CN110801516A - 一种眼部营养喷雾液及其制备方法 - Google Patents
一种眼部营养喷雾液及其制备方法 Download PDFInfo
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- CN110801516A CN110801516A CN201911042757.6A CN201911042757A CN110801516A CN 110801516 A CN110801516 A CN 110801516A CN 201911042757 A CN201911042757 A CN 201911042757A CN 110801516 A CN110801516 A CN 110801516A
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Abstract
本发明提供一种眼部营养喷雾液及其制备方法，属于眼部喷雾液领域。该喷雾液按照重量份数计，由以下原料组成：人参提取物3‑8份、灵芝提取物3‑8份、忍冬10‑30份、密蒙花10‑30份、葛根素0.5‑2份、谷胱甘肽3‑8份、蓝莓叶黄素酯1‑5份、维生素A 1‑5份、牛磺酸1‑5份、透明质酸4‑10份、寡肽‑1 1‑5份、甘油0.5‑2份、鹿骨胶原蛋白3‑8份、甘草酸二钾0.5‑2份、羟苯甲酯0.5‑2份。本发明还提供一种眼部营养喷雾液的制备方法。该眼部营养喷雾液具有营养眼部肌肤,抗菌,缓解眼部衰老、抑制黑色素生成的功能。
Description
技术领域
本发明属于眼部喷雾液领域，具体涉及一种眼部营养喷雾液及其制备方法。
背景技术
眼部是长时间暴露在空气中的部位，同时又是人体比较脆弱的部门，长时间受到灰尘、雾霾、化妆品的侵袭难免会造成皮肤粗糙、油腻、加速衰老。现有的眼部产品有的对眼部有刺激性，而且对于改善水油平衡、清洁眼部垃圾的效果不理想。
发明内容
本发明的目的是提供一种眼部营养喷雾液及其制备方法，该眼部营养喷雾液具有营养眼部肌肤,抗菌,缓解眼部衰老、抑制黑色素生成的功能。
本发明首先提供一种眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物3-8份、灵芝提取物3-8份、忍冬10-30份、密蒙花10-30份、葛根素0.5-2份、谷胱甘肽3-8份、蓝莓叶黄素酯1-5份、维生素A1-5份、牛磺酸1-5份、透明质酸4-10份、寡肽-1 1-5份、甘油0.5-2份、鹿骨胶原蛋白3-8份、甘草酸二钾0.5-2份、羟苯甲酯0.5-2份。
优选的是，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物4-6份、灵芝提取物4-6份、忍冬15-25份、密蒙花15-25份、葛根素1-1.5份、谷胱甘肽4-6份、蓝莓叶黄素酯2-4份、维生素A 2-4份、牛磺酸2-4份、透明质酸5-8份、寡肽-1 2-4份、甘油1-1.5份、鹿骨胶原蛋白4-6份、甘草酸二钾1-1.5份、羟苯甲酯1-1.5份。
优选的是，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物5份、灵芝提取物5份、忍冬20份、密蒙花20份、葛根素1份、谷胱甘肽5份、蓝莓叶黄素酯3份、维生素A 2份、牛磺酸3份、透明质酸6份、寡肽-1 3份、甘油1份、鹿骨胶原蛋白5份、甘草酸二钾1份、羟苯甲酯1份。
本发明还提供一种眼部营养喷雾液的制备方法，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700-720MPa，溶剂为乙醇，料液比为1:15，温度120-125℃，时间为20-25分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，得到眼部营养喷雾液。
优选的是，所述的步骤一提取条件为：提取压力为700MPa，溶剂为乙醇，料液比为1:15，温度120℃，时间为20分钟。
优选的是，所述的步骤四的杀菌时间为30-40分钟。
本发明中各原料的作用如下：
人参：人参为五加科人参，属植物人参的根，其成份根中含人参皂苷0.4％，人参皂苷A、B、C、D、E和F等，还有多种维生素，多种氨基酸等。它的多种营养素，可增加细胞的活力，延迟衰老，还可抑制黑色素的产生。它的提取液是化妆品中极好的营养添加剂。
灵芝：胶原蛋白和脑酰胺的生成促进，增强了皮肤细胞新陈代谢,结合它的抗氧性，有抗皱抗衰作用；提取物可用作抗炎剂、保湿剂和皮肤美白剂。
忍冬：金银花藤又名忍冬藤，为忍冬科植物忍冬的茎叶，具有清热解毒，清经络风热的作用。应用在护肤品中具有改善皮肤炎症，抵御细菌，促进毛孔收敛，使肌肤更加细腻光滑。
密蒙花：密蒙花又名小锦花、蒙花、鸡骨头花等，具有抗炎的作用，同时，成分里的苯丙素酚苷类成分有显著的抗氧化作用，所含木樨草素有显著的抗菌作用。
葛根素：葛根中的异黄酮类成分(葛根素，大豆甙，大豆甙元，染料木素，染料木甙等)其异黄酮结构与女性体内的***相似，可以起到模拟，双向调节内分泌的作用，使体内的***保持平衡。同时葛根素能显著抑制酪氨酶的催化活性，中断黑素氧化过程，抑制黑素的发生与形成，从而防止黄褐斑、日晒斑等色素沉积。
谷胱甘肽：一种抗氧化物，从药理学角度来看，可以抗衰老，从美容进度来讲，可以祛斑防皱美白，它是人体抗氧化***中最重要的组成物质，同时可以有效抑制酪氨酸酶合成黑色素，可以积极结合体内重金属及有毒物质使之和尿液一起排出体外，具有很好的排毒功能。
蓝莓叶黄素酯：成分中的蓝莓和叶黄素，可以快速补充眼睛所需要的营养成分，从而让眼部的神经得到供给和缓解，因此在预防眼睛干涩等不良反应上有很好的作用，同时对黑眼圈和眼睛肿胀也有缓解效果。
维生素A：又叫视黄醇，维生素A具有抗衰老功效，能够刺激肌肤底层的胶原蛋白大量产生，改善细纹皱纹，同时对于皮肤塌陷型痘疤也有很好的改善作用。
牛磺酸：具有赋活肌肤细胞的能力，可源源不断地提供年轻肌肤快速与持久的能量补充与多重保护。牛磺酸同时也具有提高肌肤免疫力，抵抗外界环境对肌肤的侵袭的功效。
透明质酸：是肌肤中的一种重要成份，具有表皮组织修复的功能。当皮肤组织暴露在UVB射线下时，皮肤会晒伤、发炎，真皮组织会停止产生透明质酸，同时加快透明质酸的衰退率。透明质酸大量存在于人体的***及真皮层中，拥有强大的吸水能力和保湿功能，还能增强皮肤长时间的保水能力，能帮助弹力纤维以及胶原蛋白处在充满水分的环境中，让皮肤显的更有弹性。
寡肽-1：又称作表皮生长因子(EGF)，全称是Epidermal Growth Factor，是人体内存在的生长因子，一种小肽，由53个氨基酸残基组成，在体内体外都对多种组织细胞有强烈的促***作用。功效为：(1)皮肤紧实，提高弹性。(2)提高皮肤密度和韧性。(3)减少细纹和深纹。(4)提高亮度。(5)减少色素沉着和斑点。
甘油：一种无色无味的黏性液体，具有保湿锁水的功效。甘油使用后可以在肌肤表面形成一层保护膜，保护肌肤不受空气中的灰尘和杂质的侵害，提高肌肤免疫力，使肌肤长效保持水润。同时美白补水去眼周脂肪粒的作用。
鹿骨胶原蛋白：功效如下：
1.使皮肤保水能力增加，提高保湿效果。
2.使皮肤微血管扩张，温度上升。
3.调整皮肤表层油脂成适当量。
4.使皮肤中组织结合更为紧密。
5.使皮肤表层经常维持光滑。
甘草酸二钾：能深入皮肤内部并保持高活性，美白并高效抗氧化。有效抑制黑色素生成过程中多种酶的活性，特别是抑制酪胺酸酵素活性；同时还具有防止皮肤粗糙和抗炎、抗菌的功效。
甘草酸二钾的美白原理：
1、抑制活性氧生成：甘草酸二钾是黄酮类化合物，具有较强的抗氧化活性。有研究者用超氧化物歧化酶SOD作为对照组，结果显示甘草酸二钾可以有效抑制活性氧的生产。
2.抑制酪氨酸酶：和常用的美白原料相比，甘草酸二钾的酪氨酸酶的抑制IC50很低。
3.抑制黑色素生成：选择豚鼠的背部皮肤，在UVB照射下，经0.5％甘草酸二钾预处理的皮肤要比对照组的皮肤白色系数(L值)高，并用作用显著，实验结果显示甘草酸二钾具有显著抑制黑色素生成的作用，可用来用于晒后防止皮肤色素沉着和黑色素生成。
本发明的有益效果
本发明提供一种眼部营养喷雾液及其制备方法，该喷雾液是由人参、忍冬、密蒙花、灵芝、葛根等药材，经蒸馏、回流、浓缩、精滤、灭菌等工艺制成，其中人参提取物和灵芝提取物是采用高压提取的方法获得，提取率更高，提取时间短，且提取物更加细腻，利于吸收。本发明的喷雾仪具有抗菌,缓解眼部衰老、抑制黑色素生成的功能，产品使用方便，可随时喷一喷，无刺激性。
具体实施方式
为了进一步理解本发明，下面结合具体实施方式对本发明优选实施方案进行描述，但是应当理解，这些描述只是为进一步说明本发明的特征和优点，而不是对本发明权利要求的限制。
本发明首先提供一种眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物3-8份、灵芝提取物3-8份、忍冬10-30份、密蒙花10-30份、葛根素0.5-2份、谷胱甘肽3-8份、蓝莓叶黄素酯1-5份、维生素A1-5份、牛磺酸1-5份、透明质酸4-10份、寡肽-1 1-5份、甘油0.5-2份、鹿骨胶原蛋白3-8份、甘草酸二钾0.5-2份、羟苯甲酯0.5-2份。
优选的是，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物4-6份、灵芝提取物4-6份、忍冬15-25份、密蒙花15-25份、葛根素1-1.5份、谷胱甘肽4-6份、蓝莓叶黄素酯2-4份、维生素A 2-4份、牛磺酸2-4份、透明质酸5-8份、寡肽-1 2-4份、甘油1-1.5份、鹿骨胶原蛋白4-6份、甘草酸二钾1-1.5份、羟苯甲酯1-1.5份。
更优选的是，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物5份、灵芝提取物5份、忍冬20份、密蒙花20份、葛根素1份、谷胱甘肽5份、蓝莓叶黄素酯3份、维生素A 2份、牛磺酸3份、透明质酸6份、寡肽-1 3份、甘油1份、鹿骨胶原蛋白5份、甘草酸二钾1份、羟苯甲酯1份。
本发明还提供一种眼部营养喷雾液的制备方法，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700-720MPa，优选为700MPa，溶剂为乙醇，料液比为1:15，温度120-125℃，优选为120℃，时间为20-25分钟，优选为20分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，所述的杀菌是在高压锅中1.5个大气压，时间优选为30-40分钟，得到眼部营养喷雾液。
下面结合具体实施例对本发明做进一步详细的描述，实施例中涉及到的原料均为商购获得，其中人参提取物和灵芝提取物采用高压提取法获得。
实施例1
一种眼部营养喷雾液，由以下原料组成：
人参提取物4g、灵芝提取物4g、忍冬15g、密蒙花15g、葛根素1g、谷胱甘肽4g、蓝莓叶黄素酯2g、维生素A 2g、牛磺酸2g、透明质酸5g、寡肽-1 2g、甘油1g、鹿骨胶原蛋白4g、甘草酸二钾1g、羟苯甲酯1g。
一种眼部营养喷雾液的制备方法，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700MPa，溶剂为乙醇，料液比为1:15，温度为120℃，时间为为20分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，1.5个大气压下，时间为30分钟，得到眼部营养喷雾液。
实施例2
一种眼部营养喷雾液，由以下原料组成：
人参提取物6g、灵芝提取物6g、忍冬25g、密蒙花25g、葛根素1.5g、谷胱甘肽6g、蓝莓叶黄素酯4g、维生素A 4g、牛磺酸4g、透明质酸8g、寡肽-1 4g、甘油1.5g、鹿骨胶原蛋白6g、甘草酸二钾1.5g、羟苯甲酯1.5g。
一种眼部营养喷雾液的制备方法，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700MPa，溶剂为乙醇，料液比为1:15，温度为120℃，时间为为20分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，1.5个大气压下，时间为30分钟，得到眼部营养喷雾液。
实施例3
一种眼部营养喷雾液，由以下原料组成：
人参提取物5g、灵芝提取物5g、忍冬20g、密蒙花20g、葛根素1g、谷胱甘肽5g、蓝莓叶黄素酯3g、维生素A 2g、牛磺酸3g、透明质酸6g、寡肽-1 3g、甘油1g、鹿骨胶原蛋白5g、甘草酸二钾1g、羟苯甲酯1g。
一种眼部营养喷雾液的制备方法，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700MPa，溶剂为乙醇，料液比为1:15，温度为120℃，时间为为20分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，1.5个大气压下，时间为30分钟，得到眼部营养喷雾液。
对实施例1-3的喷雾液进行性能检测。
1、实施例1-3的喷雾液的基础检测如表1所示。
表1实施例1-3的喷雾液的性能检测结果
2、抗氧化性测定
将实施例1-3得到的喷雾液进行抗氧化性测定，结果如表2所示：
表2
| 样品 | 浓度(mg/ml) | DPPH清除率(％) |
| 实施例1 | 5 | 70.9 |
| 实施例2 | 5 | 75.8 |
| 实施例3 | 5 | 80.3 |
表2说明，本发明的眼部营养喷雾液具有良好的自由基清除能力，表明该喷雾液具有抗氧化的功效，可以延缓衰老。
3、黑色素抑制实验
将实施例1-3得到的喷雾液进行黑色素含量测定，结果如表3所示：
表3
表3说明，本发明的眼部营养喷雾液具有抑制黑色素生长的能力。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (6)
1.一种眼部营养喷雾液，其特征在于，按照重量份数计，由以下原料组成：
人参提取物3-8份、灵芝提取物3-8份、忍冬10-30份、密蒙花10-30份、葛根素0.5-2份、谷胱甘肽3-8份、蓝莓叶黄素酯1-5份、维生素A1-5份、牛磺酸1-5份、透明质酸4-10份、寡肽-1 1-5份、甘油0.5-2份、鹿骨胶原蛋白3-8份、甘草酸二钾0.5-2份、羟苯甲酯0.5-2份。
2.根据权利要求1所述的一种眼部营养喷雾液，其特征在于，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物4-6份、灵芝提取物4-6份、忍冬15-25份、密蒙花15-25份、葛根素1-1.5份、谷胱甘肽4-6份、蓝莓叶黄素酯2-4份、维生素A 2-4份、牛磺酸2-4份、透明质酸5-8份、寡肽-1 2-4份、甘油1-1.5份、鹿骨胶原蛋白4-6份、甘草酸二钾1-1.5份、羟苯甲酯1-1.5份。
3.根据权利要求1所述的一种眼部营养喷雾液，其特征在于，所述的眼部营养喷雾液，按照重量份数计，由以下原料组成：
人参提取物5份、灵芝提取物5份、忍冬20份、密蒙花20份、葛根素1份、谷胱甘肽5份、蓝莓叶黄素酯3份、维生素A 2份、牛磺酸3份、透明质酸6份、寡肽-1 3份、甘油1份、鹿骨胶原蛋白5份、甘草酸二钾1份、羟苯甲酯1份。
4.权利要求1-3任何一项所述的一种眼部营养喷雾液的制备方法，其特征在于，包括：
步骤一：将人参和灵芝分别采用高压提取的方法获得人参提取物和灵芝提取物，所述的提取压力为700-720MPa，溶剂为乙醇，料液比为1:15，温度120-125℃，时间为20-25分钟；
步骤二：将密蒙花、忍冬加水蒸馏提取，得到蒸馏液；
步骤三：将葛根素、谷胱甘肽、蓝莓叶黄素酯、维生素A、牛磺酸、透明质酸、寡肽-1、甘油、鹿骨胶原蛋白加入蒸馏液中，混合均匀，得到混合液；
步骤四：将步骤一的人参提取物和灵芝提取物加入到混合液中，混合均匀后加入甘草酸二钾和羟苯甲酯，再进行杀菌，得到眼部营养喷雾液。
5.根据权利要求4所述的一种眼部营养喷雾液的制备方法，其特征在于，所述的步骤一提取条件为：提取压力为700MPa，溶剂为乙醇，料液比为1:15，温度120℃，时间为20分钟。
6.根据权利要求4所述的一种眼部营养喷雾液的制备方法，其特征在于，所述的步骤四的杀菌时间为30-40分钟。
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