CN110791950A - 一种可溶性止血纺织材料的制作方法 - Google Patents

一种可溶性止血纺织材料的制作方法 Download PDF

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CN110791950A
CN110791950A CN201911113168.2A CN201911113168A CN110791950A CN 110791950 A CN110791950 A CN 110791950A CN 201911113168 A CN201911113168 A CN 201911113168A CN 110791950 A CN110791950 A CN 110791950A
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fiber
parts
spinning
textile material
antibacterial
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黄思美
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Cheng Cheng Garment (suzhou) Co Ltd
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Abstract

本发明公布了可溶性止血纺织材料制备技术领域的一种可溶性止血纺织材料的制作方法，首先进行纺丝原浆纤维制备和抗菌液制备，然后进行纤维膜制备，在此基础上进行抗菌纤维制备，最后将抗菌纤维用4mol/L氯乙酸反应液处理，然后用盐酸溶液调节pH至中性，最后用去离子水洗涤，即可得到止血纱布用的可溶性纺织纤维材料，纱布能够更好地和伤口贴合，提高止血纱布使用时的舒适性，制得的纤维具有优良的抗菌除臭性能，还具有良好的透气性和吸水性，提高纤维材料的可溶性，同时纺织材料具有止血功能，促进伤口愈合，避免粘连形成，提高对伤口的保护性。

Description

一种可溶性止血纺织材料的制作方法
技术领域
本发明涉及可溶性止血纺织材料制备技术领域，具体为一种可溶性止血纺织材料的制作方法。
背景技术
医用止血材料是一种重要的常用医用敷料，具有使用量大、应用面广的特点，但是，常规的止血纱布会引起换药加剧患者痛苦、废弃纱布的环境污染等问题，并且医用纱布经常是裸露在外，不可避免地会附着上各种有害细菌，所以人们在使用纱布的同时，手上会沾染很多有害细菌，医用纱布和伤口的贴合则不利于伤口的生长，因此需要医用纱布具有较好的抗菌性和防粘性，因此我们提出一种可溶性止血纺织材料的制作方法。
发明内容
本发明的目的在于提供一种可溶性止血纺织材料的制作方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：一种可溶性止血纺织材料的制作方法，此种可溶性止血纺织材料的制备原料为：
(1)纺丝原浆纤维的原材料重量份数：聚对苯二甲酸乙二醇酯100份；聚丙烯腈20～30份；有机溶剂80～100份；抗静电剂10～15份；平顺剂5～10份；聚乙烯醇20～30份；含3mol/L氢氧化钠60～75％乙醇溶液。
(2)抗菌液的原材料重量份数：葡萄糖6～10份；酵母浸膏3～5份；琼脂10～15份；蛋白胨3～5份；柠檬酸4份；硝酸锌溶液2份；硝酸银溶液2份；3％的柠檬酸三钠溶液30～40份。
(3)止血纺织材料制备时所需原材料为：4mol/L氯乙酸反应液；盐酸溶液；去离子水。
此种可溶性止血纺织材料的制作方法的具体步骤为：
A：纺丝原浆纤维制备：将聚对苯二甲酸乙二醇酯、聚丙烯腈与有机溶剂混合溶解，并在100～120度下强力搅拌溶解，搅拌时间为500～600min，制得纺丝原浆纤维半成品，然后向纺丝原浆纤维半成品中加入抗静电剂、平顺剂和聚乙烯醇，并在80～100度下强力搅拌20～40分钟，然后用含3mol/L氢氧化钠60～75％乙醇溶液在40～60度下活化3～5小时，制得纺丝原浆纤维；
B：抗菌液制备：
首先将葡萄糖、酵母浸膏、琼脂、蛋白胨、去离子水混合均匀，并用柠檬酸调节pH为5.0-6.0；然后溶液经过高温灭菌后得到发酵培养基，再按接种量5-8％将木醋杆菌接种至发酵培养基中，在30度恒温培养箱中培养8-10天，取出凝胶状产物，得到细菌纤维素水凝胶膜；将细菌纤维素水凝胶膜多次浸泡在硝酸银、硝酸锌溶液中并混合均匀，再以2mL/min滴加质量分数为3％柠檬酸三钠溶液，得到银锌抗菌液；
C：纤维膜制备：将纺丝原浆纤维通过泵缓慢注入到纺丝原料罐中，同时以10r/s的速率缓慢增加至100r/s直至恒速，再将离心式纺丝机离心罐的纺丝孔打开，在重力和离心力作用下，纺丝原浆纤维经离心纺丝后得到纤维膜；
D：抗菌纤维制备：将纤维膜置于真空度为0.1MPa，温度为120-145度的真空干燥箱中干燥4h，得到干燥的纤维膜，然后将干燥的纤维膜通过95～97度热水清洗并冷却，通过抗菌液沐浴后再次置于真空干燥箱中干燥6h，即可制得抗菌纤维丝，然后将抗菌纤维丝经上油处理后制得抗菌纤维；
E：将抗菌纤维用40～60度的4mol/L氯乙酸反应液处理4～8小时，然后用盐酸溶液调节pH至6.5～7.5，最后用去离子水洗涤，即可得到止血纱布用的可溶性纺织纤维材料。
优选的，抗静电剂为脂肪酸甘油酯和聚乙二醇按重量比2：1的混合物，平顺剂为脂肪酸聚氧乙烯醇，有机溶剂为二甲基甲酰胺，聚乙烯醇的分子量为30000～35000。
优选的，步骤C中泵供量为1～1.5g/min，喷丝头为60～80孔.
优选的，步骤D中纤维膜通过热水清洗时的速率为3～5m/min，步骤D中纤维膜通过抗菌液浴时的速率为2～3m/min。
优选的，步骤A中制得纺丝原浆纤维后，取纺丝原浆纤维并平铺于具有加热和干燥功能的玻璃板上，然后取用氧化再生纤维素平铺在纺丝原浆纤维上，再取医用高分子材料，溶解后均匀倒在纺丝原浆纤维上面，用刮刀刮平，在温度为50-70度下，干燥4小时，干燥之后取下来进行消毒以留备用。
优选的，医用高分子材料是聚乳酸、医用几丁糖或胶原蛋白中的任意一种或两种及两种以上。
优选的，氧化再生纤维素是以棉、精制棉、脱脂棉、脱脂棉纱布以及以棉为原料的纺织品，或者是以棉或木浆为原料的单一或混合制成再生纤维、粘胶纤维，以及以再生纤维、粘胶纤维为原料经过可控氧化处理并能被人体吸收的多糖材料。
与现有技术相比，本发明的有益效果是：
1.该发明制备原料中的平顺剂能够使得制得的纤维表面毛刺更少、更加平顺，使其具有更好的纺织性能；增加助剂的同时还添加量一定量的聚丙烯腈，能够改善涤纶纤维的手感，使其手感不至于太生硬，以便于纺织完成的纱布能够更好地和伤口贴合，提高止血纱布使用时的舒适性；
2.本发明中的纤维的抗菌性能是通过纤维中吸附具有抗菌作用的抗菌液，随后再通过真空烘干燥箱制得，为了增进纤维的吸附性能，先需要在纤维中制造出丰富的孔洞结构，具体来说就是在纺丝原料中添加一部分能够在后续步骤中能够被去除的组分，本发明中选用的是聚乙烯醇，聚乙烯醇是一种可溶于水的高分子聚合物，其在热水中溶解度较高，提高纤维材料的可溶性；
3.将抗菌液与纺丝液混合纺丝，制得的纤维具有优良的抗菌除臭性能，本发明的抗菌液具有良好的吸水性和生物相容性，具有持久、高效的杀菌特点，利用抗菌液制得的抗菌纤维还具有良好的透气性和吸水性，同时纺织材料具有止血功能，促进伤口愈合，避免粘连形成。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种可溶性止血纺织材料的制作方法，此种可溶性止血纺织材料的制备原料为：
(1)纺丝原浆纤维的原材料重量份数：聚对苯二甲酸乙二醇酯100份；聚丙烯腈20～30份；有机溶剂80～100份；抗静电剂10～15份；平顺剂5～10份；聚乙烯醇20～30份；含3mol/L氢氧化钠60～75％乙醇溶液。
(2)抗菌液的原材料重量份数：葡萄糖6～10份；酵母浸膏3～5份；琼脂10～15份；蛋白胨3～5份；柠檬酸4份；硝酸锌溶液2份；硝酸银溶液2份；3％的柠檬酸三钠溶液30～40份。
(3)止血纺织材料制备时所需原材料为：4mol/L氯乙酸反应液；盐酸溶液；去离子水。
此种可溶性止血纺织材料的制作方法的具体步骤为：
A：纺丝原浆纤维制备：将聚对苯二甲酸乙二醇酯、聚丙烯腈与有机溶剂混合溶解，并在100度下强力搅拌溶解，搅拌时间为500min，制得纺丝原浆纤维半成品，然后向纺丝原浆纤维半成品中加入抗静电剂、平顺剂和聚乙烯醇，并在80度下强力搅拌40分钟，然后用含3mol/L氢氧化钠75％乙醇溶液在40度下活化4小时，制得纺丝原浆纤维；
B：抗菌液制备：
首先将葡萄糖、酵母浸膏、琼脂、蛋白胨、去离子水混合均匀，并用柠檬酸调节pH为5.0；然后溶液经过高温灭菌后得到发酵培养基，再按接种量8％将木醋杆菌接种至发酵培养基中，在30度恒温培养箱中培养10天，取出凝胶状产物，得到细菌纤维素水凝胶膜；将细菌纤维素水凝胶膜多次浸泡在硝酸银、硝酸锌溶液中并混合均匀，再以2mL/min滴加质量分数为3％柠檬酸三钠溶液，得到银锌抗菌液；
C：纤维膜制备：将纺丝原浆纤维通过泵缓慢注入到纺丝原料罐中，同时以10r/s的速率缓慢增加至100r/s直至恒速，再将离心式纺丝机离心罐的纺丝孔打开，在重力和离心力作用下，纺丝原浆纤维经离心纺丝后得到纤维膜；
D：抗菌纤维制备：将纤维膜置于真空度为0.1MPa，温度为145度的真空干燥箱中干燥4h，得到干燥的纤维膜，然后将干燥的纤维膜通过95度热水清洗并冷却，通过抗菌液沐浴后再次置于真空干燥箱中干燥6h，即可制得抗菌纤维丝，然后将抗菌纤维丝经上油处理后制得抗菌纤维；
E：将抗菌纤维用60度的4mol/L氯乙酸反应液处理8小时，然后用盐酸溶液调节pH至7.0，最后用去离子水洗涤，即可得到止血纱布用的可溶性纺织纤维材料。
利用市面上普通的止血材料制成的纱布和本产品制成的纱布进行实际伤口包扎测试，测试结果表如下：
Figure BDA0002273332120000061
实验数据分析：本产品相较于市面上普通的止血纱布封堵压力更大，封堵时间更短，同时出血量更少，减少血液的外流，对于伤口有较好的恢复效果，同时该产品制成的纱布使用量越大，对伤口的封堵压力更大，出血量更少，并且但凡使用该产片制成的纱布都可以在伤口痊愈后，能够较完整的去除纱布，并且对伤口没有影响，使得伤口痊愈效果更好，同时便于纺织完成的纱布能够更好地和伤口贴合，提高止血纱布使用时的舒适性，另外，此种纱布具有良好的透气性和吸水性，同时纺织材料具有止血功能，促进伤口愈合，避免粘连形成。
实施例2
一种可溶性止血纺织材料的制作方法，此种可溶性止血纺织材料的制备原料为：
(1)纺丝原浆纤维的原材料重量份数：聚对苯二甲酸乙二醇酯100份；聚丙烯腈20～30份；有机溶剂80～100份；抗静电剂10～15份；平顺剂5～10份；聚乙烯醇20～30份；含3mol/L氢氧化钠60～75％乙醇溶液。
(2)抗菌液的原材料重量份数：葡萄糖6～10份；酵母浸膏3～5份；琼脂10～15份；蛋白胨3～5份；柠檬酸4份；硝酸锌溶液2份；硝酸银溶液2份；3％的柠檬酸三钠溶液30～40份。
(3)止血纺织材料制备时所需原材料为：4mol/L氯乙酸反应液；盐酸溶液；去离子水。
此种可溶性止血纺织材料的制作方法的具体步骤为：
A：纺丝原浆纤维制备：将聚对苯二甲酸乙二醇酯、聚丙烯腈与有机溶剂混合溶解，并在120度下强力搅拌溶解，搅拌时间为600min，制得纺丝原浆纤维半成品，然后向纺丝原浆纤维半成品中加入抗静电剂、平顺剂和聚乙烯醇，并在100度下强力搅拌30分钟，然后用含3mol/L氢氧化钠60％乙醇溶液在40度下活化4小时，制得纺丝原浆纤维；
B：抗菌液制备：
首先将葡萄糖、酵母浸膏、琼脂、蛋白胨、去离子水混合均匀，并用柠檬酸调节pH为5.0；然后溶液经过高温灭菌后得到发酵培养基，再按接种量8％将木醋杆菌接种至发酵培养基中，在30度恒温培养箱中培养10天，取出凝胶状产物，得到细菌纤维素水凝胶膜；将细菌纤维素水凝胶膜多次浸泡在硝酸银、硝酸锌溶液中并混合均匀，再以2mL/min滴加质量分数为3％柠檬酸三钠溶液，得到银锌抗菌液；
C：纤维膜制备：将纺丝原浆纤维通过泵缓慢注入到纺丝原料罐中，同时以10r/s的速率缓慢增加至100r/s直至恒速，再将离心式纺丝机离心罐的纺丝孔打开，在重力和离心力作用下，纺丝原浆纤维经离心纺丝后得到纤维膜；
D：抗菌纤维制备：将纤维膜置于真空度为0.1MPa，温度为145度的真空干燥箱中干燥4h，得到干燥的纤维膜，然后将干燥的纤维膜通过95度热水清洗并冷却，通过抗菌液沐浴后再次置于真空干燥箱中干燥6h，即可制得抗菌纤维丝，然后将抗菌纤维丝经上油处理后制得抗菌纤维；
E：将抗菌纤维用60度的4mol/L氯乙酸反应液处理8小时，然后用盐酸溶液调节pH至7.0，最后用去离子水洗涤，即可得到止血纱布用的可溶性纺织纤维材料。
利用市面上普通的止血材料制成的纱布和本产品制成的纱布进行实际伤口包扎测试，测试结果表如下：
Figure BDA0002273332120000081
Figure BDA0002273332120000091
实验数据分析：本产品相较于市面上普通的止血纱布封堵压力更大，封堵时间更短，同时出血量更少，减少血液的外流，对于伤口有较好的恢复效果，同时该产品制成的纱布使用量越大，对伤口的封堵压力更大，出血量更少，并且但凡使用该产片制成的纱布都可以在伤口痊愈后，能够较完整的去除纱布，并且对伤口没有影响，使得伤口痊愈效果更好，同时便于纺织完成的纱布能够更好地和伤口贴合，提高止血纱布使用时的舒适性，另外，此种纱布具有良好的透气性和吸水性，同时纺织材料具有止血功能，促进伤口愈合，避免粘连形成。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。

Claims (8)

1.一种可溶性止血纺织材料的制作方法，其特征在于：此种可溶性止血纺织材料的制备原料为：
(1)纺丝原浆纤维的原材料重量份数：聚对苯二甲酸乙二醇酯100份；聚丙烯腈20～30份；有机溶剂80～100份；抗静电剂10～15份；平顺剂5～10份；聚乙烯醇20～30份；含3mol/L氢氧化钠60～75％乙醇溶液。
(2)抗菌液的原材料重量份数：葡萄糖6～10份；酵母浸膏3～5份；琼脂10～15份；蛋白胨3～5份；柠檬酸4份；硝酸锌溶液2份；硝酸银溶液2份；3％的柠檬酸三钠溶液30～40份。
(3)止血纺织材料制备时所需原材料为：4mol/L氯乙酸反应液；盐酸溶液；去离子水。
2.根据权利要求1所述的一种可溶性止血纺织材料的制作方法，其特征在于：此种可溶性止血纺织材料的制作方法的具体步骤为：
A：纺丝原浆纤维制备：将聚对苯二甲酸乙二醇酯、聚丙烯腈与有机溶剂混合溶解，并在100～120度下强力搅拌溶解，搅拌时间为500～600min，制得纺丝原浆纤维半成品，然后向纺丝原浆纤维半成品中加入抗静电剂、平顺剂和聚乙烯醇，并在80～100度下强力搅拌20～40分钟，然后用含3mol/L氢氧化钠60～75％乙醇溶液在40～60度下活化3～5小时，制得纺丝原浆纤维；
B：抗菌液制备：
首先将葡萄糖、酵母浸膏、琼脂、蛋白胨、去离子水混合均匀，并用柠檬酸调节pH为5.0-6.0；然后溶液经过高温灭菌后得到发酵培养基，再按接种量5-8％将木醋杆菌接种至发酵培养基中，在30度恒温培养箱中培养8-10天，取出凝胶状产物，得到细菌纤维素水凝胶膜；将细菌纤维素水凝胶膜多次浸泡在硝酸银、硝酸锌溶液中并混合均匀，再以2mL/min滴加质量分数为3％柠檬酸三钠溶液，得到银锌抗菌液；
C：纤维膜制备：将纺丝原浆纤维通过泵缓慢注入到纺丝原料罐中，同时以10r/s的速率缓慢增加至100r/s直至恒速，再将离心式纺丝机离心罐的纺丝孔打开，在重力和离心力作用下，纺丝原浆纤维经离心纺丝后得到纤维膜；
D：抗菌纤维制备：将纤维膜置于真空度为0.1MPa，温度为120-145度的真空干燥箱中干燥4h，得到干燥的纤维膜，然后将干燥的纤维膜通过95～97度热水清洗并冷却，通过抗菌液沐浴后再次置于真空干燥箱中干燥6h，即可制得抗菌纤维丝，然后将抗菌纤维丝经上油处理后制得抗菌纤维；
E：将抗菌纤维用40～60度的4mol/L氯乙酸反应液处理4～8小时，然后用盐酸溶液调节pH至6.5～7.5，最后用去离子水洗涤，即可得到止血纱布用的可溶性纺织纤维材料。
3.根据权利要求1所述的一种可溶性止血纺织材料的制作方法，其特征在于：抗静电剂为脂肪酸甘油酯和聚乙二醇按重量比2：1的混合物，平顺剂为脂肪酸聚氧乙烯醇，有机溶剂为二甲基甲酰胺，聚乙烯醇的分子量为30000～35000。
4.根据权利要求2所述的一种可溶性止血纺织材料的制作方法，其特征在于：步骤C中泵供量为1～1.5g/min，喷丝头为60～80孔。
5.根据权利要求2所述的一种可溶性止血纺织材料的制作方法，其特征在于：步骤D中纤维膜通过热水清洗时的速率为3～5m/min，步骤D中纤维膜通过抗菌液浴时的速率为2～3m/min。
6.根据权利要求2所述的一种可溶性止血纺织材料的制作方法，其特征在于：步骤A中制得纺丝原浆纤维后，取纺丝原浆纤维并平铺于具有加热和干燥功能的玻璃板上，然后取用氧化再生纤维素平铺在纺丝原浆纤维上，再取医用高分子材料，溶解后均匀倒在纺丝原浆纤维上面，用刮刀刮平，在温度为50-70度下，干燥4小时，干燥之后取下来进行消毒以留备用。
7.根据权利要求6所述的一种可溶性止血纺织材料的制作方法，其特征在于：医用高分子材料是聚乳酸、医用几丁糖或胶原蛋白中的任意一种或两种及两种以上。
8.根据权利要求6所述的一种可溶性止血纺织材料的制作方法，其特征在于：氧化再生纤维素是以棉、精制棉、脱脂棉、脱脂棉纱布以及以棉为原料的纺织品，或者是以棉或木浆为原料的单一或混合制成再生纤维、粘胶纤维，以及以再生纤维、粘胶纤维为原料经过可控氧化处理并能被人体吸收的多糖材料。
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Cited By (3)

* Cited by examiner, † Cited by third party
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CN112353996A (zh) * 2020-11-24 2021-02-12 江西美宝利医用敷料有限公司 一种可溶性止血纱布的制作方法
CN112370566A (zh) * 2020-11-24 2021-02-19 江西美宝利医用敷料有限公司 一种仿生材料止血纱布制备工艺
CN114887111A (zh) * 2022-03-28 2022-08-12 四川大学 一种可生物吸收的复合止血材料及其制备方法与应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112353996A (zh) * 2020-11-24 2021-02-12 江西美宝利医用敷料有限公司 一种可溶性止血纱布的制作方法
CN112370566A (zh) * 2020-11-24 2021-02-19 江西美宝利医用敷料有限公司 一种仿生材料止血纱布制备工艺
CN114887111A (zh) * 2022-03-28 2022-08-12 四川大学 一种可生物吸收的复合止血材料及其制备方法与应用

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