CN1108158C - Analgesic composition - Google Patents

Abstract

The present invention discloses a lenitive medicine composition which is prepared from the active ingredients of the following proportion by weight: 2 to 10 portions of berchemia lineata, 2 to 6 portions of curcuma, 1 to 5 portions of radix aconiti preparata, 2 to 12 portions of white peony, 0.5 to 5 portions of liquorice, 1 to 8 portions of corydalis, 1 to 8 portions of grassleaf sweelflag rhizome, 2 to 10 portions of stir-baked jujube kernel, 1 to 5 portions of asarum, 1 to 10 portions of pilose asiabell root, 2 to 6 portions of myrrh, 2 to 6 portions of olibanum, 2 to 6 portions of paniculate swallowwort root, 0.5 to 3 portions of hot pepper and 0.1 to 1.5 portions of scorpion. The medicine composition has the characteristics of less side effect, strong analgetic efficacy, fast action and long acting time, and the medicine composition can be used for alleviating various pains.

Description

A kind of analgesic composition

The present invention relates to a kind of lenitive pharmaceutical composition that is used for, specifically a kind of pharmaceutical composition that is applicable to various pain that combines by the animals and plants Chinese herbal medicine.

Pain is one of common pathological symptom of numerous disease.Have an intense pain or persistent pain not only can cause suffering to patient, but also can usually cause patient's anxiety, uneasiness, physiological function disorder, when serious even can cause the painful shock.Pain more makes us quailing and being difficult to standing than disease itself sometimes.The pain of various cancers (abbreviation cancer pain) is exactly one of the most typical illustration.As everyone knows, cancer is the commonly encountered diseases and the frequently-occurring disease of class prestige association's health of people and life, and its sickness rate is also increasing year by year.And cancer pain is occupied very high ratio in the cancer patient.In general, when cancer is made a definite diagnosis and cancer mid-term, have the patient main suit of 30%-45% that moderate or severe pain are arranged approximately, the cancer pain incidence rate of patient with advanced cancer is up to more than 70%.Cancer pain is having a strong impact on cancer patient's life quality.This problem has caused the great attention of The World Health Organization (WHO), and classifies cancer pain control one of as four emphasis of WHO prevention and control of cancer unified plan.Except that cancer pain, clinical releasing and alleviating pain also are the very important important steps in the numerous disease therapeutic process.At present, be used for the analgesic medicine and be broadly divided into two big classes, a class is non-opium analgesics, such as aspirin, acetaminophen, aminophenazone, ibuprofen, indometacin or the like, another kind of then is opium analgesics, such as morphine, Pethidine, codeine, bucinnazine, tramadol or the like.In cancer pain treatment, the three ladder analgesic therapies that WHO recommends also mainly are to select some drugs in the above medicine as representing medicine to be treated.Specifically, when the cancer patient be in gently～during moderate pain, by first order administration, selecting aspirin is that the non-opium analgesic of representative is treated.If reaching analgesic effect or pain continues aggravation then raises to be that secondary, selection are that the weak opioid drug of representative is treated with the codeine.If still can not control or pain continues aggravation and then enters the third level, selecting with the morphine is the strong opioid drug treatment of representative.Though existing analgesic has been alleviated the misery that pain causes to patient to a certain extent, many weak points that himself exists have still seriously limited its clinical practice.As aspirin class analgesic, analgesic activity a little less than, only effective usually to dull pains such as headache, toothache, myalgia, arthralgia, and to various severe traumas have an intense pain and visceral smooth muscle angor invalid.Long-term heavy dose of this class analgesic that uses also can cause gastrointestinal reaction, salicylism reaction, Toxicity of Kidney effect and perspire, bring out untoward reaction such as collapse in a large number.Obviously, this class medicine is unsuitable for prolonged and repeated releasing of this needs of similar cancer pain or lenitive patient use.Though opioid drug has very strong analgesic activity, it particularly uses addiction all greatly to limit its extensive use clinically to the inhibitory action and the toleration of respiratory center continuously.For overcoming the above problems, medical for a long time expert has carried out unremitting effort, for example succeeding in developing of dihydroetorphine once makes people think to have found a kind of analgesia to render a service strong and is difficult for addicted novel drugs, yet show that through clinical practice widely it still has stronger addiction, now listed in by among the medicine ranks of strict control.In Chinese medicine research, people have found that many vegetable Chinese herbal medicines all have certain analgesic activity, and for this reason, people attempt always to screen that to make a kind of toxic and side effects little and strong medicine is renderd a service in analgesia.But from present case, the analgesic effect of many analgesia Chinese patent medicines is very undesirable, for example, present commercially available YUANHU ZHITONG PIAN, it only has mitigation to mild pain, and its onset is also slower, action time is also short, thereby can not satisfy the lenitive needs of people far away.Along with pain particularly cancer pain to day all the increasing the weight of of the physically and mentally healthy influence of people, people more and more wish to develop a kind of analgesia render a service strong, the little and analgesic of addiction not of toxic and side effects.

Purpose of the present invention just provide that a kind of like this analgesic activity is strong, rapid-action, long action time, toxic and side effects is little and do not have addicted analgesic.

The realization of the object of the invention is based on modern pharmacology research, in conjunction with cognition and the Therapeutic Principle of motherland's medical science to pain, filter out have collaborative blood stasis dispelling, regulate the flow of vital energy, analgesia, each component of abirritative Chinese herbal medicine and carry out rational proportion, make it can on curative effect, produce good synergism, can reduce separately peculiar toxicity and bias again, fast and the little beneficial effect of toxic and side effects thereby the realization analgesic activity is strong.

Medicine of the present invention is made by following materials of weight proportions:

Radix berchemiae lineatae 2-10 part Radix Curcumae 2-6 part Radix Aconiti Preparata 1-5 part Radix Paeoniae Alba 2-12 part Radix Glycyrrhizae 0.5-5 part Rhizoma Corydalis 1-8 part, Rhizoma Acori Graminei 1-8 part Semen Ziziphi Spinosae (parched) 2-10 part Herba Asari 1-5 part Radix Codonopsis 1-10 part, Myrrha 2-6 part Olibanum 2-6 part Radix Cynanchi Paniculati 2-6 part Fructus Capsici 0.5-3 part, Scorpio 0.1-1.5 part.

Preferred weight proportioning of the present invention is:

Radix berchemiae lineatae 4-8 part, Radix Curcumae 2-3 part, Radix Aconiti Preparata 1.5-3 part, Radix Paeoniae Alba 3-8 part, Radix Glycyrrhizae 1-3 part, Rhizoma Corydalis 3-8 part, Rhizoma Acori Graminei 2-5 part, Semen Ziziphi Spinosae (parched) 2-6 part, Herba Asari 1-3 part Radix Codonopsis 3-5 part, Myrrha 3-5 part, Olibanum 3-5 part, Radix Cynanchi Paniculati 2-3 part, Fructus Capsici 1-2 part, Scorpio 0.5-1.5 part

Each component in the medicine of the present invention all can be bought on medical market.

Medicine of the present invention can be prepared into various oral formulations such as tablet, electuary, hard capsule, soft capsule, oral liquid, also can be prepared into the various dosage forms that are applicable to rectally such as suppository, enema etc.

The preparation method of hard capsule of the present invention is:

1, at first extracts volatile oil.Take by weighing Olibanum, Myrrha, Radix Cynanchi Paniculati, Radix Curcumae by the proportioning in the prescription of the present invention, pulverized the 40-80 mesh sieve after, in the extraction kettle of packing into, adopt supercritical fluid extraction, extraction volatile oil, standby.

2, Rhizoma Corydalis, Scorpio, Fructus Capsici are taken by weighing respectively by weight ratio after, in the container that is placed in, adopt ethanol to make solvent, it is standby to be prepared into thick extractum behind the dipping.

3, all the other components in the medicine of the present invention being taken by weighing the back by its weight proportion, to adopt decoction and alcohol sedimentation technique to be prepared into thick extractum standby.

4, above volatile oil and all thick extractum are incorporated in one, dry, be ground into fine powder, cross the 80-100 mesh sieve, include 0.45 gram medicated powder, the capsule of packing into No. 0 by every capsules.

The present invention has blood circulation promoting and blood stasis dispelling, the analgesic effect of regulating the flow of vital energy, and can be used for alleviating various pain, is particularly suitable for treating various cancer pains.

Usage and dosage of the present invention is every day 3 times, each 2-4 grain.The patient also can suitably add and subtract the amount of taking according to the light and heavy degree of pain.

Beneficial effect of the present invention shows that each component has good synergism, makes compositions have that toxic and side effects is little, characteristics strong, rapid-action, long action time are renderd a service in analgesia behind each component compatibility.

The nomenclature of drug of medicine animal of the present invention in experiment and clinical observation stops for pain is upright, and its excellent results has all obtained checking in zoopery and clinical observation.

The zooscopy method and the result of medicine of the present invention are as follows:

1, experiment material

1.1 the laboratory animal Kunming mouse, ♂, ♀ dual-purpose, body weight 20.0 ± 2.0g is provided by Beijing Medical University's Experimental Animal Center, and animal is the moving word 01-3049 of doctor qualified number.Test 18 ± 1 ℃ of real temperature.

1.2 be provided with by reagent and dosage, the upright relieving oral liquor of pain is provided along the pharmaceutical developments company limited by Shijiazhuang City development zone generation, lot number 990104, concentrated solution are 4g crude drug/ml.According to onset dosage 10g crude drug/people of people, the strongest drug effect dosage 250g crude drug/people.Body weight for humans is calculated with 60kg, and effective dosage ranges 0.17-4.17g crude drug/kg/ people, mean effective dose are 2g crude drug/kg people.With reference to mice LD ₅₀Be 222 crude drugs/kg, the dosage of establishing the mice drug effect is respectively 15,30g crude drug/kg, the Western medicine morphine, dosage is 8mg/kg, Chinese medicine positive drug YUANHU ZHITONG PIAN, and Le Rentang pharmaceutical factory, Shijiazhuang produces, according to people's dose is 6, establishes 12/kg of mice dosage, is 12 times of amounts of clinical equivalent dosage.

1.3 route of administration is except that morphine lumbar injection (0.2ml/ only), all gastric infusion 0.4ml/ only.

1.4 reagent and instrument acetic acid, Beijing chemical reagents corporation produces, lot number 971105, and it is standby to be made into 0.6% concentration.Mice is pressed the tail instrument: Japanese UGD Basie biological respinse instrument, 115 volts of voltages, pressure 1--25 gram.Hot plate electric heating constant temperature water-bath DR-HW-1, Xicheng District, Beijing medical apparatus and instruments factory produces.

2, test method and result

2.1 press the tail method to cause the influence of pain to mice

When the mouse tail root bears pressure and reaches pain, later be index with mice to afterbody, the pressure (g) of record this moment is the threshold of pain.Selecting basic pain threshold is the ♀ mice of 4-8g, is divided into 5 groups at random, 10 every group.If 2 dosage be subjected to the reagent group, 2 positive drug groups and 1 blank group, matched group is given equal-volume (0.4ml) distilled water, surveys the threshold of pain of respectively organizing mice after the administration in 10,30,60,120,180,240 minutes respectively.The results are shown in Table 1 and accompanying drawing 1.The result shows: morphine group and pain be upright stops the administration of dosage group and just can obviously improve the mice pressure tail threshold of pain in 10 minutes, p＜0.01, morphine presses the analgesic effect of tail the most obvious with 10,30 minutes to mice, descend after 60 minutes, analgesic effect faded away later on to 120 minutes, the upright heavy dose of stopping of pain presses tail that very significant analgesia role is arranged to mice, and analgesic activity continued to 180 minutes from 10 minutes and do not subtract, and is longer than the morphine analgesia time.Low dose of also had significant analgesia role in 10 minutes in administration, and upright analgesia intensity and the analgesia time that stops of pain all has tangible dose-effect positive correlation.

2.2 the mice hot plate method is caused the influence of pain

Hot plate temperature is 55 ± 0.5 ℃, and 19 ℃ of room temperatures are placed on the hot plate from mice and begin, and clock to licking metapedes for the pain response time (incubation period), detect the analgesic effect that is subjected to reagent with this.The preliminary election threshold of pain time is divided into 5 groups at random 50 of the ♀ mice of 5-30 in second, and 10 every group, blank group mouth is raised equal-volume distilled water (0.4ml).The results are shown in Table 2, accompanying drawing 2.It is similar when the result shows that pain is upright and stops heavy dose to morphinization, administration promptly has obvious analgesic activity after 10 minutes, but morphine is 2 hours to the analgesia time of mice, and the upright analgesia time that stops heavy dose of group of pain continues to 5 hours always, and upright analgesia intensity and the analgesia time that stops of pain all has tangible dose-effect positive correlation.

2.3 the mice chemistry is caused the influence of pain (writhing method)

80 of mices, ♀, ♂ half and half are divided into 10 groups at random, and 8 every group, i.e. 6 blank groups and 4 administration groups, agent is with ditto described.Whenever be subjected to the examination group all to measure after the administration 6, the acetic acid of time point causes the pain effect, before the mensuration, lumbar injection 0.6% acetic acid, 0.2ml/ are only turned round the body number of times after 5 minutes in the opening entry 10 minutes, compare with the matched group of same time point, represent to be subjected to the analgesic effect of reagent with the minimizing of turning round the body number of times.The results are shown in Table 3 and accompanying drawing 3.The result shows, pain is upright stops similarly to morphine, and administration promptly showed significant analgesia role in 10 minutes, and heavy dose of analgesic effect can continue 4 hours, 10,30,60 minutes analgesic effects are inferior to morphine behind medicine, but 120,180,240 minutes analgesic effects are better than morphine behind medicine.Upright analgesia intensity and the analgesia time that stops of pain all has tangible dose-effect positive correlation.

Table 1 pain is upright stops pressing the tail method to cause the influence (X ± SD) of pain mice pain threshold

Time (h) the basic threshold of pain 0.1 0.5 1.0 2.0 3.0 4.0 blank groups, 6.30 6.20 6.37 6.45 6.50 6.63 6.18 (10 * 2) ± 1.11 ± 1.16 ± 1.38 ± 2.14 ± 1.85 ± 1.76 ± 1.26 morphine groups 6.23 19.00 after threshold of pain pressure (gram) administration ^*23.00 ^*17.13 ^*12.40 ^*7.33 6.53 (10 * 2) ± 1.08 ± 6.96 ^##± 4.66 ^##± 6.97 ^##± 5.40 ± 2.54 ± 2.6910mg/kg YUANHU ZHITONG PIAN 6.04 7.70 7.82 ^{* *}8.80 ^*8.12 ^*6.48 6.33 (10 * 2) ± 0.83 ± 0.98 ± 1.22 ^##± 3.61 ^##± 2.30 ± 1.15 ± 1.3612/kg is upright bitterly to stop 6.00 9.98 ^*11.59 ^*12.95 ^{* *}12.40 ^{* *}10.53 ^{* * *}(7.08 10 * 2) ± 1.07 ± 4.30 ^##± 3.86 ^##± 5.04 ^##± 4.62 ^##± 4.58 ^##± 4.9330g crude drug/kg is upright bitterly to stop 6.15 9.15 ^*10.67 ^*11.98 ^*9.08 ^*5.90 6.33 (10 * 2) ± 0.90 ± 2.68 ^##± 4.81 ^##± 5.83 ^##± 4.44 ^##± 3.31 ± 1.0415g crude drug/kg annotates: be relatively * p＜0.05 * * p＜0.01 of the animal number of elements and the basic threshold of pain in ()

Compare #p＜0.05 ##p＜0.01 with matched group

The upright influence that stops hot plate method is caused pain mice pain threshold of table 2 pain

Time (h) basis pain valve 0.1 0.5 1.0 2.0 3.0 4.0 5.0 blank groups 13.11 13.43 12.56 13.59 13.64 13.26 12.93 (8+12) ± 3.51 ± 3.51 ± 3.47 ± 3.74 ± 3.88 ± 5.34 ± 3.31 morphines (8+12) 13.40 17.20 after threshold of pain time (second) administration ^*29.82 ^*21.86 ^*16.57 ^*14.31 13.5010mg/kg ± 4.16 ± 3.65## ± 8.48 ^##± 6.51 ^##± 3.66 ^##± 3.81 ± 4.35 YUANHU ZHITONG PIAN 12.57 13.56 17.73 ^*19.57 ^*19.43 ^*14.96 13.7212/kg ± 3.85 ± 2.87 ± 5.73 ^#± 6.76 ^##± 6.33 ^##± 4.08 ± 5.01 (8+12) pain is upright stops 12.95 17.28 ^*21.06 ^*24.83 ^*26.82 ^*23.15 ^*19.14 ^*17.63 ^*30g crude drug/kg ± 5.15 ± 5.24 ^#± 8.23 ^##± 9.14 ^##± 10.96 ^##± 12.45 ^##± 8.65 ^##± 10.65 ^##(8+12) pain is upright stops 13.09 15.69 18.88 ^*21.49 ^*23.98 ^*21.65 ^*14.2915g crude drug/kg ± 4.20 ± 4.14 ± 6.14 ^##± 12.2 ^##± 7.80 ^##± 10.29 ^##± 6.49 (8+12) annotate: be relatively * p＜0.05 * * p＜0.01 of the animal number of elements and the basic threshold of pain in ()

Compare #p＜0.05 ##p＜0.01 with matched group

Table 3 pain is upright stops writhing method is caused the influence (X ± SD) of pain mice pain threshold

Turn round the body number of times in 10 minutes

Time after the administration (h) 0.1 0.5 1.0 2.0 3.0 4.0

Blank group 28.05 27.75 27.88 27.25 27.75 28.14

(48) ±1.49 ±2.19 ±1.81 ±1.83 ±1.91 ±1.35

Morphine (8) 0 ^*0 ^*0 ^*15.13 ^*19.38 ^*23.88 ^*

10mg/kg ±0 ±0 ±0 ±1.64 ±1.92 ±2.30

YUANHU ZHITONG PIAN 28.00 27.38 22.25 ^*25.38 25.50 27.14

12/kg (8) ± 3.78 ± 1.51 ± 2.6 ± 2.13 ± 1.69 ± 1.86

Pain is upright stops (8) 20.63 ^*18.50 ^*3.88 ^*10.25 ^*13.63 ^*22.25 ^*

30g crude drug/kg ± 1.41 ± 2.00 ± 1.96 ± 2.55 ± 1.77 ± 2.96

Pain is upright stops (8) 23.25 ^*18.25 ^*12.75 ^*22.63 ^*23.87 26.00

15g crude drug/kg ± 2.50 ± 3.20 ± 2.38 ± 1.69 ± 3.63 ± 3.96

Annotate: be relatively * p＜0.05 * * p＜0.01 of animal number of elements and matched group in ()

Accompanying drawing 1 " pain is upright stops " improves percentile influence to pressing the tail method to cause the pain mice threshold of pain

Accompanying drawing 2 " pain is upright stops " causes the pain mice threshold of pain to hot plate method and improves percentile influence

Accompanying drawing 3 " pain is upright stops " causes the pain mice threshold of pain to writhing method and improves percentile influence

In the accompanying drawing The blank group The morphine group The Rhizoma Corydalis group The upright heavy dose of stopping of pain Pain is stood and is stopped middle dosage The upright low dose of stopping of pain

By being subjected to reagent to the research that three kinds of pain models influence, prove that the present invention has definite analgesic effect, its analgesia characteristics are

1) onset of pain control is fast, and administration just shows tangible analgesic effect after 10 minutes.2) analgesia time is long, sustainablely reaches 3-5 hour, has surpassed the analgesia time of morphine, 3) analgesic effect is strong, and its analgesic effect is obviously greater than YUANHU ZHITONG PIAN, and it presses the analgesic effect of tail method and hot plate method similar to morphine, and the analgesic activity of writhing method is only second to morphine.Writhing method is represented visceral pain, is tonicity pathology pain, and medicine of the present invention causes sustainable 4 hours of analgesic activity bitterly to writhing method, proves that it also can be used for alleviating visceral smooth muscle angor.Experiment shows also that simultaneously analgesic effect of the present invention is positive dose-effect dependency relation.

It is 222g crude drug/kg that medicine of the present invention is measured mice median lethal dose(LD 50) (LD50) with the Bliss method, is 110 times of clinical mean effective dose, so this medicine safety range is big, toxicity is low.

More than experiment shows, medicine of the present invention can be used as the analgesic that a kind of analgesia effect is good, toxic and side effects is little and is widely used in various treatment of pain, utilize the positive dose-effect dependency of its analgesic effect also can simplify the choice of drug of WHO cancer three ladder analgesic therapies greatly, the doctor only needs to select different dosage to treat according to the strong and weak degree of patient's pain in the analgesia effective range.

The analgesic effect of the present invention in cancer pain has also obtained confirmation in clinical observation.Its methods of clinical observation and result are as follows:

1, the general material of materials and methods: 1-1

Minimum 16 years old of age, maximum 75 years old, 55.9 years old mean age, male 46 years old, women 39 years old, totally 85 examples.Primary tumor site sees Table 4.Pulmonary carcinoma is the most common, secondly is gastric cancer, hepatocarcinoma, the esophageal carcinoma, breast carcinoma, rectal cancer, cancer of pancreas.Pathological diagnosis 47 examples (55.3%), clinical diagnosis 38 examples (44.7%).III phases 24 examples (28.2%) wherein, IV phases 61 examples (71.8%).Pain degree: severe pain 27 examples (31.8%), moderate pain 39 examples (45.9%), mild pain 19 examples (22.4%).Secondly types of pain is soft tissue infiltration, osteodynia, neuralgia (seeing Table 5) based on Encelialgia.

The pain therapy history: person's 55 examples (67.4%) of not using the analgesic, used non-opium medicine person 6 examples (7.1%), used weak opiates person 18 examples (21.2%), used strong opiates person 6 examples (7.1%).

The past anticancer therapy person: 21 examples of performing the operation (24.7%), chemical 19 examples (22.4%), radiotherapy 12 examples (14.1%)

Former position of table 4 tumor

Primary tumo(u)r	Example number (%)
		Lung stomach liver oesophagus mammary gland rectum pancreas other	21(24.7％) 16(18.8％) 12(14.1％) 9(10.6％) 7(8.2％) 6(7.1％) 6(7.7％) 8(9.4％)

Table 5 types of pain

Types of pain	Example number (%)
		The Encelialgia soft tissue soaks into the osteodynia neuralgia	49(57.6％) 17(20％) 11(12.9％) 8(9.4％)

The 1-2 research method

Began to observe with primary quantity by the 1st day, 1-2 days pain does not have and alleviates that individual dose is fixed bitterly at once.

1-3 analgesic effect is observed and evaluation:

The 1-3-1 pain intensity: use 0-10 mathematics pain intensity staging promptly is marked with 0-10 on horizontal line numeral, 0 for not bitterly, 10 be the utmost point bitterly, 1-3 is a mild pain, 4-6 is a moderate pain, 7-10 is a severe pain.

1-3-2 pain relief degree: 0 degree: do not alleviate; 1 degree: slight alleviate (pain relief about 1/4); 2 degree: moderate is alleviated (pain relief about 1/2); 3 degree: obviously alleviate (pain relief is about more than 3/4); 4 degree: level is separated (pain disappearance) fully.

1-3-3 pain relief rate is meant the remission rate that moderate is above, i.e. the above person of pain relief 2 degree accounts for whole experimenters' ratio.

2, result

2-1 predose, maintenance dose and maximal dose

Predose is 12/day (4 every day 3 times); Maintenance dose is 12-18 grain/sky; Maximal dose is 18/day

The 2-2 pain degree

Pain intensity is 6 before the treatment, descends day by day after the treatment

Table 6 pain intensity

	Median	Meansigma methods	Scope
				Treatment was treated the 3rd day treatment back, back second day treatment back in back first day and was treated the back the 7th day on the 4th day before the treatment	6 4 2 2 1 1	5.29 3.21 2.57 2.14 2.07 1.86	3-8 1-6 0-5 0-5 0-4 0-3

2-3 pain relief degree:

This group pain relief degree reaches 82.4% table 7 pain relief degree

The alleviation degree	Example number (%)
		4 degree (alleviating fully), 3 degree (obviously alleviating), 2 degree (moderate alleviation), 1 degree (the slight alleviation) 0 degree (not alleviating)	18(21.1％) 33(38.8％) 19(22.4％) 11(12.9％) 4(4.7％)

Reason is ended in the 2-4 treatment

This organize have in 85 examples 59 examples due to illness the close friend change drug withdrawal, 17 examples continue to take medicine, 6 example progress are changed dressings 3 routine cause death drug withdrawals.

The 2-5 untoward reaction:

Accidental drowsiness, nauseating, dysuria are not found any obvious adverse reaction.

Clinical observation shows: medicine of the present invention has good control effect to various cancer pains, and easy to use, untoward reaction is few, and withdrawal symptom or drug dependence phenomenon appear in none example after patient's drug withdrawal.Clinical effective rate 95.3%, obvious effective rate 82.4%.

One of important innovations point of the present invention is that the herbal component that filters out has good synergism each other, it is rapid-action that it has been produced, analgesia is renderd a service strong, the good efficacy of long action time, solved for a long time and can not be widely used in clinical analgesic problem because Chinese medicine analgesic curative effect is weak, it provides a kind of new selection for clinical application.

Two of important innovations point of the present invention is selected pharmaceutical composition, not only has good curative effect, also have simultaneously toxic and side effects little, do not have addicted characteristics, it provides a kind of analgesic that can relieved use for the patient of the prolonged and repeated use analgesic of needs.

The consumption proportion scope of each component of medicine of the present invention determines that through prolonged and repeated experiment screening it has guaranteed the excellent results that the present invention had.

Embodiment 1

(1) volatile oil is extracted in preparation, takes by weighing Olibanum 2kg Myrrha 6kg, Radix Cynanchi Paniculati 3kg, and Radix Curcumae 5kg pulverized in the extraction kettle of packing into behind 40 mesh sieves, fed carbon dioxide, was 50 ℃ in temperature, and pressure is under the condition of 6Mpa, extraction volatile oil.

(2) extract Rhizoma Corydalis, Scorpio, capsicum oleoresin respectively; Take by weighing Rhizoma Corydalis 3kg, Scorpio 1kg, Fructus Capsici 1kg are placed in the independent container, add 70% alcohol dipping respectively 48 hours, collect the liquid of filtering, 60 ℃ of distilling under reduced pressure, reclaim ethanol and filter, filtrate 60-70 ℃ of evaporation and concentration to 1/5 of total amount, the ethanol that adds 10 times of amounts again, stir, leave standstill, wait precipitation fully, absorb supernatant, reclaim ethanol and be condensed into behind the thick paste shape standby 60 ℃ of distilling under reduced pressure.

3) take by weighing Radix berchemiae lineatae 5kg, Radix Aconiti Preparata 1kg, Radix Paeoniae Alba 4kg, Radix Glycyrrhizae 2kg, Rhizoma Acori Graminei 5kg, Semen Ziziphi Spinosae (parched) 2kg, Herba Asari 1kg, Radix Codonopsis 5kg, be cut into coarse grain, with medicinal residues after the extraction in above-mentioned (1) (2) step together, soaked 4 hours, decocted 2 hours, filter, leave and take filtrate after, medicinal residues add water and repeated to decoct 2 hours, filter, merge filtrate twice, behind the concentrated also precipitate with ethanol of filtrate, reconcentration is to thick extractum.

(4) the said extracted thing is merged, oven dry, pulverizing medicated powder are crossed 80 orders-100 mesh sieve;

(5) by every 0.45 gram weight capsule of packing into No. 0.

Below 4 all same examples of implementation of embodiment preparation method, just the proportioning consumption difference of each component.

Table 8 is proportional quantities of each component of embodiment 2-5.

Claims (2)

1, a kind of analgesic composition, it is characterized in that making: Radix berchemiae lineatae 2-10 part Radix Curcumae 2-6 part Radix Aconiti Preparata 1-5 part Radix Paeoniae Alba 2-12 part Radix Glycyrrhizae 0.5-5 part Rhizoma Corydalis 1-8 part by following materials of weight proportions, Rhizoma Acori Graminei 1-8 part Semen Ziziphi Spinosae (parched) 2-10 part Herba Asari 1-5 part Radix Codonopsis 1-10 part, Myrrha 2-6 part Olibanum 2-6 part Radix Cynanchi Paniculati 2-6 part Fructus Capsici 0.5-3 part, Scorpio 0.1-1.5 part.

2, pharmaceutical composition according to claim 1, it is characterized in that making: Radix berchemiae lineatae 4-8 part, Radix Curcumae 2-3 part, Radix Aconiti Preparata 1.5-3 part, Radix Paeoniae Alba 3-8 part, Radix Glycyrrhizae 1-3 part, Rhizoma Corydalis 3-8 part, Rhizoma Acori Graminei 2-5 part, Semen Ziziphi Spinosae (parched) 2-6 part, Herba Asari 1-3 part Radix Codonopsis 3-5 part, Myrrha 3-5 part, Olibanum 3-5 part, Radix Cynanchi Paniculati 2-3 part, Fructus Capsici 1-2 part, Scorpio 0.5-1.5 part by following materials of weight proportions

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