 广州贝奥吉因生物科技股份有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN116473949A (en) * | 2023-06-20 | 2023-07-25 | 山东利尔康医疗科技股份有限公司 | Disinfectant containing antibacterial peptide and capable of forming film rapidly and preparation method thereof |
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Application publication date: 20200313 |
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