CN110840768A - Artemisia argyi essence stock solution and preparation method thereof - Google Patents
Artemisia argyi essence stock solution and preparation method thereof Download PDFInfo
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- CN110840768A CN110840768A CN201911169214.0A CN201911169214A CN110840768A CN 110840768 A CN110840768 A CN 110840768A CN 201911169214 A CN201911169214 A CN 201911169214A CN 110840768 A CN110840768 A CN 110840768A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention relates to the technical field of wormwood essence, and particularly relates to wormwood essence stock solution and a preparation method thereof. The essence stock solution comprises the following components: the weight ratio of the total of the wormwood hydrolat, the honeysuckle hydrolat and the folium artemisiae argyi essential oil to the agarose gel is 100: 10-30. The method for preparing the wormwood essence stock solution comprises the following steps: uniformly dispersing the wormwood hydrosol, the argyi leaf essential oil and the honeysuckle hydrosol, adding the agarose gel, stirring uniformly, and then adding the emollient oil ester. The invention provides the essential oil stock solution containing stable and volatile components of the wormwood, so that the active components of the wormwood are covered to the maximum extent, and the utilization rate of the wormwood is improved. Moreover, the mugwort essence stock solution has few additives, little irritation to human skin and high safety.
Description
Technical Field
The invention relates to the technical field of wormwood essence, and particularly relates to wormwood essence stock solution and a preparation method thereof.
Background
For the past, most of products with the effects of removing miliaria, relieving itching, preventing mosquitoes, relieving and the like aiming at skin care of infants in summer in the market adopt plant extracting solutions such as honeysuckle, wild chrysanthemum, liquorice and the like, and the extracting solutions are limited by technologies and have the problems of dark color (yellow brown or black), unpleasant smell, unstable effect and the like.
The folium Artemisiae Argyi is a Compositae plant, and has pungent, bitter, and warm nature, and enters liver, spleen, and kidney meridians. The dried leaves have effects of warming channels, stopping bleeding, dispelling cold, relieving pain, regulating menstruation, preventing miscarriage, eliminating dampness, relieving itching, dredging meridian passage, etc. The research shows that the wormwood extract has the pharmacological effects of resisting bacteria, viruses, allergy, bleeding and the like. Due to the advantages of high survival rate, easy planting and the like, the application of the wormwood and the wormwood extract can be traced to an earlier stage.
The most common uses, such as bactericidal action. Research by Song Jianyong et al in the document "Experimental observation of sterilizing effect of mugwort leaf compound disinfectant" shows that by acting a stock solution of disinfectant containing mugwort extract at 20-25 deg.C for 2-10min, more than 99.99% of various bacteria and fungi in the suspension can be killed. The disinfectant can be used for wetting the surfaces of telephone and refrigerator door handle, and can kill natural bacteria by over 99.83% after 5 min. The compound disinfectant stock solution is placed at 54 ℃ for 21 days, the effect of killing staphylococcus aureus is not obviously reduced, and the property is stable; the influence of organic matters is small; acute oral LD50 of white mouse is larger than 11000 mg-kg-1(ii) a Skin irritation tests show that the disinfectant is free of irritation, so that the disinfectant is safe to use.
Here, the use of wormwood and its extracts for skin care products is also a current focus of research.
For example, patent CN107760489A discloses a preparation method of wormwood essence cold soap capable of clearing damp, dispelling cold, reducing swelling and resolving hard mass, which is prepared by the following steps: taking a proper amount of wormwood, adding water, decocting and filtering to obtain wormwood extract for later use; preparing alkali liquor: dissolving folium Artemisiae Argyi extract in pure water, and mixing alkali with the water phase mixture until alkali is completely dissolved; (III) preparing grease; (IV) mixing alkali oil: mixing the grease with the alkali liquor, and rapidly stirring clockwise; (V) pouring the film; and (VI) demolding. The essence cold soap disclosed by the invention can thoroughly clean skin and pores; the extracted and concentrated wormwood essence acts on the thoroughly cleaned skin surface, and can effectively eliminate dampness, remove rash, remove miliaria, sterilize and relieve itching through transdermal absorption; can effectively reduce the pigmentation of the face, lighten the black spots of the face, improve acne, expel toxin and beautify the face; after long-term use, the skin care product can eliminate dampness and dispel cold, reduce swelling and eliminate stagnation, improve the skin condition and enable the skin to be more moist and fresh.
Of course, the use of mugwort extract for the prevention of mosquito bites has also been suggested. For example, patent CN104224598A discloses an folium artemisiae argyi extract essence for preventing mosquito bite of infants, which mainly comprises folium artemisiae argyi extract essence, folium eucalypti globueli extract essence, pinus sylvestris extract, flos lonicerae extract, flos chrysanthemi indici extract, elemi, mint, juniper berry extract, and vitamin B1; through mixing, sealing, soaking, stirring, extracting, purifying and other steps. The essence extracted from pure natural plants is compounded, so that the wormwood essence is extracted for preventing mosquito bites of infants, the eucalyptus leaf extract essence and the pinus sylvestris extract are fused, the skin health of infants is improved, the infants are cooled, detoxified and prevented from biting, and the wormwood essence is particularly suitable for newborn infants, calms and soothes, prevents various skin discomfort in links, and is also suitable for pregnant and lying-in women. However, the mosquito bite preventing agent is added with a large amount of mint, so that the odor is heavy and the infant is relatively rejected.
In addition, the folium artemisiae argyi extract in the above-disclosed folium artemisiae argyi-containing products is prepared by a conventional extraction process, and most of the folium artemisiae argyi extract contains stable flavonoids and polysaccharides, but the content of volatile components is low. In order to exert the efficacy and effect of the wormwood to the maximum extent and improve the utilization value of the wormwood, the preparation of the wormwood product containing volatile components and stable components is the key point of current enterprise research and development.
Disclosure of Invention
In order to solve the above problems in the prior art, the present invention aims to provide a wormwood essence stock solution, which contains active ingredients such as flavonoids and saccharides with good stability, and also contains volatile ingredients in wormwood volatile oil; the folium Artemisiae Argyi essence stock solution has good stability, and has effects of inhibiting bacteria, removing miliaria, relieving itching, etc.
In order to achieve the above object, the present invention provides the following technical solutions:
the wormwood essence stock solution comprises the following components:
the weight ratio of the total of the wormwood hydrolat, the honeysuckle hydrolat and the folium artemisiae argyi essential oil to the agarose gel is 100: 10-30.
Preferably, the content of the emollient oil ester in the wormwood essence raw liquid is 0.4-2 wt%.
Preferably, the emollient oil ester is one or more of medium chain triglyceride, a compound of cyclohexadecyldimethyl siloxane and dimethiconol, hydrogenated castor oil, isopropyl palmitate and methyl oleate.
Further preferably, the emollient oil ester is hydrogenated castor oil PEG-40.
Preferably, the essence stock solution also comprises 0.5-2 wt% of plant extract active ingredient composition, which is prepared from the following raw materials: scutellaria root extract, glycyrrhiza glabra root extract, perilla seed extract, kochia scoparia extract, magnolia biondii bud/flower extract, dictamnus root extract, centella asiatica extract, peony root extract, and saposhnikovia divaricata extract. The plant extract active component composition comprises perilla seed extract and flower bud/flower extract of Magnolia biondii Benth with anti-allergy and itching relieving effects, and radix Saposhnikoviae extract and radix Dictamni Radicis extract with antiinflammatory and antibacterial effects.
Further preferably, the plant extract active ingredient composition is prepared from the following substances in parts by weight: 15-30 parts of scutellaria root extract, 2-6 parts of glycyrrhiza glabra root extract, 20-30 parts of perilla seed extract, 7-12 parts of kochia scoparia extract, 10-20 parts of flower bud/flower extract of magnolia biondii, 10-15 parts of dictamnus dasycarpus root extract, 0.5-1 part of centella asiatica extract, 3-10 parts of peony root extract and 1-10 parts of divaricate saposhnikovia root extract. The plant extract active ingredient composition is prepared by extracting the components by adopting a conventional method in the field and then mixing the extracts. And also commercially available.
Preferably, the essence stock solution also comprises 6-10 wt% of a humectant.
Further preferably, the humectant is one or more of glycerin, propylene glycol, 1, 3-propanediol and butanediol.
Preferably, the essence stock solution also comprises 0.03-0.1 wt% of functional ingredient carboxymethyl chitosan. The carboxymethyl chitosan and the H1 histamine receptor are combined with high affinity competition, and the histamine is prevented from activating the H1 receptor which causes itch, thereby achieving the effect of relieving itching. Has the effects of promoting granulation tissue formation of wound, activating epithelial tissue, relieving fibroblast and scar proliferation, reducing or avoiding scar, recovering skin injury, and accelerating wound healing.
In the invention, test results show that the addition of the functional component carboxymethyl chitosan is also beneficial to improving the stability of the essence stock solution.
Preferably, the essence stock solution also comprises 0.05-0.2 wt% of menthyl lactate serving as a skin-feel conditioning agent.
Preferably, the essence stock solution also comprises antioxidant tea polyphenol 0.02-0.1 wt%.
Preferably, the essence stock solution also comprises 0.3-0.5 wt% of benzethonium chloride serving as a preservative.
As a preferred embodiment, the essence stock solution comprises the following components in percentage by weight:
in the invention, the wormwood hydrolat and the argyi leaf essential oil are wormwood extracts based on different polar solvent solvents, and the wormwood extracts and the argyi leaf essential oil are mixed together with the honeysuckle hydrolat, so that the active ingredients of the wormwood extracts can be fully contained.
The honeysuckle hydrolat plays a role of a matrix and disperses and dilutes the wormwood hydrolat and the wormwood leaf essential oil.
The preparation method of the wormwood essence stock solution comprises the following steps: uniformly dispersing the wormwood hydrosol, the argyi leaf essential oil and the honeysuckle hydrosol, adding the agarose gel, stirring uniformly, and then adding the emollient oil ester.
The method utilizes the moisture of the hydrolat to be rapidly solidified into gel after the agarose gel is added, the agarose gel is wrapped outside the mixture of the wormwood hydrolat, the argyi leaf essential oil and the honeysuckle hydrolat in the stirring process, the mixture of the wormwood hydrolat, the argyi leaf essential oil and the honeysuckle hydrolat is further wrapped after the skin moistening oil ester is continuously added, and therefore an active ingredient-gel layer-oil ester layer structure is formed.
The wormwood hydrolat is prepared by adopting a conventional method in the field or is purchased in the market.
For example, the preparation of the wormwood hydrosol can be prepared by referring to the method disclosed in patent CN105326691A, and the operation steps are as follows: loading folium Artemisiae Argyi into a medicinal material column connected with silica gel column, adding cyclohexane for cyclic elution with flow rate controlled at 1-2BV/h, eluting for 3-4h, removing the silica gel column, washing the silica gel column with cyclohexane 2-4 times the weight of folium Artemisiae Argyi, adding mixed solution of 20% ethyl acetate and 80% cyclohexane for cyclic elution with flow rate controlled at 1-2BV/h, eluting for 2-3h, adding the eluate into a rotary evaporator, and recovering solvent to obtain folium Artemisiae Argyi oil extract; adding 2-3 times of the folium Artemisiae Argyi oil extract weight of mixed solution composed of anhydrous ethanol and cyclohexane, ultrasonic dissolving for 20-40min, standing for layering, taking lower layer liquid, distilling at 95 deg.C, and discarding fraction when the volume of fraction is greater than 110-120% of the total volume of ethanol and cyclohexane; raising the temperature to 100 ℃, and collecting the fraction at the temperature of 100 ℃ to obtain the wormwood hydrosol.
Preferably, the honeysuckle hydrolat is prepared by the following method: putting honeysuckle into a distillation retort, adding water which is 3-8 times of the weight of the honeysuckle, introducing steam to heat the distillation retort, continuously introducing 100 ℃ of water vapor to the bottom of the distillation retort, opening a steam pipeline above the distillation retort, connecting a condensing pipe, condensing the steam, introducing the obtained liquid into an oil-water separator, separating, and collecting a water phase to obtain the honeysuckle hydrolat.
The folium artemisiae argyi essential oil is prepared by a method similar to that of honeysuckle hydrolat, but an oil phase is collected after separation in an oil-water separator and is dried by anhydrous sodium sulfate.
The technical effects obtained by the invention are as follows:
(1) the invention provides the essential oil stock solution containing stable and volatile components of the wormwood, so that the active components of the wormwood are covered to the maximum extent, and the utilization rate of the wormwood is improved.
(2) Under the specific formula, all the substances are mixed according to a specific sequence to prepare a three-layer structure of active ingredients, namely gel-oleyl ester, and the active ingredients are wrapped under the condition that no external wrapping object is added, so that the preparation process is simple, and the stability of the essence stock solution is good; and the active ingredient is easily released when used.
(3) The mugwort essence stock solution provided by the invention is less in additive amount, less in irritation to human skin and high in safety.
Detailed Description
The invention is further illustrated by the following examples. These examples are for illustrative purposes only and do not limit the scope and spirit of the present invention. Unless otherwise specified, the units of the components in the examples of the present invention are% by weight. The plant extract active ingredient composition of the examples was produced by Shanghai Kexin bioengineering, Inc., distributed by Shanghai Yuanbei Biotech, Inc., product lot 190303.
Examples 1 to 7
The following table 1 shows the formulations of the wormwood essence stock solutions provided in examples 1 to 7:
the preparation process of the wormwood essence stock solution in the embodiment comprises the following steps:
1) uniformly dispersing the wormwood hydrosol, the argyi leaf essential oil and the honeysuckle hydrosol, adding the agarose gel, uniformly stirring, adding the skin moisturizing oil ester, and mixing to fine and uniform slurry;
2) adding the rest materials, mixing, collecting partial stock solution, inspecting, and discharging.
Comparative example 1
The comparative example 1 is different from the example 1 only in that the preparation process of the wormwood essence stock solution is as follows:
mixing the materials in proportion until the mixture is uniform, taking part of stock solution, and discharging after the stock solution is qualified.
Performance testing
1. Stability of
The stability of the wormwood essence stock solutions prepared in examples 1 to 8 was measured by the following specific measurement method:
heat resistance stability: (1) placing the mixture in an electric heating constant temperature incubator at the temperature of 40-50 ℃ for 30-50 days, and observing and recording the time when the stability of the mixture changes after the temperature is recovered to the room temperature.
Cold resistance stability: (2) storing at-10 deg.C for 30-50 days, and observing and recording the time when the stability changes after the temperature is returned to room temperature.
And (3) observing items: liquid homogeneity, precipitation, microbial growth, odor changes; wherein the total number of colonies and pathogenic bacteria assay is performed according to the method of cosmetic hygiene standard GB 7916.87.
The results are shown in Table 2 below:
table 2 stability of mugwort essence stock solutions prepared in examples 1 to 8
2. Measurement of ameliorating Effect on inflammatory skin
Using the products obtained in examples 1 to 7 and comparative example as test products, 160 female skin inflammation volunteers aged 25 to 60 years were randomly selected and divided into 8 groups of 20 persons. The skin improvement of the user was determined after 1 week and 4 weeks of trial, respectively, with the test conditions fixed at 40-60% relative humidity and at 25 ℃ room temperature. The skin improvement is shown in table 3. Among them, the reduction or recovery of the skin inflammation and the elimination of acne marks of the patient are considered to improve the inflammation. The inflammation improvement rate is the number of people with inflammation improvement/the number of people who try to use the inflammation improvement.
Table 3 the effect of the stock solution of wormwood essence on improvement of inflammatory skin provided in each example
By combining the above table 3, when the improvement effect of each sample on inflammatory skin is detected, it is found that the wormwood essence stock solution prepared by the formula and the process provided by the invention can fully exert the efficacy of each active ingredient, and promote the function of the wormwood essence stock solution after long-term use due to good stability; in contrast, when mixed by other techniques (e.g., comparative example 1), the stability of the product is affected, so that the skin-improving effect is not particularly remarkable or the possibility of skin deterioration occurs with the lapse of time.
3. Sterilizing and itching relieving properties
The wormwood essence stock solution provided by the invention mainly adopts natural plant extracts with sterilizing and itching relieving effects, and can be used as a liquid miliaria-removing preparation to relieve symptoms such as skin itching of patients.
160 volunteers with the same miliaria degree are randomly selected and divided into 8 groups, 20 people in each group are applied with the same amount of talcum powder provided by each example and each comparative example on respective affected parts, the powder is continuously used for one week, and the using condition is observed and recorded. The results are given in Table 4 below.
TABLE 4 detection effect of various folium Artemisiae Argyi essence stock solutions for removing miliaria and relieving itching
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. The wormwood essence stock solution comprises the following components:
the weight ratio of the total of the wormwood hydrolat, the honeysuckle hydrolat and the folium artemisiae argyi essential oil to the agarose gel is 100: 10-30.
2. The wormwood essence stoste according to claim 1, wherein the emollient oil ester is one or more of medium chain triglyceride, a compound of cyclohexadecyldimethyl siloxane and dimethiconol, hydrogenated castor oil, isopropyl palmitate and methyl oleate.
3. The wormwood essence stock solution according to claim 1, further comprising 0.5-2 wt% of a plant extract active ingredient composition, which is prepared from the following raw materials: scutellaria root extract, glycyrrhiza glabra root extract, perilla seed extract, kochia scoparia extract, magnolia biondii bud/flower extract, dictamnus root extract, centella asiatica extract, peony root extract, and saposhnikovia divaricata extract.
4. The wormwood essence stoste of claim 1, further comprising humectant 6-10 wt%.
5. The mugwort essence stock solution according to claim 1, further comprising 0.03-0.1 wt% of carboxymethyl chitosan as an effective ingredient.
6. The wormwood essence stock solution according to claim 1, further comprising menthyl lactate as a skin feel conditioner in an amount of 0.05-0.2 wt%.
7. The wormwood essence stock solution according to claim 1, further comprising antioxidant tea polyphenols 0.02-0.1 wt%.
8. The wormwood essence stock solution according to claim 1, comprising the following components in percentage by weight:
9. a method of preparing the wormwood essence stoste of claim 1, comprising the steps of:
uniformly dispersing the wormwood hydrosol, the argyi leaf essential oil and the honeysuckle hydrosol, adding the agarose gel, stirring uniformly, and then adding the emollient oil ester.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588683A (en) * | 2020-05-29 | 2020-08-28 | 广州市博卡利生物科技有限公司 | Anti-allergy skin-soothing wormwood essence and preparation method thereof |
| CN111937905A (en) * | 2020-09-14 | 2020-11-17 | 邵阳博亿技术服务有限公司 | Mosquito-repellent incense rich in wormwood essence |
| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
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| CN110237014A (en) * | 2019-07-04 | 2019-09-17 | 上海绿瑞生物科技有限公司 | A kind of water oil dual phase composition and preparation method thereof with the effect of releiving |
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| CN104474008A (en) * | 2014-12-10 | 2015-04-01 | 遵义医学院 | Honeysuckle prickly heat water and preparation method thereof |
| CN108078830A (en) * | 2016-11-23 | 2018-05-29 | 陈君君 | A kind of herbal essences floral water and preparation method thereof |
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| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
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| CN111937905A (en) * | 2020-09-14 | 2020-11-17 | 邵阳博亿技术服务有限公司 | Mosquito-repellent incense rich in wormwood essence |
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| CN110840768B (en) | 2021-02-19 |
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