CN110859659B

CN110859659B - Endoscope positioning slow-release medicine supply device

Info

Publication number: CN110859659B
Application number: CN201911165768.3A
Authority: CN
Inventors: 扈聪; 段康佳; 陈鹏
Original assignee: Shanghai Aohua Endoscopy Co ltd
Current assignee: Shanghai Aohua Endoscopy Co ltd
Priority date: 2019-11-25
Filing date: 2019-11-25
Publication date: 2022-08-12
Anticipated expiration: 2039-11-25
Also published as: CN110859659A

Abstract

The invention discloses an endoscope positioning slow-release medicine supply device, which comprises: the head assembly is arranged at the front end of the sheath tube and is provided with a medicine carrying cavity which can be opened and closed and a medicine feeding assembly arranged in the medicine carrying cavity; the inner core assembly is arranged in the sheath tube and is connected with the head assembly at the front end of the sheath tube, and the inner core assembly can drive the administration assembly in the head assembly to carry out administration action; the handle assembly is arranged at the rear end of the sheath tube and connected with the inner core assembly, and the drug carrying cavity in the head assembly is driven to be opened or closed through the inner core assembly. The endoscope positioning slow-release drug supply device provided by the invention can be used together with an endoscope, has the functions of targeting positioning, drug attachment, drug slow release and the like, and can effectively solve the defects of the existing scheme.

Description

Endoscope positioning slow-release medicine supply device

Technical Field

The invention relates to an endoscope technology, in particular to an endoscope-based medicine supply technology.

Background

With the popularization and improvement of endoscopic diagnosis and treatment technologies, applications of ESD (endoscopic mucosal dissection), EMR (endoscopic mucosal resection) and polypectomy have been gradually popularized.

However, the current endoscopic diagnosis and treatment technologies are mostly focused on surgical operations, and there are few solutions in the field of drug therapy, and the current drug therapy is mainly focused on temporary delivery, or injection or spraying of hemostatic drugs, sclerosing agents, developing agents or staining agents through endoscopic injection needles and spraying tubes.

For the treatment of some chronic diseases, especially for the diseases on the surface layer of the digestive tract mucosa, the medicine is usually required to act on the focus for a long time, so that the medicine is required to directly act on the focus for a long time, and the medicine has a slow release function.

The existing administration mode has the following disadvantages in the application process:

1. the medicine lacks the targeting function, and the medicine can not directly act on the focus, such as oral medicine;

2. the medicine has poor adhesive force and can not act on the focus for a long time, such as spraying of hemostatic medicine;

3. the drug lacks sustained release function.

It is therefore apparent that there is a need in the art to provide a drug delivery solution that addresses the above-mentioned problems.

Disclosure of Invention

Aiming at the defects of lack of targeting positioning, poor drug adhesion capability, lack of slow release function and the like of the existing drug delivery scheme, a new drug delivery scheme capable of solving the problems is needed.

Therefore, the invention aims to provide an endoscope positioning slow-release medicine supply device which can be used by an endoscope, integrates positioning, attaching, slow-release and other functions, and can effectively solve the problems in the prior art.

In order to achieve the above object, the present invention provides an endoscopic positioning sustained-release drug delivery device, comprising: the head assembly is arranged at the front end of the sheath tube and is provided with a medicine carrying cavity which can be opened and closed and a medicine feeding assembly arranged in the medicine carrying cavity; the inner core assembly is arranged in the sheath tube and is connected with the head assembly at the front end of the sheath tube, and the inner core assembly can drive the administration assembly in the head assembly to carry out administration action; the handle assembly is arranged at the rear end of the sheath tube and connected with the inner core assembly, and the drug carrying cavity in the head assembly is driven to be opened or closed through the inner core assembly.

Furthermore, the head assembly comprises a connecting sheet, a drug delivery assembly, a cup opening and a cup opening frame, wherein the cup opening is arranged at the top end of the cup opening frame to form a drug-carrying cavity which can be opened and closed; the connecting sheet is in driving connection with the cup opening and can drive the cup opening to open and close under the action of external force; the administration assembly is secured within the mouth of the cup by an inner core assembly and is releasable by the inner core assembly to disengage from the mouth of the cup.

Further, the drug delivery assembly comprises a degradable positioner and a drug carrier arranged on the positioner.

Further, the medicine carrying body is a slow release medicine bag with a hollow inner part, and holes are formed in the slow release medicine bag.

Further, the positioner is in a needle or contoured configuration.

Furthermore, the sheath tube is of a two-cavity tube structure and comprises a release cavity channel and a traction cavity channel.

Furthermore, the pipe body of sheath pipe is polymer material and moulds the spring pipe in.

Furthermore, the sheath pipe comprises an outer sheath pipe and an inner sheath pipe, the outer sheath pipe is a metal spring pipe or a plastic-coated spring pipe, and the inner sheath pipe is a two-cavity pipe.

Further, the inner core assembly is formed by matching a traction wire and a release wire, the release wire is arranged in the sheath tube in a penetrating mode, and the head assembly and the handle assembly are connected to fasten and release the drug administration assembly in the head assembly; the traction wire is arranged in the sheath tube in a penetrating mode, the head assembly and the handle assembly are connected, and the drug loading cavity in the head assembly is driven to perform opening and closing actions.

Furthermore, the handle assembly mainly comprises a handle body and a finger ring, and the finger ring is assembled on the handle body and can move on the handle body so as to drive the inner core assembly to drive the medicine carrying cavity in the head assembly to open and close; the front end of the handle body is provided with a fixing groove, and the fixing groove can accommodate a release wire which is arranged in the sheath tube in a penetrating mode and is assembled inside through a fixing piece to form a release assembly.

The endoscope positioning slow-release drug supply device provided by the invention can be used together with an endoscope, has the functions of targeting positioning, drug attachment, drug slow release and the like, and can effectively solve the defects of the existing scheme.

The endoscope positioning slow-release medicine supply device provided by the invention can effectively enrich treatment means and relieve the pain of patients when being actually and specifically applied.

Drawings

The invention is further described below in conjunction with the appended drawings and the detailed description.

FIG. 1 is a schematic view of the overall structure of an endoscopic positioning sustained-release drug delivery device in an embodiment of the present invention;

FIG. 2 is an enlarged schematic view of a head assembly according to an embodiment of the present invention;

FIG. 3 is a schematic cross-sectional view of the head of the clip of the drug delivery assembly of the present example;

FIG. 4 is a schematic view of a handle according to an embodiment of the present invention;

fig. 5 is a schematic view of a releasing device according to an embodiment of the present invention.

The labels in the figure are:

1. a handle body; 2. a ring; 3. a traction assembly; 4. a release assembly; 5. a sheath tube; 6. a head assembly; 7. a cup holder; 8. connecting sheets; 9. a cup mouth; 10. a dosing assembly; 11. a positioner; 12. a slow release sachet; 13. pulling/releasing the filament; 14. fixing grooves; 15. a wiring trough; 16. and a fixing member.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further explained below by combining the specific drawings.

Referring to fig. 1, there is shown a composition example of an endoscopically positioning sustained-release drug delivery device given in the present example.

Referring to the attached drawings, the endoscope positioning slow-release medicine supply device provided by the embodiment mainly comprises a handle body 1, a finger ring 2, a traction component 3, a release component 4, a sheath tube 5 and a head component 6 which are matched with each other in composition structure.

The head unit 6 is herein provided at the tip of the sheath 5 as a direct acting part of the administration operation. The head assembly 6 has a drug loading chamber which can be opened and closed and a drug delivery assembly disposed within the drug loading chamber.

Release subassembly 4 wears to establish in sheath pipe 5, connects the subassembly of dosing in handle body 1 and the head subassembly 6 for in the medicine carrying cavity of subassembly fastening in head subassembly 6 of dosing, and when the operation of dosing, release the subassembly of dosing, make the subassembly of dosing can break away from head subassembly 6.

The traction component 3 is arranged in the sheath tube 5 in a penetrating way, is connected with the finger ring 2 and the head component 6 which are assembled on the handle body 1, is driven by the finger ring 2, and then drives the head component 6 to load the medicine cavity to be opened and closed.

Handle body 1 sets up the rear end at sheath pipe 5, and ring 2 assembles on handle body 1 to can move on handle body, connect simultaneously and pull subassembly 3, the accessible moves on handle body from this, pulls the opening and closing action of medicine carrying cavity in subassembly 6 with the drive in the drive of subassembly 3 drives head subassembly 6.

Referring to fig. 2, the head assembly 6 in this example is mainly formed by the cup holder 7, the connecting piece 8, the cup mouth 9, and the administration set 10 in cooperation with each other.

The holder 7 serves as a base member of the entire head unit 6 and is connected to the front end of the sheath tube 5. The specific structure of the cup holder 7 can be determined according to actual requirements. By way of example, the cup holder 7 in this example takes a cylindrical shape to fit the sheath 5.

The cup openings 9 are a plurality of, for example, 2 or more, and the cup openings 9 are oppositely arranged on the cup opening frame 7 and can move relative to each other, so that an openable and closable medicine carrying cavity (as shown in fig. 3) can be formed inside the cup openings.

The specific structure of the cup opening 9 can be determined according to actual requirements, and is not limited herein.

The connecting piece 8 is used for connecting the cup mouth 9 and the traction assembly 3, and one end of the connecting piece is connected with the traction assembly 3 to realize motion transmission; the other end is connected with the cup mouths 9, so that the traction assembly 3 is driven to move back and forth relative to the cup mouth frame 7 to drive all the cup mouths 9 to synchronously move relatively, and therefore the cup mouths are opened and closed, namely the medicine carrying cavities between the cup mouths 9 are opened and closed.

The specific configuration and arrangement of the connecting piece 8 is not limited here as long as the above-described function is achieved.

The administration set 10 is located inside the cup mouth and connected with the release set 4 for carrying the drug and performing targeted positioning, drug attachment and drug release.

By way of example, the administration set 10 in this example consists essentially of a retainer 11 and a slow release sachet 12. The locator 11 adopts a needle-shaped or configuration design structure so as to be fixed at the focus, and meanwhile, the related fixing structure of the locator 11 can be degraded in vivo so that the medicine carrier can be separated from the focus after the medicine is released. The slow release medicine bag 12 is arranged on the positioner 11 as a medicine carrying body, is used for carrying medicine and slowly releasing the medicine, and can be fixed at a focus along with the positioner 11.

By way of example, the slow release sachet 12 preferably has a hollow structure, the drug is located in the slow release sachet, and a plurality of holes are arranged on the slow release sachet 12 for drug release.

In the illustrated embodiment, when the administration set 10 is formed, the sustained-release medicine bag 12 is located on the positioner 11, the rear end and the front end of the positioner 11 both extend out of the sustained-release medicine bag 12, the extended front end is used for completing fixation, and the rear end is connected with the release set 4 and is used for being fastened in a medicine carrying cavity formed by the cup mouth 9 under the tension control of the release set 4; meanwhile, when the release component 4 releases, the whole body is separated from the medicine carrying cavity formed by the cup mouth 9.

The sheath 5 of the medicine supply device is integrally of a two-cavity tube structure, and is used for arranging the traction assembly 3 and the release assembly 4.

For example, the sheath tube 5 has a two-lumen tube structure, the tube body is made of polymer material and is internally molded with a spring tube to increase strength, and the two internal lumens are divided into a release lumen and a traction lumen according to functions.

Alternatively, the sheath tube 5 may be formed by matching an outer sheath tube and an inner sheath tube, the outer sheath tube is a metal spring tube or a plastic-coated spring tube, the inner sheath tube is a two-lumen tube, and the two internal lumens are divided into a release lumen and a traction lumen according to functions.

The handle body 1 of the medicine supply device is arranged at the rear end of the sheath tube 5 and is connected with the sheath tube 5 through a channel. The shank 1 is provided with a wire tying groove 15, the wire tying groove 15 being grooved in the axial direction of the shank 1 and being operable to restrain and guide the release assembly 4.

Further, a fixing groove 14 is provided at the front end of the handle body 1, the fixing groove 14 being in communication with a wire harness groove 15 of the handle body 1 for engagement with the release unit 4, the fixing groove 14 penetrating the front end of the handle body 1 so that a fixing member 16 can be fixed to the handle body 1 through the fixing groove 14.

Based on the handle body 1, the finger ring 2 is assembled on the handle body 1 and can move on the handle body; meanwhile, the finger ring 2 is in driving connection with the traction assembly 3, so that the traction assembly 3 can move back and forth relative to the cup frame 7.

Further, the traction assembly 3 in this embodiment is mainly composed of corresponding traction wires, the traction wires 3 (i.e., the traction assembly 3) are inserted into the traction cavity channel of the sheath tube 5, the front end of the traction wires is connected with the connecting piece 8 in the head assembly 6, and the rear end of the traction wires is connected with the finger ring 2 on the handle body 1, so that motion transmission is realized, the finger ring 2 drives the cup mouth 9 to open and close, i.e., the opening and closing of the drug-carrying cavity between the cup mouths 9 are realized.

Further, referring to fig. 3-5, the releasing assembly 4 in this embodiment is mainly formed by a releasing filament 13 and a fixing member 16, the releasing filament 13 is integrally inserted into the releasing lumen of the sheath tube 5, the releasing filament 13 passes through the tail of the positioning device 11 in the administration assembly 10, both ends of the releasing filament 13 are connected to the fixing member 16, and extend out to the handle body 1 through the sheath tube 5, the releasing filament 13 has elastic tension, the designed length of the releasing filament 13 is shorter than the length of the releasing lumen, and the releasing filament 13 is tensioned to be limited along the bundling slot 15 and the fixing slot 14; meanwhile, the fixing pieces 16 at the two ends of the release wire 13 are respectively clamped on the fixing groove 14 and the handle body 1, so as to restrain the contraction of the release wire 13. Thereby, the retainer 11 is firmly fixed in the cup mouth 9 by releasing the tension of the wire 13. Thus, when it is desired to release the administration set 10, the retainer 16 is moved upwardly out of the retaining groove 14, so that the tension on the release wire 13 is released, the retaining force of the restraint locator 11 is removed and the administration set 10 is separated from the device base.

In this manner, release of retainer 11, i.e., delivery assembly 10, is effectively achieved by engagement of fastener 16 with release wire 13 (as shown in figure 5).

According to the endoscope positioning slow-release medicine supply device, when the finger ring on the device is in an initial state, the cup opening is closed, the medicine supply assembly is positioned in the cup opening, and at the moment, the medicine can enter the body of a patient through the endoscope clamping channel. When the medicine reaches the focus, the finger ring is pushed to move forwards, the traction wire is pushed, the cup opening is opened, and the slow-release medicine bag is completely exposed out of the cup opening.

At the moment, after the to-be-released anther sac is fixed at a focus position through the positioner, the fixing piece at the handle end of the release wire is moved out of the fixing groove, the release wire is pulled, the release wire is separated from the positioner, and at the moment, the positioner and the sustained-release anther sac on the positioner are separated from the cup mouth, so that the release of the sustained-release anther sac is realized. The remaining head assembly is removed from the jaw channel to complete the release process.

The application process of the endoscopic positioning slow-release drug supply device is described below by combining a specific composition scheme.

When an endoscope positioning slow-release medicine supply device is needed in the operation process, the endoscope positioning slow-release medicine supply device enters the body of a patient through an endoscope channel. At this point, the finger ring 2 tightens the cup 9 with force applied to the pull wire 3, the head assembly 6 is in a closed state, and the administration set 10 is located within the tightened cup 9, as shown in fig. 3.

When the instrument enters the body of a patient through the endoscope channel and reaches the focus part, the finger ring 2 can be pushed to move forwards, the traction wire 3 is pushed, the cup opening 9 is opened, and the slow-release medicine bag 12 is completely exposed out of the cup opening 9.

At this time, the operation instrument pushes the sheath tube 5 forward, after the sustained-release anther sac 12 is fixed at the focus position through the head of the positioner 11, the handle end fixing piece 16 of the release wire 13 is moved out of the fixing groove 14, at this time, the tension of the release wire 13 is released, the release wire 13 is pulled, and the release wire 13 is separated from the positioner 11 at the head assembly 6, so that the release of the sustained-release anther sac 12 is realized. The remaining head assembly 6 is removed from the jaw channel and the entire release process is completed.

Finally, when the scheme is implemented, the medicine can be injected into the medicine carrier, such as a medicine carrying capsule, or the medicine is formed into the medicine carrier, such as solid pills, and the medicine carrying form and the slow release medicine bag in the scheme can play a role in slowly releasing the medicine and acting on a focus part for a long time.

In addition, aiming at the composition scheme of the release wire 13 and the traction wire 3 adopted in the embodiment scheme, in the specific implementation, the release wire can be eliminated, so that the sheath tube can be designed to be only provided with the traction channel, the front end of the traction wire is provided with the release structure, for example, the tail end of the locator 11 can be designed to be a pre-grooved stretch-break elastic structure, and the pre-grooved stretch-break elastic structure can be broken under a certain tensile force, so that the release function is realized.

The foregoing shows and describes the general principles, principal features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. Scope location slowly-releasing medicine supply device, its characterized in that includes: the head assembly is arranged at the front end of the sheath tube and is provided with a medicine carrying cavity which can be opened and closed and a medicine feeding assembly arranged in the medicine carrying cavity; the drug delivery assembly is connected with the inner core assembly and is used for bearing drugs, carrying out targeted positioning, drug attachment and drug slow release; the inner core assembly is arranged in the sheath tube and is connected with the head assembly at the front end of the sheath tube, and the inner core assembly can drive the administration assembly in the head assembly to carry out administration action; the handle assembly is arranged at the rear end of the sheath tube and connected with the inner core assembly, and the inner core assembly drives the medicine carrying cavity in the head assembly to be opened or closed; the inner core assembly is fastened in the drug carrying cavity through the tension control drug delivery assembly, and the drug delivery assembly is integrally separated from the drug carrying cavity when being released, the drug delivery assembly consists of a positioner and a slow release drug capsule, the positioner can be fixed at a focus, meanwhile, the positioner can realize degradation in vivo, and the slow release drug capsule can be separated from the focus after the drug release is finished; the slow-release medicine bag with a hollow inner part is arranged on the positioner as a medicine carrying body and used for carrying and slowly releasing medicines, and can be fixed at a focus along with the positioner;

The head assembly comprises a connecting sheet, a drug delivery assembly, a cup opening and a cup opening frame, wherein the cup opening is arranged at the top end of the cup opening frame to form a drug-carrying cavity which can be opened and closed; the connecting sheet is in driving connection with the cup opening and can drive the cup opening to open and close under the action of external force; the administration component is fastened inside the cup mouth through the inner core component and can be released through the inner core component to be separated from the cup mouth;

the inner core assembly is formed by matching a traction wire and a release wire, the release wire penetrates through the sheath tube, and is connected with the head assembly and the handle assembly to fasten and release the drug delivery assembly in the head assembly; the traction wire penetrates through the sheath tube, and is connected with the head assembly and the handle assembly to drive the medicine carrying cavity in the head assembly to open and close; the handle assembly mainly comprises a handle body and a finger ring, and the finger ring is assembled on the handle body and can move on the handle body so as to drive the inner core assembly to drive the medicine carrying cavity in the head assembly to open and close; the front end of the handle body is provided with a fixing groove, and the fixing groove can accommodate a release wire which is arranged in the sheath tube in a penetrating way and is assembled in the sheath tube through a fixing piece to form a release assembly; the release wire penetrates through the tail part of the positioner in the dosing assembly, the two ends of the release wire are connected with the fixing piece and extend out of the handle body through the sheath tube, the release wire has elastic tension, the designed length of the release wire is shorter than the length of the release cavity, and the release wire is tensioned to be limited along the wire bundling groove and the fixing groove; meanwhile, the fixing pieces at the two ends of the release wire are respectively clamped on the fixing groove and the handle body to restrain the release wire from shrinking; the positioner is firmly fixed in the cup opening by releasing the tension of the wire; when the drug delivery assembly needs to be released, the fixing piece is moved upwards out of the fixing groove, so that the tension of the release wire is released, the fixing force of the restraint positioner disappears, and the drug delivery assembly is separated from the device base body.

2. An endoscopic positioning sustained release drug delivery device according to claim 1, wherein said sustained release drug capsule is provided with holes.

3. An endoscopically positioning slow release drug delivery device according to claim 1, wherein the positioner is in a needle or hook configuration.

4. An endoscopic positioning sustained release drug delivery device according to claim 1, wherein said sheath is of a two-lumen tube structure comprising a release lumen and a drag lumen.

5. An endoscope positioning slow-release drug delivery device according to claim 4, characterized in that the tube body of the sheath tube is made of high polymer material and is internally provided with a spring tube.

6. An endoscope positioning slow-release drug delivery device according to claim 4, characterized in that said sheath comprises an outer sheath and an inner sheath, said outer sheath is a metal spring tube or a plastic-coated spring tube, and said inner sheath is a two-lumen tube.