CN110831953A - 从淫羊藿提取物中分离纯化淫羊藿苷的方法 - Google Patents
从淫羊藿提取物中分离纯化淫羊藿苷的方法 Download PDFInfo
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- CN110831953A CN110831953A CN201880038007.9A CN201880038007A CN110831953A CN 110831953 A CN110831953 A CN 110831953A CN 201880038007 A CN201880038007 A CN 201880038007A CN 110831953 A CN110831953 A CN 110831953A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
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Abstract
从淫羊藿提取物中分离纯化淫羊藿苷的方法，涉及植物提取物中单体的分离纯化的技术领域，旨在解决现有方法存在的工艺复杂、制备成本高、污染环境等技术问题。该方法包括：1）用体积分数88%‑96%丙酮水溶液对淫羊藿提取物进行打浆；2）过滤，收集滤饼，用体积分数50%‑75%乙醇水溶液溶解滤饼；3）溶解完毕后，过滤，收集滤液，将滤液浓缩去除乙醇后得浓缩液；4）在第一温度下，向浓缩液中加入丙酮均匀混合，待充分溶解后，将温度降低至第二温度，进行结晶；5）待结晶完毕后，过滤，收集滤饼，滤饼经干燥处理后即得淫羊藿苷粗品。应用该方法可获得含量高达98%以上的淫羊藿苷单体，足以满足注射剂的高纯度要求。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
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| PCT/CN2018/092098 WO2019241947A1 (zh) | 2018-06-21 | 2018-06-21 | 从淫羊藿提取物中分离纯化淫羊藿苷的方法 |
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| CN110831953A true CN110831953A (zh) | 2020-02-21 |
| CN110831953B CN110831953B (zh) | 2023-04-04 |
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| CN112961891B (zh) * | 2021-03-25 | 2024-01-26 | 西安巨子生物基因技术股份有限公司 | 利用双相酶促反应制备淫羊藿苷的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101845067A (zh) * | 2010-05-21 | 2010-09-29 | 甘肃亚兰特种药材饮片生产有限公司 | 高含量淫羊藿苷的制备方法 |
| CN104610399A (zh) * | 2014-12-16 | 2015-05-13 | 李玉山 | 一种黄酮类化合物不同色泽的控制方法 |
| CN104829667A (zh) * | 2015-05-20 | 2015-08-12 | 诸城市浩天药业有限公司 | 一种淫羊藿苷h1晶型、其制法和其药物组合物与应用 |
| CN106831913A (zh) * | 2017-02-15 | 2017-06-13 | 鲁南制药集团股份有限公司 | 一种淫羊藿苷的制备工艺 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812100A (zh) * | 2010-04-08 | 2010-08-25 | 苏州宝泽堂医药科技有限公司 | 一种制备淫羊藿苷的方法 |
| CN102070688A (zh) * | 2010-12-20 | 2011-05-25 | 大兴安岭林格贝有机食品有限责任公司 | 一种富集纯化淫羊藿中淫羊藿苷的方法 |
| CN102617670A (zh) * | 2011-01-27 | 2012-08-01 | 北京市理化分析测试中心 | 一种淫羊藿苷单体的制备方法 |
| CN103396463B (zh) * | 2013-08-22 | 2016-05-18 | 内蒙古鑫吉利生物科技有限公司 | 一种从淫羊藿中提取淫羊藿苷的方法 |
| CN106589020B (zh) * | 2016-12-31 | 2019-03-22 | 北京颐方生物科技有限公司 | 一种从淫羊藿中提取淫羊藿苷的方法 |
-
2018
- 2018-06-21 CN CN201880038007.9A patent/CN110831953B/zh active Active
- 2018-06-21 WO PCT/CN2018/092098 patent/WO2019241947A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101845067A (zh) * | 2010-05-21 | 2010-09-29 | 甘肃亚兰特种药材饮片生产有限公司 | 高含量淫羊藿苷的制备方法 |
| CN104610399A (zh) * | 2014-12-16 | 2015-05-13 | 李玉山 | 一种黄酮类化合物不同色泽的控制方法 |
| CN104829667A (zh) * | 2015-05-20 | 2015-08-12 | 诸城市浩天药业有限公司 | 一种淫羊藿苷h1晶型、其制法和其药物组合物与应用 |
| CN106831913A (zh) * | 2017-02-15 | 2017-06-13 | 鲁南制药集团股份有限公司 | 一种淫羊藿苷的制备工艺 |
Non-Patent Citations (1)
| Title |
|---|
| 赵临襄 主编: "《化学制药工艺学》", 31 August 2015 * |
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| WO2019241947A1 (zh) | 2019-12-26 |
| CN110831953B (zh) | 2023-04-04 |
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